MTNA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTNA_HUMAN
• UniProt AC: Q9BV20
• Protein Name: Methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119}
• Gene Name: MRI1 {ECO:0000255|HAMAP-Rule:MF_03119}
• Organism: Homo sapiens (Human).
• Sequence Length: 369
• Subcellular Localization: Nucleus . Cytoplasm . Cell projection . Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
• Protein Description: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover..
• Protein Sequence: MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAIRAMKVRGAPAIALVGCLSLAVELQAGAGGPGLAALVAFVRDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATEEAVRERVICCTEDMLEKDLRDNRSIGDLGARHLLERVAPSGGKVTVLTHCNTGALATAGYGTALGVIRSLHSLGRLEHAFCTETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPGIGVWNPAFDVTPHDLITGGIITELGVFAPEELRTALTTTISSRDGTLDGPQM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTLEAIRY -------CCHHHHHH	9.71	22814378
12	Phosphorylation	AIRYSRGSLQILDQL HHHHHHHHHHHHHHH	18.91	28857561
23	Ubiquitination	LDQLLLPKQSRYEAV HHHHHCCCCCHHHHH	61.96	-
32	Phosphorylation	SRYEAVGSVHQAWEA CHHHHHHHHHHHHHH	15.16	28857561
132	Sulfoxidation	VICCTEDMLEKDLRD EEEECHHHHHHHCCC	4.19	21406390
135	Ubiquitination	CTEDMLEKDLRDNRS ECHHHHHHHCCCCCC	59.09	24816145
142	Phosphorylation	KDLRDNRSIGDLGAR HHCCCCCCHHHHHHH	36.86	28857561
200	Phosphorylation	RLEHAFCTETRPYNQ CCEEEEECCCCCCCC	33.66	28857561
241	Phosphorylation	AMAHRGVSAVVVGAD HHHHCCCCEEEECCC	20.40	28857561
246	Ubiquitination	GVSAVVVGADRVVAN CCCEEEECCCEEEEC	15.34	21963094
249	Methylation	AVVVGADRVVANGDT EEEECCCEEEECCCC	25.03	115483681
259	Ubiquitination	ANGDTANKVGTYQLA ECCCCCCCCCCEEEE	39.31	-
259	Acetylation	ANGDTANKVGTYQLA ECCCCCCCCCCEEEE	39.31	25953088
264	Ubiquitination	ANKVGTYQLAIVAKH CCCCCCEEEEEEHHH	25.02	21963094
282	Phosphorylation	PFYVAAPSSSCDLRL CEEEECCCCCCCEEE	30.11	27251275
283	Phosphorylation	FYVAAPSSSCDLRLE EEEECCCCCCCEEEC	33.65	27251275
284	Phosphorylation	YVAAPSSSCDLRLET EEECCCCCCCEEECC	18.91	27251275
293	Ubiquitination	DLRLETGKEIIIEER CEEECCCCEEEEEEC	53.83	21963094
293	Acetylation	DLRLETGKEIIIEER CEEECCCCEEEEEEC	53.83	26051181
355	Phosphorylation	ELRTALTTTISSRDG HHHHHHHHCCCCCCC	24.00	28857561
356	Phosphorylation	LRTALTTTISSRDGT HHHHHHHCCCCCCCC	17.39	28857561
358	Phosphorylation	TALTTTISSRDGTLD HHHHHCCCCCCCCCC	19.75	29214152
359	Phosphorylation	ALTTTISSRDGTLDG HHHHCCCCCCCCCCC	30.46	29214152
363	Phosphorylation	TISSRDGTLDGPQM- CCCCCCCCCCCCCC-	26.43	29214152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTNA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTNA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTNA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTNA_HUMAN	MRI1	physical	16189514
PP2BA_HUMAN	PPP3CA	physical	22939629
RPE_HUMAN	RPE	physical	22939629
MTNA_HUMAN	MRI1	physical	19447967
MTNA_HUMAN	MRI1	physical	25416956
MTND_HUMAN	ADI1	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.