MTG8R_HUMAN - dbPTM
MTG8R_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTG8R_HUMAN
UniProt AC O43439
Protein Name Protein CBFA2T2
Gene Name CBFA2T2
Organism Homo sapiens (Human).
Sequence Length 604
Subcellular Localization Nucleus .
Protein Description Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. [PubMed: 12559562]
Protein Sequence MAKESGISLKEIQVLARQWKVGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4 (in isoform 2)Phosphorylation-44.6625159151
4 (in isoform 3)Phosphorylation-44.6625159151
8PhosphorylationMAKESGISLKEIQVL
CCCCCCCCHHHHHHH		36.5924275569
15 (in isoform 4)Phosphorylation-1.5421406692
16 (in isoform 4)Phosphorylation-11.6321406692
18PhosphorylationEIQVLARQWKVGPEK
HHHHHHHHHCCCCCC		38.4432142685
24PhosphorylationRQWKVGPEKRVPAMP
HHHCCCCCCCCCCCC		47.7932142685
24 (in isoform 5)Phosphorylation-47.7925849741
24 (in isoform 4)Phosphorylation-47.7921406692
33PhosphorylationRVPAMPGSPVEVKIQ
CCCCCCCCCEEEEEE		21.6523401153
38SumoylationPGSPVEVKIQSRSSP
CCCCEEEEEECCCCC		22.8628112733
38PhosphorylationPGSPVEVKIQSRSSP
CCCCEEEEEECCCCC		22.8632142685
43PhosphorylationEVKIQSRSSPPTMPP
EEEEECCCCCCCCCC		53.0626657352
44PhosphorylationVKIQSRSSPPTMPPL
EEEECCCCCCCCCCC		33.5123684312
47PhosphorylationQSRSSPPTMPPLPPI
ECCCCCCCCCCCCCC		45.7723684312
65PhosphorylationGPRPVSFTPTALSNG
CCCCCCCCCHHHCCC		16.5429449344
67PhosphorylationRPVSFTPTALSNGIN
CCCCCCCHHHCCCCC		36.8529449344
70PhosphorylationSFTPTALSNGINHSP
CCCCHHHCCCCCCCC		30.4629449344
76PhosphorylationLSNGINHSPPTLNGA
HCCCCCCCCCCCCCC		28.2526074081
79PhosphorylationGINHSPPTLNGAPSP
CCCCCCCCCCCCCCC		35.9226074081
85PhosphorylationPTLNGAPSPPQRFSN
CCCCCCCCCCCCCCC		48.9926074081
117PhosphorylationTCGARQLSKLKRFLT
CCCHHHHHHHHHHHH		27.83-
218PhosphorylationLLNTSIASPADSSEL
HHCCCCCCCCCCHHH		20.9626074081
222PhosphorylationSIASPADSSELLMEV
CCCCCCCCHHHHHHH		28.0226074081
235 (in isoform 2)Phosphorylation-38.02-
235PhosphorylationEVHGNGKRPSPERRE
HHCCCCCCCCHHHHH		38.0232142685
237PhosphorylationHGNGKRPSPERREEN
CCCCCCCCHHHHHCC		43.3528176443
245PhosphorylationPERREENSFDRDTIA
HHHHHCCCCCCCCCC		31.6325627689
255PhosphorylationRDTIAPEPPAKRVCT
CCCCCCCCCCCCEEE		32.8432142685
258AcetylationIAPEPPAKRVCTISP
CCCCCCCCCEEECCC		51.6525953088
262PhosphorylationPPAKRVCTISPAPRH
CCCCCEEECCCCCCC		22.9530266825
264PhosphorylationAKRVCTISPAPRHSP
CCCEEECCCCCCCCC		9.2419664994
270PhosphorylationISPAPRHSPALTVPL
CCCCCCCCCCCCCEE		17.10-
274 (in isoform 4)Phosphorylation-23.3721406692
281UbiquitinationTVPLMNPGGQFHPTP
CCEEECCCCCCCCCC		37.2129967540
301UbiquitinationYTLEDIATSHLYREP
CCHHHHHHHHHHCCC		19.6029967540
310UbiquitinationHLYREPNKMLEHREV
HHHCCCCCCCCCHHH		56.4229967540
323PhosphorylationEVRDRHHSLGLNGGY
HHHHHHHHCCCCCCC		20.2930576142
330PhosphorylationSLGLNGGYQDELVDH
HCCCCCCCHHHHHHH		17.75-
368PhosphorylationMVEKTRRSMAVLRRC
HHHHHHHHHHHHHHH		14.0624719451
369UbiquitinationVEKTRRSMAVLRRCQ
HHHHHHHHHHHHHHH		2.5829967540
370 (in isoform 2)Phosphorylation-9.84-
380 (in isoform 2)Phosphorylation-48.87-
380PhosphorylationRRCQESDREELNYWK
HHHHHHHHHHHHHHH		48.8733259812
383 (in isoform 2)Phosphorylation-5.22-
389UbiquitinationELNYWKRRYNENTEL
HHHHHHHHHCCCCCH		34.6029967540
398UbiquitinationNENTELRKTGTELVS
CCCCCHHHHCCHHHH		65.0229967540
399PhosphorylationENTELRKTGTELVSR
CCCCHHHHCCHHHHC		42.7919664995
400PhosphorylationNTELRKTGTELVSRQ
CCCHHHHCCHHHHCC		21.8933259812
405PhosphorylationKTGTELVSRQHSPGS
HHCCHHHHCCCCCCC		38.5626074081
408 (in isoform 4)Ubiquitination-34.55-
409PhosphorylationELVSRQHSPGSADSL
HHHHCCCCCCCCCCC		23.7128355574
412PhosphorylationSRQHSPGSADSLSND
HCCCCCCCCCCCCCC		32.0822115753
415PhosphorylationHSPGSADSLSNDSQR
CCCCCCCCCCCCCCH		33.1530108239
417PhosphorylationPGSADSLSNDSQREF
CCCCCCCCCCCCHHH		42.4120068231
419 (in isoform 4)Phosphorylation-42.6521406692
420UbiquitinationADSLSNDSQREFNSR
CCCCCCCCCHHHHCC		35.0729967540
420PhosphorylationADSLSNDSQREFNSR
CCCCCCCCCHHHHCC		35.0720068231
422 (in isoform 4)Phosphorylation-55.1921406692
430PhosphorylationEFNSRPGTGYVPVEF
HHHCCCCCCCCCHHH		28.20-
437UbiquitinationTGYVPVEFWKKTEEA
CCCCCHHHHHHHHHH		13.5929967540
440UbiquitinationVPVEFWKKTEEAVNK
CCHHHHHHHHHHHHH		52.3329967540
447AcetylationKTEEAVNKVKIQAMS
HHHHHHHHHHHHHHH		38.0025953088
449UbiquitinationEEAVNKVKIQAMSEV
HHHHHHHHHHHHHHH		30.6129967540
449SumoylationEEAVNKVKIQAMSEV
HHHHHHHHHHHHHHH		30.6128112733
457UbiquitinationIQAMSEVQKAVAEAE
HHHHHHHHHHHHHHH		24.7629967540
466UbiquitinationAVAEAEQKAFEVIAT
HHHHHHHHHHHHHHH		46.6929967540
477UbiquitinationVIATERARMEQTIAD
HHHHHHHHHHHHHHH		35.0829967540
478SulfoxidationIATERARMEQTIADV
HHHHHHHHHHHHHHH		4.3421406390
486UbiquitinationEQTIADVKRQAAEDA
HHHHHHHHHHHHHHH		39.0629967540
496 (in isoform 4)Ubiquitination-3.40-
517PhosphorylationCGRKASETCSGCNIA
CCHHHHHCCCCCCHH		14.96-
519PhosphorylationRKASETCSGCNIARY
HHHHHCCCCCCHHHH		54.52-
522PhosphorylationSETCSGCNIARYCGS
HHCCCCCCHHHHCCC		34.1832142685
542PhosphorylationDWERHHRLCGQNLHG
CHHHHHCCCCCCCCC		3.1432142685
548 (in isoform 2)Phosphorylation-39.53-
548PhosphorylationRLCGQNLHGQSPHGQ
CCCCCCCCCCCCCCC		39.5332142685
551PhosphorylationGQNLHGQSPHGQGRP
CCCCCCCCCCCCCCC		24.3724260401
561 (in isoform 4)Phosphorylation-33.9121406692
563 (in isoform 2)Phosphorylation-26.71-
568PhosphorylationPVGRGSSARSADCSV
CCCCCCCCCCCCCCC		15.9032142685
570PhosphorylationGRGSSARSADCSVPS
CCCCCCCCCCCCCCC		28.3326074081
574PhosphorylationSARSADCSVPSPALD
CCCCCCCCCCCCCCC		37.3026074081
577PhosphorylationSADCSVPSPALDKTS
CCCCCCCCCCCCCCC		22.2019664994
583PhosphorylationPSPALDKTSATTSRS
CCCCCCCCCCCCCCC		24.2219664995
584PhosphorylationSPALDKTSATTSRSS
CCCCCCCCCCCCCCC		29.3823090842
586PhosphorylationALDKTSATTSRSSTP
CCCCCCCCCCCCCCC		25.6822617229
587PhosphorylationLDKTSATTSRSSTPA
CCCCCCCCCCCCCCC		23.1223090842
588PhosphorylationDKTSATTSRSSTPAS
CCCCCCCCCCCCCCE		26.3023090842
590PhosphorylationTSATTSRSSTPASVT
CCCCCCCCCCCCEEE		38.0325159151
591PhosphorylationSATTSRSSTPASVTA
CCCCCCCCCCCEEEE		36.9825159151
592PhosphorylationATTSRSSTPASVTAI
CCCCCCCCCCEEEEE		24.9119664995
595PhosphorylationSRSSTPASVTAIDTN
CCCCCCCEEEEEECC		22.6223090842
597PhosphorylationSSTPASVTAIDTNGL
CCCCCEEEEEECCCC		18.5222115753
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTG8R_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTG8R_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTG8R_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NTAQ1_HUMANWDYHV1physical
16189514
MTG8_HUMANRUNX1T1physical
14703694
FXL19_HUMANFBXL19physical
20211142
PRD14_HUMANPRDM14physical
20211142
A4_HUMANAPPphysical
21832049
MDFI_HUMANMDFIphysical
19060904
LBP_HUMANLBPphysical
21988832
MTG8R_HUMANCBFA2T2physical
25416956
PDP1_HUMANPDP1physical
25416956
PRD14_HUMANPRDM14physical
25416956
PRDM6_HUMANPRDM6physical
26186194
PRDM6_HUMANPRDM6physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTG8R_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, AND MASSSPECTROMETRY.

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