HEAT6_HUMAN - dbPTM
HEAT6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HEAT6_HUMAN
UniProt AC Q6AI08
Protein Name HEAT repeat-containing protein 6
Gene Name HEATR6
Organism Homo sapiens (Human).
Sequence Length 1181
Subcellular Localization
Protein Description Amplification-dependent oncogene..
Protein Sequence MAAVQVVGSWPSVQPREAPREAIPERGNGFRLLSARLCALRPDDSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRLQVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNTGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLYPTPLPQYDGRTPIKPQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTGRVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRSYQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLANLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKCMGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPTGDTARRAIMGFLEEILAVCFDSSGSQGALPGLTNQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationAAVQVVGSWPSVQPR
CCEEEECCCCCCCCC
24.9725849741
12PhosphorylationQVVGSWPSVQPREAP
EEECCCCCCCCCCCC
27.4229083192
34PhosphorylationGNGFRLLSARLCALR
CCHHHHEEEEEHHCC
18.8824719451
95UbiquitinationLNQNHLVSKVSQLIH
CCCCHHHHHHHHHHH
33.4321890473
99UbiquitinationHLVSKVSQLIHHLLN
HHHHHHHHHHHHHHH
47.6322817900
100UbiquitinationLVSKVSQLIHHLLNR
HHHHHHHHHHHHHHH
2.9122817900
157PhosphorylationNGSKCQKYLPELLGN
CCHHHHHHHHHHHCC
11.121950297
220PhosphorylationAFLTILQSPKSSDMD
HHHHHHHCCCCCCCH
30.7426091039
220UbiquitinationAFLTILQSPKSSDMD
HHHHHHHCCCCCCCH
30.7422817900
221UbiquitinationFLTILQSPKSSDMDD
HHHHHHCCCCCCCHH
27.8222817900
231UbiquitinationSDMDDITFCMLLQNA
CCCHHHHHHHHHHHH
2.0522817900
232UbiquitinationDMDDITFCMLLQNAL
CCHHHHHHHHHHHHH
1.0922817900
243UbiquitinationQNALKGIQSLLNGGR
HHHHHHHHHHHCCCC
36.3722817900
267UbiquitinationGALLAVLKKFMFHGL
HHHHHHHHHHHHCCC
37.0522817900
268UbiquitinationALLAVLKKFMFHGLP
HHHHHHHHHHHCCCC
37.5922817900
297PhosphorylationLPQYDGRTPIKPQQS
CCCCCCCCCCCCCCC
34.5923312004
300UbiquitinationYDGRTPIKPQQSESS
CCCCCCCCCCCCCCC
37.6729967540
304PhosphorylationTPIKPQQSESSASRP
CCCCCCCCCCCCCCC
33.9124247654
306PhosphorylationIKPQQSESSASRPTL
CCCCCCCCCCCCCCC
36.1325159151
307PhosphorylationKPQQSESSASRPTLN
CCCCCCCCCCCCCCC
26.6425159151
309PhosphorylationQQSESSASRPTLNKK
CCCCCCCCCCCCCHH
40.5225627689
312PhosphorylationESSASRPTLNKKKKS
CCCCCCCCCCHHHHC
41.6825849741
319PhosphorylationTLNKKKKSKVKPKKI
CCCHHHHCCCCCCCC
52.1126657352
336PhosphorylationGEEEEKESSGEIEAA
CCHHHHHCCCCEEEC
55.5029255136
337PhosphorylationEEEEKESSGEIEAAP
CHHHHHCCCCEEECC
41.3529255136
346PhosphorylationEIEAAPVTGTGRVNL
CEEECCCCCCCCEEC
28.1523927012
348PhosphorylationEAAPVTGTGRVNLHE
EECCCCCCCCEECCC
16.6723403867
362PhosphorylationEGNTWCPSSLGVQSL
CCCEECCHHCCCCCC
34.7522210691
363PhosphorylationGNTWCPSSLGVQSLP
CCEECCHHCCCCCCC
17.8122210691
364UbiquitinationNTWCPSSLGVQSLPL
CEECCHHCCCCCCCC
10.2622817900
368PhosphorylationPSSLGVQSLPLDGSG
CHHCCCCCCCCCCCC
29.5527251275
370UbiquitinationSLGVQSLPLDGSGAA
HCCCCCCCCCCCCCC
33.3827667366
375UbiquitinationSLPLDGSGAAEKDGV
CCCCCCCCCCCCCCC
34.0422817900
384PhosphorylationAEKDGVSSSFSSSSW
CCCCCCCCCCCCCCC
32.7527251275
385PhosphorylationEKDGVSSSFSSSSWK
CCCCCCCCCCCCCCE
22.9525849741
387PhosphorylationDGVSSSFSSSSWKRV
CCCCCCCCCCCCEEC
31.1227251275
388PhosphorylationGVSSSFSSSSWKRVS
CCCCCCCCCCCEECC
26.7825627689
388UbiquitinationGVSSSFSSSSWKRVS
CCCCCCCCCCCEECC
26.7821890473
389PhosphorylationVSSSFSSSSWKRVSS
CCCCCCCCCCEECCC
38.7325849741
390PhosphorylationSSSFSSSSWKRVSSS
CCCCCCCCCEECCCC
38.2725849741
395PhosphorylationSSSWKRVSSSESDFS
CCCCEECCCCCCCCC
31.9825159151
396PhosphorylationSSWKRVSSSESDFSD
CCCEECCCCCCCCCC
34.9625159151
397PhosphorylationSWKRVSSSESDFSDA
CCEECCCCCCCCCCC
33.3525159151
399PhosphorylationKRVSSSESDFSDAEG
EECCCCCCCCCCCCC
46.0025159151
402PhosphorylationSSSESDFSDAEGGMQ
CCCCCCCCCCCCHHH
40.6825159151
410PhosphorylationDAEGGMQSKMRSYQA
CCCCHHHHHHHHHHH
21.3746156237
411UbiquitinationAEGGMQSKMRSYQAK
CCCHHHHHHHHHHHH
22.8021906983
440PhosphorylationSIEKKVLYGYWSAFI
HHHHHHHHCCHHHCC
15.918231689
442PhosphorylationEKKVLYGYWSAFIPD
HHHHHHCCHHHCCCC
5.228231701
460UbiquitinationLGSPQSVSLMTLTLK
CCCCCEEEEEEEEEC
20.0524816145
493PhosphorylationEGSKQFLSVAEDTSD
HCCHHHHHHHCCCCC
22.1423403867
498PhosphorylationFLSVAEDTSDHRRAF
HHHHHCCCCCHHHCC
27.7925849741
499PhosphorylationLSVAEDTSDHRRAFT
HHHHCCCCCHHHCCC
43.6825849741
509UbiquitinationRRAFTPFSVMIACSI
HHCCCHHHHHHHHHH
16.3921890473
520UbiquitinationACSIRELHRCLLLAL
HHHHHHHHHHHHHHH
17.4121890473
556UbiquitinationNAPYDRLKLSLLTKV
CCCHHHHHHHHHHHH
36.6021906983
558PhosphorylationPYDRLKLSLLTKVWN
CHHHHHHHHHHHHHH
21.5324719451
568AcetylationTKVWNQIKPYIRHKD
HHHHHHHHHHHCCCC
23.2323954790
568MalonylationTKVWNQIKPYIRHKD
HHHHHHHHHHHCCCC
23.2332601280
568UbiquitinationTKVWNQIKPYIRHKD
HHHHHHHHHHHCCCC
23.2322817900
608PhosphorylationLLLQQPCSSGLGNSN
HHHCCCCCCCCCCCC
33.8426074081
609PhosphorylationLLQQPCSSGLGNSNS
HHCCCCCCCCCCCCC
44.7626074081
614PhosphorylationCSSGLGNSNSATPHL
CCCCCCCCCCCCCCC
30.2926074081
616PhosphorylationSGLGNSNSATPHLSP
CCCCCCCCCCCCCCC
33.0826074081
618PhosphorylationLGNSNSATPHLSPPD
CCCCCCCCCCCCCCH
15.8626074081
629UbiquitinationSPPDWWKKAPAGPSL
CCCHHHHCCCCCCCC
45.9729967540
635PhosphorylationKKAPAGPSLEETSVS
HCCCCCCCCCCCCCC
47.7129255136
639PhosphorylationAGPSLEETSVSSPKG
CCCCCCCCCCCCCCC
25.6729255136
640PhosphorylationGPSLEETSVSSPKGS
CCCCCCCCCCCCCCC
24.2330266825
642PhosphorylationSLEETSVSSPKGSSE
CCCCCCCCCCCCCCC
40.4629255136
643PhosphorylationLEETSVSSPKGSSEP
CCCCCCCCCCCCCCC
28.6019664994
647PhosphorylationSVSSPKGSSEPCWLI
CCCCCCCCCCCHHHH
37.3423312004
648PhosphorylationVSSPKGSSEPCWLIR
CCCCCCCCCCHHHHH
54.9823312004
659PhosphorylationWLIRLCISIVVLPKE
HHHHHHEEEEEECCC
14.3410946623
663UbiquitinationLCISIVVLPKEDSCS
HHEEEEEECCCCCCC
3.3027667366
668PhosphorylationVVLPKEDSCSGSDAG
EEECCCCCCCCCCCC
15.9823663014
670PhosphorylationLPKEDSCSGSDAGSA
ECCCCCCCCCCCCCC
45.3323663014
672PhosphorylationKEDSCSGSDAGSAAG
CCCCCCCCCCCCCCC
14.1623663014
676PhosphorylationCSGSDAGSAAGSTYE
CCCCCCCCCCCCCCC
19.3725849741
680PhosphorylationDAGSAAGSTYEPSPM
CCCCCCCCCCCCCCH
24.0827732954
681PhosphorylationAGSAAGSTYEPSPMR
CCCCCCCCCCCCCHH
30.8727251275
682PhosphorylationGSAAGSTYEPSPMRL
CCCCCCCCCCCCHHH
27.7827732954
685PhosphorylationAGSTYEPSPMRLEAL
CCCCCCCCCHHHHHH
21.2750558309
748UbiquitinationTGLIQQYKPDSTAAP
CCHHHHCCCCCCCCC
37.70-
753UbiquitinationQYKPDSTAAPDQRAP
HCCCCCCCCCCCCCC
22.4324816145
784UbiquitinationPRALQNSEHPTLQAS
CHHHCCCCCCCHHHH
62.5327667366
795UbiquitinationLQASACDALSSILPE
HHHHHHHHHHHHCHH
14.8227667366
831UbiquitinationDSKNRLVKAATSRAL
CCCCHHHHHHHHHHH
36.5727667366
861UbiquitinationVADAANAILMSLEDK
HHHHHHHHHHHCCCC
3.1322817900
874UbiquitinationDKSLNVRAKAAWSLG
CCCCCHHHHHHHHHC
11.1024816145
885UbiquitinationWSLGNLTDTLIVNME
HHHCCCCCEEEEECC
42.5624816145
913PhosphorylationLLLKMLRSAIEASKD
HHHHHHHHHHHHCCC
29.6320363803
921AcetylationAIEASKDKDKVKSNA
HHHHCCCHHHHHHHH
64.2830586657
921UbiquitinationAIEASKDKDKVKSNA
HHHHCCCHHHHHHHH
64.2824816145
962PhosphorylationESIQALISTVLTEAA
HHHHHHHHHHHHHHH
17.2020058876
963PhosphorylationSIQALISTVLTEAAM
HHHHHHHHHHHHHHH
16.7320058876
978PhosphorylationKVRWNACYAMGNVFK
HHHHHHHHHCCCCCC
9.3825072903
982UbiquitinationNACYAMGNVFKNPAL
HHHHHCCCCCCCCCC
23.9822817900
993PhosphorylationNPALPLGTAPWTSQA
CCCCCCCCCCCHHHH
36.9125072903
993UbiquitinationNPALPLGTAPWTSQA
CCCCCCCCCCCHHHH
36.9122817900
997PhosphorylationPLGTAPWTSQAYNAL
CCCCCCCHHHHHHHH
15.2025072903
998PhosphorylationLGTAPWTSQAYNALT
CCCCCCHHHHHHHHH
14.6725072903
1001PhosphorylationAPWTSQAYNALTSVV
CCCHHHHHHHHHHHH
8.0425072903
1005PhosphorylationSQAYNALTSVVTSCK
HHHHHHHHHHHHHCC
19.6425072903
1006PhosphorylationQAYNALTSVVTSCKN
HHHHHHHHHHHHCCC
18.5525072903
1009PhosphorylationNALTSVVTSCKNFKV
HHHHHHHHHCCCCCE
26.6725072903
1010PhosphorylationALTSVVTSCKNFKVR
HHHHHHHHCCCCCEE
16.1025072903
1020PhosphorylationNFKVRIRSAAALSVP
CCCEEEEECEEECCC
21.6428842319
1029UbiquitinationAALSVPGKREQYGSV
EEECCCCCHHHCCCH
46.8422817900
1119PhosphorylationSGAEGDDTGAPHSPQ
HCCCCCCCCCCCCHH
39.7329255136
1124PhosphorylationDDTGAPHSPQERDQM
CCCCCCCCHHHHHHH
27.5029255136
1137UbiquitinationQMVRMALKHMGSIQA
HHHHHHHHHHCCCCC
23.23-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HEAT6_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HEAT6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HEAT6_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GAS8_HUMANGAS8physical
26344197
RBM15_HUMANRBM15physical
26344197
RPP30_HUMANRPP30physical
26344197

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HEAT6_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-643, AND MASSSPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642 AND SER-643, ANDMASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-643, AND MASSSPECTROMETRY.

TOP