SFXN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SFXN3_HUMAN
• UniProt AC: Q9BWM7
• Protein Name: Sideroflexin-3
• Gene Name: SFXN3
• Organism: Homo sapiens (Human).
• Sequence Length: 321
• Subcellular Localization: Mitochondrion membrane ; Multi-pass membrane protein .
• Protein Description: Potential iron transporter..
• Protein Sequence: MGELPLDINIQEPRWDQSTFLGRARHFFTVTDPRNLLLSGAQLEASRNIVQNYRAGVVTPGITEDQLWRAKYVYDSAFHPDTGEKVVLIGRMSAQVPMNMTITGCMLTFYRKTPTVVFWQWVNQSFNAIVNYSNRSGDTPITVRQLGTAYVSATTGAVATALGLKSLTKHLPPLVGRFVPFAAVAAANCINIPLMRQRELQVGIPVADEAGQRLGYSVTAAKQGIFQVVISRICMAIPAMAIPPLIMDTLEKKDFLKRRPWLGAPLQVGLVGFCLVFATPLCCALFPQKSSIHISNLEPELRAQIHEQNPSVEVVYYNKGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MGELPLDI -------CCCCCCCC	13.65	25732826
59	Phosphorylation	NYRAGVVTPGITEDQ HCCCCCCCCCCCHHH	12.55	-
63	Phosphorylation	GVVTPGITEDQLWRA CCCCCCCCHHHHHHH	17.25	-
75	Ubiquitination	WRAKYVYDSAFHPDT HHHEEEEECCCCCCC	27.03	21890473
93	Phosphorylation	VVLIGRMSAQVPMNM EEEEEEEECCCCCCC	1.91	26434552
97	Phosphorylation	GRMSAQVPMNMTITG EEEECCCCCCCEEEE	17.75	-
101	Phosphorylation	AQVPMNMTITGCMLT CCCCCCCEEEEEEEE	9.06	26434552
105	Phosphorylation	MNMTITGCMLTFYRK CCCEEEEEEEEEECC	15.47	-
108	Phosphorylation	TITGCMLTFYRKTPT EEEEEEEEEECCCCE	7.32	26434552
110	Phosphorylation	TGCMLTFYRKTPTVV EEEEEEEECCCCEEE	4.12	26434552
112	Phosphorylation	CMLTFYRKTPTVVFW EEEEEECCCCEEEEE	7.55	-
114	Phosphorylation	LTFYRKTPTVVFWQW EEEECCCCEEEEEEE	13.13	-
148	Phosphorylation	ITVRQLGTAYVSATT EEEEECCEEEECCCH	19.84	24043423
150	Phosphorylation	VRQLGTAYVSATTGA EEECCEEEECCCHHH	4.63	24043423
152	Phosphorylation	QLGTAYVSATTGAVA ECCEEEECCCHHHHH	24.33	24043423
154	Phosphorylation	GTAYVSATTGAVATA CEEEECCCHHHHHHH	8.52	24043423
155	Phosphorylation	TAYVSATTGAVATAL EEEECCCHHHHHHHH	2.66	24043423
160	Phosphorylation	ATTGAVATALGLKSL CCHHHHHHHHCHHHH	17.44	24043423
168	Phosphorylation	ALGLKSLTKHLPPLV HHCHHHHHHCCCCCC	3.37	-
169	Acetylation	LGLKSLTKHLPPLVG HCHHHHHHCCCCCCC	41.44	51083857
172	Phosphorylation	KSLTKHLPPLVGRFV HHHHHCCCCCCCCCH	24.41	-
173	Ubiquitination	SLTKHLPPLVGRFVP HHHHCCCCCCCCCHH	48.73	21890473
173	Acetylation	SLTKHLPPLVGRFVP HHHHCCCCCCCCCHH	48.73	25825284
219	Phosphorylation	QRLGYSVTAAKQGIF HCCCCCHHHHHCCHH	18.17	20068231
223	Phosphorylation	YSVTAAKQGIFQVVI CCHHHHHCCHHHHHH	18.24	-
290	Phosphorylation	CALFPQKSSIHISNL HHHCCCCCCEEECCC	2.99	27080861
291	Phosphorylation	ALFPQKSSIHISNLE HHCCCCCCEEECCCC	41.35	27080861
316	Phosphorylation	NPSVEVVYYNKGL-- CCCEEEEEEECCC--	7.35	-
320	Phosphorylation	EVVYYNKGL------ EEEEEECCC------	13.39	-
323	Ubiquitination	YYNKGL--------- EEECCC---------	45.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SFXN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SFXN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SFXN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VDAC2_HUMAN	VDAC2	physical	22939629
SURF1_HUMAN	SURF1	physical	22939629
STOM_HUMAN	STOM	physical	22939629
TOM22_HUMAN	TOMM22	physical	22939629
VDAC1_HUMAN	VDAC1	physical	22939629
SPTN1_HUMAN	SPTAN1	physical	22939629
TOM20_HUMAN	TOMM20	physical	22939629
TIM50_HUMAN	TIMM50	physical	22939629
VAMP2_HUMAN	VAMP2	physical	22939629
TI17A_HUMAN	TIMM17A	physical	22939629
ZMYM2_HUMAN	ZMYM2	physical	26186194
TRBP2_HUMAN	TARBP2	physical	26186194
PJA1_HUMAN	PJA1	physical	26186194
LAMP2_HUMAN	LAMP2	physical	28514442
TRBP2_HUMAN	TARBP2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.