MTNB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTNB_HUMAN
• UniProt AC: Q96GX9
• Protein Name: Methylthioribulose-1-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}
• Gene Name: APIP {ECO:0000255|HAMAP-Rule:MF_03116}
• Organism: Homo sapiens (Human).
• Sequence Length: 242
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death..
• Protein Sequence: MSGCDAREGDCCSRRCGAQDKEHPRYLIPELCKQFYHLGWVTGTGGGISLKHGDEIYIAPSGVQKERIQPEDMFVCDINEKDISGPSPSKKLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGREFKITHQEMIKGIKKCTSGGYYRYDDMLVVPIIENTPEEKDLKDRMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKVGLDPSQLPVGENGIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	AREGDCCSRRCGAQD CCCCCCCCCCCCCCC	29.14	20068231
19 (in isoform 3)	Phosphorylation	-	47.82	27642862
21	Acetylation	RRCGAQDKEHPRYLI CCCCCCCCCCHHHHH	45.93	23749302
26	Phosphorylation	QDKEHPRYLIPELCK CCCCCHHHHHHHHHH	17.27	28152594
57	Phosphorylation	LKHGDEIYIAPSGVQ CCCCCEEEECCCCCC	6.75	28796482
61	Phosphorylation	DEIYIAPSGVQKERI CEEEECCCCCCCCCC	42.44	29978859
65	Ubiquitination	IAPSGVQKERIQPED ECCCCCCCCCCCCCC	46.70	29967540
84	Phosphorylation	DINEKDISGPSPSKK ECCCCCCCCCCCCCC	55.58	30266825
87	Phosphorylation	EKDISGPSPSKKLKK CCCCCCCCCCCCCCH	45.38	29255136
89	Phosphorylation	DISGPSPSKKLKKSQ CCCCCCCCCCCCHHC	46.92	29255136
90	Acetylation	ISGPSPSKKLKKSQC CCCCCCCCCCCHHCC	66.56	25953088
94	Acetylation	SPSKKLKKSQCTPLF CCCCCCCHHCCCHHE	57.08	20167786
95	Phosphorylation	PSKKLKKSQCTPLFM CCCCCCHHCCCHHEE	28.97	23663014
98	Phosphorylation	KLKKSQCTPLFMNAY CCCHHCCCHHEECHH	18.52	23663014
105	Phosphorylation	TPLFMNAYTMRGAGA CHHEECHHHHCCCCE	8.96	23663014
106	Phosphorylation	PLFMNAYTMRGAGAV HHEECHHHHCCCCEE	9.66	23663014
125	Phosphorylation	SKAAVMATLLFPGRE CCHHHHHHHHCCCCE	13.09	20068231
142	Ubiquitination	ITHQEMIKGIKKCTS ECHHHHHHCHHHCCC	53.96	29967540
146	Ubiquitination	EMIKGIKKCTSGGYY HHHHCHHHCCCCCCC	40.60	29967540
188	Glutathionylation	MNEYPDSCAVLVRRH HHHCCCCEEEEEHHH	3.86	22555962
206	Acetylation	VWGETWEKAKTMCEC EEEHHHHHHHHHHHH	46.90	19608861
209	Phosphorylation	ETWEKAKTMCECYDY HHHHHHHHHHHHHHH	31.73	26552605
214	Phosphorylation	AKTMCECYDYLFDIA HHHHHHHHHHHHHHH	5.82	26552605
216	Phosphorylation	TMCECYDYLFDIAVS HHHHHHHHHHHHHHH	5.25	26552605
223	Phosphorylation	YLFDIAVSMKKVGLD HHHHHHHHHHHHCCC	18.83	26552605
225	Ubiquitination	FDIAVSMKKVGLDPS HHHHHHHHHHCCCHH	36.48	32015554
226	Ubiquitination	DIAVSMKKVGLDPSQ HHHHHHHHHCCCHHH	32.66	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTNB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTNB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTNB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUD18_HUMAN	NUDT18	physical	16189514
VPS25_HUMAN	VPS25	physical	16189514
LNX1_HUMAN	LNX1	physical	16189514
MTNB_HUMAN	APIP	physical	16189514
APAF_HUMAN	APAF1	physical	15262985
MTNB_HUMAN	APIP	physical	19060904
MTNB_HUMAN	APIP	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
PDZD4_HUMAN	PDZD4	physical	25416956
T22D4_HUMAN	TSC22D4	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
CF206_HUMAN	C6orf165	physical	25416956
HPHL1_HUMAN	HEPHL1	physical	26186194
LYG2_HUMAN	LYG2	physical	26186194
UBA3_HUMAN	UBA3	physical	26186194
DSG4_HUMAN	DSG4	physical	26186194
FAKD2_HUMAN	FASTKD2	physical	26186194
FAKD2_HUMAN	FASTKD2	physical	28514442
LYG2_HUMAN	LYG2	physical	28514442
HPHL1_HUMAN	HEPHL1	physical	28514442
UBA3_HUMAN	UBA3	physical	28514442
DSG4_HUMAN	DSG4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.