ARMT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARMT1_HUMAN
• UniProt AC: Q9H993
• Protein Name: Protein-glutamate O-methyltransferase {ECO:0000305}
• Gene Name: ARMT1 {ECO:0000303|PubMed:25732820, ECO:0000312|HGNC:HGNC:17872}
• Organism: Homo sapiens (Human).
• Sequence Length: 441
• Protein Description: O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response..
• Protein Sequence: MAVVPASLSGQDVGSFAYLTIKDRIPQILTKVIDTLHRHKSEFFEKHGEEGVEAEKKAISLLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYMYRRIHEAIIQSPPIDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDEFFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILLNDMEHLWSLLSNCKKTREKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWLIEQVKHSNHKWMSKCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAHLILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTLKAEIQVGLQPGQGEQLLASEPSWWTTGKYGIFQYDGPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVVPASLS ------CCCCCCCCC		22814378
7	Phosphorylation	-MAVVPASLSGQDVG -CCCCCCCCCCCCCC		21406692
9	Phosphorylation	AVVPASLSGQDVGSF CCCCCCCCCCCCCCE		21406692
15	Phosphorylation	LSGQDVGSFAYLTIK CCCCCCCCEEEEEHH		21406692
18	Phosphorylation	QDVGSFAYLTIKDRI CCCCCEEEEEHHHHH		21406692
20	Phosphorylation	VGSFAYLTIKDRIPQ CCCEEEEEHHHHHHH		21406692
31	Ubiquitination	RIPQILTKVIDTLHR HHHHHHHHHHHHHHH		-
31	Acetylation	RIPQILTKVIDTLHR HHHHHHHHHHHHHHH		25038526
40	Ubiquitination	IDTLHRHKSEFFEKH HHHHHHCHHHHHHHH		19608861
40	2-Hydroxyisobutyrylation	IDTLHRHKSEFFEKH HHHHHHCHHHHHHHH		-
40	Acetylation	IDTLHRHKSEFFEKH HHHHHHCHHHHHHHH		19608861
40	Malonylation	IDTLHRHKSEFFEKH HHHHHHCHHHHHHHH		26320211
41	Phosphorylation	DTLHRHKSEFFEKHG HHHHHCHHHHHHHHC		24719451
46	Ubiquitination	HKSEFFEKHGEEGVE CHHHHHHHHCHHHHH		-
56	Acetylation	EEGVEAEKKAISLLS HHHHHHHHHHHHHHH		23749302
57	Ubiquitination	EGVEAEKKAISLLSK HHHHHHHHHHHHHHH		-
60	Phosphorylation	EAEKKAISLLSKLRN HHHHHHHHHHHHHHH		24719451
63	Phosphorylation	KKAISLLSKLRNELQ HHHHHHHHHHHHHHC		-
64	Acetylation	KAISLLSKLRNELQT HHHHHHHHHHHHHCC		25953088
64	Ubiquitination	KAISLLSKLRNELQT HHHHHHHHHHHHHCC		-
73	Malonylation	RNELQTDKPFIPLVE HHHHCCCCCCHHHHH		30639696
73	2-Hydroxyisobutyrylation	RNELQTDKPFIPLVE HHHHCCCCCCHHHHH		-
73	Ubiquitination	RNELQTDKPFIPLVE HHHHCCCCCCHHHHH		19608861
73	Acetylation	RNELQTDKPFIPLVE HHHHCCCCCCHHHHH		19608861
94	Phosphorylation	IWNQYLEYQQSLLNE HHHHHHHHHHHHHHC		28348404
97	Phosphorylation	QYLEYQQSLLNESDG HHHHHHHHHHHCCCC		28348404
102	Phosphorylation	QQSLLNESDGKSRWF HHHHHHCCCCCCCCC		27251275
105	Ubiquitination	LLNESDGKSRWFYSP HHHCCCCCCCCCCCH		21906983
149	Phosphorylation	ESKEQNFYGSQESII HHHHCCCCCCHHHHH		20068231
151	Phosphorylation	KEQNFYGSQESIIAL HHCCCCCCHHHHHHH		20068231
154	Phosphorylation	NFYGSQESIIALCTH CCCCCHHHHHHHHHH		20068231
160	Phosphorylation	ESIIALCTHLQQLIR HHHHHHHHHHHHHHH		20068231
168	Phosphorylation	HLQQLIRTIEDLDEN HHHHHHHHHHHCCCC		20068231
188	Phosphorylation	FFKLLQISLWGNKCD HHHHHHHHHHCCCCE		20068231
290	Phosphorylation	KTIPWFVSDTTIHDF CCCCCEECCCCHHHH		-
431	Sumoylation	PSWWTTGKYGIFQYD CCCCCCCCCCCEECC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARMT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARMT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARMT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTNB_HUMAN	APIP	physical	26344197
PUR9_HUMAN	ATIC	physical	26344197
PYGB_HUMAN	PYGB	physical	26344197
SPB8_HUMAN	SERPINB8	physical	26344197
BUP1_HUMAN	UPB1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.