dbPTM

RAB9A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAB9A_HUMAN
UniProt AC	P51151
Protein Name	Ras-related protein Rab-9A
Gene Name	RAB9A
Organism	Homo sapiens (Human).
Sequence Length	201
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Endoplasmic reticulum membrane . Golgi apparatus membrane . Late endosome . Cytoplasmic vesicle, phagosome membrane Lipid-anchor Cytoplasmic side . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle
Protein Description	Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes..
Protein Sequence	MAGKSSLFKVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEFIYYADVKEPESFPFVILGNKIDISERQVSTEEAQAWCRDNGDYPYFETSAKDATNVAAAFEEAVRRVLATEDRSDHLIQTDTVNLHRKPKPSSSCC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGKSSLFK ------CCCCCCCEE	33.84	22814378
4	Ubiquitination	----MAGKSSLFKVI ----CCCCCCCEEEE	27.60	-
5	Phosphorylation	---MAGKSSLFKVIL ---CCCCCCCEEEEE	31.21	-
6	Phosphorylation	--MAGKSSLFKVILL --CCCCCCCEEEEEC	41.11	24719451
20	Ubiquitination	LGDGGVGKSSLMNRY CCCCCCCHHHHHHHH	34.17	-
39	Phosphorylation	FDTQLFHTIGVEFLN CCHHHHHEECCEECC	16.46	-
102	Ubiquitination	FQNLSNWKKEFIYYA HHCHHHCEEEEEEEE	46.83	-
103	Ubiquitination	QNLSNWKKEFIYYAD HCHHHCEEEEEEEEE	49.85	21890473
103	Acetylation	QNLSNWKKEFIYYAD HCHHHCEEEEEEEEE	49.85	24431187
107	Phosphorylation	NWKKEFIYYADVKEP HCEEEEEEEEECCCC	9.64	25159151
108	Phosphorylation	WKKEFIYYADVKEPE CEEEEEEEEECCCCC	7.48	28152594
116	Phosphorylation	ADVKEPESFPFVILG EECCCCCCCCEEEEC	49.27	28442448
125	Ubiquitination	PFVILGNKIDISERQ CEEEECCCCCCCCCC	39.70	-
156	Ubiquitination	PYFETSAKDATNVAA CCEECCHHHHHHHHH	47.89	-
175	Phosphorylation	AVRRVLATEDRSDHL HHHHHHCCCCCCCCE	33.97	23927012
179	Phosphorylation	VLATEDRSDHLIQTD HHCCCCCCCCEEECC	41.52	30266825
185	Phosphorylation	RSDHLIQTDTVNLHR CCCCEEECCCEECCC	27.00	30266825
187	Phosphorylation	DHLIQTDTVNLHRKP CCEEECCCEECCCCC	18.06	23401153
200	Geranylgeranylation	KPKPSSSCC------ CCCCCCCCC------	3.27	-
201	Geranylgeranylation	PKPSSSCC------- CCCCCCCC-------	7.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RAB9A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RAB9A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAB9A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RABEK_HUMAN	RABEPK	physical	9230071
RHBT3_HUMAN	RHOBTB3	physical	19490898
SC24A_HUMAN	SEC24A	physical	22939629
PCH2_HUMAN	TRIP13	physical	22939629
GDIA_HUMAN	GDI1	physical	28514442
RAE2_HUMAN	CHML	physical	28514442
RAE1_HUMAN	CHM	physical	28514442
PGTA_HUMAN	RABGGTA	physical	28514442
GDIB_HUMAN	GDI2	physical	28514442
VP13C_HUMAN	VPS13C	physical	28514442
SPHK2_HUMAN	SPHK2	physical	28514442
PGTB2_HUMAN	RABGGTB	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAB9A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, AND MASSSPECTROMETRY.	17081983 [Abstract]