SPTN1_HUMAN - dbPTM
SPTN1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPTN1_HUMAN
UniProt AC Q13813
Protein Name Spectrin alpha chain, non-erythrocytic 1
Gene Name SPTAN1
Organism Homo sapiens (Human).
Sequence Length 2472
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells..
Protein Description Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane..
Protein Sequence MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDPSGVKV
-------CCCCCCCC
22814378
302-HydroxyisobutyrylationLDRYHRFKELSTLRR
HHHHHHHHHHHHHHH
-
30AcetylationLDRYHRFKELSTLRR
HHHHHHHHHHHHHHH
26051181
33PhosphorylationYHRFKELSTLRRQKL
HHHHHHHHHHHHHHH
28857561
33 (in isoform 2)Phosphorylation-24719451
34PhosphorylationHRFKELSTLRRQKLE
HHHHHHHHHHHHHHH
23312004
51MethylationYRFQFFQRDAEELEK
HHHHHHHCCHHHHHH
115917649
58AcetylationRDAEELEKWIQEKLQ
CCHHHHHHHHHHHHH
26051181
58UbiquitinationRDAEELEKWIQEKLQ
CCHHHHHHHHHHHHH
-
632-HydroxyisobutyrylationLEKWIQEKLQIASDE
HHHHHHHHHHHCCCC
-
63UbiquitinationLEKWIQEKLQIASDE
HHHHHHHHHHHCCCC
-
72NitrationQIASDENYKDPTNLQ
HHCCCCCCCCCCCHH
-
72PhosphorylationQIASDENYKDPTNLQ
HHCCCCCCCCCCCHH
-
73AcetylationIASDENYKDPTNLQG
HCCCCCCCCCCCHHH
26051181
73UbiquitinationIASDENYKDPTNLQG
HCCCCCCCCCCCHHH
-
84AcetylationNLQGKLQKHQAFEAE
CHHHHHHHHHHHHHH
26051181
96PhosphorylationEAEVQANSGAIVKLD
HHHHHHCCCCEEEEC
25307156
1372-HydroxyisobutyrylationQWELLLEKMREKGIK
HHHHHHHHHHHHCHH
-
1442-HydroxyisobutyrylationKMREKGIKLLQAQKL
HHHHHCHHHHHHHHH
-
144UbiquitinationKMREKGIKLLQAQKL
HHHHHCHHHHHHHHH
-
150UbiquitinationIKLLQAQKLVQYLRE
HHHHHHHHHHHHHHH
-
1892-HydroxyisobutyrylationEHVEVLQKKFEEFQT
HHHHHHHHHHHHHHH
-
189UbiquitinationEHVEVLQKKFEEFQT
HHHHHHHHHHHHHHH
-
1902-HydroxyisobutyrylationHVEVLQKKFEEFQTD
HHHHHHHHHHHHHHH
-
190AcetylationHVEVLQKKFEEFQTD
HHHHHHHHHHHHHHH
26051181
190UbiquitinationHVEVLQKKFEEFQTD
HHHHHHHHHHHHHHH
-
196PhosphorylationKKFEEFQTDMAAHEE
HHHHHHHHHHHHHHH
18452278
198SulfoxidationFEEFQTDMAAHEERV
HHHHHHHHHHHHHHH
30846556
214AcetylationEVNQFAAKLIQEQHP
HHHHHHHHHHHHHCC
26051181
214UbiquitinationEVNQFAAKLIQEQHP
HHHHHHHHHHHHHCC
-
227AcetylationHPEEELIKTKQDEVN
CCHHHHHHCCHHHHH
26051181
227UbiquitinationHPEEELIKTKQDEVN
CCHHHHHHCCHHHHH
-
241UbiquitinationNAAWQRLKGLALQRQ
HHHHHHHHHHHHHHC
-
2722-HydroxyisobutyrylationDETISWIKEKEQLMA
HHHHHHHHHHHHHHC
-
2742-HydroxyisobutyrylationTISWIKEKEQLMASD
HHHHHHHHHHHHCCC
-
278SulfoxidationIKEKEQLMASDDFGR
HHHHHHHHCCCCCCH
21406390
280PhosphorylationEKEQLMASDDFGRDL
HHHHHHCCCCCCHHH
26552605
289PhosphorylationDFGRDLASVQALLRK
CCCHHHHHHHHHHHH
21964256
2962-HydroxyisobutyrylationSVQALLRKHEGLERD
HHHHHHHHCCCHHHH
-
3102-HydroxyisobutyrylationDLAALEDKVKALCAE
HHHHHHHHHHHHHHH
-
310AcetylationDLAALEDKVKALCAE
HHHHHHHHHHHHHHH
26051181
310UbiquitinationDLAALEDKVKALCAE
HHHHHHHHHHHHHHH
-
320MethylationALCAEADRLQQSHPL
HHHHHHHHHHHCCCC
115917637
324PhosphorylationEADRLQQSHPLSATQ
HHHHHHHCCCCCCCH
25307156
328PhosphorylationLQQSHPLSATQIQVK
HHHCCCCCCCHHHHH
-
330PhosphorylationQSHPLSATQIQVKRE
HCCCCCCCHHHHHHH
-
3352-HydroxyisobutyrylationSATQIQVKREELITN
CCCHHHHHHHHHCCC
-
335UbiquitinationSATQIQVKREELITN
CCCHHHHHHHHHCCC
-
335 (in isoform 2)Ubiquitination--
375PhosphorylationADFRDLTSWVTEMKA
HHHHHHHHHHHHHHH
28857561
391PhosphorylationINADELASDVAGAEA
HCHHHHHHHHHHHHH
17855441
402MethylationGAEALLDRHQEHKGE
HHHHHHHHHHHHCCC
115917641
407AcetylationLDRHQEHKGEIDAHE
HHHHHHHCCCCCCCC
26051181
416PhosphorylationEIDAHEDSFKSADES
CCCCCCHHHCCCCHH
25159151
416 (in isoform 2)Phosphorylation-27251275
4182-HydroxyisobutyrylationDAHEDSFKSADESGQ
CCCCHHHCCCCHHHH
-
419PhosphorylationAHEDSFKSADESGQA
CCCHHHCCCCHHHHH
26657352
419 (in isoform 2)Phosphorylation-27251275
423PhosphorylationSFKSADESGQALLAA
HHCCCCHHHHHHHHH
17855441
433PhosphorylationALLAAGHYASDEVRE
HHHHHCCCCCHHHHH
-
435PhosphorylationLAAGHYASDEVREKL
HHHCCCCCHHHHHHH
17855441
441MalonylationASDEVREKLTVLSEE
CCHHHHHHHHHCCHH
26320211
441UbiquitinationASDEVREKLTVLSEE
CCHHHHHHHHHCCHH
-
459MethylationLLELWELRRQQYEQC
HHHHHHHHHHHHHHH
115917645
484PhosphorylationEQVDNWMSKQEAFLL
HHHHHHHHHHHHHHH
26074081
514UbiquitinationKKHEDFEKSLSAQEE
HHHHHHHHHCHHHHH
-
517PhosphorylationEDFEKSLSAQEEKIT
HHHHHHCHHHHHHHH
17855441
5222-HydroxyisobutyrylationSLSAQEEKITALDEF
HCHHHHHHHHHHHHH
-
522UbiquitinationSLSAQEEKITALDEF
HCHHHHHHHHHHHHH
-
541SulfoxidationIQNNHYAMEDVATRR
HHCCCCCHHHHHHHH
30846556
553PhosphorylationTRRDALLSRRNALHE
HHHHHHHHHHHHHHH
17855441
572PhosphorylationRRAQLADSFHLQQFF
HHHHHHHHHHHHHHH
26657352
572 (in isoform 2)Phosphorylation-27251275
5862-HydroxyisobutyrylationFRDSDELKSWVNEKM
HCCHHHHHHHHHHHH
-
586AcetylationFRDSDELKSWVNEKM
HCCHHHHHHHHHHHH
26051181
587PhosphorylationRDSDELKSWVNEKMK
CCHHHHHHHHHHHHH
28857561
592AcetylationLKSWVNEKMKTATDE
HHHHHHHHHHHHCHH
19608861
595PhosphorylationWVNEKMKTATDEAYK
HHHHHHHHHCHHHHC
-
597PhosphorylationNEKMKTATDEAYKDP
HHHHHHHCHHHHCCC
28258704
601PhosphorylationKTATDEAYKDPSNLQ
HHHCHHHHCCCCCCC
28258704
602AcetylationTATDEAYKDPSNLQG
HHCHHHHCCCCCCCH
26051181
602UbiquitinationTATDEAYKDPSNLQG
HHCHHHHCCCCCCCH
-
605PhosphorylationDEAYKDPSNLQGKVQ
HHHHCCCCCCCHHHH
28857561
610UbiquitinationDPSNLQGKVQKHQAF
CCCCCCHHHHHHHHH
-
6132-HydroxyisobutyrylationNLQGKVQKHQAFEAE
CCCHHHHHHHHHHHH
-
613AcetylationNLQGKVQKHQAFEAE
CCCHHHHHHHHHHHH
19608861
613MalonylationNLQGKVQKHQAFEAE
CCCHHHHHHHHHHHH
26320211
613UbiquitinationNLQGKVQKHQAFEAE
CCCHHHHHHHHHHHH
-
6332-HydroxyisobutyrylationSRIDALEKAGQKLID
HHHHHHHHHHHHHHC
-
633AcetylationSRIDALEKAGQKLID
HHHHHHHHHHHHHHC
25953088
633MalonylationSRIDALEKAGQKLID
HHHHHHHHHHHHHHC
26320211
633UbiquitinationSRIDALEKAGQKLID
HHHHHHHHHHHHHHC
-
6372-HydroxyisobutyrylationALEKAGQKLIDVNHY
HHHHHHHHHHCCCCC
-
637AcetylationALEKAGQKLIDVNHY
HHHHHHHHHHCCCCC
19608861
637MalonylationALEKAGQKLIDVNHY
HHHHHHHHHHCCCCC
26320211
637UbiquitinationALEKAGQKLIDVNHY
HHHHHHHHHHCCCCC
-
644PhosphorylationKLIDVNHYAKDEVAA
HHHCCCCCCHHHHHH
20068231
6462-HydroxyisobutyrylationIDVNHYAKDEVAARM
HCCCCCCHHHHHHHH
-
646AcetylationIDVNHYAKDEVAARM
HCCCCCCHHHHHHHH
26051181
646UbiquitinationIDVNHYAKDEVAARM
HCCCCCCHHHHHHHH
-
658PhosphorylationARMNEVISLWKKLLE
HHHHHHHHHHHHHHH
24076635
6612-HydroxyisobutyrylationNEVISLWKKLLEATE
HHHHHHHHHHHHHHH
-
661AcetylationNEVISLWKKLLEATE
HHHHHHHHHHHHHHH
25953088
6622-HydroxyisobutyrylationEVISLWKKLLEATEL
HHHHHHHHHHHHHHC
-
667PhosphorylationWKKLLEATELKGIKL
HHHHHHHHHCCCCCH
20068231
6702-HydroxyisobutyrylationLLEATELKGIKLREA
HHHHHHCCCCCHHHH
-
670AcetylationLLEATELKGIKLREA
HHHHHHCCCCCHHHH
26051181
7182-HydroxyisobutyrylationTNVQNLQKKHALLEA
CCHHHHHHHHHHHHH
-
718AcetylationTNVQNLQKKHALLEA
CCHHHHHHHHHHHHH
25953088
718UbiquitinationTNVQNLQKKHALLEA
CCHHHHHHHHHHHHH
-
7192-HydroxyisobutyrylationNVQNLQKKHALLEAD
CHHHHHHHHHHHHHH
-
719UbiquitinationNVQNLQKKHALLEAD
CHHHHHHHHHHHHHH
-
733MethylationDVAAHQDRIDGITIQ
HHHHCHHHCCCEEEE
115917653
738PhosphorylationQDRIDGITIQARQFQ
HHHCCCEEEEEEEHH
-
756AcetylationHFDAENIKKKQEALV
CCCHHHHHHHHHHHH
25953088
757UbiquitinationFDAENIKKKQEALVA
CCHHHHHHHHHHHHH
-
758UbiquitinationDAENIKKKQEALVAR
CHHHHHHHHHHHHHH
-
766PhosphorylationQEALVARYEALKEPM
HHHHHHHHHHHHCCH
20068231
773SulfoxidationYEALKEPMVARKQKL
HHHHHCCHHHHHHHH
21406390
779AcetylationPMVARKQKLADSLRL
CHHHHHHHHHHHHHH
19608861
783PhosphorylationRKQKLADSLRLQQLF
HHHHHHHHHHHHHHH
21815630
783 (in isoform 2)Phosphorylation-27251275
8032-HydroxyisobutyrylationEETWIREKEPIAAST
CCHHHHCCCCCCCCC
-
803AcetylationEETWIREKEPIAAST
CCHHHHCCCCCCCCC
25953088
803UbiquitinationEETWIREKEPIAAST
CCHHHHCCCCCCCCC
-
809PhosphorylationEKEPIAASTNRGKDL
CCCCCCCCCCCCCHH
20860994
810PhosphorylationKEPIAASTNRGKDLI
CCCCCCCCCCCCHHH
20860994
8142-HydroxyisobutyrylationAASTNRGKDLIGVQN
CCCCCCCCHHHHHHH
-
814UbiquitinationAASTNRGKDLIGVQN
CCCCCCCCHHHHHHH
-
8242-HydroxyisobutyrylationIGVQNLLKKHQALQA
HHHHHHHHHHHHHHH
-
824AcetylationIGVQNLLKKHQALQA
HHHHHHHHHHHHHHH
25953088
824UbiquitinationIGVQNLLKKHQALQA
HHHHHHHHHHHHHHH
21890473
824 (in isoform 1)Ubiquitination-21890473
824 (in isoform 2)Ubiquitination-21890473
824 (in isoform 3)Ubiquitination-21890473
825UbiquitinationGVQNLLKKHQALQAE
HHHHHHHHHHHHHHH
-
825 (in isoform 2)Ubiquitination--
8462-HydroxyisobutyrylationRIKAVTQKGNAMVEE
HHHHHHCCCCCCCCC
-
846MalonylationRIKAVTQKGNAMVEE
HHHHHHCCCCCCCCC
26320211
8622-HydroxyisobutyrylationHFAAEDVKAKLHELN
CCCHHHHHHHHHHHH
-
862AcetylationHFAAEDVKAKLHELN
CCCHHHHHHHHHHHH
25953088
864AcetylationAAEDVKAKLHELNQK
CHHHHHHHHHHHHHH
25953088
864UbiquitinationAAEDVKAKLHELNQK
CHHHHHHHHHHHHHH
-
8712-HydroxyisobutyrylationKLHELNQKWEALKAK
HHHHHHHHHHHHHHH
-
871AcetylationKLHELNQKWEALKAK
HHHHHHHHHHHHHHH
25953088
871MalonylationKLHELNQKWEALKAK
HHHHHHHHHHHHHHH
26320211
9092-HydroxyisobutyrylationAESWMREKEPIVGST
HHHHHHHCCCCCCCC
-
909UbiquitinationAESWMREKEPIVGST
HHHHHHHCCCCCCCC
-
915PhosphorylationEKEPIVGSTDYGKDE
HCCCCCCCCCCCCCH
21815630
920AcetylationVGSTDYGKDEDSAEA
CCCCCCCCCHHHHHH
26051181
920UbiquitinationVGSTDYGKDEDSAEA
CCCCCCCCCHHHHHH
-
924PhosphorylationDYGKDEDSAEALLKK
CCCCCHHHHHHHHHH
-
930AcetylationDSAEALLKKHEALMS
HHHHHHHHHHHHHHH
26051181
9312-HydroxyisobutyrylationSAEALLKKHEALMSD
HHHHHHHHHHHHHHH
-
931AcetylationSAEALLKKHEALMSD
HHHHHHHHHHHHHHH
26051181
937PhosphorylationKKHEALMSDLSAYGS
HHHHHHHHHHHHHHH
20068231
937 (in isoform 2)Phosphorylation-27251275
940PhosphorylationEALMSDLSAYGSSIQ
HHHHHHHHHHHHHHH
20068231
942NitrationLMSDLSAYGSSIQAL
HHHHHHHHHHHHHHH
-
942PhosphorylationLMSDLSAYGSSIQAL
HHHHHHHHHHHHHHH
20068231
944PhosphorylationSDLSAYGSSIQALRE
HHHHHHHHHHHHHHH
17855441
976NitrationKELVLALYDYQEKSP
HHHHHHHHCCCCCCC
-
976PhosphorylationKELVLALYDYQEKSP
HHHHHHHHCCCCCCC
20068231
976 (in isoform 2)Phosphorylation-25147952
978PhosphorylationLVLALYDYQEKSPRE
HHHHHHCCCCCCCCC
26657352
9812-HydroxyisobutyrylationALYDYQEKSPREVTM
HHHCCCCCCCCCCCC
-
981AcetylationALYDYQEKSPREVTM
HHHCCCCCCCCCCCC
26051181
982PhosphorylationLYDYQEKSPREVTMK
HHCCCCCCCCCCCCC
22617229
982 (in isoform 2)Phosphorylation-24719451
990AcetylationPREVTMKKGDILTLL
CCCCCCCCCCEEEHH
26051181
990MalonylationPREVTMKKGDILTLL
CCCCCCCCCCEEEHH
26320211
990UbiquitinationPREVTMKKGDILTLL
CCCCCCCCCCEEEHH
-
995PhosphorylationMKKGDILTLLNSTNK
CCCCCEEEHHCCCCC
23312004
999PhosphorylationDILTLLNSTNKDWWK
CEEEHHCCCCCCEEE
20068231
1000PhosphorylationILTLLNSTNKDWWKV
EEEHHCCCCCCEEEE
20068231
1002AcetylationTLLNSTNKDWWKVEV
EHHCCCCCCEEEEEE
26051181
1020PhosphorylationQGFVPAAYVKKLDPA
CCEEEHHHEEECCHH
28152594
1022AcetylationFVPAAYVKKLDPAQS
EEEHHHEEECCHHHC
19608861
1023AcetylationVPAAYVKKLDPAQSA
EEHHHEEECCHHHCC
26051181
1029PhosphorylationKKLDPAQSASRENLL
EECCHHHCCCHHHHH
29255136
1029 (in isoform 2)Phosphorylation-24719451
1029 (in isoform 3)Phosphorylation-28348404
1031PhosphorylationLDPAQSASRENLLEE
CCHHHCCCHHHHHHH
19664994
1031 (in isoform 3)Phosphorylation-28348404
1041PhosphorylationNLLEEQGSIALRQEQ
HHHHHHCCHHHHHHH
19664994
1041 (in isoform 2)Phosphorylation-24719451
1053PhosphorylationQEQIDNQTRITKEAG
HHHHCCCHHHHHHHC
23312004
1053 (in isoform 3)Phosphorylation--
1056PhosphorylationIDNQTRITKEAGSVS
HCCCHHHHHHHCCCC
23828894
10572-HydroxyisobutyrylationDNQTRITKEAGSVSL
CCCHHHHHHHCCCCC
-
1057UbiquitinationDNQTRITKEAGSVSL
CCCHHHHHHHCCCCC
-
1061PhosphorylationRITKEAGSVSLRMKQ
HHHHHHCCCCCCHHH
25159151
1063PhosphorylationTKEAGSVSLRMKQVE
HHHHCCCCCCHHHHH
25159151
1063 (in isoform 2)Phosphorylation-24719451
1067UbiquitinationGSVSLRMKQVEELYH
CCCCCCHHHHHHHHH
-
1073PhosphorylationMKQVEELYHSLLELG
HHHHHHHHHHHHHHH
12446661
1073 (in isoform 2)Phosphorylation-25147952
1075PhosphorylationQVEELYHSLLELGEK
HHHHHHHHHHHHHHH
26657352
1075 (in isoform 2)Phosphorylation-24719451
10822-HydroxyisobutyrylationSLLELGEKRKGMLEK
HHHHHHHHHHCHHHH
-
1082UbiquitinationSLLELGEKRKGMLEK
HHHHHHHHHHCHHHH
-
10892-HydroxyisobutyrylationKRKGMLEKSCKKFML
HHHCHHHHHHHHHHH
-
1089AcetylationKRKGMLEKSCKKFML
HHHCHHHHHHHHHHH
26051181
1090PhosphorylationRKGMLEKSCKKFMLF
HHCHHHHHHHHHHHH
24532841
1093AcetylationMLEKSCKKFMLFREA
HHHHHHHHHHHHHHH
25825284
1115PhosphorylationNEKEAALTSEEVGAD
HHHHHHHCHHHHCCC
-
1116PhosphorylationEKEAALTSEEVGADL
HHHHHHCHHHHCCCH
-
1131UbiquitinationEQVEVLQKKFDDFQK
HHHHHHHHHHHHHHH
-
11322-HydroxyisobutyrylationQVEVLQKKFDDFQKD
HHHHHHHHHHHHHHH
-
1132AcetylationQVEVLQKKFDDFQKD
HHHHHHHHHHHHHHH
25953088
1132UbiquitinationQVEVLQKKFDDFQKD
HHHHHHHHHHHHHHH
-
1138AcetylationKKFDDFQKDLKANES
HHHHHHHHHHHHCHH
26051181
1138MethylationKKFDDFQKDLKANES
HHHHHHHHHHHHCHH
54421291
1138UbiquitinationKKFDDFQKDLKANES
HHHHHHHHHHHHCHH
-
1139 (in isoform 3)Phosphorylation-21406692
1159PhosphorylationKVAEDLESEGLMAEE
HHHHHHHHCCCCHHH
26356563
1167 (in isoform 3)Ubiquitination-21890473
1170 (in isoform 3)Phosphorylation-21406692
1176PhosphorylationAVQQQEVYGMMPRDE
HHHHHHHHCCCCCCC
12446661
1184PhosphorylationGMMPRDETDSKTASP
CCCCCCCCCCCCCCC
22167270
1186PhosphorylationMPRDETDSKTASPWK
CCCCCCCCCCCCCHH
24732914
1187UbiquitinationPRDETDSKTASPWKS
CCCCCCCCCCCCHHH
21906983
1187 (in isoform 1)Ubiquitination-21890473
1187 (in isoform 2)Ubiquitination-21890473
1188PhosphorylationRDETDSKTASPWKSA
CCCCCCCCCCCHHHH
22167270
1190PhosphorylationETDSKTASPWKSARL
CCCCCCCCCHHHHHH
22167270
1190 (in isoform 2)Phosphorylation-24719451
1193UbiquitinationSKTASPWKSARLMVH
CCCCCCHHHHHHHHH
-
1194PhosphorylationKTASPWKSARLMVHT
CCCCCHHHHHHHHHH
24719451
1194 (in isoform 2)Phosphorylation-24719451
1197 (in isoform 3)Phosphorylation-21406692
1201PhosphorylationSARLMVHTVATFNSI
HHHHHHHHHHHHHHH
26074081
1204PhosphorylationLMVHTVATFNSIKEL
HHHHHHHHHHHHHHH
26074081
1204 (in isoform 2)Phosphorylation-24719451
1207PhosphorylationHTVATFNSIKELNER
HHHHHHHHHHHHHHH
27251275
1209AcetylationVATFNSIKELNERWR
HHHHHHHHHHHHHHH
25953088
1209UbiquitinationVATFNSIKELNERWR
HHHHHHHHHHHHHHH
-
1217PhosphorylationELNERWRSLQQLAEE
HHHHHHHHHHHHHHH
19664994
1217 (in isoform 2)Phosphorylation-24719451
1226PhosphorylationQQLAEERSQLLGSAH
HHHHHHHHHHHHCHH
28857561
1226 (in isoform 2)Phosphorylation-27251275
1231PhosphorylationERSQLLGSAHEVQRF
HHHHHHHCHHHHHHH
30266825
1231 (in isoform 2)Phosphorylation-24719451
1246AcetylationHRDADETKEWIEEKN
HCCHHHHHHHHHHHH
26051181
1246UbiquitinationHRDADETKEWIEEKN
HCCHHHHHHHHHHHH
-
12522-HydroxyisobutyrylationTKEWIEEKNQALNTD
HHHHHHHHHHHCCCC
-
1252UbiquitinationTKEWIEEKNQALNTD
HHHHHHHHHHHCCCC
-
1252 (in isoform 2)Ubiquitination--
1258PhosphorylationEKNQALNTDNYGHDL
HHHHHCCCCCCCCCH
28152594
1261NitrationQALNTDNYGHDLASV
HHCCCCCCCCCHHHH
-
1261PhosphorylationQALNTDNYGHDLASV
HHCCCCCCCCCHHHH
24927040
1267PhosphorylationNYGHDLASVQALQRK
CCCCCHHHHHHHHHH
28152594
1274UbiquitinationSVQALQRKHEGFERD
HHHHHHHHCCCHHHH
-
1288AcetylationDLAALGDKVNSLGET
HHHHHHHHHHHHHHH
26051181
1288UbiquitinationDLAALGDKVNSLGET
HHHHHHHHHHHHHHH
-
1288 (in isoform 2)Ubiquitination--
1291PhosphorylationALGDKVNSLGETAER
HHHHHHHHHHHHHHH
22617229
1291 (in isoform 2)Phosphorylation-24719451
1295PhosphorylationKVNSLGETAERLIQS
HHHHHHHHHHHHHHH
30108239
1302PhosphorylationTAERLIQSHPESAED
HHHHHHHHCCCCHHH
20363803
1302 (in isoform 2)Phosphorylation-27251275
1306PhosphorylationLIQSHPESAEDLQEK
HHHHCCCCHHHHHHH
25159151
1306 (in isoform 2)Phosphorylation-24719451
1313AcetylationSAEDLQEKCTELNQA
CHHHHHHHHHHHHHH
26051181
1313UbiquitinationSAEDLQEKCTELNQA
CHHHHHHHHHHHHHH
-
1322PhosphorylationTELNQAWSSLGKRAD
HHHHHHHHHHHHHHH
30266825
1322 (in isoform 2)Phosphorylation-24719451
1323PhosphorylationELNQAWSSLGKRADQ
HHHHHHHHHHHHHHH
19664994
1323 (in isoform 2)Phosphorylation-24719451
1326AcetylationQAWSSLGKRADQRKA
HHHHHHHHHHHHHHH
25953088
1326UbiquitinationQAWSSLGKRADQRKA
HHHHHHHHHHHHHHH
-
13342-HydroxyisobutyrylationRADQRKAKLGDSHDL
HHHHHHHCCCCHHHH
-
1334AcetylationRADQRKAKLGDSHDL
HHHHHHHCCCCHHHH
23749302
1338PhosphorylationRKAKLGDSHDLQRFL
HHHCCCCHHHHHHHH
28857561
1338 (in isoform 2)Phosphorylation-24719451
1346PhosphorylationHDLQRFLSDFRDLMS
HHHHHHHHHHHHHHH
21815630
1353PhosphorylationSDFRDLMSWINGIRG
HHHHHHHHHHHHHHC
24076635
1363PhosphorylationNGIRGLVSSDELAKD
HHHHCCCCCHHHHHC
30266825
1363 (in isoform 2)Phosphorylation-27251275
1364PhosphorylationGIRGLVSSDELAKDV
HHHCCCCCHHHHHCC
30266825
1369AcetylationVSSDELAKDVTGAEA
CCCHHHHHCCCCHHH
26051181
1369 (in isoform 2)Ubiquitination--
1372PhosphorylationDELAKDVTGAEALLE
HHHHHCCCCHHHHHH
24076635
1386PhosphorylationERHQEHRTEIDARAG
HHHHHHCCHHHHCCC
17855441
1411PhosphorylationQLLAHGHYASPEIKQ
HHHHCCCCCCHHHHH
28102081
1413PhosphorylationLAHGHYASPEIKQKL
HHCCCCCCHHHHHHH
25159151
1413 (in isoform 2)Phosphorylation-24719451
1419AcetylationASPEIKQKLDILDQE
CCHHHHHHHHHHHHH
25953088
1419MalonylationASPEIKQKLDILDQE
CCHHHHHHHHHHHHH
26320211
1419UbiquitinationASPEIKQKLDILDQE
CCHHHHHHHHHHHHH
-
14322-HydroxyisobutyrylationQERADLEKAWVQRRM
HHHHHHHHHHHHHHH
-
1432AcetylationQERADLEKAWVQRRM
HHHHHHHHHHHHHHH
25953088
1464MethylationAENWMAAREAFLNTE
HHHHHHHHHHHHCCC
115386421
1470PhosphorylationAREAFLNTEDKGDSL
HHHHHHCCCCCCCCC
29214152
14732-HydroxyisobutyrylationAFLNTEDKGDSLDSV
HHHCCCCCCCCCHHH
-
1473AcetylationAFLNTEDKGDSLDSV
HHHCCCCCCCCCHHH
26051181
1473UbiquitinationAFLNTEDKGDSLDSV
HHHCCCCCCCCCHHH
-
1476PhosphorylationNTEDKGDSLDSVEAL
CCCCCCCCCHHHHHH
26657352
1476 (in isoform 2)Phosphorylation-27251275
1479PhosphorylationDKGDSLDSVEALIKK
CCCCCCHHHHHHHHH
25849741
1479 (in isoform 2)Phosphorylation-24719451
14852-HydroxyisobutyrylationDSVEALIKKHEDFDK
HHHHHHHHHCCCHHH
-
1485AcetylationDSVEALIKKHEDFDK
HHHHHHHHHCCCHHH
26051181
1485UbiquitinationDSVEALIKKHEDFDK
HHHHHHHHHCCCHHH
-
14922-HydroxyisobutyrylationKKHEDFDKAINVQEE
HHCCCHHHHHCCCHH
-
1499AcetylationKAINVQEEKIAALQA
HHHCCCHHHHHHHHH
19608861
1499UbiquitinationKAINVQEEKIAALQA
HHHCCCHHHHHHHHH
19608861
1517NitrationQLIAAGHYAKGDISS
HHHHCCCHHCCCHHH
-
1519AcetylationIAAGHYAKGDISSRR
HHCCCHHCCCHHHHH
19608861
1519UbiquitinationIAAGHYAKGDISSRR
HHCCCHHCCCHHHHH
19608861
1519 (in isoform 2)Ubiquitination--
1532MethylationRRNEVLDRWRRLKAQ
HHHHHHHHHHHHHHH
115917633
1546AcetylationQMIEKRSKLGESQTL
HHHHHHHHHCCCHHH
25953088
1546MalonylationQMIEKRSKLGESQTL
HHHHHHHHHCCCHHH
26320211
1550O-linked_GlycosylationKRSKLGESQTLQQFS
HHHHHCCCHHHHHHH
30379171
1550PhosphorylationKRSKLGESQTLQQFS
HHHHHCCCHHHHHHH
30266825
1550 (in isoform 2)Phosphorylation-24719451
1552PhosphorylationSKLGESQTLQQFSRD
HHHCCCHHHHHHHCC
30266825
1557PhosphorylationSQTLQQFSRDVDEIE
CHHHHHHHCCHHHHH
29038488
1573PhosphorylationWISEKLQTASDESYK
HHHHHHHCCCCCCCC
27732954
1575PhosphorylationSEKLQTASDESYKDP
HHHHHCCCCCCCCCC
21815630
1575 (in isoform 2)Phosphorylation-24076635
1578PhosphorylationLQTASDESYKDPTNI
HHCCCCCCCCCCCCC
21815630
1578 (in isoform 2)Phosphorylation--
1579PhosphorylationQTASDESYKDPTNIQ
HCCCCCCCCCCCCCC
28152594
1580AcetylationTASDESYKDPTNIQS
CCCCCCCCCCCCCCH
26051181
1580UbiquitinationTASDESYKDPTNIQS
CCCCCCCCCCCCCCH
-
1580 (in isoform 2)Ubiquitination--
1583PhosphorylationDESYKDPTNIQSKHQ
CCCCCCCCCCCHHHH
28152594
1587PhosphorylationKDPTNIQSKHQKHQA
CCCCCCCHHHHHHHH
23312004
1588UbiquitinationDPTNIQSKHQKHQAF
CCCCCCHHHHHHHHH
-
1589 (in isoform 2)Ubiquitination--
15912-HydroxyisobutyrylationNIQSKHQKHQAFEAE
CCCHHHHHHHHHHHH
-
1591AcetylationNIQSKHQKHQAFEAE
CCCHHHHHHHHHHHH
25825284
1612SulfoxidationRIRGVIDMGNSLIER
HHHHHEECCCCHHHC
21406390
1615PhosphorylationGVIDMGNSLIERGAC
HHEECCCCHHHCCCC
25072903
1620 (in isoform 2)Phosphorylation-24719451
1625PhosphorylationERGACAGSEDAVKAR
HCCCCCCCHHHHHHH
-
1630AcetylationAGSEDAVKARLAALA
CCCHHHHHHHHHHHH
25953088
1630UbiquitinationAGSEDAVKARLAALA
CCCHHHHHHHHHHHH
-
1647PhosphorylationWQFLVQKSAEKSQKL
HHHHHHHHHHHHHHH
24732914
1651PhosphorylationVQKSAEKSQKLKEAN
HHHHHHHHHHHHHHH
24732914
1651 (in isoform 2)Ubiquitination--
1652 (in isoform 2)Phosphorylation-24719451
16592-HydroxyisobutyrylationQKLKEANKQQNFNTG
HHHHHHHHHCCCCCC
-
1659UbiquitinationQKLKEANKQQNFNTG
HHHHHHHHHCCCCCC
-
1692PhosphorylationDYGKDLASVNNLLKK
CCCCCHHHHHHHHHH
17855441
16982-HydroxyisobutyrylationASVNNLLKKHQLLEA
HHHHHHHHHHHHHHC
-
1698UbiquitinationASVNNLLKKHQLLEA
HHHHHHHHHHHHHHC
-
16992-HydroxyisobutyrylationSVNNLLKKHQLLEAD
HHHHHHHHHHHHHCH
-
1699UbiquitinationSVNNLLKKHQLLEAD
HHHHHHHHHHHHHCH
-
1708PhosphorylationQLLEADISAHEDRLK
HHHHCHHHHCHHHHH
28674419
17152-HydroxyisobutyrylationSAHEDRLKDLNSQAD
HHCHHHHHHHHHHHH
-
1715AcetylationSAHEDRLKDLNSQAD
HHCHHHHHHHHHHHH
26051181
1715UbiquitinationSAHEDRLKDLNSQAD
HHCHHHHHHHHHHHH
-
1719PhosphorylationDRLKDLNSQADSLMT
HHHHHHHHHHHHHHH
-
1751PhosphorylationGRFQKIKSMAASRRA
HHHHHHHHHHHHHHH
23403867
1755PhosphorylationKIKSMAASRRAKLNE
HHHHHHHHHHHHCCH
23403867
1778PhosphorylationRDMDDEESWIKEKKL
HCCCCHHHHHHHCEE
21815630
1781AcetylationDDEESWIKEKKLLVG
CCHHHHHHHCEEECC
26051181
17842-HydroxyisobutyrylationESWIKEKKLLVGSED
HHHHHHCEEECCCCC
-
1784MalonylationESWIKEKKLLVGSED
HHHHHHCEEECCCCC
26320211
1789PhosphorylationEKKLLVGSEDYGRDL
HCEEECCCCCCCCCC
21406692
1792PhosphorylationLLVGSEDYGRDLTGV
EECCCCCCCCCCHHH
21406692
1797PhosphorylationEDYGRDLTGVQNLRK
CCCCCCCHHHHHHHH
21406692
18282-HydroxyisobutyrylationQGVLDTGKKLSDDNT
HHHHHCCCCCCCCCC
-
1828AcetylationQGVLDTGKKLSDDNT
HHHHHCCCCCCCCCC
26051181
18292-HydroxyisobutyrylationGVLDTGKKLSDDNTI
HHHHCCCCCCCCCCC
-
1829UbiquitinationGVLDTGKKLSDDNTI
HHHHCCCCCCCCCCC
-
18382-HydroxyisobutyrylationSDDNTIGKEEIQQRL
CCCCCCCHHHHHHHH
-
1838AcetylationSDDNTIGKEEIQQRL
CCCCCCCHHHHHHHH
26051181
1838UbiquitinationSDDNTIGKEEIQQRL
CCCCCCCHHHHHHHH
-
1843 (in isoform 2)Ubiquitination--
1853AcetylationAQFVEHWKELKQLAA
HHHHHHHHHHHHHHH
25953088
1853MalonylationAQFVEHWKELKQLAA
HHHHHHHHHHHHHHH
26320211
1853UbiquitinationAQFVEHWKELKQLAA
HHHHHHHHHHHHHHH
-
18562-HydroxyisobutyrylationVEHWKELKQLAAARG
HHHHHHHHHHHHHHC
-
1856AcetylationVEHWKELKQLAAARG
HHHHHHHHHHHHHHC
25953088
1856MalonylationVEHWKELKQLAAARG
HHHHHHHHHHHHHHC
26320211
1856UbiquitinationVEHWKELKQLAAARG
HHHHHHHHHHHHHHC
-
1898PhosphorylationTLVASEDYGDTLAAI
EEEECCCHHHHHHHH
-
19112-HydroxyisobutyrylationAIQGLLKKHEAFETD
HHHHHHHHHCHHCCC
-
1911AcetylationAIQGLLKKHEAFETD
HHHHHHHHHCHHCCC
25825284
1911UbiquitinationAIQGLLKKHEAFETD
HHHHHHHHHCHHCCC
-
19232-HydroxyisobutyrylationETDFTVHKDRVNDVC
CCCCEECHHHHHHHH
-
1923AcetylationETDFTVHKDRVNDVC
CCCCEECHHHHHHHH
26051181
1923UbiquitinationETDFTVHKDRVNDVC
CCCCEECHHHHHHHH
-
19382-HydroxyisobutyrylationTNGQDLIKKNNHHEE
CCHHHHHHCCCCCCH
-
1938AcetylationTNGQDLIKKNNHHEE
CCHHHHHHCCCCCCH
25953088
1959PhosphorylationKGLNGKVSDLEKAAA
CCCCCCHHHHHHHHH
17855441
19632-HydroxyisobutyrylationGKVSDLEKAAAQRKA
CCHHHHHHHHHHHHC
-
1963AcetylationGKVSDLEKAAAQRKA
CCHHHHHHHHHHHHC
26051181
1963UbiquitinationGKVSDLEKAAAQRKA
CCHHHHHHHHHHHHC
-
1990PhosphorylationWKADVVESWIGEKEN
CCHHHHHHHHCCCCC
24076635
1990 (in isoform 3)Phosphorylation-21406692
1995AcetylationVESWIGEKENSLKTD
HHHHHCCCCCCCCCC
26051181
1995UbiquitinationVESWIGEKENSLKTD
HHHHHCCCCCCCCCC
-
1998PhosphorylationWIGEKENSLKTDDYG
HHCCCCCCCCCCCCC
24076635
20002-HydroxyisobutyrylationGEKENSLKTDDYGRD
CCCCCCCCCCCCCCC
-
2000AcetylationGEKENSLKTDDYGRD
CCCCCCCCCCCCCCC
25953088
2009PhosphorylationDDYGRDLSSVQTLLT
CCCCCCHHHHHHHHH
25850435
2010PhosphorylationDYGRDLSSVQTLLTK
CCCCCHHHHHHHHHH
25850435
2013PhosphorylationRDLSSVQTLLTKQET
CCHHHHHHHHHHHHH
21406692
2016PhosphorylationSSVQTLLTKQETFDA
HHHHHHHHHHHHHHH
21406692
2020PhosphorylationTLLTKQETFDAGLQA
HHHHHHHHHHHHHHH
26657352
2025 (in isoform 2)Phosphorylation-27251275
2032AcetylationLQAFQQEGIANITAL
HHHHHHHCCCHHHHH
19608861
2040UbiquitinationIANITALKDQLLAAK
CCHHHHHHHHHHHHH
-
2047AcetylationKDQLLAAKHVQSKAI
HHHHHHHHHHHHHHH
25825284
2047MalonylationKDQLLAAKHVQSKAI
HHHHHHHHHHHHHHH
26320211
2047UbiquitinationKDQLLAAKHVQSKAI
HHHHHHHHHHHHHHH
-
2051PhosphorylationLAAKHVQSKAIEARH
HHHHHHHHHHHHHHH
20873877
20522-HydroxyisobutyrylationAAKHVQSKAIEARHA
HHHHHHHHHHHHHHH
-
2052AcetylationAAKHVQSKAIEARHA
HHHHHHHHHHHHHHH
19608861
2052UbiquitinationAAKHVQSKAIEARHA
HHHHHHHHHHHHHHH
-
2057AcetylationQSKAIEARHASLMKR
HHHHHHHHHHHHHHH
19608861
2057 (in isoform 2)Ubiquitination--
2060PhosphorylationAIEARHASLMKRWSQ
HHHHHHHHHHHHHHH
28188228
20632-HydroxyisobutyrylationARHASLMKRWSQLLA
HHHHHHHHHHHHHHH
-
2063AcetylationARHASLMKRWSQLLA
HHHHHHHHHHHHHHH
25953088
2066PhosphorylationASLMKRWSQLLANSA
HHHHHHHHHHHHHHH
23403867
2071 (in isoform 2)Phosphorylation-24719451
2072PhosphorylationWSQLLANSAARKKKL
HHHHHHHHHHHHHHH
20860994
2078MalonylationNSAARKKKLLEAQSH
HHHHHHHHHHHHHHH
26320211
2078UbiquitinationNSAARKKKLLEAQSH
HHHHHHHHHHHHHHH
-
2084PhosphorylationKKLLEAQSHFRKVED
HHHHHHHHHHHHHHH
28857561
20882-HydroxyisobutyrylationEAQSHFRKVEDLFLT
HHHHHHHHHHHHHHH
-
2088AcetylationEAQSHFRKVEDLFLT
HHHHHHHHHHHHHHH
26051181
2095PhosphorylationKVEDLFLTFAKKASA
HHHHHHHHHHHHHHH
23312004
2098AcetylationDLFLTFAKKASAFNS
HHHHHHHHHHHHHHH
25953088
2099UbiquitinationLFLTFAKKASAFNSW
HHHHHHHHHHHHHHH
-
2127AcetylationCNSLEEIKALREAHD
CCCHHHHHHHHHHHH
26051181
2137MethylationREAHDAFRSSLSSAQ
HHHHHHHHHHHHHHC
115386429
2138PhosphorylationEAHDAFRSSLSSAQA
HHHHHHHHHHHHHCC
28857561
2139PhosphorylationAHDAFRSSLSSAQAD
HHHHHHHHHHHHCCC
28857561
2141PhosphorylationDAFRSSLSSAQADFN
HHHHHHHHHHCCCHH
28857561
2142PhosphorylationAFRSSLSSAQADFNQ
HHHHHHHHHCCCHHH
28857561
2146 (in isoform 2)Phosphorylation-27251275
2147 (in isoform 2)Phosphorylation-24719451
2159PhosphorylationELDRQIKSFRVASNP
HHHHHHHHCCCCCCC
17855441
21842-HydroxyisobutyrylationETWRNLQKIIKEREL
HHHHHHHHHHHHHHH
-
2184AcetylationETWRNLQKIIKEREL
HHHHHHHHHHHHHHH
25953088
2187UbiquitinationRNLQKIIKERELELQ
HHHHHHHHHHHHHHH
-
2195AcetylationERELELQKEQRRQEE
HHHHHHHHHHHHHHH
23749302
2195MalonylationERELELQKEQRRQEE
HHHHHHHHHHHHHHH
26320211
2264UbiquitinationAMRSQLKKIEDLGAA
HHHHHHHHHHHHHHH
-
2281UbiquitinationEALILDNKYTEHSTV
HHHHHCCCCCCCCCC
-
2283PhosphorylationLILDNKYTEHSTVGL
HHHCCCCCCCCCCHH
28857561
2286PhosphorylationDNKYTEHSTVGLAQQ
CCCCCCCCCCHHHHH
28857561
2287PhosphorylationNKYTEHSTVGLAQQW
CCCCCCCCCHHHHHH
28857561
2304SulfoxidationLDQLGMRMQHNLEQQ
HHHHHHHHHCCHHHH
30846556
23392-HydroxyisobutyrylationFKHFDKDKSGRLNHQ
HHCCCCCCCCCCCHH
-
2340PhosphorylationKHFDKDKSGRLNHQE
HCCCCCCCCCCCHHH
17855441
2349AcetylationRLNHQEFKSCLRSLG
CCCHHHHHHHHHHCC
26051181
2401AcetylationFMISRETENVKSSEE
HHHCCCCCCCCCHHH
19608861
2404UbiquitinationSRETENVKSSEEIES
CCCCCCCCCHHHHHH
-
2405PhosphorylationRETENVKSSEEIESA
CCCCCCCCHHHHHHH
25627689
2406AcetylationETENVKSSEEIESAF
CCCCCCCHHHHHHHH
19608861
2406PhosphorylationETENVKSSEEIESAF
CCCCCCCHHHHHHHH
21815630
2406UbiquitinationETENVKSSEEIESAF
CCCCCCCHHHHHHHH
19608861
2406 (in isoform 3)Ubiquitination-21890473
2411PhosphorylationKSSEEIESAFRALSS
CCHHHHHHHHHHHHC
21815630
2417PhosphorylationESAFRALSSEGKPYV
HHHHHHHHCCCCCCC
28152594
2418PhosphorylationSAFRALSSEGKPYVT
HHHHHHHCCCCCCCC
28152594
2421AcetylationRALSSEGKPYVTKEE
HHHHCCCCCCCCHHH
19608861
2421MalonylationRALSSEGKPYVTKEE
HHHHCCCCCCCCHHH
26320211
2421UbiquitinationRALSSEGKPYVTKEE
HHHHCCCCCCCCHHH
-
2423NitrationLSSEGKPYVTKEELY
HHCCCCCCCCHHHHH
-
2423PhosphorylationLSSEGKPYVTKEELY
HHCCCCCCCCHHHHH
21082442
2425PhosphorylationSEGKPYVTKEELYQN
CCCCCCCCHHHHHHH
28796482
24262-HydroxyisobutyrylationEGKPYVTKEELYQNL
CCCCCCCHHHHHHHC
-
2426AcetylationEGKPYVTKEELYQNL
CCCCCCCHHHHHHHC
23749302
2426UbiquitinationEGKPYVTKEELYQNL
CCCCCCCHHHHHHHC
21890473
2426 (in isoform 1)Ubiquitination-21890473
2430PhosphorylationYVTKEELYQNLTREQ
CCCHHHHHHHCCHHH
21945579
2431AcetylationVTKEELYQNLTREQA
CCHHHHHHHCCHHHH
19608861
2431UbiquitinationVTKEELYQNLTREQA
CCHHHHHHHCCHHHH
19608861
2431 (in isoform 2)Ubiquitination-21890473
2434PhosphorylationEELYQNLTREQADYC
HHHHHHCCHHHHHHH
28796482
2440PhosphorylationLTREQADYCVSHMKP
CCHHHHHHHHHHCCC
-
2445SulfoxidationADYCVSHMKPYVDGK
HHHHHHHCCCCCCCC
30846556
2446AcetylationDYCVSHMKPYVDGKG
HHHHHHCCCCCCCCC
25825284
2452MalonylationMKPYVDGKGRELPTA
CCCCCCCCCCCCCCH
26320211
2452UbiquitinationMKPYVDGKGRELPTA
CCCCCCCCCCCCCCH
-
2458PhosphorylationGKGRELPTAFDYVEF
CCCCCCCCHHHHHHH
25338102
2462PhosphorylationELPTAFDYVEFTRSL
CCCCHHHHHHHHHHH
-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1073YPhosphorylationKinaseSRCP12931
PSP
1176YPhosphorylationKinaseLCKP06239
PhosphoELM
1176YPhosphorylationKinaseSRCP12931
PSP
1176YPhosphorylationKinaseSRC64-PhosphoELM

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPTN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPTN1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FANCA_HUMANFANCAphysical
10551855
FANCC_HUMANFANCCphysical
10551855
PIN4_HUMANPIN4physical
16169070
TSSC4_HUMANTSSC4physical
16169070
DESM_HUMANDESphysical
2939097
NFL_HUMANNEFLphysical
3121319
SHAN1_HUMANSHANK1physical
11509555
SPTB1_HUMANSPTBphysical
9890967
GRIA2_HUMANGRIA2physical
10576550
EPB42_HUMANEPB42physical
12049649
LMNB1_HUMANLMNB1physical
11441066
ACTS_HUMANACTA1physical
11441066
VIME_HUMANVIMphysical
11441066
PLEC_HUMANPLECphysical
11441066
MOES_HUMANMSNphysical
11441066
FANCC_HUMANFANCCphysical
19102630
FANCF_HUMANFANCFphysical
19102630
FANCG_HUMANFANCGphysical
19102630
XPF_HUMANERCC4physical
11401546
SPTB2_HUMANSPTBN1physical
22939629
SPTN2_HUMANSPTBN2physical
22939629
SYSM_HUMANSARS2physical
22939629
SPTB2_HUMANSPTBN1physical
12820899
EVL_HUMANEVLphysical
15656790
TES_RATTesphysical
15656790
TES_HUMANTESphysical
15656790
MLH1_HUMANMLH1physical
20706999
QOR_HUMANCRYZphysical
22863883
EH1L1_HUMANEHBP1L1physical
22863883
NU188_HUMANNUP188physical
22863883
PLSI_HUMANPLS1physical
22863883
LIPA1_HUMANPPFIA1physical
22863883
PP4R1_HUMANPPP4R1physical
22863883
RS24_HUMANRPS24physical
22863883
ECM29_HUMANKIAA0368physical
26344197
SPTB2_HUMANSPTBN1physical
26344197
SPTN5_HUMANSPTBN5physical
26344197
PDE4D_HUMANPDE4Dphysical
10571082
SPTB2_HUMANSPTBN1physical
17607528
SPTB1_HUMANSPTBphysical
17607528
SPTN2_HUMANSPTBN2physical
17607528
SPTN4_HUMANSPTBN4physical
17607528
KALRN_HUMANKALRNphysical
17607528
SYK_HUMANKARSphysical
17607528
AKIP1_HUMANAKIP1physical
17607528
TAF1_HUMANTAF1physical
17607528
ZN333_HUMANZNF333physical
17607528
FACD2_HUMANFANCD2physical
26297932

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613477Epileptic encephalopathy, early infantile, 5 (EIEE5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPTN1_HUMAN

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