TUSC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TUSC2_HUMAN
• UniProt AC: O75896
• Protein Name: Tumor suppressor candidate 2
• Gene Name: TUSC2
• Organism: Homo sapiens (Human).
• Sequence Length: 110
• Protein Description: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells..
• Protein Sequence: MGASGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFVFTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIHVDFPVILYEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGASGSKAR ------CCCCCCCCC	28.57	-
2	Myristoylation	------MGASGSKAR ------CCCCCCCCC	28.57	15126327
9	Methylation	GASGSKARGLWPFAS CCCCCCCCCCHHCCC	44.46	54560441
46	Phosphorylation	AVPPFVFTRRGSMFY CCCCEEEEECCCEEE	17.72	26074081
50	Phosphorylation	FVFTRRGSMFYDEDG EEEEECCCEEECCCC	12.14	30266825
53	Phosphorylation	TRRGSMFYDEDGDLA EECCCEEECCCCCCH	15.13	30266825
64	Phosphorylation	GDLAHEFYEETIVTK CCCHHHEHHEEEECC	15.18	23927012
67	Phosphorylation	AHEFYEETIVTKNGQ HHHEHHEEEECCCCH	14.60	23927012
70	Phosphorylation	FYEETIVTKNGQKRA EHHEEEECCCCHHHH	18.23	23927012
93	Acetylation	LIPQGIVKLDHPRIH CCCCCCEECCCCEEE	46.40	23749302

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TUSC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TUSC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TUSC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS74L_HUMAN	HSPA4L	physical	17353931
EBLN2_HUMAN	EBLN2	physical	17353931
SGO2_HUMAN	SGOL2	physical	17353931
LRBA_HUMAN	LRBA	physical	17353931

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"Myristoylation of the fus1 protein is required for tumor suppressionin human lung cancer cells.";
Uno F., Sasaki J., Nishizaki M., Carboni G., Xu K., Atkinson E.N.,Kondo M., Minna J.D., Roth J.A., Ji L.;
Cancer Res. 64:2969-2976(2004).
Cited for: MYRISTOYLATION AT GLY-2.
PubMed: 15126327

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY.
PubMed: 19690332