dbPTM

KIF15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KIF15_HUMAN
UniProt AC	Q9NS87
Protein Name	Kinesin-like protein KIF15
Gene Name	KIF15
Organism	Homo sapiens (Human).
Sequence Length	1388
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton, spindle. Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the c
Protein Description	Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly..
Protein Sequence	MAPGCKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFLKEKKRSES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
116	Phosphorylation	GQTGSGKTFTMMGPS EECCCCCEEEEECCC	28.06	20068231
118	Phosphorylation	TGSGKTFTMMGPSES CCCCCEEEEECCCCC	16.10	20068231
123	Phosphorylation	TFTMMGPSESDNFSH EEEEECCCCCCCCCH	43.96	20068231
125	Phosphorylation	TMMGPSESDNFSHNL EEECCCCCCCCCHHC	42.04	20068231
129	Phosphorylation	PSESDNFSHNLRGVI CCCCCCCCHHCCCCC	20.09	20068231
139	Phosphorylation	LRGVIPRSFEYLFSL CCCCCCHHHHHHHHH	19.64	20068231
142	Phosphorylation	VIPRSFEYLFSLIDR CCCHHHHHHHHHHHH	15.84	20068231
145	Phosphorylation	RSFEYLFSLIDREKE HHHHHHHHHHHHHHH	23.09	20068231
226	Phosphorylation	WRNRRVASTSMNRES CCCCCCCCCCCCCHH	20.39	-
259	Phosphorylation	EIVNIRTSLLNLVDL CEEEHHHHHHHHHHH	22.47	28387310
283	Ubiquitination	HAEGMRLKEAGNINR CHHHCCHHHHCCCHH	34.84	-
291	Phosphorylation	EAGNINRSLSCLGQV HHCCCHHHHHHHHHH	21.83	28348404
293	Phosphorylation	GNINRSLSCLGQVIT CCCHHHHHHHHHHHH	14.45	28348404
309	Ubiquitination	LVDVGNGKQRHVCYR HHCCCCCCEEEEEEE	48.43	-
350	Phosphorylation	GSRCFGETLSTLNFA CCCCCHHHHHHCCHH	26.79	-
378	Phosphorylation	EDTQGNVSQLQAEVK CCCCCCHHHHHHHHH	29.22	27050516
385	Ubiquitination	SQLQAEVKRLKEQLA HHHHHHHHHHHHHHH	43.44	-
388	Ubiquitination	QAEVKRLKEQLAELA HHHHHHHHHHHHHHH	47.66	-
396	Phosphorylation	EQLAELASGQTPPES HHHHHHHCCCCCCHH	44.02	28464451
399	Phosphorylation	AELASGQTPPESFLT HHHHCCCCCCHHHCC	44.32	25159151
403	Phosphorylation	SGQTPPESFLTRDKK CCCCCCHHHCCCCCC	31.18	26074081
412	Phosphorylation	LTRDKKKTNYMEYFQ CCCCCCCCCHHHHHH	40.22	23401153
414	Phosphorylation	RDKKKTNYMEYFQEA CCCCCCCHHHHHHHH	9.14	23401153
434	Phosphorylation	KSEQEKKSLIEKVTQ CCHHHHHHHHHHHHH	45.72	24719451
438	Ubiquitination	EKKSLIEKVTQLEDL HHHHHHHHHHHHHHH	43.52	-
448	Ubiquitination	QLEDLTLKKEKFIQS HHHHHHHCHHHHHHC	54.36	-
449	Ubiquitination	LEDLTLKKEKFIQSN HHHHHHCHHHHHHCC	70.06	-
455	Phosphorylation	KKEKFIQSNKMIVKF CHHHHHHCCCEEEEE	33.33	18452278
512	Ubiquitination	EHHPRVAKYAMENHS HHCHHHHHHHHHCCC	30.59	-
513	Phosphorylation	HHPRVAKYAMENHSL HCHHHHHHHHHCCCC	11.05	25332170
534	Ubiquitination	LRLLEPVKRAQEMDA HHHHHHHHHHHHHCH	53.37	-
539	Sulfoxidation	PVKRAQEMDAQTIAK HHHHHHHHCHHHHHH	3.26	21406390
546	Sumoylation	MDAQTIAKLEKAFSE HCHHHHHHHHHHHHH	54.02	-
546	Ubiquitination	MDAQTIAKLEKAFSE HCHHHHHHHHHHHHH	54.02	-
546	Sumoylation	MDAQTIAKLEKAFSE HCHHHHHHHHHHHHH	54.02	-
549	Ubiquitination	QTIAKLEKAFSEISG HHHHHHHHHHHHHHC	66.23	-
555	Phosphorylation	EKAFSEISGMEKSDK HHHHHHHHCCCCCCC	28.21	26074081
557	Sulfoxidation	AFSEISGMEKSDKNQ HHHHHHCCCCCCCCC	4.71	21406390
560	Phosphorylation	EISGMEKSDKNQQGF HHHCCCCCCCCCCCC	40.28	26552605
562	Ubiquitination	SGMEKSDKNQQGFSP HCCCCCCCCCCCCCH	64.84	-
568	Phosphorylation	DKNQQGFSPKAQKEP CCCCCCCCHHHCCCC	32.11	22167270
570	Ubiquitination	NQQGFSPKAQKEPCL CCCCCCHHHCCCCCC	63.35	-
573	Ubiquitination	GFSPKAQKEPCLFAN CCCHHHCCCCCCCCC	69.36	-
581	Phosphorylation	EPCLFANTEKLKAQL CCCCCCCHHHHHHHH	30.94	26074081
638	Ubiquitination	ENLLEATKACKRQEV HHHHHHHHHHHHHHH	59.85	-
646	Phosphorylation	ACKRQEVSQLNKIHA HHHHHHHHHHHHHHH	28.35	29449344
650	Ubiquitination	QEVSQLNKIHAETLK HHHHHHHHHHHHHHH	44.45	-
655	Phosphorylation	LNKIHAETLKIITTP HHHHHHHHHHEEECC	33.85	26074081
660	Phosphorylation	AETLKIITTPTKAYQ HHHHHEEECCCCHHH	30.14	24719451
661	Phosphorylation	ETLKIITTPTKAYQL HHHHEEECCCCHHHC	20.67	26074081
663	Phosphorylation	LKIITTPTKAYQLHS HHEEECCCCHHHCCC	26.64	26074081
664	Ubiquitination	KIITTPTKAYQLHSR HEEECCCCHHHCCCC	46.42	-
666	Phosphorylation	ITTPTKAYQLHSRPV EECCCCHHHCCCCCC	17.11	26074081
670	Phosphorylation	TKAYQLHSRPVPKLS CCHHHCCCCCCCCCC	47.04	26074081
677	Phosphorylation	SRPVPKLSPEMGSFG CCCCCCCCCCCCCCC	25.58	26074081
692	Phosphorylation	SLYTQNSSILDNDIL CCCCCCCCCCCCCCC	34.42	17081983
721	Phosphorylation	AISEELRTVQEQMSA HHHHHHHHHHHHHHH	38.88	20068231
726	Sulfoxidation	LRTVQEQMSALQAKL HHHHHHHHHHHHHHC	2.20	21406390
727	Phosphorylation	RTVQEQMSALQAKLD HHHHHHHHHHHHHCC	26.06	20068231
742	Ubiquitination	EEEHKNLKLQQHVDK HHHHHHHHHHHHHHH	54.35	-
763	Phosphorylation	QMQELFSSERIDWTK HHHHHHHHHCCCCHH	24.45	-
777	Phosphorylation	KQQEELLSQLNVLEK HHHHHHHHHHHHHHH	45.29	-
792	Ubiquitination	QLQETQTKNDFLKSE HHHHHHCHHHHHHHH	44.71	-
797	Acetylation	QTKNDFLKSEVHDLR HCHHHHHHHHHHHHH	44.56	19608861
812	Acetylation	VVLHSADKELSSVKL HHHHHCCCCHHCCEE	61.34	23749302
860	Ubiquitination	NEKLLESKACLQDSY CHHHHCCHHHHCCCC	33.47	-
962	Phosphorylation	KVQKLEESLLATEKV HHHHHHHHHHHHHHH	21.22	24719451
968	Ubiquitination	ESLLATEKVISSLEK HHHHHHHHHHHHHHH	40.28	-
976	Phosphorylation	VISSLEKSRDSDKKV HHHHHHHCCCCCHHH	31.76	24719451
979	Phosphorylation	SLEKSRDSDKKVVAD HHHHCCCCCHHHHHH	50.66	24719451
1009	Ubiquitination	TETIDTLKQELKDIN CCCHHHHHHHHHHCC	43.76	19608861
1009	Acetylation	TETIDTLKQELKDIN CCCHHHHHHHHHHCC	43.76	19608861
1013	Acetylation	DTLKQELKDINCKYN HHHHHHHHHCCCCCC	56.67	25953088
1018	Acetylation	ELKDINCKYNSALVD HHHHCCCCCCCCCCC	42.87	25953088
1044	Ubiquitination	EVDILDLKETLRLRI CCCEECHHHHHHHHH	48.60	-
1046	Phosphorylation	DILDLKETLRLRILS CEECHHHHHHHHHCC	18.65	-
1053	Phosphorylation	TLRLRILSEDIERDM HHHHHHCCHHHHHHC	30.74	23312004
1076	Phosphorylation	TEQLNMLTEASKKHS HHHHHHHHHHHHHHH	20.80	-
1081	Ubiquitination	MLTEASKKHSGLLQS HHHHHHHHHHCHHHH	40.27	-
1083	Phosphorylation	TEASKKHSGLLQSAQ HHHHHHHHCHHHHHH	39.76	23663014
1088	Phosphorylation	KHSGLLQSAQEELTK HHHCHHHHHHHHHHH	31.71	23312004
1094	Phosphorylation	QSAQEELTKKEALIQ HHHHHHHHHHHHHHH	43.26	29083192
1134	Phosphorylation	QLEHVMDSAAEDPQS HHHHHHHHHCCCCCC	15.98	20068231
1141	Phosphorylation	SAAEDPQSPKTPPHF HHCCCCCCCCCCHHH	33.48	23401153
1144	Phosphorylation	EDPQSPKTPPHFQTH CCCCCCCCCHHHHHH	45.49	23401153
1150	Phosphorylation	KTPPHFQTHLAKLLE CCCHHHHHHHHHHHH	20.22	20873877
1158	Phosphorylation	HLAKLLETQEQEIED HHHHHHHHHHHHHHC	37.06	29255136
1169	Phosphorylation	EIEDGRASKTSLEHL HHHCCCCCHHHHHHH	34.80	29255136
1170	Ubiquitination	IEDGRASKTSLEHLV HHCCCCCHHHHHHHH	40.94	-
1171	Phosphorylation	EDGRASKTSLEHLVT HCCCCCHHHHHHHHH	35.73	21712546
1172	Phosphorylation	DGRASKTSLEHLVTK CCCCCHHHHHHHHHH	35.18	25159151
1178	Phosphorylation	TSLEHLVTKLNEDRE HHHHHHHHHCCCCCH	35.85	24719451
1179	Ubiquitination	SLEHLVTKLNEDREV HHHHHHHHCCCCCHH	41.66	-
1187	Ubiquitination	LNEDREVKNAEILRM CCCCCHHCHHHHHHH	45.76	-
1280	Ubiquitination	VQSALYNKEMECLRM HHHHHHHCHHHHHHC	44.90	-
1355	Phosphorylation	NLHQKIQYVVRLKKE HHHHHHHHHHHHHHH	12.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH2	O43255	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KIF15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KIF15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MLP3A_HUMAN	MAP1LC3A	physical	16169070
CHD3_HUMAN	CHD3	physical	16169070
VIME_HUMAN	VIM	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
DMD_HUMAN	DMD	physical	26496610
FANCG_HUMAN	FANCG	physical	26496610
MED6_HUMAN	MED6	physical	26496610
CD2AP_HUMAN	CD2AP	physical	26496610
PISD_HUMAN	PISD	physical	26496610
RENT2_HUMAN	UPF2	physical	26496610
KBP_HUMAN	KIAA1279	physical	26496610
K1143_HUMAN	KIAA1143	physical	26496610
RM44_HUMAN	MRPL44	physical	26496610
ELMO3_HUMAN	ELMO3	physical	26496610
MTNA_HUMAN	MRI1	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KIF15_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-797 AND LYS-1009, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568, AND MASSSPECTROMETRY.	18669648 [Abstract]