CF206_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CF206_HUMAN
• UniProt AC: Q8IYR0
• Protein Name: Cilia- and flagella-associated protein 206 {ECO:0000305}
• Gene Name: CFAP206 {ECO:0000312|HGNC:HGNC:21405}
• Organism: Homo sapiens (Human).
• Sequence Length: 622
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme .
• Protein Description: May regulate cilium motility through its role in the assembly of the axonemal radial spokes..
• Protein Sequence: MPPTQAESVIRSIIREIGQECAAHGEIVSETLIAFMVKAVVLDPSNGFNMDRTLMKSDVQNLVKLCMTRLLDTKNPSLDTIKMQVYFDMNYTNRVEFLEEHHRVLESRLGSVTREITDNRACAKEELESLYRKIISYVLLRSGLGSPTDIKTVREVTAALQSVFPQAELGTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAVLHVAIPATMQHIDYQLETARSQVYRYTAILEKAANDPLMRAELQPYMLKEALYNIRQYEVFLQIILSDIITGAQEVEMMTKQLGAHLEQLKMTIKSKIAVPTSQVFPIFIALSTLWTSLQDETIVVGVLSNLFTHIQPFLGAHELYFPERVMQCHLNGATVKTDVCRMKEHMEDRVNVADFRKLEWLFPETTANFDKLLIQYRGFCAYTFAATDGLLLPGNPAIGILKYKEKYYTFNSKDAAYSFAENPEHYIDIVREKAKKNTELIQLLELHQQFETFIPYSQMRDADKHYIKPITKCESSTQTNTHILPPTIVRSYEWNEWELRRKAIKLANLRQKVTHSVQTDLSHLRRENCSQVYPPKDTSTQSMREDSTGVPRPQIYLAGLRGGKSEITDEVKVNLTRDVDET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	O-linked_Glycosylation	MPPTQAESVIRSIIR CCHHHHHHHHHHHHH		30379171
53	Phosphorylation	NGFNMDRTLMKSDVQ CCCCCCCHHHHHHHH		-
57	Phosphorylation	MDRTLMKSDVQNLVK CCCHHHHHHHHHHHH		-
111	Phosphorylation	VLESRLGSVTREITD HHHHHHHHHHHHHHC		18491316
113	Phosphorylation	ESRLGSVTREITDNR HHHHHHHHHHHHCCC		18491316
131	Phosphorylation	KEELESLYRKIISYV HHHHHHHHHHHHHHH		-
136	Phosphorylation	SLYRKIISYVLLRSG HHHHHHHHHHHHHCC		30622161
137	Phosphorylation	LYRKIISYVLLRSGL HHHHHHHHHHHHCCC		30622161
148	Phosphorylation	RSGLGSPTDIKTVRE HCCCCCCCCHHHHHH		-
232	Phosphorylation	HIDYQLETARSQVYR HHHHHHHHHHHHHHH		-
235	Phosphorylation	YQLETARSQVYRYTA HHHHHHHHHHHHHHH		-
272	Phosphorylation	ALYNIRQYEVFLQII HHHHHHHHHHHHHHH		24043423
281	Phosphorylation	VFLQIILSDIITGAQ HHHHHHHHHHHCCHH		24043423
285	Phosphorylation	IILSDIITGAQEVEM HHHHHHHCCHHHHHH		24043423
294	Phosphorylation	AQEVEMMTKQLGAHL HHHHHHHHHHHHHHH		24043423
531	Phosphorylation	LPPTIVRSYEWNEWE CCCEEEEECCCCHHH		25693802
545	Ubiquitination	ELRRKAIKLANLRQK HHHHHHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CF206_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CF206_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CF206_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CF206_HUMAN	C6orf165	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
ZBT32_HUMAN	ZBTB32	physical	21516116
CA094_HUMAN	C1orf94	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.