CQ080_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CQ080_HUMAN
• UniProt AC: Q9BSJ5
• Protein Name: Uncharacterized protein C17orf80
• Gene Name: C17orf80
• Organism: Homo sapiens (Human).
• Sequence Length: 609
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MSDNPPRMEVCPYCKKPFKRLKSHLPYCKMIGPTIPTDQKVYQSKPATLPRAKKMKGPIKDLIKAKGKELETENEERNSKLVVDKPEQTVKTFPLPAVGLERAATTKADKDIKNPIQPSFKMLKNTKPMTTFQEETKAQFYASEKTSPKRELAKDLPKSGESRCNPSEAGASLLVGSIEPSLSNQDRKYSSTLPNDVQTTSGDLKLDKIDPQRQELLVKLLDVPTGDCHISPKNVSDGVKRVRTLLSNERDSKGRDHLSGVPTDVTVTETPEKNTESLILSLKMSSLGKIQVMEKQEKGLTLGVETCGSKGNAEKSMSATEKQERTVMSHGCENFNTRDSVTGKESQGERPHLSLFIPRETTYQFHSVSQSSSQSLASLATTFLQEKKAEAQNHHCVPDVKALMESPEGQLSLEPKSDSQFQASHTGCQSPLCSAQRHTPQSPFTNHAAAAGRKTLRSCMGLEWFPELYPGYLGLGVLPGKPQCWNAMTQKPQLISPQGERLSQVSLLERSSTHIRSLEPPAGLTTSNFSLMRLLGAVQKGWIRCNTTIRKSGFGGITMLFTGYFVLCCSWSFRRLKKLCRPLPWKSTVPPCIGVAKTTGDCRSKTCLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Malonylation	DQKVYQSKPATLPRA CCCHHCCCCCCCCCH	24.13	32601280
48	Phosphorylation	VYQSKPATLPRAKKM HHCCCCCCCCCHHHC	45.91	24719451
56	Acetylation	LPRAKKMKGPIKDLI CCCHHHCCCCHHHHH	71.11	7851337
64	Acetylation	GPIKDLIKAKGKELE CCHHHHHHHHCCCCC	51.87	7851347
85	Malonylation	NSKLVVDKPEQTVKT CCCEEECCHHHEEEE	38.55	32601280
92	Phosphorylation	KPEQTVKTFPLPAVG CHHHEEEEECCCCCC	26.58	-
105	Phosphorylation	VGLERAATTKADKDI CCCHHHHCCCCCHHC	28.04	-
110	Acetylation	AATTKADKDIKNPIQ HHCCCCCHHCCCCCC	67.23	26051181
126	Phosphorylation	SFKMLKNTKPMTTFQ HHHHHCCCCCCCCCC	34.63	17192257
127	Acetylation	FKMLKNTKPMTTFQE HHHHCCCCCCCCCCH	42.03	26051181
130	Phosphorylation	LKNTKPMTTFQEETK HCCCCCCCCCCHHHH	32.74	29978859
131	Phosphorylation	KNTKPMTTFQEETKA CCCCCCCCCCHHHHH	19.64	29978859
136	Phosphorylation	MTTFQEETKAQFYAS CCCCCHHHHHHHHHC	30.81	29978859
141	Phosphorylation	EETKAQFYASEKTSP HHHHHHHHHCCCCCC	9.35	29978859
143	Phosphorylation	TKAQFYASEKTSPKR HHHHHHHCCCCCCHH	28.39	29978859
146	Phosphorylation	QFYASEKTSPKRELA HHHHCCCCCCHHHHH	46.33	29978859
147	Phosphorylation	FYASEKTSPKRELAK HHHCCCCCCHHHHHH	39.22	29978859
172	Phosphorylation	NPSEAGASLLVGSIE CHHHHCHHEEEEECC	22.71	23532336
177	Phosphorylation	GASLLVGSIEPSLSN CHHEEEEECCCCCCC	19.12	23532336
190	Phosphorylation	SNQDRKYSSTLPNDV CCCCCCCCCCCCCCC	21.63	28555341
225	Phosphorylation	VKLLDVPTGDCHISP HHHHCCCCCCCCCCC	45.56	29978859
231	Phosphorylation	PTGDCHISPKNVSDG CCCCCCCCCCCHHHH	13.22	27050516
268	Phosphorylation	VPTDVTVTETPEKNT CCCCCEEEECCCCCC	25.44	28555341
270	Phosphorylation	TDVTVTETPEKNTES CCCEEEECCCCCCHH	27.64	25627689
281	Phosphorylation	NTESLILSLKMSSLG CCHHHHHHHHHHHCC	20.96	24719451
301	Phosphorylation	EKQEKGLTLGVETCG EHHHCCCEEEEEECC	30.09	-
306	Phosphorylation	GLTLGVETCGSKGNA CCEEEEEECCCCCCH	21.54	-
340	Phosphorylation	ENFNTRDSVTGKESQ CCCCCCCCCCCCCCC	20.49	28555341
342	Phosphorylation	FNTRDSVTGKESQGE CCCCCCCCCCCCCCC	46.63	29214152
346	Phosphorylation	DSVTGKESQGERPHL CCCCCCCCCCCCCEE	47.15	29214152
404	Sulfoxidation	VPDVKALMESPEGQL CCCHHHHHCCCCCCC	5.99	21406390
406	Phosphorylation	DVKALMESPEGQLSL CHHHHHCCCCCCCCC	17.81	29523821
417	Phosphorylation	QLSLEPKSDSQFQAS CCCCCCCCCCCCHHH	53.89	22210691
419	Phosphorylation	SLEPKSDSQFQASHT CCCCCCCCCCHHHCC	39.73	22210691
424	Phosphorylation	SDSQFQASHTGCQSP CCCCCHHHCCCCCCC	15.70	22210691
439	Phosphorylation	LCSAQRHTPQSPFTN CCCCCCCCCCCCCCC	25.80	-
442	Phosphorylation	AQRHTPQSPFTNHAA CCCCCCCCCCCCHHH	24.16	25159151
552	Phosphorylation	CNTTIRKSGFGGITM CCCCHHHCCCCCEEE	29.52	22210691
558	Phosphorylation	KSGFGGITMLFTGYF HCCCCCEEEEEEEEH	15.88	22210691
562	Phosphorylation	GGITMLFTGYFVLCC CCEEEEEEEEHHHHH	27.32	22210691
605	Acetylation	TTGDCRSKTCLD--- CCCCCCCCCCCC---	24.73	7960577

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CQ080_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CQ080_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CQ080_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNA5_HUMAN	KCNA5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-126, AND MASSSPECTROMETRY.
PubMed: 18691976