| UniProt ID | RUSD3_HUMAN | |
|---|---|---|
| UniProt AC | Q6P087 | |
| Protein Name | Mitochondrial mRNA pseudouridine synthase RPUSD3 | |
| Gene Name | RPUSD3 {ECO:0000303|PubMed:27667664, ECO:0000312|HGNC:HGNC:28437} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 351 | |
| Subcellular Localization | Mitochondrion matrix . Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. | |
| Protein Description | Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. [PubMed: 27974379 As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis] | |
| Protein Sequence | MRAVLAREMDGRRVLGRFWSGWRRGLGVRPVPEDAGFGTEARHQRQPRGSCQRSGPLGDQPFAGLLPKNLSREELVDALRAAVVDRKGPLVTLNKPQGLPVTGKPGELTLFSVLPELSQSLGLREQELQVVRASGKESSGLVLLSSCPQTASRLQKYFTHARRAQRPTATYCAVTDGIPAASEGKIQAALKLEHIDGVNLTVPVKAPSRKDILEGVKKTLSHFRVVATGSGCALVQLQPLTVFSSQLQVHMVLQLCPVLGDHMYSARVGTVLGQRFLLPAENNKPQRQVLDEALLRRLHLTPSQAAQLPLHLHLHRLLLPGTRARDTPVELLAPLPPYFSRTLQCLGLRLQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 60 (in isoform 1) | Ubiquitination | - | 32.96 | 21890473 | |
| 60 (in isoform 3) | Ubiquitination | - | 32.96 | 21890473 | |
| 68 | Ubiquitination | PFAGLLPKNLSREEL CCCCCCCCCCCHHHH | 71.18 | 22817900 | |
| 68 (in isoform 2) | Ubiquitination | - | 71.18 | 21890473 | |
| 71 | Phosphorylation | GLLPKNLSREELVDA CCCCCCCCHHHHHHH | 47.22 | 14702039 | |
| 95 | Ubiquitination | GPLVTLNKPQGLPVT CCEEEECCCCCCCCC | 41.66 | 29967540 | |
| 195 | Ubiquitination | AALKLEHIDGVNLTV EEEEEEECCCCCEEE | 3.44 | 29967540 | |
| 210 | Ubiquitination | PVKAPSRKDILEGVK EECCCCHHHHHHHHH | 54.16 | 29967540 | |
| 349 | Methylation | TLQCLGLRLQ----- HHHHHCCCCC----- | 29.28 | 115492887 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RUSD3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RUSD3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RUSD3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KR107_HUMAN | KRTAP10-7 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| CH60_HUMAN | HSPD1 | physical | 28514442 | |
| NDUF7_HUMAN | NDUFAF7 | physical | 28514442 | |
| SYYM_HUMAN | YARS2 | physical | 28514442 | |
| ANXA1_HUMAN | ANXA1 | physical | 28514442 | |
| LRP1_HUMAN | LRP1 | physical | 28514442 | |
| ATPF1_HUMAN | ATPAF1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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