DLGP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLGP1_HUMAN
• UniProt AC: O14490
• Protein Name: Disks large-associated protein 1
• Gene Name: DLGAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 977
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse.
• Protein Description: Part of the postsynaptic scaffold in neuronal cells..
• Protein Sequence: MKGLSGSRSHHHGVTCDSACDSLSHHSDRKPYLLSPVEHHPADHPYYTQRNSFQAECVGPFSDPLASSTFPRRHYTSQQELKDECALVPRTLATKANRIPANLLDQFERQLPLSRDGYHTLQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGPSKGSVNGGKASPDEAQAARYGKRSKSKERRAEPKARPSTSPGWWSSDDNLDGDMCIYHAPSGVMTMGRCPDRSASQYFLEAYNTISEQAVKASRSNNDVKCSTCANLPVSLDTPLLKKSAWSSTLTVSRAREVYQKASVNMDQAMVKSESCQQERSCQYLQVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDIISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGNNTATVTTTTTIATVTTEDRKKDHFKKNRCLSIGIQVDDAEEPDKTGENKAPSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPMARQFSRDASTSTVSIQGSGNHYHACAADDDFDTDFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENNLPEDILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAESIEIYIPEAQTRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MKGLSGSRSHHHGV -CCCCCCCCCCCCCC	27.51	-
24 (in isoform 2)	Phosphorylation	-	24.09	22115753
24 (in isoform 6)	Phosphorylation	-	24.09	22115753
24 (in isoform 3)	Phosphorylation	-	24.09	22115753
24	Phosphorylation	DSACDSLSHHSDRKP HHHCHHCCCCCCCCC	24.09	-
26 (in isoform 6)	Phosphorylation	-	28.19	22115753
26 (in isoform 2)	Phosphorylation	-	28.19	22115753
26 (in isoform 3)	Phosphorylation	-	28.19	22115753
27 (in isoform 3)	Phosphorylation	-	33.42	22115753
27 (in isoform 6)	Phosphorylation	-	33.42	22115753
27 (in isoform 2)	Phosphorylation	-	33.42	22115753
52	Phosphorylation	PYYTQRNSFQAECVG CCCCCCCCCEEEEEC	22.41	27499020
67	Phosphorylation	PFSDPLASSTFPRRH CCCCCCCCCCCCCCC	37.28	28348404
68	Phosphorylation	FSDPLASSTFPRRHY CCCCCCCCCCCCCCC	28.58	28348404
69	Phosphorylation	SDPLASSTFPRRHYT CCCCCCCCCCCCCCC	34.85	28348404
75	Phosphorylation	STFPRRHYTSQQELK CCCCCCCCCCHHHHH	13.28	23403867
76	Phosphorylation	TFPRRHYTSQQELKD CCCCCCCCCHHHHHH	17.59	23403867
77	Phosphorylation	FPRRHYTSQQELKDE CCCCCCCCHHHHHHH	23.77	23403867
118	Phosphorylation	LPLSRDGYHTLQYKR CCCCCCCCCCEEEEE	8.91	-
134	Phosphorylation	AVEHRSDSPGRIRHL EECCCCCCCHHHHHH	30.42	22468782
152	Phosphorylation	VQKLFTKSHSLEGPS HHHHHHCCCCCCCCC	18.43	22210691
154	Phosphorylation	KLFTKSHSLEGPSKG HHHHCCCCCCCCCCC	34.90	24719451
162	Phosphorylation	LEGPSKGSVNGGKAS CCCCCCCCCCCCCCC	19.02	30108239
169	Phosphorylation	SVNGGKASPDEAQAA CCCCCCCCHHHHHHH	36.05	30108239
203	Phosphorylation	STSPGWWSSDDNLDG CCCCCCCCCCCCCCC	19.85	28348404
204	Phosphorylation	TSPGWWSSDDNLDGD CCCCCCCCCCCCCCC	34.95	24719451
231	Phosphorylation	MGRCPDRSASQYFLE CCCCCCCCHHHHHHH	39.38	28348404
233	Phosphorylation	RCPDRSASQYFLEAY CCCCCCHHHHHHHHH	27.02	28348404
260	Phosphorylation	SNNDVKCSTCANLPV CCCCCCCCCCCCCCC	22.32	29116813
260	O-linked_Glycosylation	SNNDVKCSTCANLPV CCCCCCCCCCCCCCC	22.32	28657654
271	Phosphorylation	NLPVSLDTPLLKKSA CCCCCCCCCHHHCCH	22.56	24719451
280	O-linked_Glycosylation	LLKKSAWSSTLTVSR HHHCCHHHCCEEHHH	17.11	28657654
280	Phosphorylation	LLKKSAWSSTLTVSR HHHCCHHHCCEEHHH	17.11	29083192
281	Phosphorylation	LKKSAWSSTLTVSRA HHCCHHHCCEEHHHH	19.41	29083192
282	Phosphorylation	KKSAWSSTLTVSRAR HCCHHHCCEEHHHHH	22.41	29083192
284	Phosphorylation	SAWSSTLTVSRAREV CHHHCCEEHHHHHHH	19.27	30631047
286	Phosphorylation	WSSTLTVSRAREVYQ HHCCEEHHHHHHHHH	18.26	29083192
314	Phosphorylation	ESCQQERSCQYLQVP HHHCCHHCCCEECCC	12.57	-
317	Phosphorylation	QQERSCQYLQVPQDE CCHHCCCEECCCHHH	11.93	-
329	Phosphorylation	QDEWTGYTPRGKDDE HHHCCCCCCCCCCCC	14.09	-
346	Phosphorylation	CRRMRSGSYIKAMGD CHHHCCCCCEEECCC	25.57	22117215
347	Phosphorylation	RRMRSGSYIKAMGDE HHHCCCCCEEECCCC	15.23	22817900
356	Phosphorylation	KAMGDEDSGDSDTSP EECCCCCCCCCCCCC	42.31	27732954
359	Phosphorylation	GDEDSGDSDTSPKPS CCCCCCCCCCCCCCC	46.44	25307156
361	Phosphorylation	EDSGDSDTSPKPSPK CCCCCCCCCCCCCHH	51.37	25307156
362	Phosphorylation	DSGDSDTSPKPSPKV CCCCCCCCCCCCHHH	35.60	27732954
366	Phosphorylation	SDTSPKPSPKVAARR CCCCCCCCHHHHHHH	43.40	25307156
375	Phosphorylation	KVAARRESYLKATQP HHHHHHHHHHHHCCC	33.67	22117215
380	O-linked_Glycosylation	RESYLKATQPSLTEL HHHHHHHCCCCCHHC	39.15	28657654
380	Phosphorylation	RESYLKATQPSLTEL HHHHHHHCCCCCHHC	39.15	30108239
383	Phosphorylation	YLKATQPSLTELTTL HHHHCCCCCHHCEEE	37.80	30108239
385	Phosphorylation	KATQPSLTELTTLKI HHCCCCCHHCEEEEE	33.03	30108239
388	Phosphorylation	QPSLTELTTLKISNE CCCCHHCEEEEECCC	24.69	30108239
389	Phosphorylation	PSLTELTTLKISNEH CCCHHCEEEEECCCC	38.38	30108239
397	Phosphorylation	LKISNEHSPKLQIRS EEECCCCCCCCEEEC	19.97	24719451
406	Phosphorylation	KLQIRSHSYLRAVSE CCEEECCHHHHHHEE	27.40	22117215
412	Phosphorylation	HSYLRAVSEVSINRS CHHHHHHEEEEECCC	31.15	27174698
415	Phosphorylation	LRAVSEVSINRSLDS HHHHEEEEECCCCCC	15.30	27174698
419	Phosphorylation	SEVSINRSLDSLDPA EEEEECCCCCCCCCC	31.85	30108239
422	Phosphorylation	SINRSLDSLDPAGLL EECCCCCCCCCCCCC	39.71	30108239
430	Phosphorylation	LDPAGLLTSPKFRSR CCCCCCCCCHHHHCC	48.29	30108239
431	Phosphorylation	DPAGLLTSPKFRSRN CCCCCCCCHHHHCCC	26.51	30108239
440	Phosphorylation	KFRSRNESYMRAMST HHHCCCHHHHHHHHH	27.98	22117215
491	Phosphorylation	PGCFRMRSHSYVRAI CCCEECCCHHHHHHH	13.87	-
493	Phosphorylation	CFRMRSHSYVRAIEK CEECCCHHHHHHHHC	26.94	22117215
500	Ubiquitination	SYVRAIEKGCSQDDE HHHHHHHCCCCCCCC	60.13	-
503	Phosphorylation	RAIEKGCSQDDECVS HHHHCCCCCCCCCEE	45.36	24076635
510	Phosphorylation	SQDDECVSLRSSSPP CCCCCCEECCCCCCC	29.71	30108239
515	Phosphorylation	CVSLRSSSPPRTTTT CEECCCCCCCCCCCE	39.92	23898821
525	O-linked_Glycosylation	RTTTTVRTIQSSTVS CCCCEEEEEECCCCC	21.02	28657654
525	Phosphorylation	RTTTTVRTIQSSTVS CCCCEEEEEECCCCC	21.02	24114839
528	Phosphorylation	TTVRTIQSSTVSSCI CEEEEEECCCCCCCE	24.91	24114839
530	Phosphorylation	VRTIQSSTVSSCITT EEEEECCCCCCCEEE	29.65	22817900
536	Phosphorylation	STVSSCITTYKKTPP CCCCCCEEECCCCCC	28.53	22817900
537	Phosphorylation	TVSSCITTYKKTPPP CCCCCEEECCCCCCC	17.27	22817900
541	Phosphorylation	CITTYKKTPPPVPPR CEEECCCCCCCCCCC	36.55	25307156
561	Phosphorylation	FISITAQSSTESAQD EEEEEECCCCHHHHH	36.44	24076635
562	Phosphorylation	ISITAQSSTESAQDA EEEEECCCCHHHHHH	24.90	24076635
563	Phosphorylation	SITAQSSTESAQDAY EEEECCCCHHHHHHH	38.92	24076635
565	Phosphorylation	TAQSSTESAQDAYMD EECCCCHHHHHHHHC	31.17	28348404
587	Phosphorylation	IISQSGLSNSTESLD CCCCCCCCCCCCCHH	32.06	25307156
589	Phosphorylation	SQSGLSNSTESLDSM CCCCCCCCCCCHHHH	30.12	20363803
590	Phosphorylation	QSGLSNSTESLDSMK CCCCCCCCCCHHHHH	33.57	27732954
592	Phosphorylation	GLSNSTESLDSMKAL CCCCCCCCHHHHHHH	37.25	20363803
595	Phosphorylation	NSTESLDSMKALTAA CCCCCHHHHHHHHHH	27.72	20363803
651	Phosphorylation	FKKNRCLSIGIQVDD CCCCCEEEEEEECCC	23.53	22617229
673	Acetylation	GENKAPSKFQSVGVQ CCCCCCCCHHCCCCE	46.49	19824837
693	Phosphorylation	CFRRFTRSNSVTTAV HHHHHHCCCCCCEEE	30.33	28348404
695	Phosphorylation	RRFTRSNSVTTAVQA HHHHCCCCCCEEEHH	23.30	27251275
697	Phosphorylation	FTRSNSVTTAVQADL HHCCCCCCEEEHHCC	14.62	28348404
698	Phosphorylation	TRSNSVTTAVQADLD HCCCCCCEEEHHCCC	23.75	28348404
932	Phosphorylation	APLIRERSLESSQRQ CCCCCHHCCCHHHHH	31.56	28355574
958	Phosphorylation	AASVRQNSATESAES HHHHHHCCCCCCCHH	28.38	15345747
960	Phosphorylation	SVRQNSATESAESIE HHHHCCCCCCCHHEE	30.23	26657352
962	Phosphorylation	RQNSATESAESIEIY HHCCCCCCCHHEEEE	32.74	24076635

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
44	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
349	S	Phosphorylation	Kinase	CAMK2B	Q13554	PSP
393	S	Phosphorylation	Kinase	CAMK2B	Q13554	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLGP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLGP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYL2_HUMAN	DYNLL2	physical	10844022
DYL1_HUMAN	DYNLL1	physical	10844022
MYO5A_HUMAN	MYO5A	physical	10844022
DLG2_HUMAN	DLG2	physical	10844022
SHAN2_HUMAN	SHANK2	physical	10844022
DLG4_HUMAN	DLG4	physical	10844022
DLG4_HUMAN	DLG4	physical	9115257
DLG1_HUMAN	DLG1	physical	9286858
DLG4_HUMAN	DLG4	physical	9286858
NMDE1_HUMAN	GRIN2A	physical	9286858
CTNB1_HUMAN	CTNNB1	physical	9286858
SHAN2_HUMAN	SHANK2	physical	10527873
DLG4_HUMAN	DLG4	physical	10527873
DLG1_HUMAN	DLG1	physical	11060025
DLG4_HUMAN	DLG4	physical	11060025
DLG4_HUMAN	DLG4	physical	9024696
DLG1_HUMAN	DLG1	physical	9024696

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.