AGRL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRL2_HUMAN
• UniProt AC: O95490
• Protein Name: Adhesion G protein-coupled receptor L2 {ECO:0000303|PubMed:25713288}
• Gene Name: ADGRL2 {ECO:0000312|HGNC:HGNC:18582}
• Organism: Homo sapiens (Human).
• Sequence Length: 1459
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis..
• Protein Sequence: MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTYKYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEATWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIISTTSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWPQTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAPSAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFEKMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHHKELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRDSPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	GLVRRELSCEGYSID CEEEEEEECCCEEEE		23403867
46	Phosphorylation	ELSCEGYSIDLRCPG EEECCCEEEEEECCC		23403867
99	N-linked_Glycosylation	IMTQRCNNRTQCIVV HHHHHCCCCCEEEEE		UniProtKB CARBOHYD
295	Phosphorylation	ISQLNPYTLRFEATW EEECCCCEEEEEEEE		24719451
331	N-linked_Glycosylation	VRSVYQDNESETGKN HHHHHCCCCCCCCCC		UniProtKB CARBOHYD
337 (in isoform 2)	Ubiquitination	-		-
339	Phosphorylation	ESETGKNSIDYIYNT CCCCCCCCEEEEEEC		-
342	Phosphorylation	TGKNSIDYIYNTRLN CCCCCEEEEEECCCC		-
408	O-linked_Glycosylation	PTTAVTITSSAELFK CCEEEEEECHHHHHH		OGP
416	O-linked_Glycosylation	SSAELFKTIISTTST CHHHHHHHHHHCCCC		OGP
416	Phosphorylation	SSAELFKTIISTTST CHHHHHHHHHHCCCC		-
419	O-linked_Glycosylation	ELFKTIISTTSTTSQ HHHHHHHHCCCCCCC		OGP
420	O-linked_Glycosylation	LFKTIISTTSTTSQK HHHHHHHCCCCCCCC		OGP
421	O-linked_Glycosylation	FKTIISTTSTTSQKG HHHHHHCCCCCCCCC		OGP
422	O-linked_Glycosylation	KTIISTTSTTSQKGP HHHHHCCCCCCCCCC		OGP
423	O-linked_Glycosylation	TIISTTSTTSQKGPM HHHHCCCCCCCCCCC		OGP
425	O-linked_Glycosylation	ISTTSTTSQKGPMST HHCCCCCCCCCCCCE		OGP
425	Phosphorylation	ISTTSTTSQKGPMST HHCCCCCCCCCCCCE		-
431	O-linked_Glycosylation	TSQKGPMSTTVAGSQ CCCCCCCCEEECCCC		OGP
431	Phosphorylation	TSQKGPMSTTVAGSQ CCCCCCCCEEECCCC		-
432	O-linked_Glycosylation	SQKGPMSTTVAGSQE CCCCCCCEEECCCCC		OGP
432	Phosphorylation	SQKGPMSTTVAGSQE CCCCCCCEEECCCCC		22210691
433	O-linked_Glycosylation	QKGPMSTTVAGSQEG CCCCCCEEECCCCCC		OGP
437	O-linked_Glycosylation	MSTTVAGSQEGSKGT CCEEECCCCCCCCCC		OGP
441	O-linked_Glycosylation	VAGSQEGSKGTKPPP ECCCCCCCCCCCCCC		OGP
441	Phosphorylation	VAGSQEGSKGTKPPP ECCCCCCCCCCCCCC		22210691
445	Acetylation	QEGSKGTKPPPAVST CCCCCCCCCCCCCCC		30589837
459	O-linked_Glycosylation	TTKIPPITNIFPLPE CCCCCCCCCCCCCCH		OGP
459	Phosphorylation	TTKIPPITNIFPLPE CCCCCCCCCCCCCCH		24667141
520	N-linked_Glycosylation	PKGPDLSNCTSHWVN CCCCCHHHCHHHHHH		UniProtKB CARBOHYD
561	Phosphorylation	VFAGDVSSSVRLMEQ CCCCCHHHHHHHHHH		21888424
562	Phosphorylation	FAGDVSSSVRLMEQL CCCCHHHHHHHHHHH		21888424
629	N-linked_Glycosylation	LESWKHMNSSEQAHT HHHHHCCCHHHHHHH		19159218
692 (in isoform 2)	Ubiquitination	-		-
705	Acetylation	QLSANTVKQNSRNGL EECCHHHCCCCCCCH		7662899
731	N-linked_Glycosylation	GQFLSTENATIKLGA HHHHCCCCCEEEECC		UniProtKB CARBOHYD
743	Methylation	LGADFIGRNSTIAVN ECCCCCCCCCEEEEC		115481869
744	N-linked_Glycosylation	GADFIGRNSTIAVNS CCCCCCCCCEEEECC		UniProtKB CARBOHYD
787	N-linked_Glycosylation	PDNYFNANCSFWNYS CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
792	N-linked_Glycosylation	NANCSFWNYSERTMM CCCCCCCCCCCCCCC		UniProtKB CARBOHYD
797	Phosphorylation	FWNYSERTMMGYWST CCCCCCCCCCCEEEC		-
801	Phosphorylation	SERTMMGYWSTQGCK CCCCCCCEEECCCEE		-
803	Phosphorylation	RTMMGYWSTQGCKLV CCCCCEEECCCEEEE		-
804	Phosphorylation	TMMGYWSTQGCKLVD CCCCEEECCCEEEEC		-
813	N-linked_Glycosylation	GCKLVDTNKTRTTCA CEEEECCCCCCCCCC		UniProtKB CARBOHYD
952	Phosphorylation	SEYSRKKYYYVAGYL HHHHCCCEEEEEEEE		-
954	Phosphorylation	YSRKKYYYVAGYLFP HHCCCEEEEEEEEEE		27762562
958	Phosphorylation	KYYYVAGYLFPATVV CEEEEEEEEEEEEEE		27762562
973	Phosphorylation	GVSAAIDYKSYGTEK EEEEEECCCCCCCCC		-
1110	Phosphorylation	YCCGGLPTESPHSSV CCCCCCCCCCCCCCC		26307563
1112	Phosphorylation	CGGLPTESPHSSVKA CCCCCCCCCCCCCCC		22617229
1115	Phosphorylation	LPTESPHSSVKASTT CCCCCCCCCCCCCCC		26307563
1116	Phosphorylation	PTESPHSSVKASTTR CCCCCCCCCCCCCCC		28450419
1128	Phosphorylation	TTRTSARYSSGTQSR CCCCCCCCCCCCHHH		24043423
1129	Phosphorylation	TRTSARYSSGTQSRI CCCCCCCCCCCHHHH		24043423
1130	Phosphorylation	RTSARYSSGTQSRIR CCCCCCCCCCHHHHH		24043423
1132	Phosphorylation	SARYSSGTQSRIRRM CCCCCCCCHHHHHHH		24043423
1134	Phosphorylation	RYSSGTQSRIRRMWN CCCCCCHHHHHHHHH		24719451
1135 (in isoform 2)	Phosphorylation	-		28450419
1135 (in isoform 4)	Phosphorylation	-		28450419
1137 (in isoform 2)	Phosphorylation	-		28450419
1137 (in isoform 4)	Phosphorylation	-		28450419
1138 (in isoform 2)	Phosphorylation	-		28450419
1138 (in isoform 4)	Phosphorylation	-		28450419
1141 (in isoform 2)	Phosphorylation	-		28450419
1141 (in isoform 4)	Phosphorylation	-		28450419
1143	Phosphorylation	IRRMWNDTVRKQSES HHHHHHHHHHHHCCC		-
1146 (in isoform 2)	Phosphorylation	-		28450419
1146 (in isoform 4)	Phosphorylation	-		28450419
1147 (in isoform 2)	Phosphorylation	-		28450419
1147 (in isoform 4)	Phosphorylation	-		28450419
1148 (in isoform 5)	Phosphorylation	-		28450419
1150 (in isoform 5)	Phosphorylation	-		28450419
1151 (in isoform 5)	Phosphorylation	-		28450419
1154 (in isoform 5)	Phosphorylation	-		28450419
1159 (in isoform 5)	Phosphorylation	-		28450419
1160 (in isoform 5)	Phosphorylation	-		28450419
1223	Phosphorylation	RDTSAMDTLPLNGNF CCCCCCCCCCCCCCC		28348404
1233	Phosphorylation	LNGNFNNSYSLHKGD CCCCCCCCCCCCCCC		25884760
1234	Phosphorylation	NGNFNNSYSLHKGDY CCCCCCCCCCCCCCC		-
1241	Phosphorylation	YSLHKGDYNDSVQVV CCCCCCCCCCCEEEE		25884760
1265	Phosphorylation	AFEKMIISELVHNNL HHHHHHHHHHHHCCC		25002506
1275	Phosphorylation	VHNNLRGSSKTHNLE HHCCCCCCCCCCCEE		29978859
1276	Phosphorylation	HNNLRGSSKTHNLEL HCCCCCCCCCCCEEE		29978859
1278	Phosphorylation	NLRGSSKTHNLELTL CCCCCCCCCCEEEEE		26471730
1284	Phosphorylation	KTHNLELTLPVKPVI CCCCEEEEEEEECCC		26471730
1294	Phosphorylation	VKPVIGGSSSEDDAI EECCCCCCCCCCCEE		25921289
1295	Phosphorylation	KPVIGGSSSEDDAIV ECCCCCCCCCCCEEE		25921289
1296	Phosphorylation	PVIGGSSSEDDAIVA CCCCCCCCCCCEEEE		25921289
1306	Phosphorylation	DAIVADASSLMHSDN CEEEEEHHHHHCCCC		26471730
1307	Phosphorylation	AIVADASSLMHSDNP EEEEEHHHHHCCCCC		26471730
1332	Phosphorylation	APLIPQRTHSLLYQP CCCCCCHHHHHHCCC		28450419
1334	Phosphorylation	LIPQRTHSLLYQPQK CCCCHHHHHHCCCCH		23898821
1337	Phosphorylation	QRTHSLLYQPQKKVK CHHHHHHCCCCHHHC		25884760
1345	Phosphorylation	QPQKKVKSEGTDSYV CCCHHHCCCCCHHHH		27732954
1348	Phosphorylation	KKVKSEGTDSYVSQL HHHCCCCCHHHHHHH		27732954
1350	Phosphorylation	VKSEGTDSYVSQLTA HCCCCCHHHHHHHHH		27732954
1351	Phosphorylation	KSEGTDSYVSQLTAE CCCCCHHHHHHHHHH		25884760
1353	Phosphorylation	EGTDSYVSQLTAEAE CCCHHHHHHHHHHHH		27732954
1356	Phosphorylation	DSYVSQLTAEAEDHL HHHHHHHHHHHHHHH		27251275
1365	Phosphorylation	EAEDHLQSPNRDSLY HHHHHHCCCCCCCCC		28192239
1370	Phosphorylation	LQSPNRDSLYTSMPN HCCCCCCCCCCCCCC		25921289
1372	Phosphorylation	SPNRDSLYTSMPNLR CCCCCCCCCCCCCCC		25884760
1373	Phosphorylation	PNRDSLYTSMPNLRD CCCCCCCCCCCCCCC		25850435
1374	Phosphorylation	NRDSLYTSMPNLRDS CCCCCCCCCCCCCCC		19664994
1381	Phosphorylation	SMPNLRDSPYPESSP CCCCCCCCCCCCCCC		19060867
1383	Phosphorylation	PNLRDSPYPESSPDM CCCCCCCCCCCCCCC		27732954
1386	Phosphorylation	RDSPYPESSPDMEED CCCCCCCCCCCCCCC		29978859
1387	Phosphorylation	DSPYPESSPDMEEDL CCCCCCCCCCCCCCC		29978859
1395	Phosphorylation	PDMEEDLSPSRRSEN CCCCCCCCCCCCCCC		29523821
1397	Phosphorylation	MEEDLSPSRRSENED CCCCCCCCCCCCCCC		29523821
1400	Phosphorylation	DLSPSRRSENEDIYY CCCCCCCCCCCCCCC		26356563
1406	Phosphorylation	RSENEDIYYKSMPNL CCCCCCCCCCCCCCC		25884760
1407	Phosphorylation	SENEDIYYKSMPNLG CCCCCCCCCCCCCCC		25884760
1409	Phosphorylation	NEDIYYKSMPNLGAG CCCCCCCCCCCCCCC		26356563
1423	Phosphorylation	GHQLQMCYQISRGNS CCEEEEEEEECCCCC		26356563
1426	Phosphorylation	LQMCYQISRGNSDGY EEEEEEECCCCCCCE		26356563
1430	Phosphorylation	YQISRGNSDGYIIPI EEECCCCCCCEEEEC		19664994
1433	Phosphorylation	SRGNSDGYIIPINKE CCCCCCCEEEECCCC		30266825
1457	Phosphorylation	EGQMQLVTSL----- CCEEEEEECC-----		27732954
1458	Phosphorylation	GQMQLVTSL------ CEEEEEECC------		23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCK1_HUMAN	NCK1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.