AGRL1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRL1_RAT
• UniProt AC: O88917
• Protein Name: Adhesion G protein-coupled receptor L1 {ECO:0000312|RGD:620768}
• Gene Name: Adgrl1 {ECO:0000312|RGD:620768}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1515
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .; Isoform 2: Cell membrane. Cell projection, axon. Cell projection, growth cone. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Colocalizes
• Protein Description: Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.; Isoform 2: Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization..
• Protein Sequence: MARLAAALWSLCVTTVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLAFPNPYQFVSSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPAPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKQNVVLEVTVLSTEGQVQELVFPQEYASESSIQLSANTIKQNSRNGVVKVVFILYNNLGLFLSTENATVKLAGEAGTGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEAKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQYEVACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGAHGSLKTSAMRSNTRYYTGTQVPGQGRHIHQVSLGPRGRSALPESQKDPGGQSGPGDPLTFGLCPSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGASGGAKGPPPEPPVPPVPGVSEDEAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPNEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAAPSLEGPGPDGDGQMQLVTSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	RLAAALWSLCVTTVL HHHHHHHHHHHHHHH		25575281
14	Phosphorylation	ALWSLCVTTVLVTSA HHHHHHHHHHHHHHH		25575281
15	Phosphorylation	LWSLCVTTVLVTSAT HHHHHHHHHHHHHHC		25575281
19	Phosphorylation	CVTTVLVTSATQGLS HHHHHHHHHHCCCHH		25575281
20	Phosphorylation	VTTVLVTSATQGLSR HHHHHHHHHCCCHHH		25575281
22	Phosphorylation	TVLVTSATQGLSRAG HHHHHHHCCCHHHCC		25575281
26	Phosphorylation	TSATQGLSRAGLPFG HHHCCCHHHCCCCCH		25575281
98	N-linked_Glycosylation	IMSQRCNNRTQCVVV HHHHHCCCCCEEEEE		-
204	Phosphorylation	VAARHTTTYRLPNRV HCCCCCCEEECCCCC		16641100
205	Phosphorylation	AARHTTTYRLPNRVD CCCCCCEEECCCCCC		16641100
531	N-linked_Glycosylation	PRGPDLSNCTSPWVN CCCCCHHCCCCHHHH		22333914
571	Phosphorylation	SIYAGDVSSSVKLME CCCCCCHHHHHHHHH		28689409
572	Phosphorylation	IYAGDVSSSVKLMEQ CCCCCHHHHHHHHHH		28689409
573	Phosphorylation	YAGDVSSSVKLMEQL CCCCHHHHHHHHHHH		28689409
640	N-linked_Glycosylation	LESWKDMNATEQVHT HHHHHCCCHHHHHHH		22333914
741	N-linked_Glycosylation	GLFLSTENATVKLAG CCEEECCCCEEEECC		22333914
800	N-linked_Glycosylation	AKNHFNANCSFWNYS HHCCCCCCCCCCCCC		22333914
805	N-linked_Glycosylation	NANCSFWNYSERSML CCCCCCCCCCCCCHH		-
826	N-linked_Glycosylation	GCRLVESNKTHTTCA CEEEEECCCCCCCHH		22333914
1036	Ubiquitination	IRSSSVLKPDSSRLD HHCCCCCCCCCHHHH		-
1120	Phosphorylation	HSYCCIRSPPGGAHG CCEEEECCCCCCCCC		30240740
1128	Phosphorylation	PPGGAHGSLKTSAMR CCCCCCCCCCHHHCC		27097102
1139 (in isoform 2)	Phosphorylation	-		25403869
1144 (in isoform 4)	Phosphorylation	-		25403869
1202	Ubiquitination	MWNDTVRKQTESSFM HHHHHHHHHCCCCCC		-
1215	Phosphorylation	FMAGDINSTPTLNRG CCCCCCCCCCCCCCC		27097102
1216	Phosphorylation	MAGDINSTPTLNRGT CCCCCCCCCCCCCCC		27097102
1218	Phosphorylation	GDINSTPTLNRGTMG CCCCCCCCCCCCCCC		27097102
1237	Methylation	TNPVLQPRGGTSPYN CCCCCCCCCCCCCCC		-
1263	Phosphorylation	SSPPVFNSPGSYREP CCCCCCCCCCCCCCC		-
1424	Phosphorylation	SSPPGRDSLYASGAN CCCCCCCCCCCCCCC		30181290
1426	Phosphorylation	PPGRDSLYASGANLR CCCCCCCCCCCCCCC		27097102
1428	Phosphorylation	GRDSLYASGANLRDS CCCCCCCCCCCCCCC		28432305
1435	Phosphorylation	SGANLRDSPSYPDSS CCCCCCCCCCCCCCC		22673903
1437	Phosphorylation	ANLRDSPSYPDSSPE CCCCCCCCCCCCCCC		22673903
1438	Phosphorylation	NLRDSPSYPDSSPEG CCCCCCCCCCCCCCC		22673903
1441	Phosphorylation	DSPSYPDSSPEGPNE CCCCCCCCCCCCCCC		22673903
1442	Phosphorylation	SPSYPDSSPEGPNEA CCCCCCCCCCCCCCC		22673903
1481	Phosphorylation	ARNPLQGYYQVRRPS ECCCCCCEEEECCCC		27097102
1482	Phosphorylation	RNPLQGYYQVRRPSH CCCCCCEEEECCCCC		27097102
1497	Phosphorylation	EGYLAAPSLEGPGPD CCEEECCCCCCCCCC		-
1513	Phosphorylation	DGQMQLVTSL----- CCCEEEEECC-----		25403869
1514	Phosphorylation	GQMQLVTSL------ CCEEEEECC------		25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRL1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRL1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRL1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of AGRL1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.