dbPTM

GCR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GCR_HUMAN
UniProt AC	P04150
Protein Name	Glucocorticoid receptor
Gene Name	NR3C1
Organism	Homo sapiens (Human).
Sequence Length	777
Subcellular Localization	Isoform Alpha: Cytoplasm . Nucleus . Mitochondrion . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . After ligand activation, translocates from the cytoplasm to the nucleus. Isoform Beta: Nucle
Protein Description	Receptor for glucocorticoids (GC). [PubMed: 27120390 Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling]
Protein Sequence	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1 (in isoform 8)	Acetylation	-	13.65	22814378
1 (in isoform 9)	Acetylation	-	13.65	22814378
6	Phosphorylation	--MDSKESLTPGREE --CCCCCCCCCCCCC	41.08	30266825
8	Phosphorylation	MDSKESLTPGREENP CCCCCCCCCCCCCCH	32.73	23401153
16	Phosphorylation	PGREENPSSVLAQER CCCCCCHHHHHHHHC	44.66	25627689
17	Phosphorylation	GREENPSSVLAQERG CCCCCHHHHHHHHCC	23.54	25627689
23	Methylation	SSVLAQERGDVMDFY HHHHHHHCCCHHHHH	34.23	-
30	Phosphorylation	RGDVMDFYKTLRGGA CCCHHHHHHHHCCCC	9.98	28674419
32	Phosphorylation	DVMDFYKTLRGGATV CHHHHHHHHCCCCEE	15.42	20068231
34	Methylation	MDFYKTLRGGATVKV HHHHHHHCCCCEEEE	46.89	-
38	Phosphorylation	KTLRGGATVKVSASS HHHCCCCEEEEEECC	24.92	20068231
42	O-linked_Glycosylation	GGATVKVSASSPSLA CCCEEEEEECCCCEE	19.40	30059200
42	Phosphorylation	GGATVKVSASSPSLA CCCEEEEEECCCCEE	19.40	25850435
44	O-linked_Glycosylation	ATVKVSASSPSLAVA CEEEEEECCCCEEEE	34.96	30059200
44	Phosphorylation	ATVKVSASSPSLAVA CEEEEEECCCCEEEE	34.96	25159151
45	O-linked_Glycosylation	TVKVSASSPSLAVAS EEEEEECCCCEEEEC	20.44	30059200
45	Phosphorylation	TVKVSASSPSLAVAS EEEEEECCCCEEEEC	20.44	25159151
47	O-linked_Glycosylation	KVSASSPSLAVASQS EEEECCCCEEEECCC	30.79	30059200
47	Phosphorylation	KVSASSPSLAVASQS EEEECCCCEEEECCC	30.79	25159151
52	O-linked_Glycosylation	SPSLAVASQSDSKQR CCCEEEECCCCCCCE	24.50	30059200
52	Phosphorylation	SPSLAVASQSDSKQR CCCEEEECCCCCCCE	24.50	22199227
54	O-linked_Glycosylation	SLAVASQSDSKQRRL CEEEECCCCCCCEEE	41.16	30059200
54	Phosphorylation	SLAVASQSDSKQRRL CEEEECCCCCCCEEE	41.16	22199227
56	O-linked_Glycosylation	AVASQSDSKQRRLLV EEECCCCCCCEEEEE	35.62	30059200
56	Phosphorylation	AVASQSDSKQRRLLV EEECCCCCCCEEEEE	35.62	22199227
57	Sumoylation	VASQSDSKQRRLLVD EECCCCCCCEEEEEE	53.46	-
57	Sumoylation	VASQSDSKQRRLLVD EECCCCCCCEEEEEE	53.46	-
57	Ubiquitination	VASQSDSKQRRLLVD EECCCCCCCEEEEEE	53.46	-
67	Sumoylation	RLLVDFPKGSVSNAQ EEEEECCCCCCCCCC	64.90	-
67	Sumoylation	RLLVDFPKGSVSNAQ EEEEECCCCCCCCCC	64.90	-
67	Ubiquitination	RLLVDFPKGSVSNAQ EEEEECCCCCCCCCC	64.90	-
69	Phosphorylation	LVDFPKGSVSNAQQP EEECCCCCCCCCCCC	28.62	28555341
79	Phosphorylation	NAQQPDLSKAVSLSM CCCCCCHHHHHHHHH	26.42	-
84	Ubiquitination	DLSKAVSLSMGLYMG CHHHHHHHHHCCCCC	3.08	11555652
89	Phosphorylation	VSLSMGLYMGETETK HHHHHCCCCCCCCCE	9.42	-
89	Ubiquitination	VSLSMGLYMGETETK HHHHHCCCCCCCCCE	9.42	11555652
93	Phosphorylation	MGLYMGETETKVMGN HCCCCCCCCCEECCC	43.13	-
95	Phosphorylation	LYMGETETKVMGNDL CCCCCCCCEECCCCC	36.04	-
96	Sumoylation	YMGETETKVMGNDLG CCCCCCCEECCCCCC	24.80	-
104	Ubiquitination	VMGNDLGFPQQGQIS ECCCCCCCCCCCEEE	6.84	11555652
111	Phosphorylation	FPQQGQISLSSGETD CCCCCEEECCCCCHH	17.82	20068231
113	Phosphorylation	QQGQISLSSGETDLK CCCEEECCCCCHHHH	29.52	7873448
114	Phosphorylation	QGQISLSSGETDLKL CCEEECCCCCHHHHH	46.04	20068231
117	Phosphorylation	ISLSSGETDLKLLEE EECCCCCHHHHHHHH	50.59	20068231
125	Phosphorylation	DLKLLEESIANLNRS HHHHHHHHHHHCCCC	20.02	29514088
132	Phosphorylation	SIANLNRSTSVPENP HHHHCCCCCCCCCCC	24.78	25159151
133	Phosphorylation	IANLNRSTSVPENPK HHHCCCCCCCCCCCC	30.42	25159151
134	Phosphorylation	ANLNRSTSVPENPKS HHCCCCCCCCCCCCC	36.60	23401153
140	Ubiquitination	TSVPENPKSSASTAV CCCCCCCCCCCCCCH	69.49	-
141	Phosphorylation	SVPENPKSSASTAVS CCCCCCCCCCCCCHH	32.18	7873448
142	Phosphorylation	VPENPKSSASTAVSA CCCCCCCCCCCCHHC	32.15	23090842
144	Phosphorylation	ENPKSSASTAVSAAP CCCCCCCCCCHHCCC	20.88	23090842
145	Phosphorylation	NPKSSASTAVSAAPT CCCCCCCCCHHCCCC	30.69	23090842
148	Phosphorylation	SSASTAVSAAPTEKE CCCCCCHHCCCCCCC	19.09	23090842
154	Acetylation	VSAAPTEKEFPKTHS HHCCCCCCCCCCCCC	68.11	23954790
154	Ubiquitination	VSAAPTEKEFPKTHS HHCCCCCCCCCCCCC	68.11	-
161	Phosphorylation	KEFPKTHSDVSSEQQ CCCCCCCCCCCHHHH	44.96	28555341
164	Phosphorylation	PKTHSDVSSEQQHLK CCCCCCCCHHHHHHC	32.90	23312004
165	Phosphorylation	KTHSDVSSEQQHLKG CCCCCCCHHHHHHCC	38.99	29449344
171	Ubiquitination	SSEQQHLKGQTGTNG CHHHHHHCCCCCCCC	47.01	-
189	Phosphorylation	KLYTTDQSTFDILQD EEEECCCCHHHHHHH	33.57	27080861
190	Phosphorylation	LYTTDQSTFDILQDL EEECCCCHHHHHHHC	21.50	27080861
200	Phosphorylation	ILQDLEFSSGSPGKE HHHHCCCCCCCCCCC	25.14	28450419
201	Phosphorylation	LQDLEFSSGSPGKET HHHCCCCCCCCCCCC	48.92	28450419
203	Phosphorylation	DLEFSSGSPGKETNE HCCCCCCCCCCCCCC	32.21	12000743
206	Ubiquitination	FSSGSPGKETNESPW CCCCCCCCCCCCCCC	65.82	-
208	Phosphorylation	SGSPGKETNESPWRS CCCCCCCCCCCCCHH	48.01	28450419
211	Phosphorylation	PGKETNESPWRSDLL CCCCCCCCCCHHCEE	31.65	12000743
215	Phosphorylation	TNESPWRSDLLIDEN CCCCCCHHCEEECCC	28.83	26074081
226	Phosphorylation	IDENCLLSPLAGEDD ECCCCEECCCCCCCC	12.62	25159151
234	Phosphorylation	PLAGEDDSFLLEGNS CCCCCCCCEEECCCC	30.07	29632367
241	Phosphorylation	SFLLEGNSNEDCKPL CEEECCCCCCCCCCC	53.07	29632367
253	Phosphorylation	KPLILPDTKPKIKDN CCCCCCCCCCCCCCC	47.51	24144214
254	Sumoylation	PLILPDTKPKIKDNG CCCCCCCCCCCCCCC	52.25	-
254	Sumoylation	PLILPDTKPKIKDNG CCCCCCCCCCCCCCC	52.25	-
258	Sumoylation	PDTKPKIKDNGDLVL CCCCCCCCCCCCEEE	51.79	28112733
266	Phosphorylation	DNGDLVLSSPSNVTL CCCCEEECCCCCCCC	32.49	22167270
267	Phosphorylation	NGDLVLSSPSNVTLP CCCEEECCCCCCCCC	28.34	23401153
269	Phosphorylation	DLVLSSPSNVTLPQV CEEECCCCCCCCCCC	45.97	22167270
272	Phosphorylation	LSSPSNVTLPQVKTE ECCCCCCCCCCCCCC	36.65	25850435
277	Sumoylation	NVTLPQVKTEKEDFI CCCCCCCCCCHHHHH	45.80	-
277	Sumoylation	NVTLPQVKTEKEDFI CCCCCCCCCCHHHHH	45.80	12144530
277	Ubiquitination	NVTLPQVKTEKEDFI CCCCCCCCCCHHHHH	45.80	-
280	Ubiquitination	LPQVKTEKEDFIELC CCCCCCCHHHHHHHC	68.74	-
288	Phosphorylation	EDFIELCTPGVIKQE HHHHHHCCCCCCCHH	35.38	21712546
293	Sumoylation	LCTPGVIKQEKLGTV HCCCCCCCHHHCCCE	50.42	-
293	Sumoylation	LCTPGVIKQEKLGTV HCCCCCCCHHHCCCE	50.42	12144530
293	Ubiquitination	LCTPGVIKQEKLGTV HCCCCCCCHHHCCCE	50.42	-
296	Ubiquitination	PGVIKQEKLGTVYCQ CCCCCHHHCCCEEEE	50.12	-
299	Phosphorylation	IKQEKLGTVYCQASF CCHHHCCCEEEEEEC	20.81	21945579
301	Phosphorylation	QEKLGTVYCQASFPG HHHCCCEEEEEECCC	4.43	21945579
305	Phosphorylation	GTVYCQASFPGANII CCEEEEEECCCCEEC	13.19	21945579
317	Phosphorylation	NIIGNKMSAISVHGV EECCCCCCEEEEEEE	24.86	30576142
322	Ubiquitination	KMSAISVHGVSTSGG CCCEEEEEEEECCCC	24.93	11555652
330	Ubiquitination	GVSTSGGQMYHYDMN EEECCCCEEEEEECC	32.55	11555652
334	Ubiquitination	SGGQMYHYDMNTASL CCCEEEEEECCHHCC	10.21	11555652
340	Phosphorylation	HYDMNTASLSQQQDQ EEECCHHCCCCCCCC	26.89	30576142
348	Sumoylation	LSQQQDQKPIFNVIP CCCCCCCCCCCEECC	48.66	-
377	Phosphorylation	SGDDNLTSLGTLNFP CCCCCCCCCEECCCC	28.15	28555341
387	Phosphorylation	TLNFPGRTVFSNGYS ECCCCCCEEEECCCC	31.64	27080861
390	Phosphorylation	FPGRTVFSNGYSSPS CCCCEEEECCCCCCC	25.63	22199227
393	Phosphorylation	RTVFSNGYSSPSMRP CEEEECCCCCCCCCC	15.38	22199227
393	Ubiquitination	RTVFSNGYSSPSMRP CEEEECCCCCCCCCC	15.38	11555652
394	Phosphorylation	TVFSNGYSSPSMRPD EEEECCCCCCCCCCC	36.85	22199227
395	Phosphorylation	VFSNGYSSPSMRPDV EEECCCCCCCCCCCC	16.71	22199227
397	Phosphorylation	SNGYSSPSMRPDVSS ECCCCCCCCCCCCCC	29.39	22199227
403	Phosphorylation	PSMRPDVSSPPSSSS CCCCCCCCCCCCCCC	44.50	22199227
404	Phosphorylation	SMRPDVSSPPSSSST CCCCCCCCCCCCCCC	40.45	22199227
407	Phosphorylation	PDVSSPPSSSSTATT CCCCCCCCCCCCCCC	46.35	22199227
408	Phosphorylation	DVSSPPSSSSTATTG CCCCCCCCCCCCCCC	33.80	22199227
409	Phosphorylation	VSSPPSSSSTATTGP CCCCCCCCCCCCCCC	35.73	22199227
410	Phosphorylation	SSPPSSSSTATTGPP CCCCCCCCCCCCCCC	24.82	22199227
411	Phosphorylation	SPPSSSSTATTGPPP CCCCCCCCCCCCCCC	29.94	22199227
413	Phosphorylation	PSSSSTATTGPPPKL CCCCCCCCCCCCCCE	32.16	27080861
419	Ubiquitination	ATTGPPPKLCLVCSD CCCCCCCCEEEEECC	58.57	1155565
480	Acetylation	CPACRYRKCLQAGMN CCHHHHHHHHHHCCC	30.29	19141540
492	Acetylation	GMNLEARKTKKKIKG CCCHHHHHHHHHHCH	72.28	19141540
494	Acetylation	NLEARKTKKKIKGIQ CHHHHHHHHHHCHHH	55.92	19141540
495	Acetylation	LEARKTKKKIKGIQQ HHHHHHHHHHCHHHH	66.03	19141540
498	Sumoylation	RKTKKKIKGIQQATT HHHHHHHCHHHHHHC	59.86	-
498	Sumoylation	RKTKKKIKGIQQATT HHHHHHHCHHHHHHC	59.86	-
498	Ubiquitination	RKTKKKIKGIQQATT HHHHHHHCHHHHHHC	59.86	-
499 (in isoform 3)	Ubiquitination	-	26.81	-
508	Phosphorylation	QQATTGVSQETSENP HHHHCCCCCCCCCCC	24.52	9038175
509	Phosphorylation	QATTGVSQETSENPG HHHCCCCCCCCCCCC	56.43	27251275
511	Phosphorylation	TTGVSQETSENPGNK HCCCCCCCCCCCCCC	33.43	28348404
635	Phosphorylation	IINEQRMTLPCMYDQ EECCCCCCCCHHHHH	29.72	20068231
640	Phosphorylation	RMTLPCMYDQCKHML CCCCCHHHHHHCHHH	15.02	20068231
648	Phosphorylation	DQCKHMLYVSSELHR HHHCHHHHHCHHHHH	7.24	20068231
650	Phosphorylation	CKHMLYVSSELHRLQ HCHHHHHCHHHHHHC	12.44	20068231
651	Phosphorylation	KHMLYVSSELHRLQV CHHHHHCHHHHHHCC	33.85	20068231
659	Phosphorylation	ELHRLQVSYEEYLCM HHHHHCCCHHHHHHH	17.54	22210691
660	Phosphorylation	LHRLQVSYEEYLCMK HHHHCCCHHHHHHHH	17.58	22210691
668	Phosphorylation	EEYLCMKTLLLLSSV HHHHHHHHHHHHHCC	8.85	21964256
673	Phosphorylation	MKTLLLLSSVPKDGL HHHHHHHHCCCCCCC	29.29	29396449
674	Phosphorylation	KTLLLLSSVPKDGLK HHHHHHHCCCCCCCC	42.27	29396449
677	Ubiquitination	LLLSSVPKDGLKSQE HHHHCCCCCCCCCHH	63.37	-
681	Sumoylation	SVPKDGLKSQELFDE CCCCCCCCCHHHHHH	56.47	-
681	Sumoylation	SVPKDGLKSQELFDE CCCCCCCCCHHHHHH	56.47	-
681	Ubiquitination	SVPKDGLKSQELFDE CCCCCCCCCHHHHHH	56.47	-
695	Ubiquitination	EIRMTYIKELGKAIV HHHHHHHHHHHHHHH	36.15	-
696 (in isoform 3)	Ubiquitination	-	53.87	-
699	Ubiquitination	TYIKELGKAIVKREG HHHHHHHHHHHHHCC	47.79	-
703	Sumoylation	ELGKAIVKREGNSSQ HHHHHHHHHCCCCCH	38.32	-
703	Sumoylation	ELGKAIVKREGNSSQ HHHHHHHHHCCCCCH	38.32	12144530
770	Ubiquitination	KYSNGNIKKLLFHQK CCCCCCCCHHHEECC	41.17	-
771	Ubiquitination	YSNGNIKKLLFHQK- CCCCCCCHHHEECC-	46.77	-
772 (in isoform 3)	Ubiquitination	-	5.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
134	S	Phosphorylation	Kinase	AKT1	P31749	PSP
134	S	Phosphorylation	Kinase	P38A	P47811	PSP
203	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
203	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
211	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
211	S	Phosphorylation	Kinase	MAPK11	Q15759	GPS
211	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
226	S	Phosphorylation	Kinase	MAPK_GROUP	-	PhosphoELM
226	S	Phosphorylation	Kinase	JNK_GROUP	-	PhosphoELM
226	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
226	S	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
226	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
226	S	Phosphorylation	Kinase	MAPK11	Q15759	GPS
226	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
226	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
226	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
404	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
508	S	Phosphorylation	Kinase	PRKDC	P78527	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:11676916
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:12897156

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
203	S	Phosphorylation	12000743
Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation.
203	S	Phosphorylation	12000743
Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity.
203	S	Phosphorylation	12000743
The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear.
211	S	Phosphorylation	12000743
The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear.
211	S	Phosphorylation	12000743
Phosphorylation at Ser-211 increases transcriptional activity.
211	S	Phosphorylation	12000743
Phosphorylation at Ser-203 and Ser-211 is not required in regulation of chromosome segregation.
226	S	Phosphorylation	18483179
The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear.
226	S	Phosphorylation	18483179
Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity.
277	K	Sumoylation	12144530
Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity.
277	K	Sumoylation	12144530
Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity (By similarity).
293	K	Sumoylation	12144530
Sumoylation at Lys-277 and Lys-293 negatively regulates its transcriptional activity.
293	K	Sumoylation	12144530
Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity (By similarity).
404	S	Phosphorylation	18838540
Phosphorylation at Ser-203, Ser-226 and Ser-404 decreases signaling capacity.
404	S	Phosphorylation	18838540
Phosphorylation at Ser-404 may protect from glucocorticoid-induced apoptosis.
404	S	Phosphorylation	18838540
The Ser-203, Ser-226 and Ser-404-phosphorylated forms are mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear.
703	K	Sumoylation	12144530
Sumoylation at Lys-703 positively regulates its transcriptional activity in the presence of RWDD3 (By similarity).
703	K	Sumoylation	12144530
Sumoylation at Lys-277 and Lys-293 is dispensable whereas sumoylation at Lys-703 is critical for the stimulatory effect of RWDD3 on its transcriptional activity (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GCR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECD_HUMAN	ECD	physical	9928932
RAD9A_HUMAN	RAD9A	physical	14966297
JUN_HUMAN	JUN	physical	14522952
STAT3_HUMAN	STAT3	physical	14522952
NCOA3_HUMAN	NCOA3	physical	12917342
SMCA4_HUMAN	SMARCA4	physical	12917342
SMRC1_HUMAN	SMARCC1	physical	12917342
SMRD1_HUMAN	SMARCD1	physical	12917342
SMCE1_HUMAN	SMARCE1	physical	12917342
NRIP1_HUMAN	NRIP1	physical	12773562
DAXX_HUMAN	DAXX	physical	12595526
SMCA4_HUMAN	SMARCA4	physical	10688647
NRIP1_HUMAN	NRIP1	physical	11266503
MED1_HUMAN	MED1	physical	11266503
NCOA3_HUMAN	NCOA3	physical	11266503
NCOA1_HUMAN	NCOA1	physical	11266503
NCOA2_HUMAN	NCOA2	physical	11266503
CBP_HUMAN	CREBBP	physical	9649342
KDM5A_HUMAN	KDM5A	physical	11358960
MED14_HUMAN	MED14	physical	10508170
TS101_HUMAN	TSG101	physical	10508170
CH60_HUMAN	HSPD1	physical	10508170
RAN_HUMAN	RAN	physical	10508170
ARPC5_HUMAN	ARPC5	physical	10508170
NCOR1_HUMAN	NCOR1	physical	12569182
HS90A_HUMAN	HSP90AA1	physical	10066374
THIO_HUMAN	TXN	physical	9915858
RT29_HUMAN	DAP3	physical	10903152
PO2F1_HUMAN	POU2F1	physical	10490647
PO2F2_HUMAN	POU2F2	physical	10490647
NRIP1_HUMAN	NRIP1	physical	10364267
ETS2_HUMAN	ETS2	physical	11279115
HNRPU_HUMAN	HNRNPU	physical	9353307
1433F_HUMAN	YWHAH	physical	9079630
NUCL_HUMAN	NCL	physical	11162542
GCR_HUMAN	NR3C1	physical	12151000
CREB1_HUMAN	CREB1	physical	8449898
NFKB1_HUMAN	NFKB1	physical	7823959
NFKB2_HUMAN	NFKB2	physical	7823959
TF65_HUMAN	RELA	physical	8290595
STA5B_HUMAN	STAT5B	physical	8878484
HMGB1_HUMAN	HMGB1	physical	9671457
HMGB2_HUMAN	HMGB2	physical	9671457
NCOR2_HUMAN	NCOR2	physical	12011091
NCOR1_HUMAN	NCOR1	physical	12011091
CALR_HUMAN	CALR	physical	8107808
STAT3_HUMAN	STAT3	physical	9388192
SMAD3_HUMAN	SMAD3	physical	10518526
HS90A_HUMAN	HSP90AA1	physical	8898375
HS90A_HUMAN	HSP90AA1	physical	8645634
HS90A_HUMAN	HSP90AA1	physical	8621522
PBX1_HUMAN	PBX1	physical	12487626
HXB1_HUMAN	HOXB1	physical	12487626
BAG1_HUMAN	BAG1	physical	9603979
PO2F1_HUMAN	POU2F1	physical	9584182
PO2F2_HUMAN	POU2F2	physical	9584182
P53_HUMAN	TP53	physical	11080152
RAF1_HUMAN	RAF1	physical	11005817
HNF6_HUMAN	ONECUT1	physical	10430878
SMCA2_HUMAN	SMARCA2	physical	17043312
MSX2_HUMAN	MSX2	physical	20211142
PML_HUMAN	PML	physical	20211142
RXRB_HUMAN	RXRB	physical	20211142
NR2E3_HUMAN	NR2E3	physical	20211142
RBM14_HUMAN	RBM14	physical	20211142
MAFF_HUMAN	MAFF	physical	20211142
ZBT20_HUMAN	ZBTB20	physical	20211142
ZBTB3_HUMAN	ZBTB3	physical	20211142
ZN496_HUMAN	ZNF496	physical	20211142
ZBTB9_HUMAN	ZBTB9	physical	20211142
HDAC1_HUMAN	HDAC1	physical	16762839
GRIP1_HUMAN	GRIP1	physical	16423881
NFKB1_HUMAN	NFKB1	physical	16380507
PTMS_HUMAN	PTMS	physical	16150697
HDAC2_HUMAN	HDAC2	physical	10958685
NCOA1_HUMAN	NCOA1	physical	9590696
NCOA2_HUMAN	NCOA2	physical	9590696
CBP_HUMAN	CREBBP	physical	9590696
COT2_HUMAN	NR2F2	physical	14739255
EP300_HUMAN	EP300	physical	17884810
P53_HUMAN	TP53	physical	11562347
MDM2_HUMAN	MDM2	physical	11562347
HDAC6_HUMAN	HDAC6	physical	20018896
CBP_HUMAN	CREBBP	physical	20018896
FRIH_HUMAN	FTH1	physical	15604093
ROA1_HUMAN	HNRNPA1	physical	15604093
LCK_HUMAN	LCK	physical	16888650
CD4_HUMAN	CD4	physical	16888650
NR0B1_HUMAN	NR0B1	physical	18160712
SRC_HUMAN	SRC	physical	18160712
NCOA3_HUMAN	NCOA3	physical	18160712
PRGC1_HUMAN	PPARGC1A	physical	18160712
TS101_HUMAN	TSG101	physical	15657031
SUMO1_HUMAN	SUMO1	physical	17081986
UB2L3_HUMAN	UBE2L3	physical	17003263
DCAF6_HUMAN	DCAF6	physical	15784617
GBB1_HUMAN	GNB1	physical	15955845
GBB2_HUMAN	GNB2	physical	15955845
RACK1_HUMAN	GNB2L1	physical	15955845
CHIP_HUMAN	STUB1	physical	20661446
FKBP5_HUMAN	FKBP5	physical	20661446
FKBP4_HUMAN	FKBP4	physical	20661446
PPP5_HUMAN	PPP5C	physical	20661446
DNJC7_HUMAN	DNAJC7	physical	20661446
PPID_HUMAN	PPID	physical	20661446
SRA1_HUMAN	SRA1	physical	20398657
NCOA2_HUMAN	NCOA2	physical	9920895
BAG1_HUMAN	BAG1	physical	23493285
CHIP_HUMAN	STUB1	physical	23493285
PPARG_HUMAN	PPARG	physical	15531761
TMF1_HUMAN	TMF1	physical	20195357
HS90A_HUMAN	HSP90AA1	physical	20195357
CENPB_HUMAN	CENPB	physical	20195357
BRCC3_HUMAN	BRCC3	physical	22863883
CD2AP_HUMAN	CD2AP	physical	22863883
GAPD1_HUMAN	GAPVD1	physical	22863883
HDAC1_HUMAN	HDAC1	physical	22863883
HNRPR_HUMAN	HNRNPR	physical	22863883
LARP7_HUMAN	LARP7	physical	22863883
MTA2_HUMAN	MTA2	physical	22863883
RABE2_HUMAN	RABEP2	physical	22863883
TIF1B_HUMAN	TRIM28	physical	22863883
TTC5_HUMAN	TTC5	physical	21147850
CBP_HUMAN	CREBBP	physical	25511704
HDAC1_HUMAN	HDAC1	physical	21127047
NCOA1_HUMAN	NCOA1	physical	16423881
MCR_HUMAN	NR3C2	physical	16131566
HS90A_HUMAN	HSP90AA1	physical	14987994
GCR_HUMAN	NR3C1	physical	21127047
STAT3_HUMAN	STAT3	physical	26508788
KMT2D_HUMAN	KMT2D	physical	28611094
SMRC2_HUMAN	SMARCC2	physical	28611094
CPVL_HUMAN	CPVL	physical	28611094
TCF20_HUMAN	TCF20	physical	28611094
NCOA6_HUMAN	NCOA6	physical	28611094
GSE1_HUMAN	GSE1	physical	28611094
ARI1A_HUMAN	ARID1A	physical	28611094
JHD2C_HUMAN	JMJD1C	physical	28611094
ARI1B_HUMAN	ARID1B	physical	28611094
SMRC1_HUMAN	SMARCC1	physical	28611094
BCOR_HUMAN	BCOR	physical	28611094
NCOA2_HUMAN	NCOA2	physical	28611094
MINT_HUMAN	SPEN	physical	28611094
NCOA3_HUMAN	NCOA3	physical	28611094
ARI3B_HUMAN	ARID3B	physical	28611094
MED1_HUMAN	MED1	physical	28611094
POGZ_HUMAN	POGZ	physical	28611094
SMCA4_HUMAN	SMARCA4	physical	28611094
KDM1A_HUMAN	KDM1A	physical	28611094
NCOR1_HUMAN	NCOR1	physical	28611094
RAI1_HUMAN	RAI1	physical	28611094
I2BP2_HUMAN	IRF2BP2	physical	28611094
RBM34_HUMAN	RBM34	physical	28611094
CATB_HUMAN	CTSB	physical	28611094
CNBP_HUMAN	CNBP	physical	28611094
H2AW_HUMAN	H2AFY2	physical	28611094
SNF5_HUMAN	SMARCB1	physical	28611094
SMHD1_HUMAN	SMCHD1	physical	28611094
PO210_HUMAN	NUP210	physical	28611094
TLE3_HUMAN	TLE3	physical	28611094
RCOR1_HUMAN	RCOR1	physical	28611094
AP2A_HUMAN	TFAP2A	physical	28611094
NCOA1_HUMAN	NCOA1	physical	28611094
ODB2_HUMAN	DBT	physical	28611094
DD19A_HUMAN	DDX19A	physical	28611094
PARP1_HUMAN	PARP1	physical	28611094
RBM14_HUMAN	RBM14	physical	28611094
LANC1_HUMAN	LANCL1	physical	28611094
HNRH3_HUMAN	HNRNPH3	physical	28611094
TOP1_HUMAN	TOP1	physical	28611094
ZN512_HUMAN	ZNF512	physical	28611094
DDX47_HUMAN	DDX47	physical	28611094
TRA2A_HUMAN	TRA2A	physical	28611094
SRSF1_HUMAN	SRSF1	physical	28611094
P5CS_HUMAN	ALDH18A1	physical	28611094
HNRDL_HUMAN	HNRNPDL	physical	28611094
SRSF9_HUMAN	SRSF9	physical	28611094
CENPV_HUMAN	CENPV	physical	28611094
MCM5_HUMAN	MCM5	physical	28611094
SYK_HUMAN	KARS	physical	28611094
IMA5_HUMAN	KPNA1	physical	28611094
SDCG3_HUMAN	SDCCAG3	physical	28611094
MOT1_HUMAN	SLC16A1	physical	28611094
ZN420_HUMAN	ZNF420	physical	28611094
CKAP4_HUMAN	CKAP4	physical	28611094
NU188_HUMAN	NUP188	physical	28611094
DDX27_HUMAN	DDX27	physical	28611094
ZFX_HUMAN	ZFX	physical	28611094
ODO2_HUMAN	DLST	physical	28611094
SSF1_HUMAN	PPAN	physical	28611094
PWP1_HUMAN	PWP1	physical	28611094
RFOX2_HUMAN	RBFOX2	physical	28611094
SEC63_HUMAN	SEC63	physical	28611094

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615962	Glucocorticoid resistance, generalized (GCCR)
138040	Glucocorticoid resistance (GCRES)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00240	Alclometasone
DB00288	Amcinonide
DB00394	Beclomethasone
DB00443	Betamethasone
DB01222	Budesonide
DB01410	Ciclesonide
DB01013	Clobetasol propionate
DB00838	Clocortolone
DB01380	Cortisone acetate
DB01260	Desonide
DB00547	Desoximetasone
DB01234	Dexamethasone
DB00223	Diflorasone
DB06781	Difluprednate
DB00687	Fludrocortisone
DB00663	Flumethasone Pivalate
DB00180	Flunisolide
DB00591	Fluocinolone Acetonide
DB01047	Fluocinonide
DB00324	Fluorometholone
DB01185	Fluoxymesterone
DB00846	Flurandrenolide
DB08906	Fluticasone furoate
DB00588	Fluticasone Propionate
DB00596	Halobetasol Propionate
DB00769	Hydrocortamate
DB00741	Hydrocortisone
DB00873	Loteprednol
DB00253	Medrysone
DB00351	Megestrol acetate
DB00959	Methylprednisolone
DB00834	Mifepristone
DB00764	Mometasone
DB01384	Paramethasone
DB01130	Prednicarbate
DB00860	Prednisolone
DB00635	Prednisone
DB00896	Rimexolone
DB00421	Spironolactone
DB00620	Triamcinolone

Regulatory Network of GCR_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134; SER-226; SER-234AND SER-267, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-8 AND SER-45, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Deciphering the phosphorylation 'code' of the glucocorticoid receptorin vivo."; Wang Z., Frederick J., Garabedian M.J.; J. Biol. Chem. 277:26573-26580(2002). Cited for: PHOSPHORYLATION AT SER-203 AND SER-211.	12000743 [Abstract]

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