GLMP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLMP_HUMAN
• UniProt AC: Q8WWB7
• Protein Name: Glycosylated lysosomal membrane protein {ECO:0000312|HGNC:HGNC:29436}
• Gene Name: GLMP {ECO:0000312|HGNC:HGNC:29436}
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Lysosome membrane ; Single-pass type I membrane protein .
• Protein Sequence: MRGSVECTWGWGHCAPSPLLLWTLLLFAAPFGLLGEKTRQVSLEVIPNWLGPLQNLLHIRAVGTNSTLHYVWSSLGPLAVVMVATNTPHSTLSVNWSLLLSPEPDGGLMVLPKDSIQFSSALVFTRLLEFDSTNVSDTAAKPLGRPYPPYSLADFSWNNITDSLDPATLSATFQGHPMNDPTRTFANGSLAFRVQAFSRSSRPAQPPRLLHTADTCQLEVALIGASPRGNRSLFGLEVATLGQGPDCPSMQEQHSIDDEYAPAVFQLDQLLWGSLPSGFAQWRPVAYSQKPGGRESALPCQASPLHPALAYSLPQSPIVRAFFGSQNNFCAFNLTFGASTGPGYWDQHYLSWSMLLGVGFPPVDGLSPLVLGIMAVALGAPGLMLLGGGLVLLLHHKKYSEYQSIN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9 (in isoform 2)	Phosphorylation	-		22210691
38 (in isoform 2)	Phosphorylation	-		22210691
44 (in isoform 2)	Phosphorylation	-		22210691
65	N-linked_Glycosylation	HIRAVGTNSTLHYVW EEEEEECCHHHHHHH		UniProtKB CARBOHYD
134	N-linked_Glycosylation	LLEFDSTNVSDTAAK HHHCCCCCCCCCCCC		UniProtKB CARBOHYD
159	N-linked_Glycosylation	LADFSWNNITDSLDP HHHCCCCCCCCCCCH		UniProtKB CARBOHYD
187	N-linked_Glycosylation	DPTRTFANGSLAFRV CCCCEECCCCEEEEE		UniProtKB CARBOHYD
200	Phosphorylation	RVQAFSRSSRPAQPP EEEEECCCCCCCCCC		27794612
201	Phosphorylation	VQAFSRSSRPAQPPR EEEECCCCCCCCCCC		24247654
226	Phosphorylation	EVALIGASPRGNRSL EEEEECCCCCCCCEE		28122231
230	N-linked_Glycosylation	IGASPRGNRSLFGLE ECCCCCCCCEECCEE		UniProtKB CARBOHYD
398	Ubiquitination	VLLLHHKKYSEYQSI HHEEECCCHHHHCCC		-
399	Phosphorylation	LLLHHKKYSEYQSIN HEEECCCHHHHCCCC		28796482
400	Phosphorylation	LLHHKKYSEYQSIN- EEECCCHHHHCCCC-		28796482
402	Phosphorylation	HHKKYSEYQSIN--- ECCCHHHHCCCC---		28796482
404	Phosphorylation	KKYSEYQSIN----- CCHHHHCCCC-----		28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLMP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLMP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLMP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB1_HUMAN	TUBB1	physical	28514442
SFXN3_HUMAN	SFXN3	physical	28514442
F118B_HUMAN	FAM118B	physical	28514442
MTG2_HUMAN	MTG2	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
DEP1A_HUMAN	DEPDC1	physical	28514442
SFXN5_HUMAN	SFXN5	physical	28514442
ORNT1_HUMAN	SLC25A15	physical	28514442
PEX16_HUMAN	PEX16	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
MCAT_HUMAN	SLC25A20	physical	28514442
ABD18_HUMAN	C4orf29	physical	28514442
COT2_HUMAN	NR2F2	physical	28514442
DHB7_HUMAN	HSD17B7	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
ADT3_HUMAN	SLC25A6	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
XRCC3_HUMAN	XRCC3	physical	28514442
NEK4_HUMAN	NEK4	physical	28514442
MIC27_HUMAN	APOOL	physical	28514442
SCMC1_HUMAN	SLC25A24	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442
RTL8C_HUMAN	FAM127A	physical	28514442
INT8_HUMAN	INTS8	physical	28514442
STX7_HUMAN	STX7	physical	28514442
MDN1_HUMAN	MDN1	physical	28514442
HEAT6_HUMAN	HEATR6	physical	28514442
TBB4A_HUMAN	TUBB4A	physical	28514442
CDC6_HUMAN	CDC6	physical	28514442
BDH_HUMAN	BDH1	physical	28514442
TTK_HUMAN	TTK	physical	28514442
FA69A_HUMAN	FAM69A	physical	28514442
HS12A_HUMAN	HSPA12A	physical	28514442
ADT1_HUMAN	SLC25A4	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
PARL_HUMAN	PARL	physical	28514442
TRUB2_HUMAN	TRUB2	physical	28514442
RPP38_HUMAN	RPP38	physical	28514442
ADCK1_HUMAN	ADCK1	physical	28514442
SYLM_HUMAN	LARS2	physical	28514442
GPD1L_HUMAN	GPD1L	physical	28514442
AB17B_HUMAN	ABHD17B	physical	28514442
INT5_HUMAN	INTS5	physical	28514442
SSDH_HUMAN	ALDH5A1	physical	28514442
TBB2A_HUMAN	TUBB2A	physical	28514442
CDYL_HUMAN	CDYL	physical	28514442
T126B_HUMAN	TMEM126B	physical	28514442
ADRO_HUMAN	FDXR	physical	28514442
IDHP_HUMAN	IDH2	physical	28514442
CQ080_HUMAN	C17orf80	physical	28514442
DECR2_HUMAN	DECR2	physical	28514442
TBA1C_HUMAN	TUBA1C	physical	28514442
NJMU_HUMAN	C17orf75	physical	28514442
CHD1L_HUMAN	CHD1L	physical	28514442
S2533_HUMAN	SLC25A33	physical	28514442
NCLN_HUMAN	NCLN	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.