| UniProt ID | AGRB2_HUMAN | |
|---|---|---|
| UniProt AC | O60241 | |
| Protein Name | Adhesion G protein-coupled receptor B2 {ECO:0000303|PubMed:25713288} | |
| Gene Name | ADGRB2 {ECO:0000312|HGNC:HGNC:944} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1585 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. [PubMed: 20367554] | |
| Protein Sequence | MENTGWMGKGHRMTPACPLLLSVILSLRLATAFDPAPSACSALASGVLYGAFSLQDLFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCAHFAPRLLPLDHYLVNFTCLRPSPEEAVAQAESEVGRPEEEEAEAAAGLELCSGSGPFTFLHFDKNFVQLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPGEAGAGSTTTTSPGPPAAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKKAAAGEIIYNKCPPNASGSASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYSGDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDAENKEKWDDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPVSAVSSDITFPMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATSGAAGSPGRGRGPGTVPPGPGHSHQRLLPADPDESSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEPLITVELSYIINGTTDPHCASWDYSRADASSGDWDTENCQTLETQAAHTRCQCQHLSTFAVLAQPPKDLTLELAGSPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGISDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQDVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGSLSFSPLPGNILVPMAASPGLGEPPPPQEANPVYMCGEGGLRQLDLTWLRPTEPGSEGDYMVLPRRTLSLQPGGGGGGGEDAPRARPEGTPRRAAKTVAHTEGYPSFLSVDHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKMGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSTAKREKRWSVSSGGAAERSVCTDKPSPGERPSLSQHRRHQSWSTFKSMTLGSLPPKPRERLTLHRAAAWEPTEPPDGDFQTEV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MENTGWMGKGH ----CCCCCCCCCCC | - | ||
| 106 | N-linked_Glycosylation | PLDHYLVNFTCLRPS CCCEEEEEEEEECCC | UniProtKB CARBOHYD | ||
| 191 | N-linked_Glycosylation | EVLLINNNNSSQFTC EEEEECCCCCCCEEE | UniProtKB CARBOHYD | ||
| 192 | N-linked_Glycosylation | VLLINNNNSSQFTCG EEEECCCCCCCEEEE | UniProtKB CARBOHYD | ||
| 279 | Phosphorylation | LFTTEMRYGEEPEEE CEECEECCCCCCCCC | 18083107 | ||
| 356 | N-linked_Glycosylation | LRETRPCNNSATCPV CCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 384 | Phosphorylation | SRSCGRGSRSRMRTC HCCCCCCCCCCCCCC | 20068231 | ||
| 386 | Phosphorylation | SCGRGSRSRMRTCVP CCCCCCCCCCCCCCC | 20068231 | ||
| 437 | N-linked_Glycosylation | PCSTSCANGTQQRSR CCCCCCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 443 | Phosphorylation | ANGTQQRSRKCSVAG CCCCCCCCCCCCCCC | 25307156 | ||
| 447 | Phosphorylation | QQRSRKCSVAGPAWA CCCCCCCCCCCCHHH | - | ||
| 455 | Phosphorylation | VAGPAWATCTGALTD CCCCHHHHCCCCCCC | - | ||
| 457 | Phosphorylation | GPAWATCTGALTDTR CCHHHHCCCCCCCCC | - | ||
| 543 | Phosphorylation | DEYVMLMTWKKAAAG CCHHHHHEEHHHHCC | - | ||
| 554 | Phosphorylation | AAAGEIIYNKCPPNA HHCCCEEEECCCCCC | - | ||
| 556 | Ubiquitination | AGEIIYNKCPPNASG CCCEEEECCCCCCCC | - | ||
| 560 | N-linked_Glycosylation | IYNKCPPNASGSASR EEECCCCCCCCCHHH | UniProtKB CARBOHYD | ||
| 594 | Phosphorylation | CISHEYRYLYLSLRE HHCHHHHHHHHHHHH | - | ||
| 596 | Phosphorylation | SHEYRYLYLSLREHL CHHHHHHHHHHHHHH | - | ||
| 645 | N-linked_Glycosylation | FSVDILRNVTDTFKR EEEEEHHHCCHHHHH | UniProtKB CARBOHYD | ||
| 655 | Phosphorylation | DTFKRATYVPSADDV HHHHHCCCCCCHHHH | - | ||
| 799 | Phosphorylation | VPPGPGHSHQRLLPA CCCCCCCCCCCCCCC | 26329039 | ||
| 843 | Phosphorylation | AVTSRVMTVTVRPPT EEEECEEEEEECCCC | - | ||
| 845 | Phosphorylation | TSRVMTVTVRPPTQP EECEEEEEECCCCCC | - | ||
| 850 | Phosphorylation | TVTVRPPTQPPAEPL EEEECCCCCCCCCCC | - | ||
| 867 | N-linked_Glycosylation | VELSYIINGTTDPHC EEEEEEECCCCCCCC | UniProtKB CARBOHYD | ||
| 1176 | Phosphorylation | MSAVLAMTDRRSVLF HHHHHHHCCHHHHHH | - | ||
| 1265 | Phosphorylation | EVNTCNPSTITGTLS ECCCCCHHHCCEEEE | 30266825 | ||
| 1266 | Phosphorylation | VNTCNPSTITGTLSR CCCCCHHHCCEEEEE | 30266825 | ||
| 1268 | Phosphorylation | TCNPSTITGTLSRLS CCCHHHCCEEEEECC | 30266825 | ||
| 1270 | Phosphorylation | NPSTITGTLSRLSLD CHHHCCEEEEECCCC | 30266825 | ||
| 1272 | Phosphorylation | STITGTLSRLSLDED HHCCEEEEECCCCCC | 30266825 | ||
| 1275 | Phosphorylation | TGTLSRLSLDEDEEP CEEEEECCCCCCCCC | 30266825 | ||
| 1351 | Phosphorylation | EPGSEGDYMVLPRRT CCCCCCCEEEECCCE | 25884760 | ||
| 1358 | Phosphorylation | YMVLPRRTLSLQPGG EEEECCCEEECCCCC | 28111955 | ||
| 1360 | Phosphorylation | VLPRRTLSLQPGGGG EECCCEEECCCCCCC | 28111955 | ||
| 1375 | Dimethylation | GGGEDAPRARPEGTP CCCCCCCCCCCCCCC | - | ||
| 1383 | Dimethylation | ARPEGTPRRAAKTVA CCCCCCCCCCHHHHH | - | ||
| 1384 | Dimethylation | RPEGTPRRAAKTVAH CCCCCCCCCHHHHHC | - | ||
| 1392 | Phosphorylation | AAKTVAHTEGYPSFL CHHHHHCCCCCCCCE | - | ||
| 1434 | Phosphorylation | PPTPSARQVPEPGER CCCCCCCCCCCCCCC | 32142685 | ||
| 1442 | Phosphorylation | VPEPGERSRTMPRTV CCCCCCCCCCCCCCC | 26437602 | ||
| 1444 | Phosphorylation | EPGERSRTMPRTVPG CCCCCCCCCCCCCCC | - | ||
| 1452 | Phosphorylation | MPRTVPGSTMKMGSL CCCCCCCCCCCCCCC | 26437602 | ||
| 1458 | Phosphorylation | GSTMKMGSLERKKLR CCCCCCCCCCCCCCC | 26091039 | ||
| 1467 | Phosphorylation | ERKKLRYSDLDFEKV CCCCCCCCCCCHHHH | 32142685 | ||
| 1482 | Phosphorylation | MHTRKRHSELYHELN HHHHHHHHHHHHHHH | 23909892 | ||
| 1485 | Phosphorylation | RKRHSELYHELNQKF HHHHHHHHHHHHHHH | 23909892 | ||
| 1511 | Phosphorylation | AKREKRWSVSSGGAA HHHHHCEEECCCCCC | 29759185 | ||
| 1513 | Phosphorylation | REKRWSVSSGGAAER HHHCEEECCCCCCCC | 29759185 | ||
| 1543 | Phosphorylation | SQHRRHQSWSTFKSM HHHHCCCCHHHHHHC | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AGRB2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AGRB2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AGRB2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AGRB2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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