dbPTM

MDFI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MDFI_HUMAN
UniProt AC	Q99750
Protein Name	MyoD family inhibitor
Gene Name	MDFI
Organism	Homo sapiens (Human).
Sequence Length	246
Subcellular Localization	Nucleus. Cytoplasm.
Protein Description	Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity)..
Protein Sequence	MYQVSGQRPSGCDAPYGAPSAAPGPAQTLSLLPGLEVVTGSTHPAEAAPEEGSLEEAATPMPQGNGPGIPQGLDSTDLDVPTEAVTCQPQGNPLGCTPLLPNDSGHPSELGGTRRAGNGALGGPKAHRKLQTHPSLASQGSKKSKSSSKSTTSQIPLQAQEDCCVHCILSCLFCEFLTLCNIVLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDLDCGILDACCESADCLEICMECCGLCFSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
129	Ubiquitination	GGPKAHRKLQTHPSL CCHHHHHHHHCCHHH	34.77	-
132	Phosphorylation	KAHRKLQTHPSLASQ HHHHHHHCCHHHHHC	46.30	23927012
135	Phosphorylation	RKLQTHPSLASQGSK HHHHCCHHHHHCCCC	29.03	23927012
138	Phosphorylation	QTHPSLASQGSKKSK HCCHHHHHCCCCCCC	40.13	20873877
141	Phosphorylation	PSLASQGSKKSKSSS HHHHHCCCCCCCCCC	29.31	20873877
142	Ubiquitination	SLASQGSKKSKSSSK HHHHCCCCCCCCCCC	68.81	-
143	Acetylation	LASQGSKKSKSSSKS HHHCCCCCCCCCCCC	65.89	20167786
144	Phosphorylation	ASQGSKKSKSSSKST HHCCCCCCCCCCCCC	41.32	27282143

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MDFI_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MDFI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MDFI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DD19A_HUMAN	DDX19A	physical	16189514
ADPPT_HUMAN	AASDHPPT	physical	16189514
AP5Z1_HUMAN	AP5Z1	physical	16189514
FZD9_HUMAN	FZD9	physical	16189514
F124B_HUMAN	FAM124B	physical	16189514
TYMOS_HUMAN	TYMSOS	physical	16189514
AK17A_HUMAN	AKAP17A	physical	16189514
BAHD1_HUMAN	BAHD1	physical	16189514
DKK1_HUMAN	DKK1	physical	16189514
IL27B_HUMAN	EBI3	physical	16189514
ZN426_HUMAN	ZNF426	physical	16189514
TM241_HUMAN	TMEM241	physical	16189514
SL9A1_HUMAN	SLC9A1	physical	16189514
SIX1_HUMAN	SIX1	physical	16189514
CHIC2_HUMAN	CHIC2	physical	16189514
MDFI_HUMAN	MDFI	physical	16189514
CJ062_HUMAN	C10orf62	physical	16189514
CC116_HUMAN	CCDC116	physical	16189514
GRIN2_HUMAN	GPRIN2	physical	16189514
ZBT24_HUMAN	ZBTB24	physical	16189514
K0408_HUMAN	KIAA0408	physical	16189514
LRRN4_HUMAN	LRRN4	physical	16189514
NR1H2_HUMAN	NR1H2	physical	16189514
ZN679_HUMAN	ZNF679	physical	16189514
S35A2_HUMAN	SLC35A2	physical	16189514
ZBT25_HUMAN	ZBTB25	physical	16189514
CS060_HUMAN	C19orf60	physical	16189514
IQUB_HUMAN	IQUB	physical	16189514
CCER1_HUMAN	CCER1	physical	16189514
ENKD1_HUMAN	ENKD1	physical	16189514
DHRS1_HUMAN	DHRS1	physical	16189514
SERF2_HUMAN	SERF2	physical	16189514
ZN559_HUMAN	ZNF559	physical	16189514
MFSD3_HUMAN	MFSD3	physical	16189514
FASTK_HUMAN	FASTK	physical	16189514
ZN607_HUMAN	ZNF607	physical	16189514
THAP7_HUMAN	THAP7	physical	16189514
OTX1_HUMAN	OTX1	physical	16189514
PIN1_HUMAN	PIN1	physical	16189514
CIKS_HUMAN	TRAF3IP2	physical	16189514
NTAQ1_HUMAN	WDYHV1	physical	16189514
ZN707_HUMAN	ZNF707	physical	16189514
ZN439_HUMAN	ZNF439	physical	16189514
FBXW5_HUMAN	FBXW5	physical	16189514
RFX2_HUMAN	RFX2	physical	16189514
CC120_HUMAN	CCDC120	physical	16189514
RABL6_HUMAN	RABL6	physical	16189514
DCAF8_HUMAN	DCAF8	physical	16189514
TINAL_HUMAN	TINAGL1	physical	16189514
ZN408_HUMAN	ZNF408	physical	16189514
SFI1_HUMAN	SFI1	physical	16189514
SPG7_HUMAN	SPG7	physical	16189514
ZN136_HUMAN	ZNF136	physical	16189514
MET17_HUMAN	METTL17	physical	16189514
6PGL_HUMAN	PGLS	physical	16189514
CTSR1_HUMAN	CATSPER1	physical	16189514
PIDD1_HUMAN	PIDD1	physical	16189514
ZN646_HUMAN	ZNF646	physical	16189514
NPDC1_HUMAN	NPDC1	physical	16189514
CF206_HUMAN	C6orf165	physical	16189514
ATG12_HUMAN	ATG12	physical	16189514
CBX2_HUMAN	CBX2	physical	16189514
ZN417_HUMAN	ZNF417	physical	16189514
TRPV6_HUMAN	TRPV6	physical	16189514
NECT2_HUMAN	PVRL2	physical	16189514
BAALC_HUMAN	BAALC	physical	16189514
ZN440_HUMAN	ZNF440	physical	16189514
LMO3_HUMAN	LMO3	physical	16189514
TAP1_HUMAN	TAP1	physical	16189514
INT11_HUMAN	CPSF3L	physical	16189514
ZN581_HUMAN	ZNF581	physical	16189514
CNNM3_HUMAN	CNNM3	physical	16189514
ZN764_HUMAN	ZNF764	physical	16189514
CC185_HUMAN	CCDC185	physical	16189514
THEG_HUMAN	THEG	physical	16189514
MTG8R_HUMAN	CBFA2T2	physical	16189514
ZN101_HUMAN	ZNF101	physical	16189514
DNPEP_HUMAN	DNPEP	physical	16189514
PHLA1_HUMAN	PHLDA1	physical	16189514
CH048_HUMAN	C8orf48	physical	16189514
VPS72_HUMAN	VPS72	physical	16189514
ZN205_HUMAN	ZNF205	physical	16189514
MYOG_HUMAN	MYOG	physical	8797820
MYF5_HUMAN	MYF5	physical	8797820
MYOD1_HUMAN	MYOD1	physical	8797820
MDFI_HUMAN	MDFI	physical	25416956
NAB2_HUMAN	NAB2	physical	25416956
REG3A_HUMAN	REG3A	physical	25416956
PIN1_HUMAN	PIN1	physical	25416956
AAKB2_HUMAN	PRKAB2	physical	25416956
NECT2_HUMAN	PVRL2	physical	25416956
SPG7_HUMAN	SPG7	physical	25416956
ELOA1_HUMAN	TCEB3	physical	25416956
VPS72_HUMAN	VPS72	physical	25416956
TGIF1_HUMAN	TGIF1	physical	25416956
TNNI1_HUMAN	TNNI1	physical	25416956
STP2_HUMAN	TNP2	physical	25416956
TYRO3_HUMAN	TYRO3	physical	25416956
NR1H2_HUMAN	NR1H2	physical	25416956
VHL_HUMAN	VHL	physical	25416956
WNT11_HUMAN	WNT11	physical	25416956
ZNF79_HUMAN	ZNF79	physical	25416956
ZN124_HUMAN	ZNF124	physical	25416956
ZN136_HUMAN	ZNF136	physical	25416956
ZN138_HUMAN	ZNF138	physical	25416956
ZN155_HUMAN	ZNF155	physical	25416956
ZN223_HUMAN	ZNF223	physical	25416956
ZN230_HUMAN	ZNF230	physical	25416956
AK17A_HUMAN	AKAP17A	physical	25416956
APEL_HUMAN	APLN	physical	25416956
TF3C5_HUMAN	GTF3C5	physical	25416956
ZN264_HUMAN	ZNF264	physical	25416956
MAGD1_HUMAN	MAGED1	physical	25416956
CREB5_HUMAN	CREB5	physical	25416956
K0040_HUMAN	KIAA0040	physical	25416956
RHG32_HUMAN	ARHGAP32	physical	25416956
ZBT24_HUMAN	ZBTB24	physical	25416956
NR1H3_HUMAN	NR1H3	physical	25416956
SPY1_HUMAN	SPRY1	physical	25416956
SPY2_HUMAN	SPRY2	physical	25416956
KAT5_HUMAN	KAT5	physical	25416956
ZN266_HUMAN	ZNF266	physical	25416956
ARI5A_HUMAN	ARID5A	physical	25416956
UBP20_HUMAN	USP20	physical	25416956
PDIA5_HUMAN	PDIA5	physical	25416956
TUSC2_HUMAN	TUSC2	physical	25416956
BAHD1_HUMAN	BAHD1	physical	25416956
MABP1_HUMAN	MAPKBP1	physical	25416956
DAAM2_HUMAN	DAAM2	physical	25416956
ZFY26_HUMAN	ZFYVE26	physical	25416956
6PGL_HUMAN	PGLS	physical	25416956
PKHG4_HUMAN	PLEKHG4	physical	25416956
HEYL_HUMAN	HEYL	physical	25416956
DCAF8_HUMAN	DCAF8	physical	25416956
CDKL3_HUMAN	CDKL3	physical	25416956
ZN581_HUMAN	ZNF581	physical	25416956
PCLI1_HUMAN	PID1	physical	25416956
FBX34_HUMAN	FBXO34	physical	25416956
CN105_HUMAN	C14orf105	physical	25416956
RYDEN_HUMAN	C19orf66	physical	25416956
TRPV6_HUMAN	TRPV6	physical	25416956
CDA7L_HUMAN	CDCA7L	physical	25416956
GPT2L_HUMAN	GPATCH2L	physical	25416956
LIMS2_HUMAN	LIMS2	physical	25416956
BEX1_HUMAN	BEX1	physical	25416956
NPDC1_HUMAN	NPDC1	physical	25416956
PAR11_HUMAN	PARP11	physical	25416956
ATL3_HUMAN	ADAMTSL3	physical	25416956
ZN490_HUMAN	ZNF490	physical	25416956
CXL16_HUMAN	CXCL16	physical	25416956
DMRT3_HUMAN	DMRT3	physical	25416956
AVPI1_HUMAN	AVPI1	physical	25416956
MAGF1_HUMAN	MAGEF1	physical	25416956
TTC23_HUMAN	TTC23	physical	25416956
FND11_HUMAN	C20orf195	physical	25416956
FXL18_HUMAN	FBXL18	physical	25416956
FP100_HUMAN	C17orf70	physical	25416956
ENKD1_HUMAN	ENKD1	physical	25416956
F161A_HUMAN	FAM161A	physical	25416956
ZN559_HUMAN	ZNF559	physical	25416956
ZN607_HUMAN	ZNF607	physical	25416956
ZN587_HUMAN	ZNF587	physical	25416956
ZN439_HUMAN	ZNF439	physical	25416956
RIPP1_HUMAN	RIPPLY1	physical	25416956
HNRLL_HUMAN	HNRNPLL	physical	25416956
ZN101_HUMAN	ZNF101	physical	25416956
PTPM1_HUMAN	PTPMT1	physical	25416956
PIHD2_HUMAN	PIH1D2	physical	25416956
ZN440_HUMAN	ZNF440	physical	25416956
CV039_HUMAN	C22orf39	physical	25416956
NEUR4_HUMAN	NEU4	physical	25416956
SPTA3_HUMAN	SPATA3	physical	25416956
DCNP1_HUMAN	DCANP1	physical	25416956
SPAT8_HUMAN	SPATA8	physical	25416956
MGT5B_HUMAN	MGAT5B	physical	25416956
ZN578_HUMAN	ZNF578	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
CD026_HUMAN	C4orf26	physical	25416956
ZN564_HUMAN	ZNF564	physical	25416956
ZN433_HUMAN	ZNF433	physical	25416956
CC116_HUMAN	CCDC116	physical	25416956
OLIG3_HUMAN	OLIG3	physical	25416956
LCE4A_HUMAN	LCE4A	physical	25416956
C2D1B_HUMAN	CC2D1B	physical	25416956
ZBTB9_HUMAN	ZBTB9	physical	25416956
TTL10_HUMAN	TTLL10	physical	25416956
ZN844_HUMAN	ZNF844	physical	25416956
RTP5_HUMAN	RTP5	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
LCE1B_HUMAN	LCE1B	physical	25416956
LCE3E_HUMAN	LCE3E	physical	25416956
CJ062_HUMAN	C10orf62	physical	25416956
TYMOS_HUMAN	TYMSOS	physical	25416956
FX4L6_HUMAN	FOXD4L6	physical	25416956
DCAF8_HUMAN	DCAF8	physical	21516116
VATL_HUMAN	ATP6V0C	physical	21516116
ZN490_HUMAN	ZNF490	physical	21516116
AVPI1_HUMAN	AVPI1	physical	21516116
TGIF1_HUMAN	TGIF1	physical	21516116
ZN136_HUMAN	ZNF136	physical	21516116
ZN223_HUMAN	ZNF223	physical	21516116
AB17A_HUMAN	ABHD17A	physical	21516116
TTC25_HUMAN	TTC25	physical	21516116
ZN559_HUMAN	ZNF559	physical	21516116
ZN439_HUMAN	ZNF439	physical	21516116
MTG8R_HUMAN	CBFA2T2	physical	21516116
HNRLL_HUMAN	HNRNPLL	physical	21516116

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MDFI_HUMAN

Related Literatures of Post-Translational Modification