NOTC3_HUMAN - dbPTM
NOTC3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOTC3_HUMAN
UniProt AC Q9UM47
Protein Name Neurogenic locus notch homolog protein 3
Gene Name NOTCH3
Organism Homo sapiens (Human).
Sequence Length 2321
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Notch 3 intracellular domain: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
Protein Description Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. [PubMed: 15350543 Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity]
Protein Sequence MGPGARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPPEPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKVEEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKAGLGPQGPRGRGKKLTLACPGPLADSSVTLSPVDSLDSPRPFGGPPASPGGFPLEGPYAAATATAVSLAQLGGPGRAGLGRQPPGGCVLSLGLLNPVAVPLDWARLPPPAPPGPSFLLPLAPGPQLLNPGTPVSPQERPPPYLAVPGHGEEYPAAGAHSSPPKARFLRVPSEHPYLTPSPESPEHWASPSPPSLSDWSESTPSPATATGAMATTTGALPAQPLPLSVPSSLAQAQTQLGPQPEVTPKRQVLA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
84PhosphorylationQLEDPCHSGPCAGRG
CCCCCCCCCCCCCCC		51.66-
118PhosphorylationGFRGPDCSLPDPCLS
CCCCCCCCCCCCCCC		50.76-
125PhosphorylationSLPDPCLSSPCAHGA
CCCCCCCCCCCCCCC		38.66-
126PhosphorylationLPDPCLSSPCAHGAR
CCCCCCCCCCCCCCC		15.85-
135PhosphorylationCAHGARCSVGPDGRF
CCCCCCCEECCCCCE		25.26-
211PhosphorylationSPCRNGGTCRQSGDL
CCCCCCCCCCCCCCC		13.10-
529PhosphorylationCVDQPDGYECRCAEG
CCCCCCCCEECCCCC		21.16-
725O-linked_GlycosylationCVCEPGWSGPRCSQS
EEECCCCCCCCCCHH		44.8528657654
1179N-linked_GlycosylationSGPRCLHNGTCVDLV
CCCCEEECCEEEECC		34.22UniProtKB CARBOHYD
1197PhosphorylationRCTCPPGYTGLRCEA
EEECCCCCCCEEEEE		11.92-
1198O-linked_GlycosylationCTCPPGYTGLRCEAD
EECCCCCCCEEEEEC		35.3428657654
1219PhosphorylationGACHAAHTRDCLQDP
CCCCCCCHHHHHHCC		24.3930631047
1239PhosphorylationCLCHAGFSGPRCQTV
EEEECCCCCCCCCEE		47.1424719451
1272O-linked_GlycosylationPGPGGGLTFTCHCAQ
CCCCCCEEEEEEECC		21.8528657654
1274O-linked_GlycosylationPGGGLTFTCHCAQPF
CCCCEEEEEEECCCC		8.9828657654
1336N-linked_GlycosylationGSPPGASNASCAAAP
CCCCCCCCCCCCCCC		35.03UniProtKB CARBOHYD
1438N-linked_GlycosylationLQCWRLFNNSRCDPA
HHHHHHHCCCCCCCC		50.59UniProtKB CARBOHYD
1632UbiquitinationPLRDVRGEPLEPPEP
CCCCCCCCCCCCCCC		35.8321890473
1672PhosphorylationARRKREHSTLWFPEG
HHHHCCCCCEECCCC		22.0524719451
1673PhosphorylationRRKREHSTLWFPEGF
HHHCCCCCEECCCCC		29.8924719451
1681PhosphorylationLWFPEGFSLHKDVAS
EECCCCCCCCHHHHC		40.1822617229
1684UbiquitinationPEGFSLHKDVASGHK
CCCCCCCHHHHCCCC		60.2222817900
1705UbiquitinationGQDALGMKNMAKGES
CCCHHCCCCHHCCCC		41.6033845483
1712PhosphorylationKNMAKGESLMGEVAT
CCHHCCCCHHHHHHH		32.1228348404
1733UbiquitinationCPEAKRLKVEEPGMG
CCHHHCCCCCCCCCC		52.1933845483
1769PhosphorylationVAPAMALTPPQGDAD
EECCHHCCCCCCCCC		24.3128555341
1849PhosphorylationALHLAARYARADAAK
HHHHHHHHHHHHHHH		8.84-
1896PhosphorylationQILIRNRSTDLDARM
HHEEECCCCCCHHHC		29.8027251275
1897PhosphorylationILIRNRSTDLDARMA
HEEECCCCCCHHHCC		37.0327251275
1908PhosphorylationARMADGSTALILAAR
HHCCCHHHHHHHHHH		30.89-
1971UbiquitinationNKDMQDSKEETPLFL
CCCCCCCCCCCCHHH		68.7929967540
1989UbiquitinationEGSYEAAKLLLDHFA
CCCHHHHHHHHHHHH		46.87-
2028PhosphorylationVRLLDQPSGPRSPPG
HHHHHCCCCCCCCCC		56.6622617229
2032PhosphorylationDQPSGPRSPPGPHGL
HCCCCCCCCCCCCCC		38.2823663014
2069UbiquitinationKSRRPPGKAGLGPQG
CCCCCCCCCCCCCCC		45.0829967540
2085PhosphorylationRGRGKKLTLACPGPL
CCCCCCEEEECCCCC		22.6126074081
2095PhosphorylationCPGPLADSSVTLSPV
CCCCCCCCCCEECCC		22.5426074081
2096PhosphorylationPGPLADSSVTLSPVD
CCCCCCCCCEECCCC		21.4826074081
2098PhosphorylationPLADSSVTLSPVDSL
CCCCCCCEECCCCCC		24.3826074081
2100PhosphorylationADSSVTLSPVDSLDS
CCCCCEECCCCCCCC		17.3226074081
2104PhosphorylationVTLSPVDSLDSPRPF
CEECCCCCCCCCCCC		34.0226074081
2107PhosphorylationSPVDSLDSPRPFGGP
CCCCCCCCCCCCCCC		28.2726074081
2117PhosphorylationPFGGPPASPGGFPLE
CCCCCCCCCCCCCCC		29.8326074081
2174MethylationAVPLDWARLPPPAPP
EEECCHHHCCCCCCC		43.4024129315
2200PhosphorylationPQLLNPGTPVSPQER
CCCCCCCCCCCCCCC		23.0526074081
2203PhosphorylationLNPGTPVSPQERPPP
CCCCCCCCCCCCCCC		23.2826074081
2211PhosphorylationPQERPPPYLAVPGHG
CCCCCCCCEECCCCC		17.0526074081
2251PhosphorylationYLTPSPESPEHWASP
CCCCCCCCCCCCCCC		38.6822468782
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseWWP2O00308
PMID:25356737
-KUbiquitinationE3 ubiquitin ligaseITCHQ96J02
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOTC3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOTC3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNW1_HUMANSNW1physical
11404076
DLL1_HUMANDLL1physical
11006133
JAG1_HUMANJAG1physical
11006133
JAG2_HUMANJAG2physical
11006133
GSK3B_HUMANGSK3Bphysical
21502811
STRAP_HUMANSTRAPphysical
21502811
CBL_HUMANCBLphysical
19966856
MPPD2_HUMANMPPED2physical
25356737
GGT6_HUMANGGT6physical
25356737
MTG8R_HUMANCBFA2T2physical
25356737
SPTC2_HUMANSPTLC2physical
25356737
RET_HUMANRETphysical
25356737
MYC_HUMANMYCphysical
25356737
VINEX_HUMANSORBS3physical
25356737
WWP2_HUMANWWP2physical
25356737
SUH_HUMANRBPJphysical
25356737
TNNT2_HUMANTNNT2physical
25356737
XKR8_HUMANXKR8physical
25356737
SNX19_HUMANSNX19physical
25356737
CNTD1_HUMANCNTD1physical
25356737
WDR25_HUMANWDR25physical
25356737
SG3A1_HUMANSCGB3A1physical
25356737
CPNE6_HUMANCPNE6physical
25356737
BAG2_HUMANBAG2physical
25356737
S39A1_HUMANSLC39A1physical
25356737
PPIA_HUMANPPIAphysical
25356737
CH076_HUMANC8orf76physical
25356737
C1QRF_HUMANC1QL1physical
25356737
TM108_HUMANTMEM108physical
25356737
CASL_HUMANNEDD9physical
25356737
RMI2_HUMANRMI2physical
25356737
CRIP2_HUMANCRIP2physical
25356737
BT3L4_HUMANBTF3L4physical
25356737
TCTP_HUMANTPT1physical
25356737
Drug and Disease Associations
Kegg Disease
H00536 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
OMIM Disease
125310Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL)
615293Myofibromatosis, infantile 2 (IMF2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOTC3_HUMAN

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Related Literatures of Post-Translational Modification

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