| UniProt ID | ZBT16_HUMAN | |
|---|---|---|
| UniProt AC | Q05516 | |
| Protein Name | Zinc finger and BTB domain-containing protein 16 | |
| Gene Name | ZBTB16 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 673 | |
| Subcellular Localization | Nucleus . Nucleus, Nuclear body . | |
| Protein Description | Acts as a transcriptional repressor. [PubMed: 24359566 May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins] | |
| Protein Sequence | MDLTKMGMIQLQNPSHPTGLLCKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLSPKTFQQILEYAYTATLQAKAEDLDDLLYAAEILEIEYLEEQCLKMLETIQASDDNDTEATMADGGAEEEEDRKARYLKNIFISKHSSEESGYASVAGQSLPGPMVDQSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQGTLQPPAGPEEPTLAGGGRHPGVAEVKTEMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVITSARELHYGREESAEQVPPPAEAGQAPTGRPEHPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGLHVQPALAVSMDFSTYGGLLPQGFIQRELFSKLGELAVGMKSESRTIGEQCSVCGVELPDNEAVEQHRKLHSGMKTYGCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSSMQKHMKGHKPEEIPPDWRIEKTYLYLCYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 76 | Phosphorylation | HYTLDFLSPKTFQQI CEEEECCCHHHHHHH | 25.09 | - | |
| 128 | Phosphorylation | MLETIQASDDNDTEA HHHHHHCCCCCCCHH | 29.17 | 30576142 | |
| 133 | Phosphorylation | QASDDNDTEATMADG HCCCCCCCHHHHCCC | 33.50 | 30576142 | |
| 154 | Ubiquitination | DRKARYLKNIFISKH HHHHHHHHHHEEECC | 38.78 | - | |
| 184 | Phosphorylation | PGPMVDQSPSVSTSF CCCCCCCCCCCCCCC | 18.06 | - | |
| 190 | Phosphorylation | QSPSVSTSFGLSAMS CCCCCCCCCCCCCCC | 15.15 | 26074081 | |
| 194 | Phosphorylation | VSTSFGLSAMSPTKA CCCCCCCCCCCCCHH | 23.46 | 26074081 | |
| 197 | Phosphorylation | SFGLSAMSPTKAAVD CCCCCCCCCCHHHHH | 29.18 | 18246121 | |
| 199 | Phosphorylation | GLSAMSPTKAAVDSL CCCCCCCCHHHHHHH | 26.47 | 26074081 | |
| 242 | Sumoylation | HPGVAEVKTEMMQVD CCCCHHHEECEECCC | 30.21 | - | |
| 242 | Sumoylation | HPGVAEVKTEMMQVD CCCCHHHEECEECCC | 30.21 | - | |
| 253 | Phosphorylation | MQVDEVPSQDSPGAA ECCCCCCCCCCCCHH | 52.36 | 22115753 | |
| 256 | Phosphorylation | DEVPSQDSPGAAESS CCCCCCCCCCHHHCH | 20.00 | 30576142 | |
| 282 | Phosphorylation | RGKEGPGTPTRSSVI CCCCCCCCCCHHHHH | 25.31 | 30576142 | |
| 284 | Phosphorylation | KEGPGTPTRSSVITS CCCCCCCCHHHHHHH | 42.92 | 22115753 | |
| 286 | Phosphorylation | GPGTPTRSSVITSAR CCCCCCHHHHHHHCC | 31.28 | 22115753 | |
| 287 | Phosphorylation | PGTPTRSSVITSARE CCCCCHHHHHHHCCH | 17.78 | 22115753 | |
| 290 | Phosphorylation | PTRSSVITSARELHY CCHHHHHHHCCHHHC | 17.74 | 22115753 | |
| 291 | Phosphorylation | TRSSVITSARELHYG CHHHHHHHCCHHHCC | 17.76 | 22115753 | |
| 334 | Phosphorylation | PEKHLGIYSVLPNHK CHHCCCEEEECCCCC | 7.31 | 27642862 | |
| 386 | Phosphorylation | FIQRELFSKLGELAV HHHHHHHHHHCHHHH | 39.33 | 24719451 | |
| 387 | Methylation | IQRELFSKLGELAVG HHHHHHHHHCHHHHC | 53.85 | - | |
| 387 | Sumoylation | IQRELFSKLGELAVG HHHHHHHHHCHHHHC | 53.85 | - | |
| 387 | "N6,N6-dimethyllysine" | IQRELFSKLGELAVG HHHHHHHHHCHHHHC | 53.85 | - | |
| 396 | Methylation | GELAVGMKSESRTIG CHHHHCCCCCCCCHH | 45.18 | - | |
| 396 | Sumoylation | GELAVGMKSESRTIG CHHHHCCCCCCCCHH | 45.18 | - | |
| 396 | "N6,N6-dimethyllysine" | GELAVGMKSESRTIG CHHHHCCCCCCCCHH | 45.18 | - | |
| 401 | Phosphorylation | GMKSESRTIGEQCSV CCCCCCCCHHCCCCC | 42.48 | 18452278 | |
| 407 | Phosphorylation | RTIGEQCSVCGVELP CCHHCCCCCCCCCCC | 21.82 | 18452278 | |
| 455 | Phosphorylation | RMHLLAHSAGAKAFV HHHHHHHHCCCCEEE | 23.84 | 24247654 | |
| 562 | Acetylation | FRDESTLKSHKRIHT CCCHHHHHCCCCCCC | 51.07 | 15964811 | |
| 565 | Acetylation | ESTLKSHKRIHTGEK HHHHHCCCCCCCCCC | 61.20 | 15964811 | |
| 569 | Phosphorylation | KSHKRIHTGEKPYEC HCCCCCCCCCCCEEC | 44.67 | 20736484 | |
| 597 | Phosphorylation | ETHYRVHTGEKPFEC EEEEEECCCCCCEEC | 44.15 | - | |
| 628 | Phosphorylation | LRTHNGASPYQCTIC HHHCCCCCCCCCEEC | 26.07 | - | |
| 630 | Phosphorylation | THNGASPYQCTICTE HCCCCCCCCCEECHH | 17.45 | - | |
| 647 | Acetylation | PSLSSMQKHMKGHKP CCHHHHHHHHCCCCC | 36.70 | 15964811 | |
| 650 | Acetylation | SSMQKHMKGHKPEEI HHHHHHHCCCCCCCC | 58.54 | 15964811 | |
| 653 | Acetylation | QKHMKGHKPEEIPPD HHHHCCCCCCCCCCC | 63.89 | 15964811 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 76 | S | Phosphorylation | Kinase | PDPK1 | O15530 | Uniprot |
| 184 | S | Phosphorylation | Kinase | PDPK1 | O15530 | Uniprot |
| 197 | S | Phosphorylation | Kinase | CDK2 | P24941 | PSP |
| 197 | S | Phosphorylation | Kinase | PDPK1 | O15530 | Uniprot |
| 256 | S | Phosphorylation | Kinase | PDPK1 | O15530 | Uniprot |
| 282 | T | Phosphorylation | Kinase | CDK2 | P24941 | PSP |
| 282 | T | Phosphorylation | Kinase | PDPK1 | O15530 | Uniprot |
| 628 | S | Phosphorylation | Kinase | PDPK1 | O15530 | Uniprot |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZBT16_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZBT16_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 612447 | Skeletal defects, genital hypoplasia, and mental retardation (SGYMR) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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