ZBT32_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT32_HUMAN
• UniProt AC: Q9Y2Y4
• Protein Name: Zinc finger and BTB domain-containing protein 32
• Gene Name: ZBTB32
• Organism: Homo sapiens (Human).
• Sequence Length: 487
• Subcellular Localization: Nucleus . Located in nuclear speckles.
• Protein Description: DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity)..
• Protein Sequence: MSLPPIRLPSPYGSDRLVQLAARLRPALCDTLITVGSQEFPAHSLVLAGVSQQLGRRGQWALGEGISPSTFAQLLNFVYGESVELQPGELRPLQEAARALGVQSLEEACWRARGDRAKKPDPGLKKHQEEPEKPSRNPERELGDPGEKQKPEQVSRTGGREQEMLHKHSPPRGRPEMAGATQEAQQEQTRSKEKRLQAPVGQRGADGKHGVLTWLRENPGGSEESLRKLPGPLPPAGSLQTSVTPRPSWAEAPWLVGGQPALWSILLMPPRYGIPFYHSTPTTGAWQEVWREQRIPLSLNAPKGLWSQNQLASSSPTPGSLPQGPAQLSPGEMEESDQGHTGALATCAGHEDKAGCPPRPHPPPAPPARSRPYACSVCGKRFSLKHQMETHYRVHTGEKPFSCSLCPQRSRDFSAMTKHLRTHGAAPYRCSLCGAGCPSLASMQAHMRGHSPSQLPPGWTIRSTFLYSSSRPSRPSTSPCCPSSSTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLPPIRLP ------CCCCCCCCC	49.97	23663014
10	Phosphorylation	LPPIRLPSPYGSDRL CCCCCCCCCCCHHHH	35.03	23663014
12	Phosphorylation	PIRLPSPYGSDRLVQ CCCCCCCCCHHHHHH	33.33	23663014
14	Phosphorylation	RLPSPYGSDRLVQLA CCCCCCCHHHHHHHH	17.45	23663014
169	Phosphorylation	QEMLHKHSPPRGRPE HHHHHHCCCCCCCHH	41.21	30108239
213	Phosphorylation	DGKHGVLTWLRENPG CCCCCEEEEHHHCCC	21.75	18785766
373	Phosphorylation	PPARSRPYACSVCGK CCCCCCCEEEEECCC	21.09	20090780
396	Phosphorylation	ETHYRVHTGEKPFSC EEEEEEECCCCCCCC	44.15	29449344
402	Phosphorylation	HTGEKPFSCSLCPQR ECCCCCCCCEECCCC	16.01	29449344
404	Phosphorylation	GEKPFSCSLCPQRSR CCCCCCCEECCCCCC	31.63	29449344
410	Phosphorylation	CSLCPQRSRDFSAMT CEECCCCCCCHHHHH	30.84	29449344
417	Phosphorylation	SRDFSAMTKHLRTHG CCCHHHHHHHHHHHC	18.28	28290473
451	Phosphorylation	QAHMRGHSPSQLPPG HHHHCCCCHHHCCCC	29.13	30108239
453	Phosphorylation	HMRGHSPSQLPPGWT HHCCCCHHHCCCCCE	47.57	28348404
476	Phosphorylation	SSRPSRPSTSPCCPS CCCCCCCCCCCCCCC	40.17	30576142
477	Phosphorylation	SRPSRPSTSPCCPSS CCCCCCCCCCCCCCC	39.09	30108239
478	Phosphorylation	RPSRPSTSPCCPSSS CCCCCCCCCCCCCCC	21.93	30108239
483	Phosphorylation	STSPCCPSSSTT--- CCCCCCCCCCCC---	24.01	30108239
484	Phosphorylation	TSPCCPSSSTT---- CCCCCCCCCCC----	19.49	30576142
485	Phosphorylation	SPCCPSSSTT----- CCCCCCCCCC-----	40.16	30108239
486	Phosphorylation	PCCPSSSTT------ CCCCCCCCC------	38.17	30576142
487	Phosphorylation	CCPSSSTT------- CCCCCCCC-------	38.26	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBT32_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBT32_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT32_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHXF2_HUMAN	RHOXF2	physical	16189514
FANCC_HUMAN	FANCC	physical	10572087
ZBT16_HUMAN	ZBTB16	physical	10572087
ZN490_HUMAN	ZNF490	physical	20211142
ANDR_HUMAN	AR	physical	20147518
RHXF2_HUMAN	RHOXF2	physical	19447967
FMOD_HUMAN	FMOD	physical	25011449
RHXF2_HUMAN	RHOXF2	physical	25416956
PRDM1_HUMAN	PRDM1	physical	22851713

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.