HPHL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPHL1_HUMAN
• UniProt AC: Q6MZM0
• Protein Name: Hephaestin-like protein 1
• Gene Name: HEPHL1
• Organism: Homo sapiens (Human).
• Sequence Length: 1159
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: May function as a ferroxidase and may be involved in copper transport and homeostasis..
• Protein Sequence: MPRKQPAGCIFLLTFLGLSGLVGTVTRTYYIGIVEEYWNYVPQGKNVITGKSFTEDKLATLFLERGPNRIGSIYKKAVYRRFTDGTYSIEIPKPPWLGFLGPILRAEVGDVIVIHLKNFASRPYSLHPHGVFYNKDSEGALYPDGTSGRNKNDDMVPPGKNYTYVWPVREEYAPTPADANCLTWVYHSHIDAPKDICSGLIGPLLVCKEGILNRYSGTRNDVDREFVIMFTLVDENQSWYLNENIKHFCTNPDSVDKKDAVFQRSNKMHALNGYLFGNFPEPDMCVGESVSWHLFGMGNEIDIHSIYFYGNTFISRGHRTDVVNLFPATFLTTEMIAENPGKWMITCQVSDHLQAGMLGQYNVDNCKSDIFYPKMKGQQRRYFIAAEKILWDYAPQGYNKFSGLPLNASGSDSDLYFTQGDNRIGGKYWKVRYTEFVDATFTKRKRLSAEEAHLGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKASDAAPNLDGFVKPGAHVKPGETFTYKWTVPESVSPTAGDPPCLTYLYFSAVDPIKDTSSGLVGPLLVCKKGVLNADGTQKGIDKEFYLLFTVFDENLSRYFDENIQKFIWHPFSIDKEDKEFVKSNRMHAVNGYMYGNQPGLNMCKRDRVSWHLIGLGTDTDMHGIVFQGNTIHLRGTHRDSLALFPHMATTAFMQPDHAGIFRVFCATMPHLSRGMGQIYEVSSCDNRDPSEQRYGMIRTFYIAAEEVEWDYAPNKNWEFEKQHVDARGERHGDIFMNRTENWIGSQYKKVVYREYTDGEFVEIKARPPREEHLELLGPMIHAEVGNTVLIIFKNKASRPYSISAQGVEEMDSGKQFQVPMTKPGEVKTYRWNIPKRSGPGPSDPNCIPWVYYSTVNFVKDTYSGLMGPLITCRKGVLNEKGRRSDVDYEFALLFLVFNENESWYLDDNIKKYLNKDPRDFKRTDDFEESNRMHAINGKIFGNLHGLIMNEDTMTNWYLLGIGSEVDIHTIHYHAESFLFKIDKSYREDVYDLFPGTFQTIELFADHPGTWLLHCHVSDHIHAGMETTYTVLRNIDNRIPYSTTSPGVASHPATVPSNERPGKEQLYFFGKNLGPTGAKAALVILFIIGLLLLITTVILSLRLCSAMKQTDYQQVQSCALPTDAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	GTVTRTYYIGIVEEY CCCCEEEEEEEHHHH	7.64	29759185
51	2-Hydroxyisobutyrylation	GKNVITGKSFTEDKL CCCEECCCCCCHHHH	33.47	-
74	Phosphorylation	PNRIGSIYKKAVYRR CCCCHHHHHHHHHHC	14.24	18083107
79	Phosphorylation	SIYKKAVYRRFTDGT HHHHHHHHHCCCCCE	10.84	-
137	Phosphorylation	GVFYNKDSEGALYPD CCEECCCCCCCCCCC	39.27	29759185
161	N-linked_Glycosylation	DMVPPGKNYTYVWPV CCCCCCCCCEEEEEC	40.05	31125343
215	Phosphorylation	KEGILNRYSGTRNDV CCCHHHHCCCCCCCC	15.46	24144214
216	Phosphorylation	EGILNRYSGTRNDVD CCHHHHCCCCCCCCC	30.37	24144214
218	Phosphorylation	ILNRYSGTRNDVDRE HHHHCCCCCCCCCCE	21.99	24144214
231	Phosphorylation	REFVIMFTLVDENQS CEEEEEEEEECCCCC	14.43	24144214
236	N-linked_Glycosylation	MFTLVDENQSWYLNE EEEEECCCCCEEECC	36.40	UniProtKB CARBOHYD
238	Phosphorylation	TLVDENQSWYLNENI EEECCCCCEEECCCC	29.30	24144214
240	Phosphorylation	VDENQSWYLNENIKH ECCCCCEEECCCCHH	12.61	24144214
258	Methylation	NPDSVDKKDAVFQRS CHHHCCHHHHHHHHH	46.59	-
407	N-linked_Glycosylation	KFSGLPLNASGSDSD CCCCCCCCCCCCCCC	30.07	31125343
468	Phosphorylation	IKAEVGDTLLVTFAN EEEECCCEEEEEECC	18.96	-
481	Phosphorylation	ANKADKVYSILPHGV CCCCCCEEEECCCCE	8.85	-
537	Phosphorylation	AGDPPCLTYLYFSAV CCCCCCEEEEEEECC	20.42	22210691
538	Phosphorylation	GDPPCLTYLYFSAVD CCCCCEEEEEEECCC	6.10	22210691
542	Phosphorylation	CLTYLYFSAVDPIKD CEEEEEEECCCCCCC	17.52	22210691
589	N-linked_Glycosylation	LFTVFDENLSRYFDE EEEECCHHHHHHHCC	45.20	UniProtKB CARBOHYD
627	Phosphorylation	RMHAVNGYMYGNQPG CCEEECCEECCCCCC	5.07	-
629	Phosphorylation	HAVNGYMYGNQPGLN EEECCEECCCCCCCC	12.39	-
644	Phosphorylation	MCKRDRVSWHLIGLG CCCCCCCEEEEEECC	15.07	26074081
652	Phosphorylation	WHLIGLGTDTDMHGI EEEEECCCCCCCEEE	40.54	26074081
654	Phosphorylation	LIGLGTDTDMHGIVF EEECCCCCCCEEEEE	34.75	26074081
665	Phosphorylation	GIVFQGNTIHLRGTH EEEECCCEEEECCCC	19.32	26074081
772	N-linked_Glycosylation	RHGDIFMNRTENWIG HCCCCCCCCCCCCCC	36.65	31125343
909	Ubiquitination	GPLITCRKGVLNEKG HHHEEEECCCCCCCC	56.36	29967540
935	N-linked_Glycosylation	LFLVFNENESWYLDD EEHHCCCCCCEECCH	50.10	UniProtKB CARBOHYD
1075	Phosphorylation	NIDNRIPYSTTSPGV CCCCCCCCCCCCCCC	19.11	27251275
1076	Phosphorylation	IDNRIPYSTTSPGVA CCCCCCCCCCCCCCC	21.61	27251275
1077	Phosphorylation	DNRIPYSTTSPGVAS CCCCCCCCCCCCCCC	26.00	27251275
1078	Phosphorylation	NRIPYSTTSPGVASH CCCCCCCCCCCCCCC	27.30	27251275
1079	Phosphorylation	RIPYSTTSPGVASHP CCCCCCCCCCCCCCC	21.53	27251275
1084	Phosphorylation	TTSPGVASHPATVPS CCCCCCCCCCCCCCC	27.83	27251275
1088	Phosphorylation	GVASHPATVPSNERP CCCCCCCCCCCCCCC	37.08	27251275
1146	Phosphorylation	SAMKQTDYQQVQSCA HHHCCCCHHHHHHCC	12.30	-
1156	Phosphorylation	VQSCALPTDAL---- HHHCCCCCCCC----	34.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPHL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPHL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPHL1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HPHL1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.