RECO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RECO_HUMAN
• UniProt AC: P35243
• Protein Name: Recoverin
• Gene Name: RCVRN
• Organism: Homo sapiens (Human).
• Sequence Length: 200
• Protein Description: Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse..
• Protein Sequence: MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDTDPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANKEILRLIQFEPQKVKEKMKNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNSKSGAL ------CCCCCCCCC	47.31	-
30	Phosphorylation	FSEEELCSWYQSFLK CCHHHHHHHHHHHHH	41.25	22617229
32	Phosphorylation	EEELCSWYQSFLKDC HHHHHHHHHHHHHHC	4.31	22617229
34	Phosphorylation	ELCSWYQSFLKDCPT HHHHHHHHHHHHCCC	19.49	24719451
39	Oxidation	YQSFLKDCPTGRITQ HHHHHHHCCCCCCCH	2.88	-
45	Phosphorylation	DCPTGRITQQQFQSI HCCCCCCCHHHHHHH	20.97	26699800
51	Phosphorylation	ITQQQFQSIYAKFFP CCHHHHHHHHHHHCC	20.89	26699800
53	Phosphorylation	QQQFQSIYAKFFPDT HHHHHHHHHHHCCCC	14.69	26699800
60	Phosphorylation	YAKFFPDTDPKAYAQ HHHHCCCCCHHHHHH	55.21	26699800
86	Phosphorylation	GTLDFKEYVIALHMT CCCCHHHHHEEEEEE	9.57	-
147	Phosphorylation	LLPDDENTPEKRAEK CCCCCCCCHHHHHHH	30.67	-
158	Phosphorylation	RAEKIWKYFGKNDDD HHHHHHHHHCCCCCC	11.54	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RECO_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
39	C	Oxidation	Oxidation on Cys-39 occurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RECO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRK5_HUMAN	GRK5	physical	12507501
GRK6_HUMAN	GRK6	physical	12507501
CAV1_HUMAN	CAV1	physical	12507501
SMAD3_HUMAN	SMAD3	physical	21988832
TGFR2_HUMAN	TGFBR2	physical	21988832
SCRN3_HUMAN	SCRN3	physical	28514442
RAB9A_HUMAN	RAB9A	physical	28514442
HIKES_HUMAN	C11orf73	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.