dbPTM

CE126_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CE126_HUMAN
UniProt AC	Q9P2H0
Protein Name	Centrosomal protein of 126 kDa {ECO:0000303\|PubMed:24867236, ECO:0000312\|HGNC:HGNC:29264}
Gene Name	CEP126 {ECO:0000303\|PubMed:24867236, ECO:0000312\|HGNC:HGNC:29264}
Organism	Homo sapiens (Human).
Sequence Length	1117
Subcellular Localization	Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body .
Protein Description	Participates in cytokinesis. [PubMed: 19799413 Necessary for microtubules and mitotic spindle organization]
Protein Sequence	MLAGRPGTRSAVGELGTESSDNLDRAPLGPRESGGHHRPGSYLDMKIHLEKNLEEERQILLQQQKICRNRARKYFVESNRRKKAFEEKRKEQEEKEHQIREQILQQRKQKFEEVTEKFQRAHVPLSQRRKAVSRKPVPPLEEALKQIQESNLKSEVNLPFSRRPTINWRAIDSALPSALSKNDHKHQKQLLSKINCEKEMNENMRATLATSKNVFQLKLEETQKLLEDQHLSNLQKFGDEVNQITNSETLSSIDSLEATEHEEIYLTLNKEHSTSIQRNTISLKPANMQSTNLSCFDEDKLAFSKTQHINNWLTNLDASNTQNVTAFSDILSKSNVLPSWEYFNSKEQNPSPLNGTVERATNTANNSVPFVSSPPMFVLDKKCEKTSETSTMRTTDSTSGAFKRERPLVTESPTFKFSKSQSTSDSLTQEVATFPDQEKYSELNQENGTTSIPTSCVPVATPLVLPSNIQSARPSAKNSIHIKEIDAVQCSDKLDELKDGKEEEIKYFNCNKEELPLFSDSFQDAYIPHNPDSKDEKQKLAETSSLSNVTSNYDFVGQHKKMKYNIHERNGVRFLKSILKKESKYEHGYLKALIINQSFKFGNQKAAAIRDSIELTKEKGAEIPKTIKKLRWFDETSNIENNAENSHSLKNKTGTTQQHSQQFHIQSGAGSNIISVSTCAVNSADTKKSREDSISENVTTLGGSGADHMPLNCFIPSGYNFAKHAWPASKKEESKIPVHDDSKTKQGKPQRGRAKIIRKPGSAKVQSGFICTNRKGAVIQPQSASKVNIFTQAQGKLIIPCPPPQSTSNIRSGKNIQVSQCQPVTPENPQNIITHNSFNSKHVLPTEHSLNQWNQESSSPLSNACSDLVTVIPSLPSYCSSECQTFAKINHSNGTQAVARQDATLYCTQRSPVCEESYPSVTLRTAEEESVPLWKRGPNVLHQNKRATGSTVMRRKRIAETKRRNILEQKRQNPGSVGQKYSEQINNFGQSVLLSSSEPKQTTRGTSYIEEVSDSTSEFLMAENLVKASVPEDEILTVLNSKQIQKSNLPLNKTQQFNICTLSAEEQKILESLNDLSERLHYIQESICKNPSIKNTLQIIPLLEKREDRTSSCRDKR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
17	Phosphorylation	SAVGELGTESSDNLD CCCCCCCCCCCCCCC	-
74	Phosphorylation	CRNRARKYFVESNRR HHHHHHHHHHHHHHH	27794612
78	Phosphorylation	ARKYFVESNRRKKAF HHHHHHHHHHHHHHH	27794612
83	Acetylation	VESNRRKKAFEEKRK HHHHHHHHHHHHHHH	7671085
88	Acetylation	RKKAFEEKRKEQEEK HHHHHHHHHHHHHHH	7671093
161	Phosphorylation	SEVNLPFSRRPTINW CCCCCCCCCCCCCCH	23401153
192	Phosphorylation	KHQKQLLSKINCEKE HHHHHHHHHHHHHHH	24719451
390	Phosphorylation	CEKTSETSTMRTTDS CCCCCCCCCCCCCCC	30631047
391	Phosphorylation	EKTSETSTMRTTDST CCCCCCCCCCCCCCC	30631047
410	Phosphorylation	KRERPLVTESPTFKF CCCCCCCCCCCCEEC	21712546
412	Phosphorylation	ERPLVTESPTFKFSK CCCCCCCCCCEECCC	21712546
420	Phosphorylation	PTFKFSKSQSTSDSL CCEECCCCCCCCCCC	-
440	Phosphorylation	TFPDQEKYSELNQEN CCCCHHHHHHHHCCC	22210691
450	Phosphorylation	LNQENGTTSIPTSCV HHCCCCCCCCCCCCC	22210691
471	Phosphorylation	VLPSNIQSARPSAKN ECCCCHHCCCCCCCC	22210691
577	Phosphorylation	NGVRFLKSILKKESK HHHHHHHHHHHCCCC	24719451
580	Ubiquitination	RFLKSILKKESKYEH HHHHHHHHCCCCCCC	-
655	Phosphorylation	SLKNKTGTTQQHSQQ CCCCCCCCCHHHHEE	25954137
660	Phosphorylation	TGTTQQHSQQFHIQS CCCCHHHHEEEEEEC	25954137
671	Phosphorylation	HIQSGAGSNIISVST EEECCCCCCEEEEEE	25954137
677	Phosphorylation	GSNIISVSTCAVNSA CCCEEEEEEEECCCC	25954137
678	Phosphorylation	SNIISVSTCAVNSAD CCEEEEEEEECCCCC	25954137
686	Phosphorylation	CAVNSADTKKSREDS EECCCCCCCCHHHHH	25954137
734	Phosphorylation	PASKKEESKIPVHDD CCCCCCCCCCCCCCC	-
742	Phosphorylation	KIPVHDDSKTKQGKP CCCCCCCCCCCCCCC	-
785	Phosphorylation	VIQPQSASKVNIFTQ EECCCCCCCCCEEEE	-
922	Phosphorylation	EESYPSVTLRTAEEE CCCCCCEEEEECCCC	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CE126_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CE126_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CE126_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CE126_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CE126_HUMAN

Related Literatures of Post-Translational Modification