dbPTM

PGTB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PGTB2_HUMAN
UniProt AC	P53611
Protein Name	Geranylgeranyl transferase type-2 subunit beta
Gene Name	RABGGTB
Organism	Homo sapiens (Human).
Sequence Length	331
Subcellular Localization
Protein Description	Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A..
Protein Sequence	MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGTPQKDVI ------CCCCCCCEE	46.21	19413330
3	Phosphorylation	-----MGTPQKDVII -----CCCCCCCEEE	22.65	23401153
6	Acetylation	--MGTPQKDVIIKSD --CCCCCCCEEECCC	55.98	23749302
6	Ubiquitination	--MGTPQKDVIIKSD --CCCCCCCEEECCC	55.98	-
11	Sumoylation	PQKDVIIKSDAPDTL CCCCEEECCCCCCEE	31.03	-
11	Ubiquitination	PQKDVIIKSDAPDTL CCCCEEECCCCCCEE	31.03	21906983
11	Sumoylation	PQKDVIIKSDAPDTL CCCCEEECCCCCCEE	31.03	-
12	Phosphorylation	QKDVIIKSDAPDTLL CCCEEECCCCCCEEH	28.70	25850435
17	Phosphorylation	IKSDAPDTLLLEKHA ECCCCCCEEHHHHHH	20.46	27251275
22	Ubiquitination	PDTLLLEKHADYIAS CCEEHHHHHHHHHHH	44.02	21906983
22	Acetylation	PDTLLLEKHADYIAS CCEEHHHHHHHHHHH	44.02	27452117
29	Phosphorylation	KHADYIASYGSKKDD HHHHHHHHCCCCCCH	22.07	28152594
30	Phosphorylation	HADYIASYGSKKDDY HHHHHHHCCCCCCHH	19.18	28152594
32	Phosphorylation	DYIASYGSKKDDYEY HHHHHCCCCCCHHHH	28.44	28152594
33	Ubiquitination	YIASYGSKKDDYEYC HHHHCCCCCCHHHHH	56.72	21906983
34	Ubiquitination	IASYGSKKDDYEYCM HHHCCCCCCHHHHHH	58.49	-
37	Phosphorylation	YGSKKDDYEYCMSEY CCCCCCHHHHHHHHH	20.94	28674419
39	Phosphorylation	SKKDDYEYCMSEYLR CCCCHHHHHHHHHHH	6.29	27642862
124	Acetylation	NKVVEYVKGLQKEDG HHHHHHHHCCCCCCC	53.66	27452117
124	Ubiquitination	NKVVEYVKGLQKEDG HHHHHHHHCCCCCCC	53.66	21906983
241	Phosphorylation	EKLPDVCYSWWVLAS HHCCCHHHHHHHHHH	13.74	24719451
248	Phosphorylation	YSWWVLASLKIIGRL HHHHHHHHHHHHHHC	26.49	24719451
307	Sumoylation	LLGEEQIKPVNPVFC HCCCHHCCCCCCCEE	42.48	-
331	Phosphorylation	NVQPELVS------- CCCHHHCC-------	47.32	28102081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PGTB2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PGTB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PGTB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAB3A_HUMAN	RAB3A	physical	8706741
TP4A2_HUMAN	PTP4A2	physical	11447212
FBXL2_HUMAN	FBXL2	physical	24035498
WDR4_HUMAN	WDR4	physical	25416956
B4GT7_HUMAN	B4GALT7	physical	25416956
TMM25_HUMAN	TMEM25	physical	25416956
RAB37_HUMAN	RAB37	physical	25416956
F19A1_HUMAN	FAM19A1	physical	25416956
I5P1_HUMAN	INPP5A	physical	26186194
PRC2C_HUMAN	PRRC2C	physical	26186194
PI51C_HUMAN	PIP5K1C	physical	26186194
PI51A_HUMAN	PIP5K1A	physical	26186194
AKA11_HUMAN	AKAP11	physical	26186194
PALM_HUMAN	PALM	physical	26186194
NOTC3_HUMAN	NOTCH3	physical	26186194
NOTC2_HUMAN	NOTCH2	physical	26186194
MAGD4_HUMAN	MAGED4B	physical	26186194
MCMBP_HUMAN	MCMBP	physical	26186194
BORA_HUMAN	BORA	physical	26186194
ABRX1_HUMAN	FAM175A	physical	26186194
CACO1_HUMAN	CALCOCO1	physical	26186194
TRI33_HUMAN	TRIM33	physical	26186194
PTAR1_HUMAN	PTAR1	physical	26186194
RHBT3_HUMAN	RHOBTB3	physical	26186194
RRAS2_HUMAN	RRAS2	physical	26186194
RASH_HUMAN	HRAS	physical	26186194
RASN_HUMAN	NRAS	physical	26186194
PAXI_HUMAN	PXN	physical	26186194
RB40C_HUMAN	RAB40C	physical	26186194
RAP2A_HUMAN	RAP2A	physical	26186194
PGTA_HUMAN	RABGGTA	physical	26186194
ARHG6_HUMAN	ARHGEF6	physical	26186194
ACOT9_HUMAN	ACOT9	physical	26186194
TP4A1_HUMAN	PTP4A1	physical	26186194
TP4A2_HUMAN	PTP4A2	physical	26186194
KAPCB_HUMAN	PRKACB	physical	26186194
MCM5_HUMAN	MCM5	physical	26186194
F219A_HUMAN	FAM219A	physical	26186194
KAP1_HUMAN	PRKAR1B	physical	26186194
FOXK1_HUMAN	FOXK1	physical	26186194
NCOA1_HUMAN	NCOA1	physical	26186194
GNB1L_HUMAN	GNB1L	physical	26186194
HOOK1_HUMAN	HOOK1	physical	26186194
GIT1_HUMAN	GIT1	physical	26186194
GIT2_HUMAN	GIT2	physical	26186194
PP16A_HUMAN	PPP1R16A	physical	26186194
ZCCHL_HUMAN	ZC3HAV1L	physical	26186194
PGBD5_HUMAN	PGBD5	physical	26186194
TRM2_HUMAN	TRMT2B	physical	26186194
YKT6_HUMAN	YKT6	physical	26186194
PGTA_HUMAN	RABGGTA	physical	26344197
PTAR1_HUMAN	PTAR1	physical	28514442
PGTA_HUMAN	RABGGTA	physical	28514442
PGBD5_HUMAN	PGBD5	physical	28514442
PAXI_HUMAN	PXN	physical	28514442
NCOA1_HUMAN	NCOA1	physical	28514442
PI51C_HUMAN	PIP5K1C	physical	28514442
PI51A_HUMAN	PIP5K1A	physical	28514442
PP16A_HUMAN	PPP1R16A	physical	28514442
I5P1_HUMAN	INPP5A	physical	28514442
TRI33_HUMAN	TRIM33	physical	28514442
RB40C_HUMAN	RAB40C	physical	28514442
CACO1_HUMAN	CALCOCO1	physical	28514442
ARHG6_HUMAN	ARHGEF6	physical	28514442
PALM_HUMAN	PALM	physical	28514442
NOTC2_HUMAN	NOTCH2	physical	28514442
TP4A2_HUMAN	PTP4A2	physical	28514442
ACOT9_HUMAN	ACOT9	physical	28514442
BORA_HUMAN	BORA	physical	28514442
F219A_HUMAN	FAM219A	physical	28514442
ABRX1_HUMAN	FAM175A	physical	28514442
RHBT3_HUMAN	RHOBTB3	physical	28514442
FXL20_HUMAN	FBXL20	physical	28514442
AKA11_HUMAN	AKAP11	physical	28514442
RASH_HUMAN	HRAS	physical	28514442
TRM2_HUMAN	TRMT2B	physical	28514442
RAP2A_HUMAN	RAP2A	physical	28514442
YKT6_HUMAN	YKT6	physical	28514442
GIT1_HUMAN	GIT1	physical	28514442
GNB1L_HUMAN	GNB1L	physical	28514442
HOOK1_HUMAN	HOOK1	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
PRC2C_HUMAN	PRRC2C	physical	28514442
TP4A1_HUMAN	PTP4A1	physical	28514442
RASN_HUMAN	NRAS	physical	28514442
MCMBP_HUMAN	MCMBP	physical	28514442
NOTC3_HUMAN	NOTCH3	physical	28514442
GIT2_HUMAN	GIT2	physical	28514442
KAPCB_HUMAN	PRKACB	physical	28514442
RAP2C_HUMAN	RAP2C	physical	28514442
ZCCHL_HUMAN	ZC3HAV1L	physical	28514442
MCM3_HUMAN	MCM3	physical	28514442
XRCC3_HUMAN	XRCC3	genetic	27453043
ATAD5_HUMAN	ATAD5	genetic	27453043
BLM_HUMAN	BLM	genetic	27453043
MTOR_HUMAN	MTOR	genetic	27453043
RS19_HUMAN	RPS19	genetic	27453043

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PGTB2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3, AND MASSSPECTROMETRY.	17081983 [Abstract]