| UniProt ID | TRM2_HUMAN | |
|---|---|---|
| UniProt AC | Q96GJ1 | |
| Protein Name | tRNA (uracil(54)-C(5))-methyltransferase homolog | |
| Gene Name | TRMT2B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 504 | |
| Subcellular Localization | ||
| Protein Description | Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity).. | |
| Protein Sequence | MAGLKRRVPLHSLRYFISMVGLFSKPGLLPWYARNPPGWSQLFLGTVCKGDFTRVIATKCQKGQKSQKKPSHLGPLDGSWQERLADVVTPLWRLSYEEQLKVKFAAQKKILQRLESYIQMLNGVSVTTAVPKSERLSCLLHPIIPSPVINGYRNKSTFSVNRGPDGNPKTVGFYLGTWRDGNVVCVQSNHLKNIPEKHSQVAQYYEVFLRQSPLEPCLVFHEGGYWRELTVRTNSQGHTMAIITFHPQKLSQEELHVQKEIVKEFFIRGPGAACGLTSLYFQESTMTRCSHQQSPYQLLFGEPYIFEELLSLKIRISPDAFFQINTAGAEMLYRTVGELTGVNSDTILLDICCGTGVIGLSLAQHTSRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKSKEDGQSIVAVVNPARAGLHYKVIQAIRNFRAIHTLVFVSCKLHGESTRNVIELCCPPDPAKKLLGEPFVLQQAVPVDLFPHTPHCELVLLFTR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | KRRVPLHSLRYFISM CCCCCHHHHHHHHHH | 23.40 | 23403867 | |
| 24 | Phosphorylation | ISMVGLFSKPGLLPW HHHHHHHCCCCCCHH | 42.88 | 24719451 | |
| 89 | Phosphorylation | ERLADVVTPLWRLSY HHHHHHHHHHHHCCH | 16.71 | - | |
| 96 (in isoform 3) | Phosphorylation | - | 28.25 | - | |
| 125 | Phosphorylation | IQMLNGVSVTTAVPK HHHHCCCCEEECCCH | 18.36 | 29759185 | |
| 133 | Phosphorylation | VTTAVPKSERLSCLL EEECCCHHHHHHHHH | 23.14 | 29759185 | |
| 156 | Phosphorylation | INGYRNKSTFSVNRG CCCCCCCCCEEEEEC | 37.93 | 28348404 | |
| 157 | Phosphorylation | NGYRNKSTFSVNRGP CCCCCCCCEEEEECC | 22.87 | 28348404 | |
| 159 | Phosphorylation | YRNKSTFSVNRGPDG CCCCCCEEEEECCCC | 20.69 | 27251275 | |
| 233 | Phosphorylation | WRELTVRTNSQGHTM EEEEEEEECCCCCEE | 34.58 | - | |
| 235 | Phosphorylation | ELTVRTNSQGHTMAI EEEEEECCCCCEEEE | 36.61 | - | |
| 251 | Phosphorylation | TFHPQKLSQEELHVQ EECHHHCCHHHHHHC | 42.45 | - | |
| 259 | Ubiquitination | QEELHVQKEIVKEFF HHHHHHCHHHHHHHH | 48.60 | - | |
| 263 | Ubiquitination | HVQKEIVKEFFIRGP HHCHHHHHHHHHCCC | 55.24 | - | |
| 296 | Phosphorylation | CSHQQSPYQLLFGEP CCCCCCCCHHHHCCC | 19.62 | - | |
| 304 | Phosphorylation | QLLFGEPYIFEELLS HHHHCCCCHHHHHHC | 17.59 | - | |
| 311 | Phosphorylation | YIFEELLSLKIRISP CHHHHHHCCCEEECC | 40.00 | 24719451 | |
| 333 | Phosphorylation | TAGAEMLYRTVGELT CCHHHHHHCHHHHHH | 11.70 | - | |
| 403 | Ubiquitination | FHTGQAEKILPGLLK CCCCCHHHHCCCHHC | 53.19 | - | |
| 410 | Ubiquitination | KILPGLLKSKEDGQS HHCCCHHCCCCCCCE | 65.60 | - | |
| 412 | Ubiquitination | LPGLLKSKEDGQSIV CCCHHCCCCCCCEEE | 59.23 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRM2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRM2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRM2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TRM2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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