RUSD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUSD4_HUMAN
• UniProt AC: Q96CM3
• Protein Name: Mitochondrial RNA pseudouridine synthase RPUSD4
• Gene Name: RPUSD4 {ECO:0000303|PubMed:27667664, ECO:0000312|HGNC:HGNC:25898}
• Organism: Homo sapiens (Human).
• Sequence Length: 377
• Subcellular Localization: Mitochondrion matrix . Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly.
• Protein Description: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. [PubMed: 27974379 Acts on position 39 in mitochondrial tRNA(Phe)]
• Protein Sequence: MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNAQVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKLSVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEMPNEDQNENNEAKCLGAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	DTKKEPVSTNAVQRR CCCCCCCCHHHHHHH	27.02	21964256
66	Phosphorylation	TKKEPVSTNAVQRRV CCCCCCCHHHHHHHH	27.68	21964256
142	Ubiquitination	AKMLHGHKAEPLHLC HHHHCCCCCCCHHHH	60.06	-
156	Phosphorylation	CHRLDKETTGVMVLA HHCCCCCCCCEEEEE	34.29	-
157	Phosphorylation	HRLDKETTGVMVLAW HCCCCCCCCEEEEEE	28.95	-
185	Phosphorylation	TRQVVKKYWAITVHV HHHHHHHEEEEEEEC	8.38	24719451
189	Phosphorylation	VKKYWAITVHVPMPS HHHEEEEEEECCCCC	9.23	24719451
196	Phosphorylation	TVHVPMPSAGVVDIP EEECCCCCCCEEEEE	31.25	24719451
217	Ubiquitination	QGQQQHHKMTLSPSY CCCCCCCCEEECCEE	31.30	-
219	Phosphorylation	QQQHHKMTLSPSYRM CCCCCCEEECCEEEC	28.96	25072903
221	Phosphorylation	QHHKMTLSPSYRMDD CCCCEEECCEEECCC	11.57	25159151
223	Phosphorylation	HKMTLSPSYRMDDGK CCEEECCEEECCCCC	23.22	25072903
224	Phosphorylation	KMTLSPSYRMDDGKM CEEECCEEECCCCCE	17.22	25072903
299	Ubiquitination	WNRLAPQKLSVGTLK HHHCCCCCCCHHHHH	41.49	-
307	Ubiquitination	LSVGTLKKLGLEQSK CCHHHHHHHCCCHHH	51.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUSD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUSD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUSD4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RUSD4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.