dbPTM

GIT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GIT2_HUMAN
UniProt AC	Q14161
Protein Name	ARF GTPase-activating protein GIT2
Gene Name	GIT2
Organism	Homo sapiens (Human).
Sequence Length	759
Subcellular Localization
Protein Description	GTPase-activating protein for the ADP ribosylation factor family..
Protein Sequence	MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMRLQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSKRLRSSEVCADC -CCCCCCCCCCCCCC	35.13	23663014
8	Phosphorylation	MSKRLRSSEVCADCS CCCCCCCCCCCCCCC	27.84	23663014
20	Phosphorylation	DCSGPDPSWASVNRG CCCCCCCCHHCCCCC	42.53	27080861
23	Phosphorylation	GPDPSWASVNRGTFL CCCCCHHCCCCCCEE	17.42	27080861
28	Phosphorylation	WASVNRGTFLCDECC HHCCCCCCEECHHHH	15.36	27080861
36	Phosphorylation	FLCDECCSVHRSLGR EECHHHHHHHHHHHH	32.39	27080861
46	Phosphorylation	RSLGRHISQVRHLKH HHHHHHHHHHCCCCC	19.25	23532336
98	Ubiquitination	RKANPQDKVHPNKAE CCCCCCCCCCCCHHH	36.88	-
103	Ubiquitination	QDKVHPNKAEFIRAK CCCCCCCHHHHHHHH	54.46	-
127	Phosphorylation	LPCRDDDSVTAKDLS CCCCCCCCCCHHHHH	28.50	28857561
129	Phosphorylation	CRDDDSVTAKDLSKQ CCCCCCCCHHHHHHH	31.76	28857561
131	Ubiquitination	DDDSVTAKDLSKQLH CCCCCCHHHHHHHHH	50.24	-
135	Acetylation	VTAKDLSKQLHSSVR CCHHHHHHHHHHHHH	65.26	25953088
135	Malonylation	VTAKDLSKQLHSSVR CCHHHHHHHHHHHHH	65.26	26320211
135	Ubiquitination	VTAKDLSKQLHSSVR CCHHHHHHHHHHHHH	65.26	-
139	Phosphorylation	DLSKQLHSSVRTGNL HHHHHHHHHHHHCCH	38.84	28857561
154	Phosphorylation	ETCLRLLSLGAQANF HHHHHHHHHCCCCEE	29.37	28857561
166	Acetylation	ANFFHPEKGNTPLHV CEECCCCCCCCCCHH	63.01	25953088
195	Phosphorylation	VYGADPGTQDSSGKT HHCCCCCCCCCCCCC	34.29	-
224	Phosphorylation	ERLVEIQYELTDRLA HHHHHHHHHHHHHHH	20.68	27642862
227	Phosphorylation	VEIQYELTDRLAFYL HHHHHHHHHHHHHHH	13.72	24719451
255	Phosphorylation	IIPQMADSSLDLSEL EECCCCCCCCCHHHH	24.22	24247654
258 (in isoform 10)	Phosphorylation	-	50.53	22617229
262 (in isoform 10)	Phosphorylation	-	5.49	-
286	Phosphorylation	EELAMDVYDEVDRRE HHHHHHHHHHHHHHH	11.34	22817900
360	Phosphorylation	AKRRQQGSSLSGSKD HHHHHCCCCCCCCHH	24.62	23403867
361	Phosphorylation	KRRQQGSSLSGSKDN HHHHCCCCCCCCHHH	33.12	23403867
363	Phosphorylation	RQQGSSLSGSKDNVE HHCCCCCCCCHHHHH	42.86	23403867
365	Phosphorylation	QGSSLSGSKDNVELI CCCCCCCCHHHHHHH	33.20	23401153
366	Ubiquitination	GSSLSGSKDNVELIL CCCCCCCHHHHHHHH	57.77	-
375	Phosphorylation	NVELILKTINNQHSV HHHHHHHHHHCCCCC	26.03	23927012
381	Phosphorylation	KTINNQHSVESQDND HHHHCCCCCCCCCCC	20.16	23927012
381 (in isoform 11)	Phosphorylation	-	20.16	-
381 (in isoform 2)	Phosphorylation	-	20.16	-
384	Phosphorylation	NNQHSVESQDNDQPD HCCCCCCCCCCCCCC	40.45	23927012
384 (in isoform 11)	Phosphorylation	-	40.45	-
384 (in isoform 2)	Phosphorylation	-	40.45	-
392	Phosphorylation	QDNDQPDYDSVASDE CCCCCCCCCCCCCCC	19.46	23927012
392 (in isoform 11)	Phosphorylation	-	19.46	-
392 (in isoform 2)	Phosphorylation	-	19.46	-
394	Phosphorylation	NDQPDYDSVASDEDT CCCCCCCCCCCCCCC	17.22	23927012
394 (in isoform 11)	Phosphorylation	-	17.22	-
394 (in isoform 2)	Phosphorylation	-	17.22	-
397	Phosphorylation	PDYDSVASDEDTDLE CCCCCCCCCCCCCHH	39.10	25159151
397 (in isoform 11)	Phosphorylation	-	39.10	-
397 (in isoform 2)	Phosphorylation	-	39.10	-
401	Phosphorylation	SVASDEDTDLETTAS CCCCCCCCCHHHHCC	40.20	30278072
405	Phosphorylation	DEDTDLETTASKTNR CCCCCHHHHCCHHHH	34.65	23927012
406	Phosphorylation	EDTDLETTASKTNRQ CCCCHHHHCCHHHHC	21.40	23927012
408	Phosphorylation	TDLETTASKTNRQKS CCHHHHCCHHHHCHH	37.61	23927012
410	Phosphorylation	LETTASKTNRQKSLD HHHHCCHHHHCHHCC	32.89	26074081
415	Phosphorylation	SKTNRQKSLDSDLSD CHHHHCHHCCCCCCC	29.13	30266825
415 (in isoform 11)	Phosphorylation	-	29.13	-
415 (in isoform 2)	Phosphorylation	-	29.13	-
418	Phosphorylation	NRQKSLDSDLSDGPV HHCHHCCCCCCCCCE	45.83	30266825
418 (in isoform 11)	Phosphorylation	-	45.83	-
418 (in isoform 2)	Phosphorylation	-	45.83	-
421	Phosphorylation	KSLDSDLSDGPVTVQ HHCCCCCCCCCEEHH	45.58	30266825
421 (in isoform 11)	Phosphorylation	-	45.58	-
421 (in isoform 2)	Phosphorylation	-	45.58	-
426	Phosphorylation	DLSDGPVTVQEFMEV CCCCCCEEHHHHHHH	21.43	30266825
434	Ubiquitination	VQEFMEVKNALVASE HHHHHHHHHHHHHCH	24.17	-
443	Ubiquitination	ALVASEAKIQQLMKV HHHHCHHHHHHHHHH	36.68	-
449	Ubiquitination	AKIQQLMKVNNNLSD HHHHHHHHHCCCHHH	50.86	-
455	Phosphorylation	MKVNNNLSDELRIMQ HHHCCCHHHHHHHHH	31.03	29978859
464	Ubiquitination	ELRIMQKKLQTLQSE HHHHHHHHHHHHHHC	29.00	-
467	Phosphorylation	IMQKKLQTLQSENSN HHHHHHHHHHHCCCH	36.88	22210691
470	Phosphorylation	KKLQTLQSENSNLRK HHHHHHHHCCCHHHH	41.69	29978859
473	Phosphorylation	QTLQSENSNLRKQAT HHHHHCCCHHHHHCC	32.94	23401153
477	Ubiquitination	SENSNLRKQATTNVY HCCCHHHHHCCCCEE	47.66	-
480	Phosphorylation	SNLRKQATTNVYQVQ CHHHHHCCCCEEEEE	19.19	21945579
481	Phosphorylation	NLRKQATTNVYQVQT HHHHHCCCCEEEEEC	26.21	21945579
484	Phosphorylation	KQATTNVYQVQTGSE HHCCCCEEEEECCCC	12.68	21945579
486 (in isoform 11)	Phosphorylation	-	2.77	-
488	Phosphorylation	TNVYQVQTGSEYTDT CCEEEEECCCCCCCC	43.76	21945579
490	Phosphorylation	VYQVQTGSEYTDTSN EEEEECCCCCCCCCC	30.71	21945579
492	Phosphorylation	QVQTGSEYTDTSNHS EEECCCCCCCCCCCC	16.18	21945579
493	Phosphorylation	VQTGSEYTDTSNHSS EECCCCCCCCCCCCH	28.84	21945579
495	Phosphorylation	TGSEYTDTSNHSSLK CCCCCCCCCCCCHHC	24.51	23401153
496	Phosphorylation	GSEYTDTSNHSSLKR CCCCCCCCCCCHHCC	35.04	23401153
499	Phosphorylation	YTDTSNHSSLKRRPS CCCCCCCCHHCCCCC	41.43	21945579
500	Phosphorylation	TDTSNHSSLKRRPSA CCCCCCCHHCCCCCC	30.29	21945579
506	Phosphorylation	SSLKRRPSARGSRPM CHHCCCCCCCCCCCC	28.87	24144214
510	Phosphorylation	RRPSARGSRPMSMYE CCCCCCCCCCCCEEE	27.88	23927012
514	Phosphorylation	ARGSRPMSMYETGSG CCCCCCCCEEECCCC	22.39	23927012
516	Phosphorylation	GSRPMSMYETGSGQK CCCCCCEEECCCCCC	11.75	30576142
518	Phosphorylation	RPMSMYETGSGQKPY CCCCEEECCCCCCCC	21.11	28450419
520	Phosphorylation	MSMYETGSGQKPYLP CCEEECCCCCCCCCC	45.53	23927012
525	Phosphorylation	TGSGQKPYLPMGEAS CCCCCCCCCCCCCCC	30.39	23927012
532	Phosphorylation	YLPMGEASRPEESRM CCCCCCCCCCHHHHC	44.03	23927012
537	Phosphorylation	EASRPEESRMRLQPF CCCCCHHHHCCCCCC	29.70	23312004
551	Phosphorylation	FPAHIGRSALVTSSS CCCHHCCCEEEECCC	22.27	28450419
555	O-linked_Glycosylation	IGRSALVTSSSSLPS HCCCEEEECCCCCCC	24.60	28657654
555	Phosphorylation	IGRSALVTSSSSLPS HCCCEEEECCCCCCC	24.60	28450419
556	O-linked_Glycosylation	GRSALVTSSSSLPSF CCCEEEECCCCCCCC	22.27	28657654
556	Phosphorylation	GRSALVTSSSSLPSF CCCEEEECCCCCCCC	22.27	26657352
557	O-linked_Glycosylation	RSALVTSSSSLPSFP CCEEEECCCCCCCCC	18.00	28657654
557	Phosphorylation	RSALVTSSSSLPSFP CCEEEECCCCCCCCC	18.00	27794612
558	Phosphorylation	SALVTSSSSLPSFPS CEEEECCCCCCCCCC	35.34	22617229
559	O-linked_Glycosylation	ALVTSSSSLPSFPST EEEECCCCCCCCCCC	46.37	28657654
559	Phosphorylation	ALVTSSSSLPSFPST EEEECCCCCCCCCCC	46.37	22617229
562	Phosphorylation	TSSSSLPSFPSTLSW ECCCCCCCCCCCCCC	55.90	27794612
565	Phosphorylation	SSLPSFPSTLSWSRD CCCCCCCCCCCCCCC	39.71	29507054
566	O-linked_Glycosylation	SLPSFPSTLSWSRDE CCCCCCCCCCCCCCH	25.67	28657654
566	Phosphorylation	SLPSFPSTLSWSRDE CCCCCCCCCCCCCCH	25.67	29507054
568	O-linked_Glycosylation	PSFPSTLSWSRDESA CCCCCCCCCCCCHHH	24.08	28657654
568	Phosphorylation	PSFPSTLSWSRDESA CCCCCCCCCCCCHHH	24.08	22617229
570	O-linked_Glycosylation	FPSTLSWSRDESARR CCCCCCCCCCHHHHH	26.86	28657654
570	Phosphorylation	FPSTLSWSRDESARR CCCCCCCCCCHHHHH	26.86	28450419
574	Phosphorylation	LSWSRDESARRASRL CCCCCCHHHHHHHHH	31.22	29978859
579	Phosphorylation	DESARRASRLEKQNS CHHHHHHHHHHHHCC	35.27	26437602
586	Phosphorylation	SRLEKQNSTPESDYD HHHHHHCCCCCHHCC	42.73	23401153
587	Phosphorylation	RLEKQNSTPESDYDN HHHHHCCCCCHHCCC	38.33	23911959
590	Phosphorylation	KQNSTPESDYDNTPN HHCCCCCHHCCCCCC	42.55	24043423
592	Phosphorylation	NSTPESDYDNTPNDM CCCCCHHCCCCCCCC	22.00	20007894
595	Phosphorylation	PESDYDNTPNDMEPD CCHHCCCCCCCCCCC	22.14	23403867
596 (in isoform 11)	Phosphorylation	-	40.87	-
606	Phosphorylation	MEPDGMGSSRKGRQR CCCCCCCCCCCCCCC	20.34	23403867
607	Phosphorylation	EPDGMGSSRKGRQRS CCCCCCCCCCCCCCC	32.08	23403867
614	Phosphorylation	SRKGRQRSMVWPGDG CCCCCCCCCCCCCCC	14.89	22617229
626	Phosphorylation	GDGLVPDTAEPHVAP CCCCCCCCCCCCCCC	27.18	28464451
634	Phosphorylation	AEPHVAPSPTLPSTE CCCCCCCCCCCCCHH	22.30	25627689
668	Phosphorylation	AQENKHDSYIPCSER HHHCCCCCCCCHHHH	25.36	23663014
669	Phosphorylation	QENKHDSYIPCSERI HHCCCCCCCCHHHHH	18.23	23403867
673	Phosphorylation	HDSYIPCSERIHVAV CCCCCCHHHHHHHHH	25.26	-
693	Phosphorylation	LFPKKPKSDMVRTSL HCCCCCCHHHHHHHH	39.19	-
698	Phosphorylation	PKSDMVRTSLRLLTS CCHHHHHHHHHHHHH	22.24	-
699	Phosphorylation	KSDMVRTSLRLLTSS CHHHHHHHHHHHHHH	10.83	25137130
717	Phosphorylation	LQSECKKTLPGDPGS HHHHHHHCCCCCCCC	24.55	28450419
724	Phosphorylation	TLPGDPGSPTDVQLV CCCCCCCCCCHHHHH	29.98	28450419
726	Phosphorylation	PGDPGSPTDVQLVTQ CCCCCCCCHHHHHHH	50.96	28464451
732	Phosphorylation	PTDVQLVTQQVIQCA CCHHHHHHHHHHHHH	23.13	22199227
740	Phosphorylation	QQVIQCAYDIAKAAK HHHHHHHHHHHHHHH	18.60	20068231
747	Ubiquitination	YDIAKAAKQLVTITT HHHHHHHHHHHEEEE	49.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
195	T	Phosphorylation	Kinase	ATM	Q13315	PSP
384	S	Phosphorylation	Kinase	ATM	Q13315	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GIT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GIT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARBK1_HUMAN	ADRBK1	physical	10896954
PAXI_HUMAN	PXN	physical	11251077
PCLO_HUMAN	PCLO	physical	12473661
GIT1_HUMAN	GIT1	physical	12473661
GIT2_HUMAN	GIT2	physical	12473661
TRAF1_HUMAN	TRAF1	physical	21988832
TSN_HUMAN	TSN	physical	21988832
NEMO_HUMAN	IKBKG	physical	21988832
TNIP1_HUMAN	TNIP1	physical	21988832
BGLR_HUMAN	GUSB	physical	21988832
TNAP3_HUMAN	TNFAIP3	physical	21988832
SHLB2_HUMAN	SH3GLB2	physical	21988832
K1C18_HUMAN	KRT18	physical	21988832
HGD_HUMAN	HGD	physical	21988832
LMNB1_HUMAN	LMNB1	physical	21988832
SMAD3_HUMAN	SMAD3	physical	21988832
IKBB_HUMAN	NFKBIB	physical	21988832
NDKB_HUMAN	NME2	physical	21988832
PROX1_HUMAN	PROX1	physical	21988832
RECO_HUMAN	RCVRN	physical	21988832
SPOP_HUMAN	SPOP	physical	21988832
SAFB2_HUMAN	SAFB2	physical	21988832
RUSC2_HUMAN	RUSC2	physical	21988832
MVP_HUMAN	MVP	physical	21988832
HNRL1_HUMAN	HNRNPUL1	physical	21988832
NADC_HUMAN	QPRT	physical	21988832
UBQL1_HUMAN	UBQLN1	physical	21988832
KCTD5_HUMAN	KCTD5	physical	21988832
RUFY1_HUMAN	RUFY1	physical	21988832
USBP1_HUMAN	USHBP1	physical	21988832
RPA2_HUMAN	POLR1B	physical	21988832
ARHG6_HUMAN	ARHGEF6	physical	28514442
ARHG7_HUMAN	ARHGEF7	physical	28514442
GIT1_HUMAN	GIT1	physical	28514442
PKN3_HUMAN	PKN3	physical	27173435
NCK5L_HUMAN	NCKAP5L	physical	27173435
TFPT_HUMAN	TFPT	physical	27173435
CCHCR_HUMAN	CCHCR1	physical	27173435
YETS4_HUMAN	YEATS4	physical	27173435
TUFT1_HUMAN	TUFT1	physical	27173435
GOGA5_HUMAN	GOLGA5	physical	27173435
RBG10_HUMAN	RABGAP1L	physical	27173435
RBG1L_HUMAN	RABGAP1L	physical	27173435
CLOCK_HUMAN	CLOCK	physical	27173435
PSMD9_HUMAN	PSMD9	physical	27173435
VPS53_HUMAN	VPS53	physical	27173435
DZIP3_HUMAN	DZIP3	physical	27173435
GRAP1_HUMAN	GRIPAP1	physical	27173435
RCOR1_HUMAN	RCOR1	physical	27173435
HM20A_HUMAN	HMG20A	physical	27173435
VPS50_HUMAN	CCDC132	physical	27173435
CCD93_HUMAN	CCDC93	physical	27173435
MS18B_HUMAN	OIP5	physical	27173435
PF21A_HUMAN	PHF21A	physical	27173435
CAVN1_HUMAN	PTRF	physical	27173435
PHLB3_HUMAN	PHLDB3	physical	27173435
HAUS6_HUMAN	HAUS6	physical	27173435
RPR1A_HUMAN	RPRD1A	physical	27173435
RABX5_HUMAN	RABGEF1	physical	27173435
BMAL1_HUMAN	ARNTL	physical	27173435
NUF2_HUMAN	NUF2	physical	27173435
THA11_HUMAN	THAP11	physical	27173435
VPS51_HUMAN	VPS51	physical	27173435
EIPR1_HUMAN	TSSC1	physical	27173435
RABE1_HUMAN	RABEP1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GIT2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; SER-397; SER-559AND SER-614, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394 AND SER-397, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-559 AND SER-614, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; SER-397; SER-415;SER-418 AND SER-421, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-488 AND SER-496, ANDMASS SPECTROMETRY.	15144186 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-484 AND TYR-492, ANDMASS SPECTROMETRY.	15592455 [Abstract]