PP2BA_HUMAN - dbPTM
PP2BA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PP2BA_HUMAN
UniProt AC Q08209
Protein Name Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene Name PPP3CA {ECO:0000312|HGNC:HGNC:9314}
Organism Homo sapiens (Human).
Sequence Length 521
Subcellular Localization Cytoplasm . Cell membrane
Peripheral membrane protein . Cell membrane, sarcolemma . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, dendritic spine . Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similar
Protein Description Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. [PubMed: 15671020]
Protein Sequence MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSEPKAIDP
------CCCCCCCCC		63.7124719451
2Acetylation------MSEPKAIDP
------CCCCCCCCC		63.7122814378
16MethylationPKLSTTDRVVKAVPF
CCCCCCCCEECCCCC		32.79115488605
32UbiquitinationPSHRLTAKEVFDNDG
CCCCCCHHHHCCCCC		49.5321890473
32 (in isoform 2)Ubiquitination-49.5321890473
32UbiquitinationPSHRLTAKEVFDNDG
CCCCCCHHHHCCCCC		49.5321890473
32 (in isoform 1)Ubiquitination-49.5321890473
32UbiquitinationPSHRLTAKEVFDNDG
CCCCCCHHHHCCCCC		49.5321890473
32UbiquitinationPSHRLTAKEVFDNDG
CCCCCCHHHHCCCCC		49.5321890473
32MalonylationPSHRLTAKEVFDNDG
CCCCCCHHHHCCCCC		49.5326320211
47UbiquitinationKPRVDILKAHLMKEG
CCHHHHHHHHHHHCC		33.81-
59PhosphorylationKEGRLEESVALRIIT
HCCCCCHHHHHHHHH		11.8724076635
66PhosphorylationSVALRIITEGASILR
HHHHHHHHHHHHHHH		26.4523312004
70PhosphorylationRIITEGASILRQEKN
HHHHHHHHHHHHHCC		32.7723312004
75UbiquitinationGASILRQEKNLLDID
HHHHHHHHCCCCCCC		37.16-
96UbiquitinationGDIHGQFFDLMKLFE
CCCHHHHHHHHHHHC		5.61-
107PhosphorylationKLFEVGGSPANTRYL
HHHCCCCCCCCCEEE		18.2124076635
119PhosphorylationRYLFLGDYVDRGYFS
EEEECCCCCCCCCCH		11.49-
142 (in isoform 1)Ubiquitination-44.2821890473
142UbiquitinationALKILYPKTLFLLRG
HHHHHCCHHHHHHCC		44.2821890473
142 (in isoform 2)Ubiquitination-44.2821890473
142UbiquitinationALKILYPKTLFLLRG
HHHHHCCHHHHHHCC		44.2821890473
142UbiquitinationALKILYPKTLFLLRG
HHHHHCCHHHHHHCC		44.2821890473
152UbiquitinationFLLRGNHECRHLTEY
HHHCCCCHHHHHHHE		36.93-
159PhosphorylationECRHLTEYFTFKQEC
HHHHHHHEEEECCHH		11.59-
163UbiquitinationLTEYFTFKQECKIKY
HHHEEEECCHHCCCC		41.97-
192UbiquitinationLPLAALMNQQFLCVH
HHHHHHHCCCEEECC		33.0921890473
219 (in isoform 2)Ubiquitination-70.92-
224NitrationRFKEPPAYGPMCDIL
HCCCCCCCCCCCCEE		27.77-
224NitrationRFKEPPAYGPMCDIL
HCCCCCCCCCCCCEE		27.77-
224Nitrated tyrosineRFKEPPAYGPMCDIL
HCCCCCCCCCCCCEE		27.77-
256UbiquitinationTHNTVRGCSYFYSYP
CCCCCCCCCHHHCHH		1.7721890473
293UbiquitinationAGYRMYRKSQTTGFP
HCCCCHHHHCCCCCC		29.45-
323 (in isoform 2)Ubiquitination-43.8721890473
323 (in isoform 1)Ubiquitination-43.8721890473
323UbiquitinationNNKAAVLKYENNVMN
CCCEEEEEEECCEEC		43.8721890473
323UbiquitinationNNKAAVLKYENNVMN
CCCEEEEEEECCEEC		43.8721890473
357UbiquitinationFTWSLPFVGEKVTEM
HHCCCCCCCHHHHHH		10.26-
373PhosphorylationVNVLNICSDDELGSE
HHHHHHCCCCCCCCC		44.2828348404
374UbiquitinationNVLNICSDDELGSEE
HHHHHCCCCCCCCCC		49.33-
379PhosphorylationCSDDELGSEEDGFDG
CCCCCCCCCCCCCCH		50.8928348404
396 (in isoform 3)Phosphorylation-4.1625159151
399UbiquitinationRKEVIRNKIRAIGKM
HHHHHHHHHHHHHHH		24.58-
406SulfoxidationKIRAIGKMARVFSVL
HHHHHHHHHHHHHHH		2.1318275158
411PhosphorylationGKMARVFSVLREESE
HHHHHHHHHHHHHCC		19.8624247654
424 (in isoform 2)Ubiquitination-46.7921890473
424 (in isoform 1)Ubiquitination-46.7921890473
424UbiquitinationSESVLTLKGLTPTGM
CCCEEEECCCCCCCC		46.7921906983
427PhosphorylationVLTLKGLTPTGMLPS
EEEECCCCCCCCCCC		27.7228857561
429PhosphorylationTLKGLTPTGMLPSGV
EECCCCCCCCCCCCC		29.9528348404
438 (in isoform 2)Phosphorylation-42.9925159151
438PhosphorylationMLPSGVLSGGKQTLQ
CCCCCCCCCCCHHHH		42.9927050516
441 (in isoform 2)Ubiquitination-43.5721890473
441UbiquitinationSGVLSGGKQTLQSAT
CCCCCCCCHHHHHCE		43.57-
456 (in isoform 2)Ubiquitination-60.38-
462PhosphorylationDEAIKGFSPQHKITS
HHHHCCCCCCCCCCC		32.1129496963
466UbiquitinationKGFSPQHKITSFEEA
CCCCCCCCCCCHHHH		42.29-
468PhosphorylationFSPQHKITSFEEAKG
CCCCCCCCCHHHHCC		31.9728348404
469PhosphorylationSPQHKITSFEEAKGL
CCCCCCCCHHHHCCH		33.8530624053
474UbiquitinationITSFEEAKGLDRINE
CCCHHHHCCHHHHHH		64.38-
490SulfoxidationMPPRRDAMPSDANLN
CCCCCCCCCCCCCHH		3.7021406390
492PhosphorylationPRRDAMPSDANLNSI
CCCCCCCCCCCHHHH		35.9523911959
498PhosphorylationPSDANLNSINKALTS
CCCCCHHHHHHHHHH		30.6123186163
504PhosphorylationNSINKALTSETNGTD
HHHHHHHHHCCCCCC		29.4023090842
505PhosphorylationSINKALTSETNGTDS
HHHHHHHHCCCCCCC		43.1823090842
507PhosphorylationNKALTSETNGTDSNG
HHHHHHCCCCCCCCC		38.4223090842
510PhosphorylationLTSETNGTDSNGSNS
HHHCCCCCCCCCCCC		38.0223090842
512PhosphorylationSETNGTDSNGSNSSN
HCCCCCCCCCCCCCC		42.8223090842
515PhosphorylationNGTDSNGSNSSNIQ-
CCCCCCCCCCCCCC-		37.4823090842
517PhosphorylationTDSNGSNSSNIQ---
CCCCCCCCCCCC---		26.8523090842
518PhosphorylationDSNGSNSSNIQ----
CCCCCCCCCCC----		42.0523090842
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PP2BA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PP2BA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PP2BA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CP074_HUMANC16orf74physical
16189514
RCAN2_HUMANRCAN2physical
12102656
AKAP5_HUMANAKAP5physical
9765270
CABIN_HUMANCABIN1physical
9655484
MYOZ2_HUMANMYOZ2physical
11114196
MYOZ1_HUMANMYOZ1physical
11114196
AKT1_HUMANAKT1physical
20605778
PHLP2_HUMANPHLPP2physical
20605778
PTEN_HUMANPTENphysical
20605778
PSA6_HUMANPSMA6physical
21420386
PDE4D_HUMANPDE4Dphysical
20647544
CSEN_HUMANKCNIP3physical
17102134
RHOC_HUMANRHOCphysical
22939629
RCAN1_HUMANRCAN1physical
23118980
ALY1_YEASTALY1physical
23824189
HNRH1_HUMANHNRNPH1physical
22863883
P3H1_HUMANP3H1physical
22863883
SETLP_HUMANSETSIPphysical
22863883
MAT2B_HUMANMAT2Bphysical
22863883
NASP_HUMANNASPphysical
22863883
NRDC_HUMANNRD1physical
22863883
PDIA6_HUMANPDIA6physical
22863883
PFD5_HUMANPFDN5physical
22863883
2ABA_HUMANPPP2R2Aphysical
22863883
TNPO1_HUMANTNPO1physical
22863883
TSN_HUMANTSNphysical
22863883
PFD3_HUMANVBP1physical
22863883
XPO5_HUMANXPO5physical
22863883
JUN_HUMANJUNphysical
17215518
CANB1_HUMANPPP3R1physical
25416956
CP074_HUMANC16orf74physical
25416956
CANB1_HUMANPPP3R1physical
26186194
RCAN1_HUMANRCAN1physical
26186194
NFAC4_HUMANNFATC4physical
26186194
SIK3_HUMANSIK3physical
26186194
ARFP1_HUMANARFIP1physical
26344197
ARMT1_HUMANC6orf211physical
26344197
CANB1_HUMANPPP3R1physical
21516116
ARMT1_HUMANC6orf211physical
27880917
LBH_HUMANLBHphysical
27880917
CND3_HUMANNCAPGphysical
27880917
CANB1_HUMANPPP3R1physical
27880917
RCAN1_HUMANRCAN1physical
27880917
TBA1B_HUMANTUBA1Bphysical
27880917
NFAC4_HUMANNFATC4physical
28514442
SIK3_HUMANSIK3physical
28514442
CANB1_HUMANPPP3R1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PP2BA_HUMAN

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