MAFF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAFF_HUMAN
• UniProt AC: Q9ULX9
• Protein Name: Transcription factor MafF
• Gene Name: MAFF
• Organism: Homo sapiens (Human).
• Sequence Length: 164
• Subcellular Localization: Nucleus.
• Protein Description: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. [PubMed: 8932385 However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene]
• Protein Sequence: MSVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGLSAEEVTRLKQRRRTLKNRGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAMRLELDALRGKCEALQGFARSVAAARGPATLVAPASVITIVKSTPGSGSGPAHGPDPAHGPASCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVDPLSSK ------CCCCCCCHH	34.92	30206219
7	Phosphorylation	-MSVDPLSSKALKIK -CCCCCCCHHHHHHH	34.87	30206219
8	Phosphorylation	MSVDPLSSKALKIKR CCCCCCCHHHHHHHH	29.63	30206219
9	Acetylation	SVDPLSSKALKIKRE CCCCCCHHHHHHHHH	55.13	25953088
18	Phosphorylation	LKIKRELSENTPHLS HHHHHHHHCCCCCCC	24.85	28355574
21	Phosphorylation	KRELSENTPHLSDEA HHHHHCCCCCCCHHH	14.18	20068231
25	Phosphorylation	SENTPHLSDEALMGL HCCCCCCCHHHHHCC	30.30	24247654
33	Phosphorylation	DEALMGLSVRELNRH HHHHHCCCHHHHHHH	17.25	24719451
47	Ubiquitination	HLRGLSAEEVTRLKQ HHCCCCHHHHHHHHH	50.01	29967540
76	Ubiquitination	RVKRVCQKEELQKQK HHHHHHCHHHHHHHH	48.29	29967540
81	Ubiquitination	CQKEELQKQKSELER HCHHHHHHHHHHHHH	72.77	29967540
110	Ubiquitination	ELDALRGKCEALQGF HHHHHHHHHHHHHHH	23.59	29967540
120	Phosphorylation	ALQGFARSVAAARGP HHHHHHHHHHHHHCC	16.81	20068231
129	Phosphorylation	AAARGPATLVAPASV HHHHCCCEEEECCEE	25.54	20068231
141	Acetylation	ASVITIVKSTPGSGS CEEEEEEECCCCCCC	44.77	26051181
142	Phosphorylation	SVITIVKSTPGSGSG EEEEEEECCCCCCCC	29.01	25627689
143	Phosphorylation	VITIVKSTPGSGSGP EEEEEECCCCCCCCC	26.42	25627689
146	Phosphorylation	IVKSTPGSGSGPAHG EEECCCCCCCCCCCC	30.87	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAFF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAFF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAFF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAP_HUMAN	PSAP	physical	16169070
NF2L2_HUMAN	NFE2L2	physical	12490281
NRF1_HUMAN	NRF1	physical	12490281
MAFF_HUMAN	MAFF	physical	12490281
NF2L1_HUMAN	NFE2L1	physical	8932385
BACH2_HUMAN	BACH2	physical	23661758
BACH1_HUMAN	BACH1	physical	23661758
NF2L3_HUMAN	NFE2L3	physical	23661758
NF2L2_HUMAN	NFE2L2	physical	23661758
NF2L1_HUMAN	NFE2L1	physical	23661758
MAFG_HUMAN	MAFG	physical	23661758
MAFF_HUMAN	MAFF	physical	23661758
BATF3_HUMAN	BATF3	physical	23661758
BATF2_HUMAN	BATF2	physical	23661758
ATF3_HUMAN	ATF3	physical	23661758
FOS_HUMAN	FOS	physical	23661758
NFIL3_HUMAN	NFIL3	physical	23661758
OVOL1_HUMAN	OVOL1	physical	21988832
NF2L2_HUMAN	NFE2L2	physical	23737527
SP16H_HUMAN	SUPT16H	physical	26186194
CCDC6_HUMAN	CCDC6	physical	26186194
RTL6_HUMAN	LDOC1L	physical	26186194
G3PT_HUMAN	GAPDHS	physical	26186194
NF2L2_HUMAN	NFE2L2	physical	26186194
CACO1_HUMAN	CALCOCO1	physical	26186194
BACH2_HUMAN	BACH2	physical	26186194
BACH1_HUMAN	BACH1	physical	26186194
NEK9_HUMAN	NEK9	physical	26186194
MIS12_HUMAN	MIS12	physical	26186194
NF2L1_HUMAN	NFE2L1	physical	26186194
NF2L3_HUMAN	NFE2L3	physical	26186194
GIT1_HUMAN	GIT1	physical	26186194
GIT2_HUMAN	GIT2	physical	26186194
NF2L1_HUMAN	NFE2L1	physical	28514442
NF2L2_HUMAN	NFE2L2	physical	28514442
RTL6_HUMAN	LDOC1L	physical	28514442
NF2L3_HUMAN	NFE2L3	physical	28514442
BACH2_HUMAN	BACH2	physical	28514442
CACO1_HUMAN	CALCOCO1	physical	28514442
CCDC6_HUMAN	CCDC6	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442
GIT1_HUMAN	GIT1	physical	28514442
MIS12_HUMAN	MIS12	physical	28514442
GIT2_HUMAN	GIT2	physical	28514442
NEK9_HUMAN	NEK9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.