PDZD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDZD4_HUMAN
• UniProt AC: Q76G19
• Protein Name: PDZ domain-containing protein 4
• Gene Name: PDZD4
• Organism: Homo sapiens (Human).
• Sequence Length: 769
• Subcellular Localization: Cytoplasm, cell cortex . Mainly localized under the plasma membrane.
• Protein Sequence: MGCNMCVVQKPEEQYKVMLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDSSCHDLQLVDSGTQTDITFEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDRIIQINGVDVQNREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEGELRARKLKSPPAQQPGNEEEKGAPDAGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGDEPPSSTNTPGSLRKFGLQGDALQSRDFHFSMDSLLAEGAGLGGGDVPGLTDEEYERYRELLEIKCHLENGNQLGLLFPRASGGNSALDVNRNESLGHEMAMLEEELRHLEFKCRNILRAQKMQQLRERCMKAWLLEEESLYDLAASEPKKHELSDISELPEKSDKDSTSAYNTGESCRSTPLLVEPLPESPLRRAMAGNSNLNRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQHAEERGRRNPKTGLTLERVGPESSPYLSRRHRGQGQEGEHYHSCVQLAPTRGLEELGHGPLSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFMMQSRLECLREQQNGDSKPELNIIALSHRKTMKKRNKKILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Ubiquitination	VMLQVNGKELSKLSQ EEEEECHHHHHHCCH	50.72	-
27	Phosphorylation	QVNGKELSKLSQEQT EECHHHHHHCCHHHH	32.42	-
30	Phosphorylation	GKELSKLSQEQTLQA HHHHHHCCHHHHHHH	35.09	-
34	Phosphorylation	SKLSQEQTLQALRSS HHCCHHHHHHHHHCC	21.78	-
40	Phosphorylation	QTLQALRSSKEPLVI HHHHHHHCCCCCHHH	46.76	-
53	Phosphorylation	VIQVLRRSPRLRGDS HHHHHHCCCCCCCCC	14.13	17081983
225	Phosphorylation	LAKRWKDSDRDDFLD HHHHHCCCCCHHHHH	30.71	30266825
236	Phosphorylation	DFLDDFGSENEGELR HHHHHCCCCCHHHHH	36.92	19664994
249	Phosphorylation	LRARKLKSPPAQQPG HHHHHCCCCCCCCCC	46.69	21406692
271	Phosphorylation	PDAGPGLSNSQELDS CCCCCCCCCCCHHCC	40.11	30266825
273	Phosphorylation	AGPGLSNSQELDSGV CCCCCCCCCHHCCCC	22.96	30266825
278	Phosphorylation	SNSQELDSGVGRTDE CCCCHHCCCCCCCCH	48.26	30266825
283	Phosphorylation	LDSGVGRTDESTRNE HCCCCCCCCHHHCCC	37.88	21406692
286	Phosphorylation	GVGRTDESTRNEESS CCCCCCHHHCCCCCC	35.16	21406692
287	Phosphorylation	VGRTDESTRNEESSE CCCCCHHHCCCCCCC	35.15	21406692
292	Phosphorylation	ESTRNEESSEHDLLG HHHCCCCCCCCCCCC	34.54	21406692
293	Phosphorylation	STRNEESSEHDLLGD HHCCCCCCCCCCCCC	42.08	21406692
304	Phosphorylation	LLGDEPPSSTNTPGS CCCCCCCCCCCCCCC	61.58	21406692
305	Phosphorylation	LGDEPPSSTNTPGSL CCCCCCCCCCCCCCH	31.30	21406692
306	Phosphorylation	GDEPPSSTNTPGSLR CCCCCCCCCCCCCHH	47.66	21406692
308	Phosphorylation	EPPSSTNTPGSLRKF CCCCCCCCCCCHHHH	29.17	21406692
311	Phosphorylation	SSTNTPGSLRKFGLQ CCCCCCCCHHHHCCC	26.63	21406692
314	Ubiquitination	NTPGSLRKFGLQGDA CCCCCHHHHCCCCCH	49.42	-
394	Phosphorylation	LDVNRNESLGHEMAM CCCCCCHHHHHHHHH	43.11	-
412	Ubiquitination	ELRHLEFKCRNILRA HHHHHHHHHHHHHHH	23.94	-
439	Phosphorylation	AWLLEEESLYDLAAS HHHHCHHCHHHHHCC	35.19	26074081
441	Phosphorylation	LLEEESLYDLAASEP HHCHHCHHHHHCCCC	20.42	25884760
446	Phosphorylation	SLYDLAASEPKKHEL CHHHHHCCCCCCCCC	49.15	26074081
454	Phosphorylation	EPKKHELSDISELPE CCCCCCCCCHHHCCC	29.88	21406692
457	Phosphorylation	KHELSDISELPEKSD CCCCCCHHHCCCCCC	37.76	24719451
462	Ubiquitination	DISELPEKSDKDSTS CHHHCCCCCCCCCCC	63.11	-
463	Phosphorylation	ISELPEKSDKDSTSA HHHCCCCCCCCCCCC	48.51	24719451
468	Phosphorylation	EKSDKDSTSAYNTGE CCCCCCCCCCCCCCC	27.75	-
490	Phosphorylation	LVEPLPESPLRRAMA EEEECCCCHHHHHHC	27.56	30266825
523	Phosphorylation	KAAPPPGSPAKFRSL CCCCCCCCCHHHHHH	27.71	24173317
552	Phosphorylation	RGRRNPKTGLTLERV HHCCCCCCCCEEEEC	38.39	26074081
555	Phosphorylation	RNPKTGLTLERVGPE CCCCCCCEEEECCCC	28.11	26074081
563	Phosphorylation	LERVGPESSPYLSRR EEECCCCCCCCCCCC	39.48	26074081
564	Phosphorylation	ERVGPESSPYLSRRH EECCCCCCCCCCCCC	18.85	26074081
566	Phosphorylation	VGPESSPYLSRRHRG CCCCCCCCCCCCCCC	21.18	26074081
568	Phosphorylation	PESSPYLSRRHRGQG CCCCCCCCCCCCCCC	22.79	26074081
581	Phosphorylation	QGQEGEHYHSCVQLA CCCCCCCCCCCEECC	7.36	27642862
602	Phosphorylation	ELGHGPLSLAGGPRV HHCCCCCCCCCCCCC	21.21	22210691
617	Phosphorylation	GGVAAAATEAPRMEW CCEEEECCCCCCCEE	28.14	22210691
658	Phosphorylation	LKIREERSGMTTDDD HHHHHHHCCCCCCHH	35.87	26471730
661	Phosphorylation	REERSGMTTDDDAVS HHHHCCCCCCHHHHH	30.51	26471730
662	Phosphorylation	EERSGMTTDDDAVSE HHHCCCCCCHHHHHH	28.65	26471730
668	Phosphorylation	TTDDDAVSEMKMGRY CCCHHHHHHHHHHCC	33.42	29083192
675	Phosphorylation	SEMKMGRYWSKEERK HHHHHHCCCCHHHHH	14.33	29083192
677	Phosphorylation	MKMGRYWSKEERKQH HHHHCCCCHHHHHHH	22.66	29083192
701	Phosphorylation	RREFMMQSRLECLRE HHHHHHHHHHHHHHH	22.42	-
724	Phosphorylation	ELNIIALSHRKTMKK HHHHHHHHCHHHHHH	16.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDZD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDZD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDZD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.