dbPTM

LRBA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LRBA_HUMAN
UniProt AC	P50851
Protein Name	Lipopolysaccharide-responsive and beige-like anchor protein
Gene Name	LRBA
Organism	Homo sapiens (Human).
Sequence Length	2863
Subcellular Localization	Cell membrane Single-pass membrane protein . Endoplasmic reticulum. Golgi apparatus, trans-Golgi network. Lysosome.
Protein Description	May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules..
Protein Sequence	MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGESINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDKGRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFVGGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQMTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNGLRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKASPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQFRSFDRSVIVAAKKSAVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTVDSVSQDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLRENSKATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRGVVVVRQVSDLKQLFAYPGCDAGIRAMALSYDQRCIISGMASGSIVLFYNDFNRWHHEYQTRY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASEDNRVP ------CCCCCCCCC	32.69	21406692
3	Phosphorylation	-----MASEDNRVPS -----CCCCCCCCCC	58.29	29116813
10	Phosphorylation	SEDNRVPSPPPTGDD CCCCCCCCCCCCCCC	47.37	19664994
14	Phosphorylation	RVPSPPPTGDDGGGG CCCCCCCCCCCCCCC	60.04	23927012
26	Phosphorylation	GGGGREETPTEGGAL CCCCCCCCCCCCCCC	30.66	29116813
28	Phosphorylation	GGREETPTEGGALSL CCCCCCCCCCCCCCC	55.47	26074081
34	Phosphorylation	PTEGGALSLKPGLPI CCCCCCCCCCCCCCC	33.54	26074081
36	Ubiquitination	EGGALSLKPGLPIRG CCCCCCCCCCCCCCC	33.39	29967540
95	Ubiquitination	EGESINCMVDLLEKC CCCEECCHHHHHHHC	1.96	27667366
97	Ubiquitination	ESINCMVDLLEKCDI CEECCHHHHHHHCCC	20.75	27667366
159	Ubiquitination	LVDMLGVLASYNLTV HHHHHHHHHHCCCCH	2.19	22817900
161	Ubiquitination	DMLGVLASYNLTVRE HHHHHHHHCCCCHHH	15.47	22817900
167	Ubiquitination	ASYNLTVRELKLFFS HHCCCCHHHHHHHHH	37.99	22817900
169	Ubiquitination	YNLTVRELKLFFSKL CCCCHHHHHHHHHHH	4.01	22817900
195	Acetylation	GKLLSVLKHMPQKYG HHHHHHHHHCHHHHC	35.38	25953088
195	Ubiquitination	GKLLSVLKHMPQKYG HHHHHHHHHCHHHHC	35.38	23503661
200	Ubiquitination	VLKHMPQKYGPDAFF HHHHCHHHHCCCCCC	46.43	23503661
200 (in isoform 2)	Ubiquitination	-	46.43	-
201	Phosphorylation	LKHMPQKYGPDAFFN HHHCHHHHCCCCCCC	28.74	22817900
255	Phosphorylation	DKDKPYLYCFRTSKG CCCCCEEEEEECCCC	5.45	28634298
259	Phosphorylation	PYLYCFRTSKGLGYS CEEEEEECCCCCCCC	17.97	28634298
260	Phosphorylation	YLYCFRTSKGLGYSA EEEEEECCCCCCCCE	22.07	28634298
393	Acetylation	YKGTFKFKAESDLFL CCEEEEEEECCCEEE	52.41	19809579
393	Ubiquitination	YKGTFKFKAESDLFL CCEEEEEEECCCEEE	52.41	29967540
405	Ubiquitination	LFLAEHHKLLLYDGK EEEEECCEEEEECCC	42.62	29967540
409	Phosphorylation	EHHKLLLYDGKLSSA ECCEEEEECCCCCCE	23.71	22817900
414	Phosphorylation	LLYDGKLSSAIAFTY EEECCCCCCEEEEEC	22.62	30576142
421	Phosphorylation	SSAIAFTYNPRATDA CCEEEEECCCCCCCC	19.40	30576142
535	Phosphorylation	IGYSLEKSSKSHVSR EEEECCCCCCHHHHH	33.35	20363803
541	Phosphorylation	KSSKSHVSRAVLELC CCCCHHHHHHHHHHH	14.75	20363803
591	Phosphorylation	AKVQLMLYTYLSTEF HHHHHHHHHHHCCCC	4.56	24043423
592	Phosphorylation	KVQLMLYTYLSTEFI HHHHHHHHHHCCCCC	17.64	23401153
593	Phosphorylation	VQLMLYTYLSTEFIG HHHHHHHHHCCCCCC	5.77	24043423
595	Phosphorylation	LMLYTYLSTEFIGTV HHHHHHHCCCCCCCC	18.58	23401153
596	Phosphorylation	MLYTYLSTEFIGTVN HHHHHHCCCCCCCCH	32.11	23401153
601	Phosphorylation	LSTEFIGTVNIYNTI HCCCCCCCCHHHHHH	12.93	23401153
605	Phosphorylation	FIGTVNIYNTIRRVG CCCCCHHHHHHHHHH	10.89	23401153
607	Phosphorylation	GTVNIYNTIRRVGTV CCCHHHHHHHHHHHH	10.01	23401153
613	Phosphorylation	NTIRRVGTVLLIMHT HHHHHHHHHHHHHHH	12.72	22210691
620	Phosphorylation	TVLLIMHTLKYYYWA HHHHHHHHHHHHHHC	13.94	20068231
635	Ubiquitination	VNPQDRSGITPKGLD CCCCCCCCCCCCCCC	28.78	23000965
637	Ubiquitination	PQDRSGITPKGLDGP CCCCCCCCCCCCCCC	23.60	23000965
639	Ubiquitination	DRSGITPKGLDGPRP CCCCCCCCCCCCCCC	64.55	23000965
683	Phosphorylation	ELQAILNYLLTMHED HHHHHHHHHHHHCCC	10.31	24275569
705	Phosphorylation	QLLVALMSEHPNSMI HHHHHHHCCCCCCCC	33.34	24275569
726	Ubiquitination	NGLRVIYKLLASKSE CCHHHHHHHHHCCCC	26.37	33845483
731	Ubiquitination	IYKLLASKSEGIRVQ HHHHHHCCCCCHHHH	47.09	32015554
745	Phosphorylation	QALKAMGYFLKHLAP HHHHHHHHHHHHHCH	7.83	-
820	Ubiquitination	IQNPQILKVIATLLR CCCHHHHHHHHHHHH	32.97	21906983
820 (in isoform 2)	Ubiquitination	-	32.97	-
824	Phosphorylation	QILKVIATLLRNSPQ HHHHHHHHHHHCCCC	18.39	24719451
836	Sulfoxidation	SPQCPESMEVRRAFL CCCCCCCHHHHHHHH	5.42	21406390
968	Phosphorylation	IRRDINVSVGSQQPD CCCCEEEEECCCCCC	19.10	25159151
971	Phosphorylation	DINVSVGSQQPDTKD CEEEEECCCCCCCCC	24.40	28348404
976	Phosphorylation	VGSQQPDTKDSPVCP ECCCCCCCCCCCCCC	43.35	23401153
979	Phosphorylation	QQPDTKDSPVCPHFT CCCCCCCCCCCCCCC	22.31	23401153
986	Phosphorylation	SPVCPHFTTNGNENS CCCCCCCCCCCCCCC	19.13	30576142
987	Phosphorylation	PVCPHFTTNGNENSS CCCCCCCCCCCCCCC	39.94	30108239
993	Phosphorylation	TTNGNENSSIEKTSS CCCCCCCCCCEECCC	26.89	30108239
994	Phosphorylation	TNGNENSSIEKTSSL CCCCCCCCCEECCCC	46.48	30108239
998	Phosphorylation	ENSSIEKTSSLESAS CCCCCEECCCCHHHC	27.17	28348404
999	Phosphorylation	NSSIEKTSSLESASN CCCCEECCCCHHHCC	43.95	28348404
1000	Phosphorylation	SSIEKTSSLESASNI CCCEECCCCHHHCCE	41.19	29496963
1003	Phosphorylation	EKTSSLESASNIELQ EECCCCHHHCCEEEE	42.14	28348404
1005	Phosphorylation	TSSLESASNIELQTT CCCCHHHCCEEEEEC	47.85	28270605
1011	Phosphorylation	ASNIELQTTNTSYEE HCCEEEEECCCCHHH	34.34	28270605
1012	Phosphorylation	SNIELQTTNTSYEEM CCEEEEECCCCHHHH	24.44	28270605
1014	Phosphorylation	IELQTTNTSYEEMKA EEEEECCCCHHHHHH	30.50	28985074
1015	Phosphorylation	ELQTTNTSYEEMKAE EEEECCCCHHHHHHH	32.39	21815630
1016	Phosphorylation	LQTTNTSYEEMKAEQ EEECCCCHHHHHHHH	17.55	28270605
1033	Phosphorylation	QELPDEGTLEETLTN CCCCCCCCHHHHHCC	29.02	28348404
1051	Phosphorylation	NADDLEVSSDIIEAV CHHHCEECHHHHHHH	16.96	30278072
1052	Phosphorylation	ADDLEVSSDIIEAVA HHHCEECHHHHHHHE	37.70	30278072
1061	Phosphorylation	IIEAVAISSNSFITT HHHHHEECCCCCEEC	17.46	27080861
1062	Phosphorylation	IEAVAISSNSFITTG HHHHEECCCCCEECC	30.31	20068231
1064	Phosphorylation	AVAISSNSFITTGKD HHEECCCCCEECCCC	21.70	20068231
1067	Phosphorylation	ISSNSFITTGKDSMT ECCCCCEECCCCCEE	27.73	20068231
1068	Phosphorylation	SSNSFITTGKDSMTV CCCCCEECCCCCEEE	37.10	20068231
1072	Phosphorylation	FITTGKDSMTVSEVT CEECCCCCEEEEEEE	21.60	27251275
1074	Phosphorylation	TTGKDSMTVSEVTAS ECCCCCEEEEEEEEE	25.49	27251275
1076	Phosphorylation	GKDSMTVSEVTASIS CCCCEEEEEEEEECC	19.72	27251275
1079	Phosphorylation	SMTVSEVTASISSPS CEEEEEEEEECCCCC	15.61	28060719
1081	Phosphorylation	TVSEVTASISSPSEE EEEEEEEECCCCCHH	17.40	26657352
1083	Phosphorylation	SEVTASISSPSEEDA EEEEEECCCCCHHHH	33.43	26657352
1084	Phosphorylation	EVTASISSPSEEDAS EEEEECCCCCHHHHH	30.67	30278072
1086	Phosphorylation	TASISSPSEEDASEM EEECCCCCHHHHHHC	56.41	26657352
1091	Phosphorylation	SPSEEDASEMPEFLD CCCHHHHHHCCHHHH	46.91	30576142
1100	Phosphorylation	MPEFLDKSIVEEEED CCHHHHHHHCCCCCC	31.37	19664994
1110	Phosphorylation	EEEEDDDYVELKVEG CCCCCCCCEEEEEEC	11.65	28102081
1118	Phosphorylation	VELKVEGSPTEEANL EEEEEECCCCCCCCC	18.36	29255136
1120	Phosphorylation	LKVEGSPTEEANLPT EEEECCCCCCCCCCC	48.42	29255136
1127	Phosphorylation	TEEANLPTELQDNSL CCCCCCCCHHCCCCC	53.12	21955146
1133	Phosphorylation	PTELQDNSLSPAASE CCHHCCCCCCHHHHH	38.21	30278072
1135	Phosphorylation	ELQDNSLSPAASEAG HHCCCCCCHHHHHHH	16.59	28355574
1139	Phosphorylation	NSLSPAASEAGEKLD CCCCHHHHHHHHCCC	30.04	25159151
1160	Ubiquitination	KLIFQEGKPVTEKQT CEEEECCCCCCCCCC	35.25	29967540
1165	Ubiquitination	EGKPVTEKQTDTETQ CCCCCCCCCCCCCCC	49.48	29967540
1167	Phosphorylation	KPVTEKQTDTETQDS CCCCCCCCCCCCCCC	56.83	-
1171	Phosphorylation	EKQTDTETQDSKDSG CCCCCCCCCCCCCCC	39.51	-
1185	Phosphorylation	GIQTMTASGSSAMSP CCEEEECCCCCCCCC	30.00	28348404
1187	Phosphorylation	QTMTASGSSAMSPET EEEECCCCCCCCCCC	16.66	28348404
1188	Phosphorylation	TMTASGSSAMSPETT EEECCCCCCCCCCCC	31.36	21712546
1191	Phosphorylation	ASGSSAMSPETTVSQ CCCCCCCCCCCCHHH	21.21	21712546
1194	Phosphorylation	SSAMSPETTVSQIAV CCCCCCCCCHHHHHH	35.56	21712546
1195	Phosphorylation	SAMSPETTVSQIAVE CCCCCCCCHHHHHHH	19.25	28348404
1197	Phosphorylation	MSPETTVSQIAVESD CCCCCCHHHHHHHCH	17.49	28348404
1222	Phosphorylation	ATNLTRETKLINDCH HCCCCHHHHCHHHCC	28.06	-
1231	Phosphorylation	LINDCHGSVSEASSE CHHHCCCCHHCCCCC	9.98	25159151
1233	Phosphorylation	NDCHGSVSEASSEQK HHCCCCHHCCCCCHH	29.19	29978859
1236	Phosphorylation	HGSVSEASSEQKIAK CCCHHCCCCCHHHEE	30.29	23312004
1237	Phosphorylation	GSVSEASSEQKIAKL CCHHCCCCCHHHEEE	51.61	28102081
1240	Ubiquitination	SEASSEQKIAKLDVS HCCCCCHHHEEECHH	40.35	22817900
1243	Ubiquitination	SSEQKIAKLDVSNVA CCCHHHEEECHHHCC	49.01	21906983
1247	Phosphorylation	KIAKLDVSNVATDTE HHEEECHHHCCCCHH	25.83	26055452
1251	Phosphorylation	LDVSNVATDTERLEL ECHHHCCCCHHHEEE	38.89	23403867
1253	Phosphorylation	VSNVATDTERLELKA HHHCCCCHHHEEEEC	20.74	23403867
1259	Ubiquitination	DTERLELKASPNVEA CHHHEEEECCCCCCC	37.13	21906983
1259 (in isoform 2)	Ubiquitination	-	37.13	-
1261	Phosphorylation	ERLELKASPNVEAPQ HHEEEECCCCCCCCC	18.54	23401153
1277	Phosphorylation	HRHVLEISRQHEQPG CCCHHHHHCCCCCCC	19.26	28555341
1299	Phosphorylation	VNGQRRDSRSTVFRI CCCCCCCCCCCEEEC	26.73	30183078
1301	Phosphorylation	GQRRDSRSTVFRIPE CCCCCCCCCEEECCC	32.64	30183078
1302	Phosphorylation	QRRDSRSTVFRIPEF CCCCCCCCEEECCCC	23.66	24719451
1465	Ubiquitination	CQQHSQLKTRGDKAL HHHHHHHHCCCCHHC	28.65	-
1470	Ubiquitination	QLKTRGDKALKPMHS HHHCCCCHHCCCHHH	59.45	22817900
1473	Ubiquitination	TRGDKALKPMHSLIP CCCCHHCCCHHHCCC	45.19	22817900
1473 (in isoform 1)	Ubiquitination	-	45.19	21890473
1473 (in isoform 2)	Ubiquitination	-	45.19	21890473
1477	Phosphorylation	KALKPMHSLIPLGKS HHCCCHHHCCCCCCC	23.03	29514088
1483	Ubiquitination	HSLIPLGKSAAKSPV HHCCCCCCCCCCCCC	44.60	27667366
1484	Phosphorylation	SLIPLGKSAAKSPVD HCCCCCCCCCCCCCC	31.49	21712546
1487	Ubiquitination	PLGKSAAKSPVDIVT CCCCCCCCCCCCEEC	55.82	21906983
1487 (in isoform 2)	Ubiquitination	-	55.82	-
1488	Phosphorylation	LGKSAAKSPVDIVTG CCCCCCCCCCCEECC	25.98	28355574
1494	Phosphorylation	KSPVDIVTGGISPVR CCCCCEECCCCCCHH	29.99	29255136
1498	Phosphorylation	DIVTGGISPVRDLDR CEECCCCCCHHHHHH	22.18	29255136
1566	Phosphorylation	HSQSCTETGSENENV CCCCCCCCCCCCCCC	28.05	27080861
1568	Phosphorylation	QSCTETGSENENVSL CCCCCCCCCCCCCCH	44.67	30624053
1574	Phosphorylation	GSENENVSLSEITPA CCCCCCCCHHHCCHH	37.45	27080861
1576	Phosphorylation	ENENVSLSEITPAAF CCCCCCHHHCCHHHH	21.32	27080861
1579	Phosphorylation	NVSLSEITPAAFSTL CCCHHHCCHHHHCCC	11.65	27080861
1587	Phosphorylation	PAAFSTLTTASVEES HHHHCCCEEECHHHC	22.02	27080861
1594	Phosphorylation	TTASVEESESTSSAR EEECHHHCCCCCCCC	24.28	26074081
1596	Phosphorylation	ASVEESESTSSARRR ECHHHCCCCCCCCHH	42.75	26074081
1597	Phosphorylation	SVEESESTSSARRRD CHHHCCCCCCCCHHC	23.73	26074081
1598	Phosphorylation	VEESESTSSARRRDS HHHCCCCCCCCHHCC	31.14	26074081
1599	Phosphorylation	EESESTSSARRRDSG HHCCCCCCCCHHCCC	26.36	26074081
1605	Phosphorylation	SSARRRDSGIGEETA CCCCHHCCCCCCCCC	30.42	26657352
1611	Phosphorylation	DSGIGEETATGLGSH CCCCCCCCCCCCCCC	25.80	26074081
1613	Phosphorylation	GIGEETATGLGSHVE CCCCCCCCCCCCCEE	40.12	26074081
1617	Phosphorylation	ETATGLGSHVEVTPH CCCCCCCCCEEECCC	29.42	29496963
1622	Phosphorylation	LGSHVEVTPHTAPPG CCCCEEECCCCCCCC	8.88	26074081
1625	Phosphorylation	HVEVTPHTAPPGVSA CEEECCCCCCCCCCC	41.90	27080861
1631	Phosphorylation	HTAPPGVSAGPDAIS CCCCCCCCCCHHHHH	33.16	26074081
1638	Phosphorylation	SAGPDAISEVLSTLS CCCHHHHHHHHHHHC	24.31	29496963
1654	Phosphorylation	EVNKSPETKNDRGND CCCCCCCCCCCCCCC	38.23	20860994
1664	Phosphorylation	DRGNDLDTKATPSVS CCCCCCCCCCCCCCE	29.85	29214152
1665	Ubiquitination	RGNDLDTKATPSVSV CCCCCCCCCCCCCEE	50.35	21906983
1667	Phosphorylation	NDLDTKATPSVSVSK CCCCCCCCCCCEECC	20.04	25159151
1669	Phosphorylation	LDTKATPSVSVSKNV CCCCCCCCCEECCCC	23.75	29396449
1671	Phosphorylation	TKATPSVSVSKNVNV CCCCCCCEECCCCCH	25.63	29396449
1673	Phosphorylation	ATPSVSVSKNVNVKD CCCCCEECCCCCHHH	15.82	27251275
1674	Ubiquitination	TPSVSVSKNVNVKDI CCCCEECCCCCHHHH	63.86	27667366
1679	Ubiquitination	VSKNVNVKDILRSLV ECCCCCHHHHHHHHC	33.57	33845483
1712	Phosphorylation	LGALGDLSVEQPVQF HHHHCCCCCCCCCCC	28.48	28348404
1721	Phosphorylation	EQPVQFRSFDRSVIV CCCCCCCCCCHHHEE	32.56	28857561
1725	Phosphorylation	QFRSFDRSVIVAAKK CCCCCCHHHEEEEEC	20.31	23401153
1731	Acetylation	RSVIVAAKKSAVSPS HHHEEEEECCCCCHH	37.21	25953088
1733	Phosphorylation	VIVAAKKSAVSPSTF HEEEEECCCCCHHHC	32.94	27080861
1736	Phosphorylation	AAKKSAVSPSTFNTS EEECCCCCHHHCCCC	16.92	18669648
1738	Phosphorylation	KKSAVSPSTFNTSIP ECCCCCHHHCCCCCC	37.82	30624053
1739	Phosphorylation	KSAVSPSTFNTSIPT CCCCCHHHCCCCCCC	25.04	30624053
1742	Phosphorylation	VSPSTFNTSIPTNAV CCHHHCCCCCCCCCE	24.68	30624053
1743	Phosphorylation	SPSTFNTSIPTNAVS CHHHCCCCCCCCCEE	27.89	18669648
1746	Phosphorylation	TFNTSIPTNAVSVVS HCCCCCCCCCEEEEE	33.85	29978859
1750	Phosphorylation	SIPTNAVSVVSSVDS CCCCCCEEEEECCCH	17.87	29978859
1753	Phosphorylation	TNAVSVVSSVDSAQA CCCEEEEECCCHHHH	23.61	26657352
1754	Phosphorylation	NAVSVVSSVDSAQAS CCEEEEECCCHHHHH	20.52	29978859
1757	Phosphorylation	SVVSSVDSAQASDMG EEEECCCHHHHHCCC	21.81	30576142
1761	Phosphorylation	SVDSAQASDMGGESP CCCHHHHHCCCCCCC	18.95	28450419
1767	Phosphorylation	ASDMGGESPGSRSSN HHCCCCCCCCCCCCC	37.52	30278072
1770	Phosphorylation	MGGESPGSRSSNAKL CCCCCCCCCCCCCCC	32.16	30278072
1772	Phosphorylation	GESPGSRSSNAKLPS CCCCCCCCCCCCCCC	29.64	23401153
1773	Phosphorylation	ESPGSRSSNAKLPSV CCCCCCCCCCCCCCC	39.43	26074081
1776	Ubiquitination	GSRSSNAKLPSVPTV CCCCCCCCCCCCCCC	66.24	21906983
1776 (in isoform 2)	Ubiquitination	-	66.24	-
1779	Phosphorylation	SSNAKLPSVPTVDSV CCCCCCCCCCCCCCC	51.68	28450419
1782	Phosphorylation	AKLPSVPTVDSVSQD CCCCCCCCCCCCCCC	34.49	26657352
1785	Phosphorylation	PSVPTVDSVSQDPVS CCCCCCCCCCCCCCC	21.23	26657352
1787	Phosphorylation	VPTVDSVSQDPVSNM CCCCCCCCCCCCCCC	32.58	17525332
1792	Phosphorylation	SVSQDPVSNMSITER CCCCCCCCCCCHHHH	32.00	26074081
1794	Sulfoxidation	SQDPVSNMSITERLE CCCCCCCCCHHHHHH	2.09	21406390
1795	Phosphorylation	QDPVSNMSITERLEH CCCCCCCCHHHHHHH	30.52	26074081
1797	Phosphorylation	PVSNMSITERLEHAL CCCCCCHHHHHHHHH	14.03	26074081
1806	Ubiquitination	RLEHALEKAAPLLRE HHHHHHHHHHHHHHH	51.18	21890473
1806 (in isoform 1)	Ubiquitination	-	51.18	21890473
1806 (in isoform 2)	Ubiquitination	-	51.18	21890473
1885	Phosphorylation	VNEGRLLSQTMKDHL HHHCCCCHHHHHHHH	28.35	30576142
1887	Phosphorylation	EGRLLSQTMKDHLVR HCCCCHHHHHHHHHH	23.86	20068231
1889	Ubiquitination	RLLSQTMKDHLVRVA CCCHHHHHHHHHHHH	45.44	22817900
1889 (in isoform 1)	Ubiquitination	-	45.44	21890473
1889 (in isoform 2)	Ubiquitination	-	45.44	21890473
1904	Phosphorylation	NEAEFILSRQRAEDI HHHHHHHHHHHHHHH	22.88	28348404
1928	Ubiquitination	CAQYSADKREDEKMC HHHHCCCCCCHHHHH	58.36	29967540
1944	Phosphorylation	HLIRAAKYRDHVTAT HHHHHHHHCCCCCHH	19.29	20049867
1974	Phosphorylation	AWGNSAVSRPLEFWR CCCCCCCCCCCHHHC	28.09	30576142
2024	Ubiquitination	CIFKLRENSKATDED EEEEECCCCCCCCHH	42.23	29967540
2028	Phosphorylation	LRENSKATDEDILAK ECCCCCCCCHHHHHH	43.59	21945579
2035	Ubiquitination	TDEDILAKGKQSIRS CCHHHHHHHHHHHHH	64.29	33845483
2039	Phosphorylation	ILAKGKQSIRSQALG HHHHHHHHHHHHHCC	24.37	-
2042	Phosphorylation	KGKQSIRSQALGNQN HHHHHHHHHHCCCCC	20.38	21955146
2050	Phosphorylation	QALGNQNSENEILLE HHCCCCCCCCCEEEE	31.84	21955146
2062	Phosphorylation	LLEGDDDTLSSVDEK EEECCCCCCCCCCHH	35.22	30278072
2064	Phosphorylation	EGDDDTLSSVDEKDL ECCCCCCCCCCHHHH	30.33	28355574
2065	Phosphorylation	GDDDTLSSVDEKDLE CCCCCCCCCCHHHHH	36.38	30278072
2105	Acetylation	SVTSSELYFEVDEED EEECCEEEEEECCCC	8.14	19608861
2106	Acetylation	VTSSELYFEVDEEDP EECCEEEEEECCCCC	13.26	19608861
2110	Ubiquitination	ELYFEVDEEDPNFKK EEEEEECCCCCCCCC	70.27	29967540
2116	Acetylation	DEEDPNFKKIDPKIL CCCCCCCCCCCHHHH	56.30	19608861
2117	Acetylation	EEDPNFKKIDPKILA CCCCCCCCCCHHHHH	48.48	19608861
2121	Ubiquitination	NFKKIDPKILAYTEG CCCCCCHHHHHHCCC	46.75	29967540
2125	Phosphorylation	IDPKILAYTEGLHGK CCHHHHHHCCCCCCC	11.24	29083192
2126	Phosphorylation	DPKILAYTEGLHGKW CHHHHHHCCCCCCCH	20.26	29083192
2146	Phosphorylation	RSIFSRRYLLQNTAL HHHHHHHHHHHHHHH	15.62	-
2188	Phosphorylation	PRVGVGTSFGLPQTR CCCCCCCCCCCCCCC	16.04	27080861
2194	Phosphorylation	TSFGLPQTRRISLAS CCCCCCCCCCEECCC	21.70	27080861
2196	Ubiquitination	FGLPQTRRISLASPR CCCCCCCCEECCCHH	26.66	27667366
2198	Phosphorylation	LPQTRRISLASPRQL CCCCCCEECCCHHHH	18.97	28060719
2201	Phosphorylation	TRRISLASPRQLFKA CCCEECCCHHHHHHH	26.38	25867546
2207	Ubiquitination	ASPRQLFKASNMTQR CCHHHHHHHCCCCHH	60.54	27667366
2260	Ubiquitination	YESEELDLTLPTNFR CCCCCCCCCCCCCHH	9.18	22817900
2260 (in isoform 2)	Ubiquitination	-	9.18	21890473
2268	Ubiquitination	TLPTNFRDLSKPIGA CCCCCHHHCCCCCCC	51.67	27667366
2268 (in isoform 2)	Ubiquitination	-	51.67	-
2270	Phosphorylation	PTNFRDLSKPIGALN CCCHHHCCCCCCCCC	40.45	20860994
2271	Ubiquitination	TNFRDLSKPIGALNP CCHHHCCCCCCCCCH	48.21	21906983
2271 (in isoform 1)	Ubiquitination	-	48.21	21890473
2279	Ubiquitination	PIGALNPKRAAFFAE CCCCCCHHHHHHHHH	54.30	27667366
2322	Phosphorylation	LLRIEPFTTYFLNLQ HHCCCCCEEEEEECC	31.16	30266825
2323	Phosphorylation	LRIEPFTTYFLNLQG HCCCCCEEEEEECCC	16.80	30266825
2324	Phosphorylation	RIEPFTTYFLNLQGG CCCCCEEEEEECCCC	11.74	30266825
2338	Methylation	GKFDHADRTFSSISR CCCCCCCCCHHHHHH	38.15	115482225
2341	Phosphorylation	DHADRTFSSISRAWR CCCCCCHHHHHHHHH	26.58	22617229
2342	Phosphorylation	HADRTFSSISRAWRN CCCCCHHHHHHHHHH	22.01	29523821
2344	Phosphorylation	DRTFSSISRAWRNSQ CCCHHHHHHHHHHCC	20.21	29523821
2491	Phosphorylation	EPHPPRGSAMQVSPL ECCCCCCCCCCCCCC	23.11	23312004
2496	Phosphorylation	RGSAMQVSPLMFTDK CCCCCCCCCCEECCC	8.74	27499020
2510	Sulfoxidation	KAQQDVIMVLKFPSN CCCCCEEEEEECCCC	2.65	21406390
2518	O-linked_Glycosylation	VLKFPSNSPVTHVAA EEECCCCCCCCCCEE	25.69	23301498
2518	Phosphorylation	VLKFPSNSPVTHVAA EEECCCCCCCCCCEE	25.69	25332170
2533	Phosphorylation	NTQPGLATPAVITVT CCCCCCCCCEEEEEE	19.47	25332170
2540	O-linked_Glycosylation	TPAVITVTANRLFAV CCEEEEEECCCCEEC	15.01	23301498
2540	Phosphorylation	TPAVITVTANRLFAV CCEEEEEECCCCEEC	15.01	25332170
2642	Phosphorylation	FGHWDVVTCLARSES CCCCCHHHHHHCCCC	11.14	-
2647	Phosphorylation	VVTCLARSESYIGGN HHHHHHCCCCEECCC	25.86	28152594
2649	Phosphorylation	TCLARSESYIGGNCY HHHHCCCCEECCCEE	24.24	28152594
2650	Phosphorylation	CLARSESYIGGNCYI HHHCCCCEECCCEEE	10.26	28152594
2730	Ubiquitination	IHSMNGDLLRTLEGP EEECCCCHHHHCCCC	3.55	23000965
2731	Ubiquitination	HSMNGDLLRTLEGPE EECCCCHHHHCCCCC	4.71	23000965
2732	Ubiquitination	SMNGDLLRTLEGPEN ECCCCHHHHCCCCCC	44.56	23000965
2733	Ubiquitination	MNGDLLRTLEGPENC CCCCHHHHCCCCCCC	29.18	23000965
2736	Ubiquitination	DLLRTLEGPENCLKP CHHHHCCCCCCCCCH	37.62	23000965
2738	Ubiquitination	LRTLEGPENCLKPKL HHHCCCCCCCCCHHH	72.01	23000965
2742	Acetylation	EGPENCLKPKLIQAS CCCCCCCCHHHHHHH	42.16	25953088
2742	Ubiquitination	EGPENCLKPKLIQAS CCCCCCCCHHHHHHH	42.16	23000965
2744	Ubiquitination	PENCLKPKLIQASRE CCCCCCHHHHHHHCC	57.55	23000965
2747	Ubiquitination	CLKPKLIQASREGHC CCCHHHHHHHCCCCE	43.66	23000965
2749	Ubiquitination	KPKLIQASREGHCVI CHHHHHHHCCCCEEE	17.94	23000965
2776	Sulfoxidation	NGKLQATMETDDNIR CCEEEEEEECCCCEE	6.14	21406390
2793	Phosphorylation	QLSRDGQYLLTGGDR EECCCCCEEECCCCC	14.81	29496963
2796	Phosphorylation	RDGQYLLTGGDRGVV CCCCEEECCCCCCEE	36.20	29496963
2809	Phosphorylation	VVVVRQVSDLKQLFA EEEEEECCCHHHHHC	28.96	28450419
2849	Phosphorylation	SGSIVLFYNDFNRWH CCEEEEEEECHHHHH	15.06	24719451
2859	Phosphorylation	FNRWHHEYQTRY--- HHHHHHCCCCCC---	15.72	28796482
2861	Phosphorylation	RWHHEYQTRY----- HHHHCCCCCC-----	30.91	28796482
2863	Phosphorylation	HHEYQTRY------- HHCCCCCC-------	26.71	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of LRBA_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LRBA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LRBA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ICAL_HUMAN	CAST	physical	22863883
KIF15_HUMAN	KIF15	physical	22863883
MLF2_HUMAN	MLF2	physical	22863883
TERA_HUMAN	VCP	physical	22863883

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614700	Immunodeficiency, common variable, 8, with autoimmunity (CVID8)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LRBA_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT TYR-1016; SER-1118; THR-1120 AND SER-1135, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2116 AND LYS-2117, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT TYR-1016; SER-1118; THR-1120 AND SER-1135, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-979, AND MASSSPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1787, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1667, AND MASSSPECTROMETRY.	19007248 [Abstract]