FAKD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAKD2_HUMAN
• UniProt AC: Q9NYY8
• Protein Name: FAST kinase domain-containing protein 2, mitochondrial
• Gene Name: FASTKD2 {ECO:0000303|PubMed:27667664, ECO:0000312|HGNC:HGNC:29160}
• Organism: Homo sapiens (Human).
• Sequence Length: 710
• Subcellular Localization: Mitochondrion matrix, mitochondrion nucleoid . Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids.
• Protein Description: Plays an important role in assembly of the mitochondrial large ribosomal subunit. [PubMed: 25683715 As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation]
• Protein Sequence: MLTTLKPFGSVSVESKMNNKAGSFFWNLRQFSTLVSTSRTMRLCCLGLCKPKIVHSNWNILNNFHNRMQSTDIIRYLFQDAFIFKSDVGFQTKGISTLTALRIERLLYAKRLFFDSKQSLVPVDKSDDELKKVNLNHEVSNEDVLTKETKPNRISSRKLSEECNSLSDVLDAFSKAPTFPSSNYFTAMWTIAKRLSDDQKRFEKRLMFSHPAFNQLCEHMMREAKIMQYKYLLFSLHAIVKLGIPQNTILVQTLLRVTQERINECDEICLSVLSTVLEAMEPCKNVHVLRTGFRILVDQQVWKIEDVFTLQVVMKCIGKDAPIALKRKLEMKALRELDRFSVLNSQHMFEVLAAMNHRSLILLDECSKVVLDNIHGCPLRIMINILQSCKDLQYHNLDLFKGLADYVAATFDIWKFRKVLFILILFENLGFRPVGLMDLFMKRIVEDPESLNMKNILSILHTYSSLNHVYKCQNKEQFVEVMASALTGYLHTISSENLLDAVYSFCLMNYFPLAPFNQLLQKDIISELLTSDDMKNAYKLHTLDTCLKLDDTVYLRDIALSLPQLPRELPSSHTNAKVAEVLSSLLGGEGHFSKDVHLPHNYHIDFEIRMDTNRNQVLPLSDVDTTSATDIQRVAVLCVSRSAYCLGSSHPRGFLAMKMRHLNAMGFHVILVNNWEMDKLEMEDAVTFLKTKIYSVEALPVAAVNVQSTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	KMNNKAGSFFWNLRQ CCCCCCCHHHCCHHH	23.33	25849741
32	Phosphorylation	FWNLRQFSTLVSTSR HCCHHHHHHHHCCCH	16.70	26552605
33	Phosphorylation	WNLRQFSTLVSTSRT CCHHHHHHHHCCCHH	32.25	26552605
36	Phosphorylation	RQFSTLVSTSRTMRL HHHHHHHCCCHHHHH	24.63	26552605
37	Phosphorylation	QFSTLVSTSRTMRLC HHHHHHCCCHHHHHH	18.10	26552605
38	Phosphorylation	FSTLVSTSRTMRLCC HHHHHCCCHHHHHHH	20.46	26552605
40	Phosphorylation	TLVSTSRTMRLCCLG HHHCCCHHHHHHHHH	13.35	26552605
86	Phosphorylation	QDAFIFKSDVGFQTK CCCEEECCCCCCCCC	27.12	-
92	Phosphorylation	KSDVGFQTKGISTLT CCCCCCCCCCHHHHH	29.04	24719451
93 (in isoform 2)	Ubiquitination	-	43.39	21906983
93 (in isoform 1)	Ubiquitination	-	43.39	21906983
93	Ubiquitination	SDVGFQTKGISTLTA CCCCCCCCCHHHHHH	43.39	21906983
96	Phosphorylation	GFQTKGISTLTALRI CCCCCCHHHHHHHHH	26.49	28348404
97	Phosphorylation	FQTKGISTLTALRIE CCCCCHHHHHHHHHH	26.63	24719451
99	Phosphorylation	TKGISTLTALRIERL CCCHHHHHHHHHHHH	24.59	20068231
108	Phosphorylation	LRIERLLYAKRLFFD HHHHHHHHHHHHHCC	18.05	24719451
125	Ubiquitination	QSLVPVDKSDDELKK CCCEECCCCCHHHHH	56.89	-
126	Phosphorylation	SLVPVDKSDDELKKV CCEECCCCCHHHHHC	45.92	30266825
132 (in isoform 2)	Ubiquitination	-	49.32	21906983
132 (in isoform 1)	Ubiquitination	-	49.32	21906983
132	Ubiquitination	KSDDELKKVNLNHEV CCCHHHHHCCCCCCC	49.32	21906983
140	Phosphorylation	VNLNHEVSNEDVLTK CCCCCCCCCHHHCCC	31.36	23186163
147	Ubiquitination	SNEDVLTKETKPNRI CCHHHCCCCCCCCCC	60.26	-
155	Phosphorylation	ETKPNRISSRKLSEE CCCCCCCCHHHHHHH	22.35	27282143
158	Ubiquitination	PNRISSRKLSEECNS CCCCCHHHHHHHHHC	59.31	-
160	Phosphorylation	RISSRKLSEECNSLS CCCHHHHHHHHHCHH	34.09	30108239
165	Phosphorylation	KLSEECNSLSDVLDA HHHHHHHCHHHHHHH	40.69	30108239
167	Phosphorylation	SEECNSLSDVLDAFS HHHHHCHHHHHHHHH	26.03	23927012
174	Phosphorylation	SDVLDAFSKAPTFPS HHHHHHHHCCCCCCC	29.63	-
181	Phosphorylation	SKAPTFPSSNYFTAM HCCCCCCCCHHHHHH	27.33	-
200	Ubiquitination	KRLSDDQKRFEKRLM HHCCHHHHHHHHHHH	67.08	-
229	Phosphorylation	REAKIMQYKYLLFSL HHHHHHHHHHHHHHH	5.57	-
326	Ubiquitination	KDAPIALKRKLEMKA CCCCHHHHHHHHHHH	38.16	-
326	2-Hydroxyisobutyrylation	KDAPIALKRKLEMKA CCCCHHHHHHHHHHH	38.16	-
341	Phosphorylation	LRELDRFSVLNSQHM HHHHHHHHHCCCHHH	26.96	22210691
345	Phosphorylation	DRFSVLNSQHMFEVL HHHHHCCCHHHHHHH	19.80	22210691
367	Phosphorylation	LILLDECSKVVLDNI EEEHHHCCCHHHHHC	26.83	22210691
377	S-nitrosylation	VLDNIHGCPLRIMIN HHHHCCCCCHHHHHH	1.45	19483679
377	S-nitrosocysteine	VLDNIHGCPLRIMIN HHHHCCCCCHHHHHH	1.45	-
388	Phosphorylation	IMINILQSCKDLQYH HHHHHHHHCCCCCCC	21.49	-
394	Phosphorylation	QSCKDLQYHNLDLFK HHCCCCCCCCCCHHH	10.44	-
406	Phosphorylation	LFKGLADYVAATFDI HHHHHHHHHHHHHHH	6.08	-
453	Sulfoxidation	EDPESLNMKNILSIL CCHHHCCHHHHHHHH	4.22	21406390
487	Phosphorylation	EVMASALTGYLHTIS HHHHHHHHHHHHHCC	24.40	23879269
535 (in isoform 1)	Ubiquitination	-	45.48	21906983
535 (in isoform 2)	Ubiquitination	-	45.48	21906983
535	Ubiquitination	LLTSDDMKNAYKLHT HCCCHHHHHHHHHCC	45.48	2190698
621	Phosphorylation	RNQVLPLSDVDTTSA CCCEEEHHHCCCCCC	33.38	-
625	Phosphorylation	LPLSDVDTTSATDIQ EEHHHCCCCCCHHHH	23.62	21406692
626	Phosphorylation	PLSDVDTTSATDIQR EHHHCCCCCCHHHHH	16.35	21406692
627	Phosphorylation	LSDVDTTSATDIQRV HHHCCCCCCHHHHHH	31.12	21406692
629	Phosphorylation	DVDTTSATDIQRVAV HCCCCCCHHHHHHHH	33.14	21406692
687	Phosphorylation	LEMEDAVTFLKTKIY CHHHHHHHHHHHCEE	25.60	20860994
690	Ubiquitination	EDAVTFLKTKIYSVE HHHHHHHHHCEEEEE	43.51	-
692	Ubiquitination	AVTFLKTKIYSVEAL HHHHHHHCEEEEEEC	37.75	-
695	Phosphorylation	FLKTKIYSVEALPVA HHHHCEEEEEECEEE	19.56	23186163
708	Phosphorylation	VAAVNVQSTQ----- EEEEECCCCC-----	25.21	30266825
709	Phosphorylation	AAVNVQSTQ------ EEEECCCCC------	22.62	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAKD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAKD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAKD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLH1_HUMAN	CLTC	physical	26344197
NGRN_HUMAN	NGRN	physical	27667664
RCC1L_HUMAN	WBSCR16	physical	27667664
TRUB2_HUMAN	TRUB2	physical	27667664
RUSD4_HUMAN	RPUSD4	physical	27667664
TRUB2_HUMAN	TRUB2	physical	28514442
SYYM_HUMAN	YARS2	physical	28514442
MTEF3_HUMAN	MTERF3	physical	28514442
NGRN_HUMAN	NGRN	physical	28514442
PTCD1_HUMAN	PTCD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.