dbPTM

HEAT6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HEAT6_HUMAN
UniProt AC	Q6AI08
Protein Name	HEAT repeat-containing protein 6
Gene Name	HEATR6
Organism	Homo sapiens (Human).
Sequence Length	1181
Subcellular Localization
Protein Description	Amplification-dependent oncogene..
Protein Sequence	MAAVQVVGSWPSVQPREAPREAIPERGNGFRLLSARLCALRPDDSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRLQVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNTGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLYPTPLPQYDGRTPIKPQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTGRVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRSYQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLANLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKCMGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPTGDTARRAIMGFLEEILAVCFDSSGSQGALPGLTNQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AAVQVVGSWPSVQPR CCEEEECCCCCCCCC	24.97	25849741
12	Phosphorylation	QVVGSWPSVQPREAP EEECCCCCCCCCCCC	27.42	29083192
34	Phosphorylation	GNGFRLLSARLCALR CCHHHHEEEEEHHCC	18.88	24719451
95	Ubiquitination	LNQNHLVSKVSQLIH CCCCHHHHHHHHHHH	33.43	21890473
99	Ubiquitination	HLVSKVSQLIHHLLN HHHHHHHHHHHHHHH	47.63	22817900
100	Ubiquitination	LVSKVSQLIHHLLNR HHHHHHHHHHHHHHH	2.91	22817900
157	Phosphorylation	NGSKCQKYLPELLGN CCHHHHHHHHHHHCC	11.12	1950297
220	Phosphorylation	AFLTILQSPKSSDMD HHHHHHHCCCCCCCH	30.74	26091039
220	Ubiquitination	AFLTILQSPKSSDMD HHHHHHHCCCCCCCH	30.74	22817900
221	Ubiquitination	FLTILQSPKSSDMDD HHHHHHCCCCCCCHH	27.82	22817900
231	Ubiquitination	SDMDDITFCMLLQNA CCCHHHHHHHHHHHH	2.05	22817900
232	Ubiquitination	DMDDITFCMLLQNAL CCHHHHHHHHHHHHH	1.09	22817900
243	Ubiquitination	QNALKGIQSLLNGGR HHHHHHHHHHHCCCC	36.37	22817900
267	Ubiquitination	GALLAVLKKFMFHGL HHHHHHHHHHHHCCC	37.05	22817900
268	Ubiquitination	ALLAVLKKFMFHGLP HHHHHHHHHHHCCCC	37.59	22817900
297	Phosphorylation	LPQYDGRTPIKPQQS CCCCCCCCCCCCCCC	34.59	23312004
300	Ubiquitination	YDGRTPIKPQQSESS CCCCCCCCCCCCCCC	37.67	29967540
304	Phosphorylation	TPIKPQQSESSASRP CCCCCCCCCCCCCCC	33.91	24247654
306	Phosphorylation	IKPQQSESSASRPTL CCCCCCCCCCCCCCC	36.13	25159151
307	Phosphorylation	KPQQSESSASRPTLN CCCCCCCCCCCCCCC	26.64	25159151
309	Phosphorylation	QQSESSASRPTLNKK CCCCCCCCCCCCCHH	40.52	25627689
312	Phosphorylation	ESSASRPTLNKKKKS CCCCCCCCCCHHHHC	41.68	25849741
319	Phosphorylation	TLNKKKKSKVKPKKI CCCHHHHCCCCCCCC	52.11	26657352
336	Phosphorylation	GEEEEKESSGEIEAA CCHHHHHCCCCEEEC	55.50	29255136
337	Phosphorylation	EEEEKESSGEIEAAP CHHHHHCCCCEEECC	41.35	29255136
346	Phosphorylation	EIEAAPVTGTGRVNL CEEECCCCCCCCEEC	28.15	23927012
348	Phosphorylation	EAAPVTGTGRVNLHE EECCCCCCCCEECCC	16.67	23403867
362	Phosphorylation	EGNTWCPSSLGVQSL CCCEECCHHCCCCCC	34.75	22210691
363	Phosphorylation	GNTWCPSSLGVQSLP CCEECCHHCCCCCCC	17.81	22210691
364	Ubiquitination	NTWCPSSLGVQSLPL CEECCHHCCCCCCCC	10.26	22817900
368	Phosphorylation	PSSLGVQSLPLDGSG CHHCCCCCCCCCCCC	29.55	27251275
370	Ubiquitination	SLGVQSLPLDGSGAA HCCCCCCCCCCCCCC	33.38	27667366
375	Ubiquitination	SLPLDGSGAAEKDGV CCCCCCCCCCCCCCC	34.04	22817900
384	Phosphorylation	AEKDGVSSSFSSSSW CCCCCCCCCCCCCCC	32.75	27251275
385	Phosphorylation	EKDGVSSSFSSSSWK CCCCCCCCCCCCCCE	22.95	25849741
387	Phosphorylation	DGVSSSFSSSSWKRV CCCCCCCCCCCCEEC	31.12	27251275
388	Phosphorylation	GVSSSFSSSSWKRVS CCCCCCCCCCCEECC	26.78	25627689
388	Ubiquitination	GVSSSFSSSSWKRVS CCCCCCCCCCCEECC	26.78	21890473
389	Phosphorylation	VSSSFSSSSWKRVSS CCCCCCCCCCEECCC	38.73	25849741
390	Phosphorylation	SSSFSSSSWKRVSSS CCCCCCCCCEECCCC	38.27	25849741
395	Phosphorylation	SSSWKRVSSSESDFS CCCCEECCCCCCCCC	31.98	25159151
396	Phosphorylation	SSWKRVSSSESDFSD CCCEECCCCCCCCCC	34.96	25159151
397	Phosphorylation	SWKRVSSSESDFSDA CCEECCCCCCCCCCC	33.35	25159151
399	Phosphorylation	KRVSSSESDFSDAEG EECCCCCCCCCCCCC	46.00	25159151
402	Phosphorylation	SSSESDFSDAEGGMQ CCCCCCCCCCCCHHH	40.68	25159151
410	Phosphorylation	DAEGGMQSKMRSYQA CCCCHHHHHHHHHHH	21.37	46156237
411	Ubiquitination	AEGGMQSKMRSYQAK CCCHHHHHHHHHHHH	22.80	21906983
440	Phosphorylation	SIEKKVLYGYWSAFI HHHHHHHHCCHHHCC	15.91	8231689
442	Phosphorylation	EKKVLYGYWSAFIPD HHHHHHCCHHHCCCC	5.22	8231701
460	Ubiquitination	LGSPQSVSLMTLTLK CCCCCEEEEEEEEEC	20.05	24816145
493	Phosphorylation	EGSKQFLSVAEDTSD HCCHHHHHHHCCCCC	22.14	23403867
498	Phosphorylation	FLSVAEDTSDHRRAF HHHHHCCCCCHHHCC	27.79	25849741
499	Phosphorylation	LSVAEDTSDHRRAFT HHHHCCCCCHHHCCC	43.68	25849741
509	Ubiquitination	RRAFTPFSVMIACSI HHCCCHHHHHHHHHH	16.39	21890473
520	Ubiquitination	ACSIRELHRCLLLAL HHHHHHHHHHHHHHH	17.41	21890473
556	Ubiquitination	NAPYDRLKLSLLTKV CCCHHHHHHHHHHHH	36.60	21906983
558	Phosphorylation	PYDRLKLSLLTKVWN CHHHHHHHHHHHHHH	21.53	24719451
568	Acetylation	TKVWNQIKPYIRHKD HHHHHHHHHHHCCCC	23.23	23954790
568	Malonylation	TKVWNQIKPYIRHKD HHHHHHHHHHHCCCC	23.23	32601280
568	Ubiquitination	TKVWNQIKPYIRHKD HHHHHHHHHHHCCCC	23.23	22817900
608	Phosphorylation	LLLQQPCSSGLGNSN HHHCCCCCCCCCCCC	33.84	26074081
609	Phosphorylation	LLQQPCSSGLGNSNS HHCCCCCCCCCCCCC	44.76	26074081
614	Phosphorylation	CSSGLGNSNSATPHL CCCCCCCCCCCCCCC	30.29	26074081
616	Phosphorylation	SGLGNSNSATPHLSP CCCCCCCCCCCCCCC	33.08	26074081
618	Phosphorylation	LGNSNSATPHLSPPD CCCCCCCCCCCCCCH	15.86	26074081
629	Ubiquitination	SPPDWWKKAPAGPSL CCCHHHHCCCCCCCC	45.97	29967540
635	Phosphorylation	KKAPAGPSLEETSVS HCCCCCCCCCCCCCC	47.71	29255136
639	Phosphorylation	AGPSLEETSVSSPKG CCCCCCCCCCCCCCC	25.67	29255136
640	Phosphorylation	GPSLEETSVSSPKGS CCCCCCCCCCCCCCC	24.23	30266825
642	Phosphorylation	SLEETSVSSPKGSSE CCCCCCCCCCCCCCC	40.46	29255136
643	Phosphorylation	LEETSVSSPKGSSEP CCCCCCCCCCCCCCC	28.60	19664994
647	Phosphorylation	SVSSPKGSSEPCWLI CCCCCCCCCCCHHHH	37.34	23312004
648	Phosphorylation	VSSPKGSSEPCWLIR CCCCCCCCCCHHHHH	54.98	23312004
659	Phosphorylation	WLIRLCISIVVLPKE HHHHHHEEEEEECCC	14.34	10946623
663	Ubiquitination	LCISIVVLPKEDSCS HHEEEEEECCCCCCC	3.30	27667366
668	Phosphorylation	VVLPKEDSCSGSDAG EEECCCCCCCCCCCC	15.98	23663014
670	Phosphorylation	LPKEDSCSGSDAGSA ECCCCCCCCCCCCCC	45.33	23663014
672	Phosphorylation	KEDSCSGSDAGSAAG CCCCCCCCCCCCCCC	14.16	23663014
676	Phosphorylation	CSGSDAGSAAGSTYE CCCCCCCCCCCCCCC	19.37	25849741
680	Phosphorylation	DAGSAAGSTYEPSPM CCCCCCCCCCCCCCH	24.08	27732954
681	Phosphorylation	AGSAAGSTYEPSPMR CCCCCCCCCCCCCHH	30.87	27251275
682	Phosphorylation	GSAAGSTYEPSPMRL CCCCCCCCCCCCHHH	27.78	27732954
685	Phosphorylation	AGSTYEPSPMRLEAL CCCCCCCCCHHHHHH	21.27	50558309
748	Ubiquitination	TGLIQQYKPDSTAAP CCHHHHCCCCCCCCC	37.70	-
753	Ubiquitination	QYKPDSTAAPDQRAP HCCCCCCCCCCCCCC	22.43	24816145
784	Ubiquitination	PRALQNSEHPTLQAS CHHHCCCCCCCHHHH	62.53	27667366
795	Ubiquitination	LQASACDALSSILPE HHHHHHHHHHHHCHH	14.82	27667366
831	Ubiquitination	DSKNRLVKAATSRAL CCCCHHHHHHHHHHH	36.57	27667366
861	Ubiquitination	VADAANAILMSLEDK HHHHHHHHHHHCCCC	3.13	22817900
874	Ubiquitination	DKSLNVRAKAAWSLG CCCCCHHHHHHHHHC	11.10	24816145
885	Ubiquitination	WSLGNLTDTLIVNME HHHCCCCCEEEEECC	42.56	24816145
913	Phosphorylation	LLLKMLRSAIEASKD HHHHHHHHHHHHCCC	29.63	20363803
921	Acetylation	AIEASKDKDKVKSNA HHHHCCCHHHHHHHH	64.28	30586657
921	Ubiquitination	AIEASKDKDKVKSNA HHHHCCCHHHHHHHH	64.28	24816145
962	Phosphorylation	ESIQALISTVLTEAA HHHHHHHHHHHHHHH	17.20	20058876
963	Phosphorylation	SIQALISTVLTEAAM HHHHHHHHHHHHHHH	16.73	20058876
978	Phosphorylation	KVRWNACYAMGNVFK HHHHHHHHHCCCCCC	9.38	25072903
982	Ubiquitination	NACYAMGNVFKNPAL HHHHHCCCCCCCCCC	23.98	22817900
993	Phosphorylation	NPALPLGTAPWTSQA CCCCCCCCCCCHHHH	36.91	25072903
993	Ubiquitination	NPALPLGTAPWTSQA CCCCCCCCCCCHHHH	36.91	22817900
997	Phosphorylation	PLGTAPWTSQAYNAL CCCCCCCHHHHHHHH	15.20	25072903
998	Phosphorylation	LGTAPWTSQAYNALT CCCCCCHHHHHHHHH	14.67	25072903
1001	Phosphorylation	APWTSQAYNALTSVV CCCHHHHHHHHHHHH	8.04	25072903
1005	Phosphorylation	SQAYNALTSVVTSCK HHHHHHHHHHHHHCC	19.64	25072903
1006	Phosphorylation	QAYNALTSVVTSCKN HHHHHHHHHHHHCCC	18.55	25072903
1009	Phosphorylation	NALTSVVTSCKNFKV HHHHHHHHHCCCCCE	26.67	25072903
1010	Phosphorylation	ALTSVVTSCKNFKVR HHHHHHHHCCCCCEE	16.10	25072903
1020	Phosphorylation	NFKVRIRSAAALSVP CCCEEEEECEEECCC	21.64	28842319
1029	Ubiquitination	AALSVPGKREQYGSV EEECCCCCHHHCCCH	46.84	22817900
1119	Phosphorylation	SGAEGDDTGAPHSPQ HCCCCCCCCCCCCHH	39.73	29255136
1124	Phosphorylation	DDTGAPHSPQERDQM CCCCCCCCHHHHHHH	27.50	29255136
1137	Ubiquitination	QMVRMALKHMGSIQA HHHHHHHHHHCCCCC	23.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HEAT6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HEAT6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HEAT6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GAS8_HUMAN	GAS8	physical	26344197
RBM15_HUMAN	RBM15	physical	26344197
RPP30_HUMAN	RPP30	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HEAT6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-643, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642 AND SER-643, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-643, AND MASSSPECTROMETRY.	18691976 [Abstract]