PTCD1_HUMAN - dbPTM
PTCD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTCD1_HUMAN
UniProt AC O75127
Protein Name Pentatricopeptide repeat-containing protein 1, mitochondrial
Gene Name PTCD1
Organism Homo sapiens (Human).
Sequence Length 700
Subcellular Localization Mitochondrion . Mitochondrion matrix.
Protein Description Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs..
Protein Sequence MDFVRLARLFARARPMGLFILQHLDPCRARWAGGREGLMRPMWAPFSSSSSQLPLGQERQENTGSLGSDPSHSNSTATQEEDEEEEESFGTLSDKYSSRRLFRKSAAQFHNLRFGERRDEQMEPEPKLWRGRRNTPYWYFLQCKHLIKEGKLVEALDLFERQMLKEERLQPMESNYTVLIGGCGRVGYLKKAFNLYNQMKKRDLEPSDATYTALFNVCAESPWKDSALQSALKLRQQLQAKNFELNLKTYHALLKMAAKCADLRMCLDVFKEIIHKGHVVTEETFSFLLMGCIQDKKTGFRYALQVWRLMLSLGLQPSRDSYNLLLVAARDCGLGDPQVASELLLKPREEATVLQPPVSRQRPRRTAQAKAGNLMSAMLHVEALERQLFLEPSQALGPPEPPEARVPGKAQPEVDTKAEPSHTAALTAVALKPPPVELEVNLLTPGAVPPTVVSFGTVTTPADRLALIGGLEGFLSKMAEHRQQPDIRTLTLLAEVVESGSPAESLLLALLDEHQVEADLTFFNTLVRKKSKLGDLEGAKALLPVLAKRGLVPNLQTFCNLAIGCHRPKDGLQLLTDMKKSQVTPNTHIYSALINAAIRKLNYTYLISILKDMKQNRVPVNEVVIRQLEFAAQYPPTFDRYQGKNTYLEKIDGFRAYYKQWLTVMPAEETPHPWQKFRTKPQGDQDTGKEADDGCALGGR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
63PhosphorylationGQERQENTGSLGSDP
CCCCCCCCCCCCCCC		27.6526471730
65PhosphorylationERQENTGSLGSDPSH
CCCCCCCCCCCCCCC		27.7626471730
71PhosphorylationGSLGSDPSHSNSTAT
CCCCCCCCCCCCCCC		44.5326471730
73PhosphorylationLGSDPSHSNSTATQE
CCCCCCCCCCCCCCC		36.4926471730
75PhosphorylationSDPSHSNSTATQEED
CCCCCCCCCCCCCHH		23.5726471730
76PhosphorylationDPSHSNSTATQEEDE
CCCCCCCCCCCCHHH		37.6626471730
78PhosphorylationSHSNSTATQEEDEEE
CCCCCCCCCCHHHHH		36.2826471730
88PhosphorylationEDEEEEESFGTLSDK
HHHHHHHHHCCCCHH		32.0526471730
105PhosphorylationSRRLFRKSAAQFHNL
HHHHHHHHHHHHHCC		25.2825159151
165UbiquitinationLFERQMLKEERLQPM
HHHHHHHHHHHCCCC		52.79-
201AcetylationNLYNQMKKRDLEPSD
HHHHHHHHCCCCCCH		45.8918528441
201UbiquitinationNLYNQMKKRDLEPSD
HHHHHHHHCCCCCCH		45.89-
226PhosphorylationAESPWKDSALQSALK
HCCCCCHHHHHHHHH		27.4428102081
230PhosphorylationWKDSALQSALKLRQQ
CCHHHHHHHHHHHHH		36.1028102081
235DimethylationLQSALKLRQQLQAKN
HHHHHHHHHHHHHCC		22.17-
235MethylationLQSALKLRQQLQAKN
HHHHHHHHHHHHHCC		22.1724376729
241UbiquitinationLRQQLQAKNFELNLK
HHHHHHHCCCCCHHH		49.5721890473
250PhosphorylationFELNLKTYHALLKMA
CCCHHHHHHHHHHHH		5.41-
312PhosphorylationQVWRLMLSLGLQPSR
HHHHHHHHCCCCCCC		13.36-
341PhosphorylationLGDPQVASELLLKPR
CCCHHHHHHHHCCCH		29.8923684312
352PhosphorylationLKPREEATVLQPPVS
CCCHHHCCCCCCCCC		25.6530576142
359PhosphorylationTVLQPPVSRQRPRRT
CCCCCCCCCCCCCHH		28.5930576142
532UbiquitinationTLVRKKSKLGDLEGA
HHHHHHHHCCCHHHH		66.42-
603PhosphorylationAAIRKLNYTYLISIL
HHHHHCCHHHHHHHH		13.7529759185
604PhosphorylationAIRKLNYTYLISILK
HHHHCCHHHHHHHHH		15.6929759185
608PhosphorylationLNYTYLISILKDMKQ
CCHHHHHHHHHHHHC		21.1924719451
659UbiquitinationDGFRAYYKQWLTVMP
CCHHHHHHHHEEEEC		23.4821890473
676UbiquitinationETPHPWQKFRTKPQG
CCCCCCHHHCCCCCC		32.7021890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTCD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTCD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTCD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PTCD1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTCD1_HUMAN

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Related Literatures of Post-Translational Modification

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