NGRN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NGRN_HUMAN
• UniProt AC: Q9NPE2
• Protein Name: Neugrin
• Gene Name: NGRN {ECO:0000303|PubMed:27667664, ECO:0000312|HGNC:HGNC:18077}
• Organism: Homo sapiens (Human).
• Sequence Length: 291
• Subcellular Localization: Nucleus . Secreted . Mitochondrion membrane .
• Protein Description: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system..
• Protein Sequence: MAVTLSLLLGGRVCAAVTRCGFATRGVAGPGPIGREPDPDSDWEPEERELQEVESTLKRQKQAIRFQKIRRQMEAPGAPPRTLTWEAMEQIRYLHEEFPESWSVPRLAEGFDVSTDVIRRVLKSKFLPTLEQKLKQDQKVLKKAGLAHSLQHLRGSGNTSKLLPAGHSVSGSLLMPGHEASSKDPNHSTALKVIESDTHRTNTPRRRKGRNKEIQDLEESFVPVAAPLGHPRELQKYSSDSESPRGTGSGALPSGQKLEELKAEEPDNFSSKVVQRGREFFDSNGNFLYRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41 (in isoform 3)	Phosphorylation	-	50.43	29507054
41	Phosphorylation	GREPDPDSDWEPEER CCCCCCCCCCCHHHH	50.43	23401153
135	Acetylation	PTLEQKLKQDQKVLK HHHHHHHHHHHHHHH	59.88	90487
158	N-linked_Glycosylation	QHLRGSGNTSKLLPA HHHHCCCCCCCCCCC	42.76	UniProtKB CARBOHYD
168	Phosphorylation	KLLPAGHSVSGSLLM CCCCCCCCCCCCCCC	19.63	21406692
170	Phosphorylation	LPAGHSVSGSLLMPG CCCCCCCCCCCCCCC	26.19	21406692
172	Phosphorylation	AGHSVSGSLLMPGHE CCCCCCCCCCCCCCC	15.72	21406692
181	Phosphorylation	LMPGHEASSKDPNHS CCCCCCCCCCCCCCC	34.63	21406692
182	Phosphorylation	MPGHEASSKDPNHST CCCCCCCCCCCCCCH	48.39	21406692
186	N-linked_Glycosylation	EASSKDPNHSTALKV CCCCCCCCCCHHHHH	52.45	UniProtKB CARBOHYD
201	Phosphorylation	IESDTHRTNTPRRRK HHCCCCCCCCCHHCC	35.52	24719451
203	Phosphorylation	SDTHRTNTPRRRKGR CCCCCCCCCHHCCCC	19.98	24719451
237	Phosphorylation	HPRELQKYSSDSESP CHHHHHHHCCCCCCC	10.63	28985074
238	Phosphorylation	PRELQKYSSDSESPR HHHHHHHCCCCCCCC	34.40	25262027
239	Phosphorylation	RELQKYSSDSESPRG HHHHHHCCCCCCCCC	41.91	25627689
241	Phosphorylation	LQKYSSDSESPRGTG HHHHCCCCCCCCCCC	41.75	25627689
243	Phosphorylation	KYSSDSESPRGTGSG HHCCCCCCCCCCCCC	24.69	21815630
247	Phosphorylation	DSESPRGTGSGALPS CCCCCCCCCCCCCCC	29.47	25627689
249	Phosphorylation	ESPRGTGSGALPSGQ CCCCCCCCCCCCCCH	22.26	25627689
268	N-linked_Glycosylation	LKAEEPDNFSSKVVQ HHCCCCCCHHHHHHH	49.79	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NGRN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NGRN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NGRN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RCC1L_HUMAN	WBSCR16	physical	27667664
RUSD3_HUMAN	RPUSD3	physical	27667664
RUSD4_HUMAN	RPUSD4	physical	27667664
TRUB2_HUMAN	TRUB2	physical	27667664
FAKD2_HUMAN	FASTKD2	physical	27667664

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.