TB10C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TB10C_HUMAN
• UniProt AC: Q8IV04
• Protein Name: Carabin
• Gene Name: TBC1D10C
• Organism: Homo sapiens (Human).
• Sequence Length: 446
• Protein Description: Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras..
• Protein Sequence: MAQALGEDLVQPPELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQLPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRPQRGSTSFLDTRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	PPELQDDSSSLGSDS CCCCCCCCCCCCCCC	30.07	30108239
20	Phosphorylation	PELQDDSSSLGSDSE CCCCCCCCCCCCCCH	36.25	30108239
21	Phosphorylation	ELQDDSSSLGSDSEL CCCCCCCCCCCCCHH	40.47	30108239
24	Phosphorylation	DDSSSLGSDSELSGP CCCCCCCCCCHHCCC	43.17	30108239
26	Phosphorylation	SSSLGSDSELSGPGP CCCCCCCCHHCCCCC	41.98	30108239
29	Phosphorylation	LGSDSELSGPGPYRQ CCCCCHHCCCCCCCC	38.60	30108239
40	Phosphorylation	PYRQADRYGFIGGSS CCCCCCCCCCCCCCC	19.55	27642862
46	Phosphorylation	RYGFIGGSSAEPGPG CCCCCCCCCCCCCCC	22.59	29978859
47	Phosphorylation	YGFIGGSSAEPGPGH CCCCCCCCCCCCCCC	39.67	29978859
66	Ubiquitination	LIRQREMKWVEMTSH HHHHHHCCHHHHCHH	43.25	-
71	Phosphorylation	EMKWVEMTSHWEKTM HCCHHHHCHHHHHHH	12.16	30631047
72	Phosphorylation	MKWVEMTSHWEKTMS CCHHHHCHHHHHHHH	25.87	30631047
76	Ubiquitination	EMTSHWEKTMSRRYK HHCHHHHHHHHHHHH	44.32	-
77	Phosphorylation	MTSHWEKTMSRRYKK HCHHHHHHHHHHHHH	14.63	-
79	Phosphorylation	SHWEKTMSRRYKKVK HHHHHHHHHHHHHHH	20.88	30631047
91	Ubiquitination	KVKMQCRKGIPSALR HHHHHHHCCCCHHHH	69.67	29967540
268	Phosphorylation	ARSLPFPTVLRVWDA HHCCCCCHHHHHHHH	32.33	-
347	Ubiquitination	RDLQREIKAQLAQLP HHHHHHHHHHHHCCC	25.90	-
388	Ubiquitination	AGVRRGAKPEVPRIV HCCCCCCCCCCCEEE	44.53	-
414	Ubiquitination	RKPQTRGKTFHGLLT CCCCCCCCCHHHHHH	44.73	-
415	Phosphorylation	KPQTRGKTFHGLLTR CCCCCCCCHHHHHHH	24.56	26657352
421	Phosphorylation	KTFHGLLTRARGPPI CCHHHHHHHCCCCCC	27.59	27251275
424	Methylation	HGLLTRARGPPIEGP HHHHHHCCCCCCCCC	55.66	115387557
438	Phosphorylation	PPRPQRGSTSFLDTR CCCCCCCCCCCCCCC	24.06	23401153
439	Phosphorylation	PRPQRGSTSFLDTRF CCCCCCCCCCCCCCC	26.73	20058876
440	Phosphorylation	RPQRGSTSFLDTRF- CCCCCCCCCCCCCC-	26.05	28450419
444	Phosphorylation	GSTSFLDTRF----- CCCCCCCCCC-----	35.80	23684312

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TB10C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TB10C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TB10C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.