UniProt ID | HEAT6_HUMAN | |
---|---|---|
UniProt AC | Q6AI08 | |
Protein Name | HEAT repeat-containing protein 6 | |
Gene Name | HEATR6 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1181 | |
Subcellular Localization | ||
Protein Description | Amplification-dependent oncogene.. | |
Protein Sequence | MAAVQVVGSWPSVQPREAPREAIPERGNGFRLLSARLCALRPDDSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRLQVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNTGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLYPTPLPQYDGRTPIKPQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTGRVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRSYQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLANLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKCMGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPTGDTARRAIMGFLEEILAVCFDSSGSQGALPGLTNQ | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
9 | Phosphorylation | AAVQVVGSWPSVQPR CCEEEECCCCCCCCC | 24.97 | 25849741 | |
12 | Phosphorylation | QVVGSWPSVQPREAP EEECCCCCCCCCCCC | 27.42 | 29083192 | |
34 | Phosphorylation | GNGFRLLSARLCALR CCHHHHEEEEEHHCC | 18.88 | 24719451 | |
95 | Ubiquitination | LNQNHLVSKVSQLIH CCCCHHHHHHHHHHH | 33.43 | 21890473 | |
99 | Ubiquitination | HLVSKVSQLIHHLLN HHHHHHHHHHHHHHH | 47.63 | 22817900 | |
100 | Ubiquitination | LVSKVSQLIHHLLNR HHHHHHHHHHHHHHH | 2.91 | 22817900 | |
157 | Phosphorylation | NGSKCQKYLPELLGN CCHHHHHHHHHHHCC | 11.12 | 1950297 | |
220 | Phosphorylation | AFLTILQSPKSSDMD HHHHHHHCCCCCCCH | 30.74 | 26091039 | |
220 | Ubiquitination | AFLTILQSPKSSDMD HHHHHHHCCCCCCCH | 30.74 | 22817900 | |
221 | Ubiquitination | FLTILQSPKSSDMDD HHHHHHCCCCCCCHH | 27.82 | 22817900 | |
231 | Ubiquitination | SDMDDITFCMLLQNA CCCHHHHHHHHHHHH | 2.05 | 22817900 | |
232 | Ubiquitination | DMDDITFCMLLQNAL CCHHHHHHHHHHHHH | 1.09 | 22817900 | |
243 | Ubiquitination | QNALKGIQSLLNGGR HHHHHHHHHHHCCCC | 36.37 | 22817900 | |
267 | Ubiquitination | GALLAVLKKFMFHGL HHHHHHHHHHHHCCC | 37.05 | 22817900 | |
268 | Ubiquitination | ALLAVLKKFMFHGLP HHHHHHHHHHHCCCC | 37.59 | 22817900 | |
297 | Phosphorylation | LPQYDGRTPIKPQQS CCCCCCCCCCCCCCC | 34.59 | 23312004 | |
300 | Ubiquitination | YDGRTPIKPQQSESS CCCCCCCCCCCCCCC | 37.67 | 29967540 | |
304 | Phosphorylation | TPIKPQQSESSASRP CCCCCCCCCCCCCCC | 33.91 | 24247654 | |
306 | Phosphorylation | IKPQQSESSASRPTL CCCCCCCCCCCCCCC | 36.13 | 25159151 | |
307 | Phosphorylation | KPQQSESSASRPTLN CCCCCCCCCCCCCCC | 26.64 | 25159151 | |
309 | Phosphorylation | QQSESSASRPTLNKK CCCCCCCCCCCCCHH | 40.52 | 25627689 | |
312 | Phosphorylation | ESSASRPTLNKKKKS CCCCCCCCCCHHHHC | 41.68 | 25849741 | |
319 | Phosphorylation | TLNKKKKSKVKPKKI CCCHHHHCCCCCCCC | 52.11 | 26657352 | |
336 | Phosphorylation | GEEEEKESSGEIEAA CCHHHHHCCCCEEEC | 55.50 | 29255136 | |
337 | Phosphorylation | EEEEKESSGEIEAAP CHHHHHCCCCEEECC | 41.35 | 29255136 | |
346 | Phosphorylation | EIEAAPVTGTGRVNL CEEECCCCCCCCEEC | 28.15 | 23927012 | |
348 | Phosphorylation | EAAPVTGTGRVNLHE EECCCCCCCCEECCC | 16.67 | 23403867 | |
362 | Phosphorylation | EGNTWCPSSLGVQSL CCCEECCHHCCCCCC | 34.75 | 22210691 | |
363 | Phosphorylation | GNTWCPSSLGVQSLP CCEECCHHCCCCCCC | 17.81 | 22210691 | |
364 | Ubiquitination | NTWCPSSLGVQSLPL CEECCHHCCCCCCCC | 10.26 | 22817900 | |
368 | Phosphorylation | PSSLGVQSLPLDGSG CHHCCCCCCCCCCCC | 29.55 | 27251275 | |
370 | Ubiquitination | SLGVQSLPLDGSGAA HCCCCCCCCCCCCCC | 33.38 | 27667366 | |
375 | Ubiquitination | SLPLDGSGAAEKDGV CCCCCCCCCCCCCCC | 34.04 | 22817900 | |
384 | Phosphorylation | AEKDGVSSSFSSSSW CCCCCCCCCCCCCCC | 32.75 | 27251275 | |
385 | Phosphorylation | EKDGVSSSFSSSSWK CCCCCCCCCCCCCCE | 22.95 | 25849741 | |
387 | Phosphorylation | DGVSSSFSSSSWKRV CCCCCCCCCCCCEEC | 31.12 | 27251275 | |
388 | Phosphorylation | GVSSSFSSSSWKRVS CCCCCCCCCCCEECC | 26.78 | 25627689 | |
388 | Ubiquitination | GVSSSFSSSSWKRVS CCCCCCCCCCCEECC | 26.78 | 21890473 | |
389 | Phosphorylation | VSSSFSSSSWKRVSS CCCCCCCCCCEECCC | 38.73 | 25849741 | |
390 | Phosphorylation | SSSFSSSSWKRVSSS CCCCCCCCCEECCCC | 38.27 | 25849741 | |
395 | Phosphorylation | SSSWKRVSSSESDFS CCCCEECCCCCCCCC | 31.98 | 25159151 | |
396 | Phosphorylation | SSWKRVSSSESDFSD CCCEECCCCCCCCCC | 34.96 | 25159151 | |
397 | Phosphorylation | SWKRVSSSESDFSDA CCEECCCCCCCCCCC | 33.35 | 25159151 | |
399 | Phosphorylation | KRVSSSESDFSDAEG EECCCCCCCCCCCCC | 46.00 | 25159151 | |
402 | Phosphorylation | SSSESDFSDAEGGMQ CCCCCCCCCCCCHHH | 40.68 | 25159151 | |
410 | Phosphorylation | DAEGGMQSKMRSYQA CCCCHHHHHHHHHHH | 21.37 | 46156237 | |
411 | Ubiquitination | AEGGMQSKMRSYQAK CCCHHHHHHHHHHHH | 22.80 | 21906983 | |
440 | Phosphorylation | SIEKKVLYGYWSAFI HHHHHHHHCCHHHCC | 15.91 | 8231689 | |
442 | Phosphorylation | EKKVLYGYWSAFIPD HHHHHHCCHHHCCCC | 5.22 | 8231701 | |
460 | Ubiquitination | LGSPQSVSLMTLTLK CCCCCEEEEEEEEEC | 20.05 | 24816145 | |
493 | Phosphorylation | EGSKQFLSVAEDTSD HCCHHHHHHHCCCCC | 22.14 | 23403867 | |
498 | Phosphorylation | FLSVAEDTSDHRRAF HHHHHCCCCCHHHCC | 27.79 | 25849741 | |
499 | Phosphorylation | LSVAEDTSDHRRAFT HHHHCCCCCHHHCCC | 43.68 | 25849741 | |
509 | Ubiquitination | RRAFTPFSVMIACSI HHCCCHHHHHHHHHH | 16.39 | 21890473 | |
520 | Ubiquitination | ACSIRELHRCLLLAL HHHHHHHHHHHHHHH | 17.41 | 21890473 | |
556 | Ubiquitination | NAPYDRLKLSLLTKV CCCHHHHHHHHHHHH | 36.60 | 21906983 | |
558 | Phosphorylation | PYDRLKLSLLTKVWN CHHHHHHHHHHHHHH | 21.53 | 24719451 | |
568 | Acetylation | TKVWNQIKPYIRHKD HHHHHHHHHHHCCCC | 23.23 | 23954790 | |
568 | Malonylation | TKVWNQIKPYIRHKD HHHHHHHHHHHCCCC | 23.23 | 32601280 | |
568 | Ubiquitination | TKVWNQIKPYIRHKD HHHHHHHHHHHCCCC | 23.23 | 22817900 | |
608 | Phosphorylation | LLLQQPCSSGLGNSN HHHCCCCCCCCCCCC | 33.84 | 26074081 | |
609 | Phosphorylation | LLQQPCSSGLGNSNS HHCCCCCCCCCCCCC | 44.76 | 26074081 | |
614 | Phosphorylation | CSSGLGNSNSATPHL CCCCCCCCCCCCCCC | 30.29 | 26074081 | |
616 | Phosphorylation | SGLGNSNSATPHLSP CCCCCCCCCCCCCCC | 33.08 | 26074081 | |
618 | Phosphorylation | LGNSNSATPHLSPPD CCCCCCCCCCCCCCH | 15.86 | 26074081 | |
629 | Ubiquitination | SPPDWWKKAPAGPSL CCCHHHHCCCCCCCC | 45.97 | 29967540 | |
635 | Phosphorylation | KKAPAGPSLEETSVS HCCCCCCCCCCCCCC | 47.71 | 29255136 | |
639 | Phosphorylation | AGPSLEETSVSSPKG CCCCCCCCCCCCCCC | 25.67 | 29255136 | |
640 | Phosphorylation | GPSLEETSVSSPKGS CCCCCCCCCCCCCCC | 24.23 | 30266825 | |
642 | Phosphorylation | SLEETSVSSPKGSSE CCCCCCCCCCCCCCC | 40.46 | 29255136 | |
643 | Phosphorylation | LEETSVSSPKGSSEP CCCCCCCCCCCCCCC | 28.60 | 19664994 | |
647 | Phosphorylation | SVSSPKGSSEPCWLI CCCCCCCCCCCHHHH | 37.34 | 23312004 | |
648 | Phosphorylation | VSSPKGSSEPCWLIR CCCCCCCCCCHHHHH | 54.98 | 23312004 | |
659 | Phosphorylation | WLIRLCISIVVLPKE HHHHHHEEEEEECCC | 14.34 | 10946623 | |
663 | Ubiquitination | LCISIVVLPKEDSCS HHEEEEEECCCCCCC | 3.30 | 27667366 | |
668 | Phosphorylation | VVLPKEDSCSGSDAG EEECCCCCCCCCCCC | 15.98 | 23663014 | |
670 | Phosphorylation | LPKEDSCSGSDAGSA ECCCCCCCCCCCCCC | 45.33 | 23663014 | |
672 | Phosphorylation | KEDSCSGSDAGSAAG CCCCCCCCCCCCCCC | 14.16 | 23663014 | |
676 | Phosphorylation | CSGSDAGSAAGSTYE CCCCCCCCCCCCCCC | 19.37 | 25849741 | |
680 | Phosphorylation | DAGSAAGSTYEPSPM CCCCCCCCCCCCCCH | 24.08 | 27732954 | |
681 | Phosphorylation | AGSAAGSTYEPSPMR CCCCCCCCCCCCCHH | 30.87 | 27251275 | |
682 | Phosphorylation | GSAAGSTYEPSPMRL CCCCCCCCCCCCHHH | 27.78 | 27732954 | |
685 | Phosphorylation | AGSTYEPSPMRLEAL CCCCCCCCCHHHHHH | 21.27 | 50558309 | |
748 | Ubiquitination | TGLIQQYKPDSTAAP CCHHHHCCCCCCCCC | 37.70 | - | |
753 | Ubiquitination | QYKPDSTAAPDQRAP HCCCCCCCCCCCCCC | 22.43 | 24816145 | |
784 | Ubiquitination | PRALQNSEHPTLQAS CHHHCCCCCCCHHHH | 62.53 | 27667366 | |
795 | Ubiquitination | LQASACDALSSILPE HHHHHHHHHHHHCHH | 14.82 | 27667366 | |
831 | Ubiquitination | DSKNRLVKAATSRAL CCCCHHHHHHHHHHH | 36.57 | 27667366 | |
861 | Ubiquitination | VADAANAILMSLEDK HHHHHHHHHHHCCCC | 3.13 | 22817900 | |
874 | Ubiquitination | DKSLNVRAKAAWSLG CCCCCHHHHHHHHHC | 11.10 | 24816145 | |
885 | Ubiquitination | WSLGNLTDTLIVNME HHHCCCCCEEEEECC | 42.56 | 24816145 | |
913 | Phosphorylation | LLLKMLRSAIEASKD HHHHHHHHHHHHCCC | 29.63 | 20363803 | |
921 | Acetylation | AIEASKDKDKVKSNA HHHHCCCHHHHHHHH | 64.28 | 30586657 | |
921 | Ubiquitination | AIEASKDKDKVKSNA HHHHCCCHHHHHHHH | 64.28 | 24816145 | |
962 | Phosphorylation | ESIQALISTVLTEAA HHHHHHHHHHHHHHH | 17.20 | 20058876 | |
963 | Phosphorylation | SIQALISTVLTEAAM HHHHHHHHHHHHHHH | 16.73 | 20058876 | |
978 | Phosphorylation | KVRWNACYAMGNVFK HHHHHHHHHCCCCCC | 9.38 | 25072903 | |
982 | Ubiquitination | NACYAMGNVFKNPAL HHHHHCCCCCCCCCC | 23.98 | 22817900 | |
993 | Phosphorylation | NPALPLGTAPWTSQA CCCCCCCCCCCHHHH | 36.91 | 25072903 | |
993 | Ubiquitination | NPALPLGTAPWTSQA CCCCCCCCCCCHHHH | 36.91 | 22817900 | |
997 | Phosphorylation | PLGTAPWTSQAYNAL CCCCCCCHHHHHHHH | 15.20 | 25072903 | |
998 | Phosphorylation | LGTAPWTSQAYNALT CCCCCCHHHHHHHHH | 14.67 | 25072903 | |
1001 | Phosphorylation | APWTSQAYNALTSVV CCCHHHHHHHHHHHH | 8.04 | 25072903 | |
1005 | Phosphorylation | SQAYNALTSVVTSCK HHHHHHHHHHHHHCC | 19.64 | 25072903 | |
1006 | Phosphorylation | QAYNALTSVVTSCKN HHHHHHHHHHHHCCC | 18.55 | 25072903 | |
1009 | Phosphorylation | NALTSVVTSCKNFKV HHHHHHHHHCCCCCE | 26.67 | 25072903 | |
1010 | Phosphorylation | ALTSVVTSCKNFKVR HHHHHHHHCCCCCEE | 16.10 | 25072903 | |
1020 | Phosphorylation | NFKVRIRSAAALSVP CCCEEEEECEEECCC | 21.64 | 28842319 | |
1029 | Ubiquitination | AALSVPGKREQYGSV EEECCCCCHHHCCCH | 46.84 | 22817900 | |
1119 | Phosphorylation | SGAEGDDTGAPHSPQ HCCCCCCCCCCCCHH | 39.73 | 29255136 | |
1124 | Phosphorylation | DDTGAPHSPQERDQM CCCCCCCCHHHHHHH | 27.50 | 29255136 | |
1137 | Ubiquitination | QMVRMALKHMGSIQA HHHHHHHHHHCCCCC | 23.23 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HEAT6_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HEAT6_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HEAT6_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
GAS8_HUMAN | GAS8 | physical | 26344197 | |
RBM15_HUMAN | RBM15 | physical | 26344197 | |
RPP30_HUMAN | RPP30 | physical | 26344197 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-643, AND MASSSPECTROMETRY. | |
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642, AND MASSSPECTROMETRY. | |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642 AND SER-643, ANDMASS SPECTROMETRY. | |
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-643, AND MASSSPECTROMETRY. |