SHAN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHAN1_HUMAN
• UniProt AC: Q9Y566
• Protein Name: SH3 and multiple ankyrin repeat domains protein 1
• Gene Name: SHANK1
• Organism: Homo sapiens (Human).
• Sequence Length: 2161
• Subcellular Localization: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Colocalizes with alpha-latrotoxin receptor 1..
• Protein Description: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction..
• Protein Sequence: MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGADKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGTGLTVPPALLRANSDTSMALPDWMVFSAPGAASSGAPGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPREGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQAEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQESKQESRSDKAKRLFRHYTVGSYDSFDAPSLMDGIGPGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKAPQQAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPVPSSSGRLTPSPRGGPFNPGSGGPLPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGGSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQPPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGYRAGLGSQEKSLPASPPAARRSLLHRLPPTAPGVGPLLLQLGTEPPAPHPGVSKPWRSAAPEEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALATVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTHSPATSE ------CCCCCCCCH	42.22	24043423
4	Phosphorylation	----MTHSPATSEDE ----CCCCCCCCHHH	24.54	24043423
7	Phosphorylation	-MTHSPATSEDEERH -CCCCCCCCHHHHHH	35.71	24043423
8	Phosphorylation	MTHSPATSEDEERHS CCCCCCCCHHHHHHC	45.19	24043423
15	Phosphorylation	SEDEERHSASECPEG CHHHHHHCHHCCCCC	39.45	-
17	Phosphorylation	DEERHSASECPEGGS HHHHHCHHCCCCCCC	42.62	-
24	Phosphorylation	SECPEGGSESDSSPD HCCCCCCCCCCCCCC	44.79	-
26	Phosphorylation	CPEGGSESDSSPDGP CCCCCCCCCCCCCCC	44.48	-
40	Phosphorylation	PGRGPRGTRGQGSGA CCCCCCCCCCCCCCC	32.67	22210691
76	Methylation	HFSMMVFRIGIPDLH HHHEEEEECCCCCHH	18.14	115389579
86	Ubiquitination	IPDLHQTKCLRFNPD CCCHHHCCCCCCCCC	25.38	-
161	Phosphorylation	FRYKTRVYKQTNLDE EEEEEEEEECCCCCH	8.29	22461510
169	Acetylation	KQTNLDEKQLAKLHT ECCCCCHHHHHHHHH	50.72	20167786
186	Phosphorylation	GLKKFLEYVQLGTSD HHHHHHHHHHHCCHH	8.81	27196784
275	Phosphorylation	DLGGSPNYKDRRGLT HCCCCCCCCCCCCCC	20.04	18083107
287	Phosphorylation	GLTPLFHTAMVGGDP CCCCHHHHHHCCCCH	14.76	-
413	Phosphorylation	DVVPFQESPKYAARR CCCCCCCCHHHHHHH	18.86	24076635
482	Phosphorylation	SAPTTKLSSGTLRSA CCCCCCCCCCCCCCC	28.42	23312004
483	Phosphorylation	APTTKLSSGTLRSAS CCCCCCCCCCCCCCC	46.35	23312004
485	Phosphorylation	TTKLSSGTLRSASSP CCCCCCCCCCCCCCC	22.42	23312004
488	Phosphorylation	LSSGTLRSASSPRGA CCCCCCCCCCCCCCC	35.30	26699800
490	Phosphorylation	SGTLRSASSPRGARA CCCCCCCCCCCCCCC	41.96	26699800
491	Phosphorylation	GTLRSASSPRGARAR CCCCCCCCCCCCCCC	20.52	26699800
510	Acetylation	GRHPEDAKRQPRGRP CCCHHHHCCCCCCCC	64.98	7340263
520	Phosphorylation	PRGRPSSSGTPREGP CCCCCCCCCCCCCCC	51.53	24667141
531	Phosphorylation	REGPAGGTGGSGGPG CCCCCCCCCCCCCCC	37.13	24667141
534	Phosphorylation	PAGGTGGSGGPGGSL CCCCCCCCCCCCCCC	41.75	22210691
540	Phosphorylation	GSGGPGGSLGSRGRR CCCCCCCCCCCHHCH	35.16	19413330
543	Phosphorylation	GPGGSLGSRGRRRKL CCCCCCCCHHCHHHC	36.53	23532336
544	Methylation	PGGSLGSRGRRRKLY CCCCCCCHHCHHHCE	40.62	-
551	Phosphorylation	RGRRRKLYSAVPGRS HHCHHHCEECCCCCC	9.53	21945579
552	Phosphorylation	GRRRKLYSAVPGRSF HCHHHCEECCCCCCE	32.97	21945579
574	Phosphorylation	AQAEGEISLSKGEKI CCCCCEEECCCCCEE	23.45	24719451
638 (in isoform 3)	Phosphorylation	-	22.79	22617229
641 (in isoform 3)	Phosphorylation	-	19.45	22617229
671	Phosphorylation	VLLQKKDSEGFGFVL EEEEECCCCCCCEEE	48.80	-
786	Phosphorylation	PPTISLRSKSMTSEL CCCEECCCCCCCHHH	34.08	28674151
788	Phosphorylation	TISLRSKSMTSELEE CEECCCCCCCHHHHH	28.65	28674151
791	Phosphorylation	LRSKSMTSELEEMEY CCCCCCCHHHHHHHH	31.38	-
887	Methylation	PGPGLMLRQKSIGAA CCCCCEECCCCCCCC	28.10	115916857
890	Phosphorylation	GLMLRQKSIGAAEDD CCEECCCCCCCCCCC	20.23	28450419
946	Phosphorylation	PSSSGRLTPSPRGGP CCCCCCCCCCCCCCC	21.99	22210691
948	Phosphorylation	SSGRLTPSPRGGPFN CCCCCCCCCCCCCCC	23.22	22210691
950	Methylation	GRLTPSPRGGPFNPG CCCCCCCCCCCCCCC	68.02	-
974	Phosphorylation	PASFDGPSPPDTRVG CCCCCCCCCCCCCCC	55.37	24076635
1051	Methylation	QPSLRGWRGGGPSPT CCCCCCCCCCCCCCC	36.38	-
1056	Phosphorylation	GWRGGGPSPTPGAPS CCCCCCCCCCCCCCC	44.68	26552605
1058	Phosphorylation	RGGGPSPTPGAPSPS CCCCCCCCCCCCCCC	38.40	26552605
1063	Phosphorylation	SPTPGAPSPSHHGSA CCCCCCCCCCCCCCC	38.20	26552605
1065	Phosphorylation	TPGAPSPSHHGSAGG CCCCCCCCCCCCCCC	32.24	26552605
1069	Phosphorylation	PSPSHHGSAGGGGGS CCCCCCCCCCCCCCC	21.27	26552605
1076	Phosphorylation	SAGGGGGSSQGPALR CCCCCCCCCCCCCCC	23.82	26552605
1077	Phosphorylation	AGGGGGSSQGPALRY CCCCCCCCCCCCCCE	42.29	26552605
1084	Phosphorylation	SQGPALRYFQLPPRA CCCCCCCEECCCHHH	9.13	26552605
1090	Methylation	RYFQLPPRAASAAMY CEECCCHHHCCCCEE	40.63	-
1093	Phosphorylation	QLPPRAASAAMYVPA CCCHHHCCCCEEEEC	18.64	26552605
1097	Phosphorylation	RAASAAMYVPARSGR HHCCCCEEEECCCCC	9.88	26552605
1101	Methylation	AAMYVPARSGRGRKG CCEEEECCCCCCCCC	33.31	-
1134	Phosphorylation	PPAPSPTSPASPQPP CCCCCCCCCCCCCCC	23.12	23532336
1176	Phosphorylation	GRSSQGSSTEAEPPT CCCCCCCCCCCCCCC	36.77	28787133
1196	Phosphorylation	GGGGGGGSSPSPAPA CCCCCCCCCCCCCCC	42.21	28787133
1197	Phosphorylation	GGGGGGSSPSPAPAM CCCCCCCCCCCCCCC	32.45	28787133
1199	Phosphorylation	GGGGSSPSPAPAMSP CCCCCCCCCCCCCCC	35.32	28787133
1253	Asymmetric dimethylarginine	WQNEARRRSTLFLST CCCHHHHCCEEEEEC	28.56	-
1253	Methylation	WQNEARRRSTLFLST CCCHHHHCCEEEEEC	28.56	-
1254	Phosphorylation	QNEARRRSTLFLSTD CCHHHHCCEEEEECC	27.87	25841592
1255	Phosphorylation	NEARRRSTLFLSTDA CHHHHCCEEEEECCC	21.51	25841592
1259	Phosphorylation	RRSTLFLSTDAGDED HCCEEEEECCCCCCC	19.53	25841592
1260	Phosphorylation	RSTLFLSTDAGDEDG CCEEEEECCCCCCCC	31.83	25841592
1274	Phosphorylation	GGDGGLGTGAAPGPR CCCCCCCCCCCCCCC	28.79	25841592
1287	Phosphorylation	PRLRHSKSIDEGMFS CCCCCCCCCCCCCCC	37.98	30266825
1294	Phosphorylation	SIDEGMFSAEPYLRL CCCCCCCCCCCCEEE	23.88	30266825
1303	Phosphorylation	EPYLRLESAGSGAGY CCCEEEEECCCCCCC	42.39	28111955
1306	Phosphorylation	LRLESAGSGAGYGGY EEEEECCCCCCCCCC	25.78	28111955
1310	Phosphorylation	SAGSGAGYGGYGAGS ECCCCCCCCCCCCCC	13.57	28111955
1313	Phosphorylation	SGAGYGGYGAGSRAY CCCCCCCCCCCCCCC	10.23	28111955
1317	Phosphorylation	YGGYGAGSRAYGGGG CCCCCCCCCCCCCCC	17.13	28111955
1320	Phosphorylation	YGAGSRAYGGGGGSS CCCCCCCCCCCCCCC	18.39	28111955
1326	Phosphorylation	AYGGGGGSSAFTSFL CCCCCCCCCCCHHCC	23.05	28111955
1327	Phosphorylation	YGGGGGSSAFTSFLP CCCCCCCCCCHHCCC	30.58	28111955
1330	Phosphorylation	GGGSSAFTSFLPPRP CCCCCCCHHCCCCCC	20.48	28111955
1331	Phosphorylation	GGSSAFTSFLPPRPL CCCCCCHHCCCCCCC	20.52	28111955
1382	Phosphorylation	QPPPRPPSPRYEAPP CCCCCCCCCCCCCCC	25.37	26846344
1411	Phosphorylation	VLRLWGASPPDPARR CHHHCCCCCCCHHHH	32.78	27732954
1423	Methylation	ARRELGYRAGLGSQE HHHHHHHCCCCCCCC	22.00	-
1432	Phosphorylation	GLGSQEKSLPASPPA CCCCCCCCCCCCCHH	38.54	23312004
1436	Phosphorylation	QEKSLPASPPAARRS CCCCCCCCCHHHHHH	29.49	27732954
1443	Phosphorylation	SPPAARRSLLHRLPP CCHHHHHHHHHHCCC	29.72	28634298
1451	Phosphorylation	LLHRLPPTAPGVGPL HHHHCCCCCCCCHHH	43.47	28634298
1464	Phosphorylation	PLLLQLGTEPPAPHP HHHHHCCCCCCCCCC	54.64	28634298
1474	Phosphorylation	PAPHPGVSKPWRSAA CCCCCCCCCCHHHCC	38.63	28634298
1479	Phosphorylation	GVSKPWRSAAPEEPE CCCCCHHHCCCCCCC	25.55	28122231
1506	Phosphorylation	QPRAPVTSGRGPPSE CCCCCCCCCCCCCCC	27.08	-
1512	Phosphorylation	TSGRGPPSEDGPGVP CCCCCCCCCCCCCCC	51.99	-
1522	Phosphorylation	GPGVPPPSPRRSVPP CCCCCCCCCCCCCCC	36.49	-
1530	Phosphorylation	PRRSVPPSPTSPRAS CCCCCCCCCCCCCCC	34.44	26437602
1533	Phosphorylation	SVPPSPTSPRASEEN CCCCCCCCCCCCHHC	18.77	21406692
1788	O-linked_Glycosylation	TPTSPTVSVTGAGTD CCCCCCEEECCCCHH	19.21	28657654
1790	O-linked_Glycosylation	TSPTVSVTGAGTDGL CCCCEEECCCCHHCH	17.51	28657654
1794	O-linked_Glycosylation	VSVTGAGTDGLLALR EEECCCCHHCHHHHH	26.76	28657654
1831	Phosphorylation	PVPLPTASSLPRKLL CCCCCCCCCCCCCCC	34.58	29262532
1832	Phosphorylation	VPLPTASSLPRKLLP CCCCCCCCCCCCCCC	39.67	24719451
1869	O-linked_Glycosylation	ALATVKASIISELSS HHHHHHHHHHHHHHH	18.10	28657654
1895	Methylation	GGALPWARGGSGGGG CCCCCCCCCCCCCCC	46.25	-
1931	Phosphorylation	LSDDSQSSLLSKPVS CCCCHHHHHHCCCHH	26.20	24719451
2000	Phosphorylation	PLLRRAPSPSLLPAS CHHHCCCCCCCCCCC	26.57	25841592
2002	Phosphorylation	LRRAPSPSLLPASEH HHCCCCCCCCCCCCC	47.04	25841592
2007	Phosphorylation	SPSLLPASEHKVSPA CCCCCCCCCCCCCCC	37.99	18767875
2016	Methylation	HKVSPAPRPSSLPIL CCCCCCCCCCCCCCC	45.93	-
2018	Phosphorylation	VSPAPRPSSLPILPS CCCCCCCCCCCCCCC	45.87	27732954
2019	Phosphorylation	SPAPRPSSLPILPSG CCCCCCCCCCCCCCC	40.63	27732954
2025	Phosphorylation	SSLPILPSGPLYPGL CCCCCCCCCCCCCCC	49.99	27732954
2036	Methylation	YPGLFDIRGSPTGGA CCCCEEECCCCCCCC	41.19	-
2074	Methylation	GALSGASRSLSPTRL HHHCCCCCCCCCCCH	40.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHAN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHAN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHAN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLGP1_HUMAN	DLGAP1	physical	12954649
SHAN1_HUMAN	SHANK1	physical	12954649
ARHG7_HUMAN	ARHGEF7	physical	12626503
BAIP2_HUMAN	BAIAP2	physical	12504591
SSR2_HUMAN	SSTR2	physical	10551867
SHRPN_HUMAN	SHARPIN	physical	11178875
AGRL2_HUMAN	LPHN2	physical	10964907
AGRB2_HUMAN	BAI2	physical	10964907
AGRL1_RAT	Lphn1	physical	10964907
SHAN1_HUMAN	SHANK1	physical	23897824
SHAN3_HUMAN	SHANK3	physical	23897824

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-275, AND MASSSPECTROMETRY.
PubMed: 18083107