dbPTM

LRP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LRP1_HUMAN
UniProt AC	Q07954
Protein Name	Prolow-density lipoprotein receptor-related protein 1
Gene Name	LRP1
Organism	Homo sapiens (Human).
Sequence Length	4544
Subcellular Localization	Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane Single-pass type I membrane protein. Membrane, coated pit. Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane Peripheral membrane protein E
Protein Description	Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. [PubMed: 11907044]
Protein Sequence	MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGVVFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLTPPLLLLL -----CCCHHHHHHH	34.42	24043423
14	Phosphorylation	LLLLPLLSALVAAAI HHHHHHHHHHHHHHH	27.52	24043423
114	N-linked_Glycosylation	HCRELQGNCSRLGCQ HHHHHHCCHHHCCCC	13.97	UniProtKB CARBOHYD
136	N-linked_Glycosylation	DGPTCYCNSSFQLQA CCCCEEECCCEEEEC	17.76	UniProtKB CARBOHYD
185	N-linked_Glycosylation	GYLLQPDNRSCKAKN EEEECCCCCCCCCCC	44.44	UniProtKB CARBOHYD
239	N-linked_Glycosylation	AMDFSYANETVCWVH CEECCCCCCEEEEEE	36.92	UniProtKB CARBOHYD
274	N-linked_Glycosylation	FVDEHTINISLSLHH CCCCCEEEEEEEEHH	20.96	UniProtKB CARBOHYD
313	Phosphorylation	VCNRNGDTCVTLLDL EECCCCCEEEEEEEE	15.41	26503892
323	Phosphorylation	TLLDLELYNPKGIAL EEEEEEEECCCCCCC	21.75	26503892
336	Ubiquitination	ALDPAMGKVFFTDYG CCCHHHCCEEEECCC	23.84	-
357	N-linked_Glycosylation	RCDMDGQNRTKLVDS EECCCCCCCCEEECC	60.15	UniProtKB CARBOHYD
446	N-linked_Glycosylation	VIRVNRFNSTEYQVV EEEEECCCCCEEEEE	44.80	16335952
458	Methylation	QVVTRVDKGGALHIY EEEEEEECCCEEEEE	57.28	23644510
508	Phosphorylation	ARTCRCRSGFSLGSD CCCCCCCCCCCCCCC	48.06	23312004
511	Phosphorylation	CRCRSGFSLGSDGKS CCCCCCCCCCCCCCC	35.03	23312004
514	Phosphorylation	RSGFSLGSDGKSCKK CCCCCCCCCCCCCCC	48.78	23312004
530	Phosphorylation	EHELFLVYGKGRPGI CCEEEEEEECCCCCC	18.44	-
539	Dimethylation	KGRPGIIRGMDMGAK CCCCCCCCCCCCCCC	32.25	-
539	Methylation	KGRPGIIRGMDMGAK CCCCCCCCCCCCCCC	32.25	24410437
648	Phosphorylation	TLIEGKMTHPRAIVV HHHCCCCCCCCEEEE	32.01	-
729	N-linked_Glycosylation	RIETILLNGTDRKIV HHHHHCCCCCCCEEE	48.12	19139490
847	O-linked_Glycosylation	VTCLANPSYVPPPQC CEECCCCCCCCCCCC	38.27	OGP
894	O-linked_Glycosylation	PALCHQHTCPSDRFK CHHCCCCCCCCCCCC	21.38	55825003
897	O-linked_Glycosylation	CHQHTCPSDRFKCEN CCCCCCCCCCCCCCC	43.49	55825009
928	N-linked_Glycosylation	GNSEDESNATCSART CCCCCCCCCEECCCC	36.90	UniProtKB CARBOHYD
935	O-linked_Glycosylation	NATCSARTCPPNQFS CCEECCCCCCCCCEE	29.13	OGP
975	O-linked_Glycosylation	SASCAYPTCFPLTQF HHCCCCCCCCCCCEE	17.69	OGP
1014	O-linked_Glycosylation	DEAGCSHSCSSTQFK CCCCCCCCCCCCEEE	10.21	OGP
1050	N-linked_Glycosylation	YSDETHANCTNQATR CCCCCCCCCCCCCCC	26.07	UniProtKB CARBOHYD
1056	O-linked_Glycosylation	ANCTNQATRPPGGCH CCCCCCCCCCCCCCC	33.66	OGP
1101	O-linked_Glycosylation	EKSCEGVTHVCDPSV CHHCCCCCCCCCCCC	21.32	55835637
1154	N-linked_Glycosylation	PPSHPCANNTSVCLP CCCCCCCCCCCEECC	60.06	UniProtKB CARBOHYD
1155	N-linked_Glycosylation	PSHPCANNTSVCLPP CCCCCCCCCCEECCH	18.40	UniProtKB CARBOHYD
1195	N-linked_Glycosylation	NNGGCSHNCSVAPGE CCCCCCCCCCCCCCC	11.94	UniProtKB CARBOHYD
1218	N-linked_Glycosylation	GMELGPDNHTCQIQS CCCCCCCCCCCHHHH	35.19	UniProtKB CARBOHYD
1409	Phosphorylation	FWTDWDASLPRIEAA EEECCCCCCCHHHHH	36.11	24719451
1417	Phosphorylation	LPRIEAASMSGAGRR CCHHHHHHCCCCCCC	22.11	21406692
1419	Phosphorylation	RIEAASMSGAGRRTV HHHHHHCCCCCCCEE	24.01	24670416
1430	Phosphorylation	RRTVHRETGSGGWPN CCEECCCCCCCCCCC	36.28	-
1432	Phosphorylation	TVHRETGSGGWPNGL EECCCCCCCCCCCCE	41.37	-
1440	Phosphorylation	GGWPNGLTVDYLEKR CCCCCCEEEEHHCCE	16.84	-
1443	Phosphorylation	PNGLTVDYLEKRILW CCCEEEEHHCCEEEE	16.66	-
1498	Phosphorylation	VYWTDWRTNTLAKAN EEEEECCCCCHHHHC	28.44	-
1500	Phosphorylation	WTDWRTNTLAKANKW EEECCCCCHHHHCCC	27.72	28258704
1511	N-linked_Glycosylation	ANKWTGHNVTVVQRT HCCCCCCCEEEEEEC	32.28	19139490
1513	Phosphorylation	KWTGHNVTVVQRTNT CCCCCCEEEEEECCC	21.92	28258704
1558	N-linked_Glycosylation	HLCLINYNRTVSCAC EEEEEECCCEEECCC	28.76	UniProtKB CARBOHYD
1575	N-linked_Glycosylation	LMKLHKDNTTCYEFK HHHHCCCCCCHHHHH	41.93	19159218
1587	Phosphorylation	EFKKFLLYARQMEIR HHHHHHHHHHHCHHC	11.24	-
1616	N-linked_Glycosylation	FTVPDIDNVTVLDYD EECCCCCCCEEECCC	31.52	19159218
1645	N-linked_Glycosylation	AIKRAFINGTGVETV HHHHHHHCCCCCEEE	35.20	19159218
1723	N-linked_Glycosylation	LYWTDGDNISMANMD EEEECCCCEEEEECC	33.49	UniProtKB CARBOHYD
1733	N-linked_Glycosylation	MANMDGSNRTLLFSG EEECCCCCCEEEECC	46.62	UniProtKB CARBOHYD
1754	Phosphorylation	LAIDFPESKLYWISS EEEECCHHHEEEEEC	28.35	-
1763	N-linked_Glycosylation	LYWISSGNHTINRCN EEEEECCCCEEECCC	30.95	19159218
1784	Phosphorylation	EVIDAMRSQLGKATA HHHHHHHHHCCHHHH	19.37	29396449
1788	Acetylation	AMRSQLGKATALAIM HHHHHCCHHHHHHHH	51.67	7710339
1790	Phosphorylation	RSQLGKATALAIMGD HHHCCHHHHHHHHCC	26.20	29396449
1825	N-linked_Glycosylation	SGSVVLRNSTTLVMH CCCEEEECCCEEEEE	39.28	UniProtKB CARBOHYD
1826	Phosphorylation	GSVVLRNSTTLVMHM CCEEEECCCEEEEEE	19.14	20068231
1836	Phosphorylation	LVMHMKVYDESIQLD EEEEEEEECCCCCCC	14.42	30576142
1847	Phosphorylation	IQLDHKGTNPCSVNN CCCCCCCCCCCCCCC	40.57	30576142
1864	Phosphorylation	CSQLCLPTSETTRSC CCCCCCCCCCCCCCC	26.67	30576142
1878	Phosphorylation	CMCTAGYSLRSGQQA CCCCCCCHHCCCCHH	19.18	24719451
1922	Phosphorylation	LVPVSGTSLAVGIDF EEECCCCEEEEEEEE	20.18	28985074
1933	N-linked_Glycosylation	GIDFHAENDTIYWVD EEEEECCCCEEEEEE	53.13	UniProtKB CARBOHYD
1935	Phosphorylation	DFHAENDTIYWVDMG EEECCCCEEEEEECC	27.78	28985074
1937	Phosphorylation	HAENDTIYWVDMGLS ECCCCEEEEEECCHH	11.06	28985074
1947	Phosphorylation	DMGLSTISRAKRDQT ECCHHHHHHHHCCCC	26.69	28985074
1980	Phosphorylation	DWIAGNIYWTDQGFD EEECCCEEECCCCCE	13.27	22210691
1982	Phosphorylation	IAGNIYWTDQGFDVI ECCCEEECCCCCEEE	11.06	22210691
1995	N-linked_Glycosylation	VIEVARLNGSFRYVV EEEEEECCCCEEEEE	38.21	UniProtKB CARBOHYD
1997	Phosphorylation	EVARLNGSFRYVVIS EEEECCCCEEEEEEE	12.89	28258704
2000	Phosphorylation	RLNGSFRYVVISQGL ECCCCEEEEEEECCC	9.32	22210691
2004	Phosphorylation	SFRYVVISQGLDKPR CEEEEEEECCCCCCE	13.44	22210691
2009	Acetylation	VISQGLDKPRAITVH EEECCCCCCEEEEEC	41.25	-
2048	N-linked_Glycosylation	TERVVLVNVSISWPN CCEEEEEEEEEECCC	20.05	UniProtKB CARBOHYD
2083	Phosphorylation	IERIDLETGENREVV EEEEECCCCCCCEEE	58.03	23403867
2117	N-linked_Glycosylation	WSDRTHANGSIKRGS CCCCCCCCCCCCCCC	36.82	UniProtKB CARBOHYD
2127	N-linked_Glycosylation	IKRGSKDNATDSVPL CCCCCCCCCCCCCCC	48.77	16335952
2143	Ubiquitination	TGIGVQLKDIKVFNR CCCCEEEEEEEEEEC	40.07	-
2146	Ubiquitination	GVQLKDIKVFNRDRQ CEEEEEEEEEECCCC	51.40	-
2156	Phosphorylation	NRDRQKGTNVCAVAN ECCCCCCCCEEEEEC	31.36	-
2186	Sulfoxidation	ACACAHGMLAEDGAS HHHHHHCCCCCCCCC	1.99	30846556
2290	Phosphorylation	GSVEGLAYHRGWDTL CCCCCEECCCCCCEE	9.33	-
2370	Phosphorylation	LSGANVLTLIEKDIR HCCCCHHHHHHCCCC	22.77	28060719
2472	N-linked_Glycosylation	MGIIAVANDTNSCEL CEEEEEECCCCCCCC	50.47	UniProtKB CARBOHYD
2502	N-linked_Glycosylation	LTHQGHVNCSCRGGR EECCCCCEEEECCCE	13.30	UniProtKB CARBOHYD
2521	N-linked_Glycosylation	DLTCRAVNSSCRAQD CCEEEECCCCCCCCC	27.50	UniProtKB CARBOHYD
2539	N-linked_Glycosylation	CANGECINFSLTCDG ECCCEEEEEEEEECC	31.92	UniProtKB CARBOHYD
2559	Phosphorylation	DKSDEKPSYCNSRRC CCCCCCCCCCCCHHH	54.08	24719451
2560	Phosphorylation	KSDEKPSYCNSRRCK CCCCCCCCCCCHHHH	12.27	24719451
2563	Phosphorylation	EKPSYCNSRRCKKTF CCCCCCCCHHHHHHH	19.96	24719451
2577	Methylation	FRQCSNGRCVSNMLW HHHCCCCCEECCCEE	23.16	115386245
2601	N-linked_Glycosylation	GSDEIPCNKTACGVG CCCCCCCCCCEECCC	39.08	UniProtKB CARBOHYD
2603	Phosphorylation	DEIPCNKTACGVGEF CCCCCCCCEECCCEE	17.12	29759185
2620	N-linked_Glycosylation	RDGTCIGNSSRCNQF CCCCEECCCCCCCCE	19.53	UniProtKB CARBOHYD
2621	Phosphorylation	DGTCIGNSSRCNQFV CCCEECCCCCCCCEE	17.59	-
2638	N-linked_Glycosylation	EDASDEMNCSATDCS CCCCCCCCCCCCCCH	17.97	UniProtKB CARBOHYD
2663	Phosphorylation	LFQPCERTSLCYAPS EEEECCCCCCEECCC	12.08	30576142
2670	Phosphorylation	TSLCYAPSWVCDGAN CCCEECCCEECCCCC	24.78	30576142
2682	Phosphorylation	GANDCGDYSDERDCP CCCCCCCCCCCCCCC	11.87	30576142
2773	O-linked_Glycosylation	AAHCEGKTCGPSSFS CCCCCCCCCCCCCCC	33.29	55829451
2815	N-linked_Glycosylation	IAAGCLYNSTCDDRE CCHHHHCCCCCCCHH	20.21	19159218
2857	O-linked_Glycosylation	SPECEYPTCGPSEFR CCCCCCCCCCCHHEE	29.23	55823861
2905	N-linked_Glycosylation	TSQEHKCNASSQFLC CCCCCCCCCCHHEEC	47.89	UniProtKB CARBOHYD
2950	Phosphorylation	ECLSRKLSGCSQDCE HHHHHHCCCCCCCHH	40.57	28258704
2953	Phosphorylation	SRKLSGCSQDCEDLK HHHCCCCCCCHHHCC	32.36	28348404
3048	N-linked_Glycosylation	KLNLDGSNYTLLKQG ECCCCCCHHHHHHHH	39.06	16335952
3089	N-linked_Glycosylation	MIRRMHLNGSNVQVL EEEEEEECCCCCEEE	36.85	19159218
3142	Phosphorylation	YRTVLVSSGLREPRA CCEEEECCCCCCCEE	34.07	-
3212	Phosphorylation	WADAREDYIEFASLD ECCCCCCEEEEEECC	9.52	20068231
3217	Phosphorylation	EDYIEFASLDGSNRH CCEEEEEECCCCCCE	32.11	20068231
3221	Phosphorylation	EFASLDGSNRHVVLS EEEECCCCCCEEEEC	30.29	20068231
3261	Phosphorylation	INRAHKTTGTNKTLL CCCCCCCCCCCCEEE	46.97	21712546
3264	N-linked_Glycosylation	AHKTTGTNKTLLIST CCCCCCCCCEEEEEE	36.34	UniProtKB CARBOHYD
3333	N-linked_Glycosylation	DGRTCVSNCTASQFV CCCCCCCCCCHHHEE	13.53	UniProtKB CARBOHYD
3452	O-linked_Glycosylation	ERDCPEVTCAPNQFQ CCCCCCCCCCCCEEE	10.99	OGP
3488	N-linked_Glycosylation	DGSDEPANCTQMTCG CCCCCCCCCCCCEEC	39.83	19159218
3493	O-linked_Glycosylation	PANCTQMTCGVDEFR CCCCCCCEECCEEEE	9.04	OGP
3500	Methylation	TCGVDEFRCKDSGRC EECCEEEEECCCCCE	25.24	115386253
3528	Ubiquitination	GDGSDEPKEECDERT CCCCCCCHHHCCCCC	65.19	-
3535	O-linked_Glycosylation	KEECDERTCEPYQFR HHHCCCCCCCCEEEE	21.12	55833233
3571	O-linked_Glycosylation	NSDEESCTPRPCSES CCCCCCCCCCCCCCC	31.45	OGP
3662	N-linked_Glycosylation	PLDEFQCNNTLCKPL CCCCCCCCCCCCCCC	33.46	UniProtKB CARBOHYD
3726	Phosphorylation	TDNCGDGTDEEDCEP CCCCCCCCCHHHCCC	45.00	30576142
3735	O-linked_Glycosylation	EEDCEPPTAHTTHCK HHHCCCCCCCCCCCC	41.61	55831327
3738	Phosphorylation	CEPPTAHTTHCKDKK CCCCCCCCCCCCCHH	18.77	30576142
3739	Phosphorylation	EPPTAHTTHCKDKKE CCCCCCCCCCCCHHH	18.53	30576142
3756	Phosphorylation	CRNQRCLSSSLRCNM ECCHHHHCCCCCCCC	22.85	28634120
3788	N-linked_Glycosylation	KLTSCATNASICGDE HHCCCCCCCCCCCCH	17.11	19159218
3839	N-linked_Glycosylation	GTCSQLCNNTKGGHL CCHHHHCCCCCCCCH	68.73	UniProtKB CARBOHYD
3915	Phosphorylation	HVKAGRVYWTNWHTG EEECCCEEEEECCCC	12.73	22210691
3923	Phosphorylation	WTNWHTGTISYRSLP EEECCCCEEEECCCC	14.12	22210691
3928	Phosphorylation	TGTISYRSLPPAAPP CCEEEECCCCCCCCC	36.67	28258704
3936	Phosphorylation	LPPAAPPTTSNRHRR CCCCCCCCCCCCHHH	41.62	28258704
3938	Phosphorylation	PAAPPTTSNRHRRQI CCCCCCCCCCHHHHC	34.05	22210691
3950	Phosphorylation	RQIDRGVTHLNISGL HHCCCCCCEEECCCC	24.38	29083192
3953	N-linked_Glycosylation	DRGVTHLNISGLKMP CCCCCEEECCCCCCC	20.83	19159218
3955	Phosphorylation	GVTHLNISGLKMPRG CCCEEECCCCCCCCC	36.68	29083192
3988	Acetylation	VIEVAQMKGENRKTL EEHHHCCCCCCCCEE	51.50	11688253
4028	Phosphorylation	GNHPKIETAAMDGTL CCCCCCCCEECCCCH	24.16	28258704
4034	Phosphorylation	ETAAMDGTLRETLVQ CCEECCCCHHHHHHH	20.55	28258704
4067	Phosphorylation	YWADAKLSVIGSIRL EEECCEEEEEEEEEC	15.81	-
4071	Phosphorylation	AKLSVIGSIRLNGTD CEEEEEEEEECCCCC	8.07	21406692
4075	N-linked_Glycosylation	VIGSIRLNGTDPIVA EEEEEECCCCCCEEE	41.28	19159218
4077	Phosphorylation	GSIRLNGTDPIVAAD EEEECCCCCCEEEEC	37.21	28387310
4125	N-linked_Glycosylation	FGHSPLVNLTGGLSH CCCCCCEECCCCCCH	39.30	19159218
4179	N-linked_Glycosylation	PNGKRLDNGTCVPVP CCCCCCCCCCEEECC	52.87	UniProtKB CARBOHYD
4249	Phosphorylation	NGGTCAASPSGMPTC CCCCCCCCCCCCCCC	10.90	20363803
4278	N-linked_Glycosylation	VCAGYCANNSTCTVN EECCEECCCCEEEEC	39.15	UniProtKB CARBOHYD
4279	N-linked_Glycosylation	CAGYCANNSTCTVNQ ECCEECCCCEEEECC	21.85	UniProtKB CARBOHYD
4283	Phosphorylation	CANNSTCTVNQGNQP ECCCCEEEECCCCCC	23.68	28787133
4364	N-linked_Glycosylation	QSGDVTCNCTDGRVA CCCCEEEEECCCCCC	23.51	UniProtKB CARBOHYD
4452	Ubiquitination	KRRVQGAKGFQHQRM HHHHCCCCCCCHHCC	68.06	-
4460	Phosphorylation	GFQHQRMTNGAMNVE CCCHHCCCCCCEEEE	32.46	21945579
4472	Phosphorylation	NVEIGNPTYKMYEGG EEEECCCCEEEECCC	39.51	21945579
4473	Phosphorylation	VEIGNPTYKMYEGGE EEECCCCEEEECCCC	8.60	21945579
4476	Phosphorylation	GNPTYKMYEGGEPDD CCCCEEEECCCCCCC	13.79	27642862
4507	Phosphorylation	TNFTNPVYATLYMGG CCCCCCCEEEEECCC	8.64	21650223
4509	Phosphorylation	FTNPVYATLYMGGHG CCCCCEEEEECCCCC	10.75	27642862
4511	Phosphorylation	NPVYATLYMGGHGSR CCCEEEEECCCCCCC	6.86	25884760
4517	Phosphorylation	LYMGGHGSRHSLAST EECCCCCCCCCCCCH	22.58	15272003
4520	Phosphorylation	GGHGSRHSLASTDEK CCCCCCCCCCCHHHH	25.23	28355574
4523	Phosphorylation	GSRHSLASTDEKREL CCCCCCCCHHHHHHH	41.50	29255136
4524	Phosphorylation	SRHSLASTDEKRELL CCCCCCCHHHHHHHC	42.44	23663014
4527	Ubiquitination	SLASTDEKRELLGRG CCCCHHHHHHHCCCC	54.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4460	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
4473	Y	Phosphorylation	Kinase	SRC	P12931	PSP
4507	Y	Phosphorylation	Kinase	SRC	P12931	PSP
4507	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
4517	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
4517	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
4517	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
4520	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
4520	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
4520	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
4520	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
4523	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LRP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LRP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAI1_HUMAN	SERPINE1	physical	15001579
CALX_HUMAN	CANX	physical	14980518
CALR_HUMAN	CALR	physical	14980518
PDIA2_HUMAN	PDIA2	physical	14980518
MMP14_HUMAN	MMP14	physical	14645246
CALCR_HUMAN	CALCR	physical	12821648
GIPC1_HUMAN	GIPC1	physical	10827173
JIP1_HUMAN	MAPK8IP1	physical	10827173
DLG4_HUMAN	DLG4	physical	10827173
JIP2_HUMAN	MAPK8IP2	physical	10827173
SYJ2B_HUMAN	SYNJ2BP	physical	10827173
CAPON_HUMAN	NOS1AP	physical	10827173
SCN3A_HUMAN	SCN3A	physical	10827173
APBA2_HUMAN	APBA2	physical	10827173
DAB1_HUMAN	DAB1	physical	10827173
ITBP1_HUMAN	ITGB1BP1	physical	10827173
APC10_HUMAN	ANAPC10	physical	10827173
A2MG_HUMAN	A2M	physical	10652313
PDGFB_HUMAN	PDGFB	physical	11854294
SHC1_HUMAN	SHC1	physical	11854294
FA8_HUMAN	F8	physical	12522143
GULP1_HUMAN	GULP1	physical	11729193
UPAR_HUMAN	PLAUR	physical	11359936
AMRP_HUMAN	LRPAP1	physical	1374383
LIPL_HUMAN	LPL	physical	1281473
LIPC_HUMAN	LIPC	physical	7721852
SNX17_HUMAN	SNX17	physical	12169628
APBB1_HUMAN	APBB1	physical	9837937
DAB1_HUMAN	DAB1	physical	9837937
TSP1_HUMAN	THBS1	physical	7775583
RIC8B_HUMAN	RIC8B	physical	20205790
C2D1A_HUMAN	CC2D1A	physical	20205790
RU17_HUMAN	SNRNP70	physical	20205790
JIP1_HUMAN	MAPK8IP1	physical	20205790
ANS1B_HUMAN	ANKS1B	physical	20205790
PCLI1_HUMAN	PID1	physical	20205790
HNRDL_HUMAN	HNRNPDL	physical	20205790
MARE1_HUMAN	MAPRE1	physical	20205790
CHFR_HUMAN	CHFR	physical	23241409
A4_HUMAN	APP	physical	19251705
KCD18_HUMAN	KCTD18	physical	28514442
TNKS2_HUMAN	TNKS2	physical	28514442
TNKS1_HUMAN	TNKS	physical	28514442
FOXF2_HUMAN	FOXF2	physical	28514442
ODBB_HUMAN	BCKDHB	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
SAMD1_HUMAN	SAMD1	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
LOXL2_HUMAN	LOXL2	physical	28514442
MTG2_HUMAN	MTG2	physical	28514442
ADT3_HUMAN	SLC25A6	physical	28514442
KMCP1_HUMAN	SLC25A30	physical	28514442
GATB_HUMAN	GATB	physical	28514442
SMOC1_HUMAN	SMOC1	physical	28514442
CQ080_HUMAN	C17orf80	physical	28514442
HASP_HUMAN	GSG2	physical	28514442
NDKM_HUMAN	NME4	physical	28514442
SYHM_HUMAN	HARS2	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
TBB4A_HUMAN	TUBB4A	physical	28514442
SCMC3_HUMAN	SLC25A23	physical	28514442
NOCT_HUMAN	CCRN4L	physical	28514442
TCAF1_HUMAN	FAM115A	physical	28514442
SCMC2_HUMAN	SLC25A25	physical	28514442
MTO1_HUMAN	MTO1	physical	28514442
GLMP_HUMAN	C1orf85	physical	28514442
PYC_HUMAN	PC	physical	28514442
PGES2_HUMAN	PTGES2	physical	28514442
S26A6_HUMAN	SLC26A6	physical	28514442
GFPT2_HUMAN	GFPT2	physical	28514442
GFPT1_HUMAN	GFPT1	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
TBB2A_HUMAN	TUBB2A	physical	28514442
NPC2_HUMAN	NPC2	physical	28514442
PAPD1_HUMAN	MTPAP	physical	28514442
TBB4B_HUMAN	TUBB4B	physical	28514442
GBB2_HUMAN	GNB2	physical	28514442
NPRL3_HUMAN	NPRL3	physical	28514442
ERFE_HUMAN	FAM132B	physical	28514442
TBB2B_HUMAN	TUBB2B	physical	28514442
PTCD2_HUMAN	PTCD2	physical	28514442
SENP1_HUMAN	SENP1	physical	28514442
MP2K7_HUMAN	MAP2K7	physical	28514442
RTEL1_HUMAN	RTEL1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LRP1_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-446; ASN-729; ASN-1511;ASN-1575; ASN-1616; ASN-1645; ASN-1763; ASN-2127; ASN-2815; ASN-3048;ASN-3089; ASN-3488; ASN-3788; ASN-3953; ASN-4075 AND ASN-4125, ANDMASS SPECTROMETRY.	19159218 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-446; ASN-729; ASN-2127 ANDASN-3048, AND MASS SPECTROMETRY.	16335952 [Abstract]
Phosphorylation
Reference	PubMed
"Platelet-derived growth factor (PDGF)-induced tyrosinephosphorylation of the low density lipoprotein receptor-relatedprotein (LRP). Evidence for integrated co-receptor function betwennLRP and the PDGF."; Loukinova E., Ranganathan S., Kuznetsov S., Gorlatova N.,Migliorini M.M., Loukinov D., Ulery P.G., Mikhailenko I.,Lawrence D.A., Strickland D.K.; J. Biol. Chem. 277:15499-15506(2002). Cited for: PHOSPHORYLATION AT TYR-4507, MUTAGENESIS OF 4470-ASN--TYR-4473 AND4504-ASN--TYR-4507, AND INTERACTION WITH PDGF.	11854294 [Abstract]