dbPTM

DSG4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DSG4_HUMAN
UniProt AC	Q86SJ6
Protein Name	Desmoglein-4
Gene Name	DSG4
Organism	Homo sapiens (Human).
Sequence Length	1040
Subcellular Localization	Cell membrane Single-pass type I membrane protein. Cell junction, desmosome.
Protein Description	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity)..
Protein Sequence	MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACREGEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLCATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGSDRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYSVASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGNPATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTATGTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWDVRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGAAGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQPEGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYAAGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKFRTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPVVHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYNNVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGSTSPMTSRHRVTRYSNIHYTQQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	EFDIENGTTKWQTVR EEECCCCCCCCHHHH	36.46	20068231
39	Phosphorylation	FDIENGTTKWQTVRR EECCCCCCCCHHHHH	31.51	20068231
43	Phosphorylation	NGTTKWQTVRRQKRE CCCCCCHHHHHHHHH	18.18	20068231
65	Phosphorylation	CREGEDNSKRNPIAK HHCCCCCCCCCCCHH	45.36	30301811
72	Ubiquitination	SKRNPIAKIRSDCES CCCCCCHHHHHHHHC	39.10	29967540
110	N-linked_Glycosylation	NPRTGEINITSVVDR CCCCCEEEEEEEECC	27.47	UniProtKB CARBOHYD
120	Phosphorylation	SVVDREITPLFLIYC EEECCCCHHHHHHHH	14.80	-
200	Phosphorylation	KIAYKIVSQEPSGAP CHHHHHHCCCCCCCC	32.09	20068231
204	Phosphorylation	KIVSQEPSGAPMFIL HHHCCCCCCCCEEEE	47.00	20068231
214	Phosphorylation	PMFILNRYTGEVCTM CEEEEECCCCCEEEH	20.30	-
215	Phosphorylation	MFILNRYTGEVCTMS EEEEECCCCCEEEHH	24.51	-
222	Phosphorylation	TGEVCTMSSFLDREQ CCCEEEHHHHCCHHH	10.37	30631047
223	Phosphorylation	GEVCTMSSFLDREQH CCEEEHHHHCCHHHH	21.00	30631047
388	Phosphorylation	EGPAFHPSTMAFSVR CCCCCCCCCEEEEEC	23.42	23898821
389	Phosphorylation	GPAFHPSTMAFSVRE CCCCCCCCEEEEECC	19.57	23898821
449	Phosphorylation	RTGEIQFSREFDKKS CCCEEEEEECCCCCC	17.96	20068231
544	Phosphorylation	DMWDVRSTNATSAIL CCCCCCCCCCCHHHH	20.50	-
545	N-linked_Glycosylation	MWDVRSTNATSAILT CCCCCCCCCCHHHHH	42.33	UniProtKB CARBOHYD
704 (in isoform 2)	Phosphorylation	-	39.02	22210691
715	Phosphorylation	RMDSSEIYTNTYAAG CCCCCCEEECCCCCC	7.01	24275569
724	Phosphorylation	NTYAAGGTVEGGVSG CCCCCCCEEECCCCC	17.92	24275569
753	Phosphorylation	AAGAAGASGAARKRS HHHHCCCCHHHHHCC	28.22	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DSG4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DSG4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DSG4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DSG4_HUMAN !!

Drug and Disease Associations

Kegg Disease
H00784	Localized autosomal recessive hypotrichosis
OMIM Disease
607903	Hypotrichosis 6 (HYPT6)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DSG4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-38, AND MASSSPECTROMETRY.	17924679 [Abstract]