SHAN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHAN2_HUMAN
• UniProt AC: Q9UPX8
• Protein Name: SH3 and multiple ankyrin repeat domains protein 2
• Gene Name: SHANK2
• Organism: Homo sapiens (Human).
• Sequence Length: 1470
• Subcellular Localization: Apical cell membrane. Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine. Colocalizes with cortactin in growth cones in different
• Protein Description: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction..
• Protein Sequence: MKSLLNAFTKKEVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPPPSPTTYNCPKSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYSLDSEDLYSRNAGPQANFRNKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAAAIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQLSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGNYVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAGFPTVTRQNTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVDATKLDNALQEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGSMEEAVILPFRIPPPPLASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQKKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSSDHHLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSNALYQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAKVLQPRTSKLWGDVTEIKSPILSGPKANVISELNSILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTVRPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLPAPLSAATASPSPALSDVFSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16 (in isoform 2)	Phosphorylation	-	32.85	23663014
16 (in isoform 4)	Phosphorylation	-	32.85	23663014
18 (in isoform 2)	Phosphorylation	-	6.97	23663014
18 (in isoform 4)	Phosphorylation	-	6.97	23663014
20 (in isoform 3)	Phosphorylation	-	27.68	-
21	Phosphorylation	PFREAPAYSNRRRRP CCCCCCCCCCCCCCC	12.86	23312004
22	Phosphorylation	FREAPAYSNRRRRPP CCCCCCCCCCCCCCC	26.43	23312004
28 (in isoform 3)	Phosphorylation	-	25.36	-
41	Phosphorylation	APRVLLRSNSDNNLN CCEEEECCCCCCCCC	40.43	22617229
43	Phosphorylation	RVLLRSNSDNNLNAS EEEECCCCCCCCCCC	42.85	30278072
50	Phosphorylation	SDNNLNASAPDWAVC CCCCCCCCCCCEEHH	38.98	28857561
56 (in isoform 3)	Phosphorylation	-	2.00	29978859
58	Phosphorylation	APDWAVCSTATSHRS CCCEEHHHHHCCCCC	17.93	26330541
59	Phosphorylation	PDWAVCSTATSHRSL CCEEHHHHHCCCCCC	28.91	26330541
61	Phosphorylation	WAVCSTATSHRSLSP EEHHHHHCCCCCCCH	25.75	27251275
62	Phosphorylation	AVCSTATSHRSLSPQ EHHHHHCCCCCCCHH	17.90	27251275
65	Phosphorylation	STATSHRSLSPQLLQ HHHCCCCCCCHHHHH	27.98	22617229
67	Phosphorylation	ATSHRSLSPQLLQQM HCCCCCCCHHHHHCC	16.31	30278072
69 (in isoform 3)	Phosphorylation	-	51.97	29978859
76	Phosphorylation	QLLQQMPSKPEGAAK HHHHCCCCCCCCCHH	56.34	21406692
79 (in isoform 3)	Phosphorylation	-	66.26	-
84	Phosphorylation	KPEGAAKTIGSYVPG CCCCCHHCHHHCCCC	26.33	22199227
87	Phosphorylation	GAAKTIGSYVPGPRS CCHHCHHHCCCCCCC	21.07	24719451
88	Phosphorylation	AAKTIGSYVPGPRSR CHHCHHHCCCCCCCC	12.88	22199227
90 (in isoform 3)	Phosphorylation	-	38.55	30257219
94	Phosphorylation	SYVPGPRSRSPSLNR HCCCCCCCCCCCHHC	40.00	22199227
96	Phosphorylation	VPGPRSRSPSLNRLG CCCCCCCCCCHHCCC	21.78	22199227
98	Phosphorylation	GPRSRSPSLNRLGGA CCCCCCCCHHCCCCC	39.25	22199227
101 (in isoform 3)	Phosphorylation	-	39.75	-
120	Phosphorylation	QPLWHVGSPFALGAN CCCEECCCCCCCCCC	18.76	29514088
130	Phosphorylation	ALGANKDSLSAFEYP CCCCCCCCCCCCCCC	26.32	28348404
132	Phosphorylation	GANKDSLSAFEYPGP CCCCCCCCCCCCCCC	34.56	28348404
144	Phosphorylation	PGPKRKLYSAVPGRL CCCCCEEEEECCCCE	9.53	21945579
145	Phosphorylation	GPKRKLYSAVPGRLF CCCCEEEEECCCCEE	32.97	21945579
149 (in isoform 3)	Phosphorylation	-	32.12	24719451
154	Phosphorylation	VPGRLFVAVKPYQPQ CCCCEEEEECCCCCC	9.04	-
158	Phosphorylation	LFVAVKPYQPQVDGE EEEEECCCCCCCCCC	27.40	-
163 (in isoform 4)	Phosphorylation	-	43.70	27732954
165 (in isoform 4)	Phosphorylation	-	36.65	27732954
166 (in isoform 4)	Phosphorylation	-	5.56	27732954
202 (in isoform 3)	Phosphorylation	-	65.20	-
211	Phosphorylation	VQCKPRDSQAETRAD ECCCCCCCHHCHHHH	32.35	28348404
228	Phosphorylation	KKLFRHYTVGSYDSF HHHHHHCCCCCCCCC	16.56	-
231	Phosphorylation	FRHYTVGSYDSFDTS HHHCCCCCCCCCCCC	22.79	24719451
233 (in isoform 3)	Phosphorylation	-	44.52	27251275
234	Phosphorylation	YTVGSYDSFDTSSDC CCCCCCCCCCCCCCE	19.45	28348404
237	Phosphorylation	GSYDSFDTSSDCIIE CCCCCCCCCCCEEEE	28.28	24719451
243	Phosphorylation	DTSSDCIIEEKTVVL CCCCCEEEEECEEEE	7.61	-
249 (in isoform 3)	Phosphorylation	-	5.92	25332170
309	Phosphorylation	TGDFLIEVNNENVVK CCCEEEEECCCCEEE	8.06	-
329	Phosphorylation	VVNMIRQGGNHLVLK HHHHHEECCCEEEEE	29.08	-
339	Phosphorylation	HLVLKVVTVTRNLDP EEEEEEEEEECCCCC	21.10	26356563
340	Phosphorylation	LVLKVVTVTRNLDPD EEEEEEEEECCCCCC	2.98	-
341	Phosphorylation	VLKVVTVTRNLDPDD EEEEEEEECCCCCCC	12.41	26356563
349	Phosphorylation	RNLDPDDTARKKAPP CCCCCCCHHHHCCCC	35.42	-
352	Phosphorylation	DPDDTARKKAPPPPK CCCCHHHHCCCCCCC	51.31	-
363	Phosphorylation	PPPKRAPTTALTLRS CCCCCCCCCCHHHCC	24.58	23312004
364	Phosphorylation	PPKRAPTTALTLRSK CCCCCCCCCHHHCCC	20.72	29083192
367	Phosphorylation	RAPTTALTLRSKSMT CCCCCCHHHCCCCCH	20.05	23312004
370	Phosphorylation	TTALTLRSKSMTSEL CCCHHHCCCCCHHHH	31.99	29759185
371	Phosphorylation	TALTLRSKSMTSELE CCHHHCCCCCHHHHH	37.50	-
372	Phosphorylation	ALTLRSKSMTSELEE CHHHCCCCCHHHHHH	28.65	29759185
374	Phosphorylation	TLRSKSMTSELEELV HHCCCCCHHHHHHHH	26.58	29759185
375	Phosphorylation	LRSKSMTSELEELVD HCCCCCHHHHHHHHH	31.38	-
379	Phosphorylation	SMTSELEELVDKASV CCHHHHHHHHHHHHH	67.71	-
385	Phosphorylation	EELVDKASVRKKKDK HHHHHHHHHHCCCCC	28.35	29759185
401	Phosphorylation	EEIVPASKPSRAAEN HHHCCCCCCCHHHHH	49.47	-
402	Phosphorylation	EIVPASKPSRAAENM HHCCCCCCCHHHHHC	26.93	-
434	Phosphorylation	FPAGSDMNSVYERQG CCCCCCCCCHHHHCC	33.06	-
435	Phosphorylation	PAGSDMNSVYERQGI CCCCCCCCHHHHCCE	21.31	30257219
437	Phosphorylation	GSDMNSVYERQGIAV CCCCCCHHHHCCEEE	12.76	30257219
440	Phosphorylation	MNSVYERQGIAVMTP CCCHHHHCCEEEECC	35.39	-
446	Phosphorylation	RQGIAVMTPTVPGSP HCCEEEECCCCCCCC	14.81	23312004
448	Phosphorylation	GIAVMTPTVPGSPKA CEEEECCCCCCCCCC	30.11	25311616
452	Phosphorylation	MTPTVPGSPKAPFLG ECCCCCCCCCCCCCC	19.70	28355574
455	Phosphorylation	TVPGSPKAPFLGIPR CCCCCCCCCCCCCCC	11.94	-
470	Phosphorylation	GTMRRQKSIDSRIFL CCCCCCCCCCCCHHH	24.24	-
478	Phosphorylation	IDSRIFLSGITEEER CCCCHHHCCCCHHHH	19.87	-
481	O-linked_Glycosylation	RIFLSGITEEERQFL CHHHCCCCHHHHHHH	40.65	28657654
481	Phosphorylation	RIFLSGITEEERQFL CHHHCCCCHHHHHHH	40.65	-
498	Phosphorylation	PMLKFTRSLSMPDTS CCHHHHCCCCCCCCC	23.03	28348404
500	Phosphorylation	LKFTRSLSMPDTSED HHHHCCCCCCCCCCC	29.52	28348404
504	Phosphorylation	RSLSMPDTSEDIPPP CCCCCCCCCCCCCCC	28.31	28348404
505	Phosphorylation	SLSMPDTSEDIPPPP CCCCCCCCCCCCCCC	40.42	28348404
511	Phosphorylation	TSEDIPPPPQSVPPS CCCCCCCCCCCCCCC	33.92	-
516	Phosphorylation	PPPPQSVPPSPPPPS CCCCCCCCCCCCCCC	28.97	-
518	Phosphorylation	PPQSVPPSPPPPSPT CCCCCCCCCCCCCCC	43.92	27251275
538	Phosphorylation	KSPTPRVYGTIKPAF CCCCCCCCCEECCCC	15.16	25394399
540	Phosphorylation	PTPRVYGTIKPAFNQ CCCCCCCEECCCCCC	14.24	28152594
549	Phosphorylation	KPAFNQNSAAKVSPA CCCCCCCCCCCCCCC	21.60	27307780
559	Phosphorylation	KVSPATRSDTVATMM CCCCCCCCHHHHHHH	33.02	-
561	Phosphorylation	SPATRSDTVATMMRE CCCCCCHHHHHHHHH	17.18	23312004
564	Phosphorylation	TRSDTVATMMREKGM CCCHHHHHHHHHCCC	13.73	23312004
580	Phosphorylation	FRRELDRYSLDSEDL HHHHHHHCCCCHHHH	17.16	26657352
581	Phosphorylation	RRELDRYSLDSEDLY HHHHHHCCCCHHHHH	26.96	22617229
584	Phosphorylation	LDRYSLDSEDLYSRN HHHCCCCHHHHHHCC	38.00	28450419
588	Phosphorylation	SLDSEDLYSRNAGPQ CCCHHHHHHCCCCCC	20.22	25884760
589	Phosphorylation	LDSEDLYSRNAGPQA CCHHHHHHCCCCCCC	26.76	28450419
610	Phosphorylation	GQMPENPYSEVGKIA CCCCCCCHHHHHHHH	29.10	27273156
611	Phosphorylation	QMPENPYSEVGKIAS CCCCCCHHHHHHHHC	27.36	25884760
613	Phosphorylation	PENPYSEVGKIASKA CCCCHHHHHHHHCEE	8.55	-
622	Phosphorylation	KIASKAVYVPAKPAR HHHCEEEEECCCCCH	12.94	28102081
626	Phosphorylation	KAVYVPAKPARRKGM EEEEECCCCCHHCCC	32.89	-
638	Phosphorylation	KGMLVKQSNVEDSPE CCCEEECCCCCCCCC	36.81	30278072
643	Phosphorylation	KQSNVEDSPEKTCSI ECCCCCCCCCCCCCC	22.81	30278072
647	Phosphorylation	VEDSPEKTCSIPIPT CCCCCCCCCCCCCCE	15.15	30278072
649	Phosphorylation	DSPEKTCSIPIPTII CCCCCCCCCCCCEEE	36.31	28348404
660	Phosphorylation	PTIIVKEPSTSSSGK CEEEEECCCCCCCCC	36.87	-
661	Phosphorylation	TIIVKEPSTSSSGKS EEEEECCCCCCCCCC	41.85	24719451
662	Phosphorylation	IIVKEPSTSSSGKSS EEEECCCCCCCCCCC	43.26	22798277
663	Phosphorylation	IVKEPSTSSSGKSSQ EEECCCCCCCCCCCC	27.18	27251275
664	Phosphorylation	VKEPSTSSSGKSSQG EECCCCCCCCCCCCC	43.10	18452278
665	Phosphorylation	KEPSTSSSGKSSQGS ECCCCCCCCCCCCCC	50.43	22798277
668	Phosphorylation	STSSSGKSSQGSSME CCCCCCCCCCCCCCE	31.27	28348404
669	Phosphorylation	TSSSGKSSQGSSMEI CCCCCCCCCCCCCEE	41.89	28348404
672	Phosphorylation	SGKSSQGSSMEIDPQ CCCCCCCCCCEECCC	20.90	28348404
673	Phosphorylation	GKSSQGSSMEIDPQA CCCCCCCCCEECCCC	27.53	28348404
681	Phosphorylation	MEIDPQAPEPPSQLR CEECCCCCCCHHHCC	49.75	-
685	Phosphorylation	PQAPEPPSQLRPDES CCCCCCHHHCCCCCC	53.19	28102081
690	Phosphorylation	PPSQLRPDESLTVSS CHHHCCCCCCCCCCC	52.24	-
720	Phosphorylation	RLEARRNSPAFLSTD HHHHHHCCCCCCCCC	18.78	30278072
722	Phosphorylation	EARRNSPAFLSTDLG HHHHCCCCCCCCCCC	20.17	-
725	Phosphorylation	RNSPAFLSTDLGDED HCCCCCCCCCCCCCC	17.27	30278072
726	Phosphorylation	NSPAFLSTDLGDEDV CCCCCCCCCCCCCCC	37.07	30278072
785	Phosphorylation	FVGGAEASAPGEAGR CCCCCCCCCCCCCCC	26.88	24850871
792	Phosphorylation	SAPGEAGRPLNSTSK CCCCCCCCCCCCCCC	39.31	-
813	Phosphorylation	SPAVPSASSGTAGPG CCCCCCCCCCCCCCC	33.37	-
822	Phosphorylation	GTAGPGNYVHPLTGR CCCCCCCCCCCCCCC	13.17	19060867
827	Phosphorylation	GNYVHPLTGRLLDPS CCCCCCCCCCCCCCC	25.38	-
834	Phosphorylation	TGRLLDPSSPLALAL CCCCCCCCCHHHHHH	44.23	27050516
835	Phosphorylation	GRLLDPSSPLALALS CCCCCCCCHHHHHHH	29.35	22199227
842	Phosphorylation	SPLALALSARDRAMK CHHHHHHHHHHHHHH	18.69	-
860	Phosphorylation	QGPKGEAPKADLNKP CCCCCCCCHHHCCCC	28.23	-
869	Phosphorylation	ADLNKPLYIDTKMRP HHCCCCEEEECCCCC	12.79	-
877	Phosphorylation	IDTKMRPSLDAGFPT EECCCCCCCCCCCCC	28.63	23312004
890	Phosphorylation	PTVTRQNTRGPLRRQ CCCCCCCCCCCCCHH	28.76	24719451
894	Phosphorylation	RQNTRGPLRRQETEN CCCCCCCCCHHHHCC	8.63	-
899	Phosphorylation	GPLRRQETENKYETD CCCCHHHHCCCCCCC	36.20	25849741
903	Phosphorylation	RQETENKYETDLGRD HHHHCCCCCCCCCCC	35.33	23312004
905	Phosphorylation	ETENKYETDLGRDRK HHCCCCCCCCCCCCC	33.17	23312004
926	Phosphorylation	MLIDIMDTSQQKSAG CEEEEEECCHHHHCC	15.85	25690035
927	Phosphorylation	LIDIMDTSQQKSAGL EEEEEECCHHHHCCE	26.75	25690035
931	Phosphorylation	MDTSQQKSAGLLMVH EECCHHHHCCEEEEE	24.19	28348404
939	Phosphorylation	AGLLMVHTVDATKLD CCEEEEEEECHHHHH	14.52	-
943	Phosphorylation	MVHTVDATKLDNALQ EEEEECHHHHHHHHH	27.89	-
964	Phosphorylation	EVEMKPDSSPSEVPE CCCCCCCCCCCCCCC	53.31	28348404
965	Phosphorylation	VEMKPDSSPSEVPEG CCCCCCCCCCCCCCC	39.56	28348404
967	Phosphorylation	MKPDSSPSEVPEGVS CCCCCCCCCCCCCCC	53.85	28348404
995	Phosphorylation	PTTVPGRTIVAVGSM CCCCCCCEEEEEECC	26.22	27732954
1001	Phosphorylation	RTIVAVGSMEEAVIL CEEEEEECCCEEEEE	19.20	30278072
1025	Phosphorylation	ASVDLDEDFIFTEPL CCCCCCCCCEECCCC	41.42	-
1051	Phosphorylation	IPDDRAASVPALSDL CCCCHHHHCHHHHHH	27.87	27251275
1052	Phosphorylation	PDDRAASVPALSDLV CCCHHHHCHHHHHHH	2.49	17081983
1060	Phosphorylation	PALSDLVKQKKSDTP HHHHHHHHHCCCCCC	64.79	17081983
1064	Phosphorylation	DLVKQKKSDTPQSPS HHHHHCCCCCCCCCC	54.47	30278072
1066	Phosphorylation	VKQKKSDTPQSPSLN HHHCCCCCCCCCCCC	30.25	30278072
1069	Phosphorylation	KKSDTPQSPSLNSSQ CCCCCCCCCCCCCCC	20.05	25849741
1071	Phosphorylation	SDTPQSPSLNSSQPT CCCCCCCCCCCCCCC	45.49	30278072
1073	Phosphorylation	TPQSPSLNSSQPTNS CCCCCCCCCCCCCCC	43.91	-
1074	Phosphorylation	PQSPSLNSSQPTNSA CCCCCCCCCCCCCCC	35.33	27732954
1075	Phosphorylation	QSPSLNSSQPTNSAD CCCCCCCCCCCCCCC	38.82	23312004
1080	Phosphorylation	NSSQPTNSADSKKPA CCCCCCCCCCCCCCC	35.61	-
1103	Phosphorylation	SFLPPPESFDAVADS HHCCCCHHCCHHHHC	33.91	28348404
1121	Phosphorylation	EVDSRSSSDHHLETT CCCCCCCCCCCCCCC	42.06	-
1125	Phosphorylation	RSSSDHHLETTSTIS CCCCCCCCCCCCCEE	5.85	-
1173	Phosphorylation	PVPPKPKMKPIIHKS CCCCCCCCCCCCCCC	9.41	-
1175	Phosphorylation	PPKPKMKPIIHKSNA CCCCCCCCCCCCCCC	27.54	-
1177	Phosphorylation	KPKMKPIIHKSNALY CCCCCCCCCCCCCCH	4.55	-
1186	Phosphorylation	KSNALYQDALVEEDV CCCCCHHCCCEECCC	28.45	-
1222	Phosphorylation	AKVLQPRTSKLWGDV HHHHCCCCCHHCCCC	36.58	24719451
1230	Phosphorylation	SKLWGDVTEIKSPIL CHHCCCCCCCCCCHH	36.41	29514088
1234	Phosphorylation	GDVTEIKSPILSGPK CCCCCCCCCHHCCCC	23.88	22199227
1238	Phosphorylation	EIKSPILSGPKANVI CCCCCHHCCCCHHHH	54.49	29514088
1269	Phosphorylation	KPGEGLDSPMGAKSA CCCCCCCCCCCCCHH	23.10	23312004
1275	Phosphorylation	DSPMGAKSASLAPRS CCCCCCCHHHCCCCC	23.66	22199227
1277	Phosphorylation	PMGAKSASLAPRSPE CCCCCHHHCCCCCHH	31.96	24719451
1282	O-linked_Glycosylation	SASLAPRSPEIMSTI HHHCCCCCHHHHHEE	26.31	28657654
1282	Phosphorylation	SASLAPRSPEIMSTI HHHCCCCCHHHHHEE	26.31	30278072
1287	O-linked_Glycosylation	PRSPEIMSTISGTRS CCCHHHHHEECCCCC	28.40	28657654
1287	Phosphorylation	PRSPEIMSTISGTRS CCCHHHHHEECCCCC	28.40	28102081
1288	O-linked_Glycosylation	RSPEIMSTISGTRST CCHHHHHEECCCCCE	11.20	28657654
1288	Phosphorylation	RSPEIMSTISGTRST CCHHHHHEECCCCCE	11.20	28102081
1296	O-linked_Glycosylation	ISGTRSTTVTFTVRP ECCCCCEEEEEEECC	20.85	28657654
1330	Phosphorylation	SGTRRAPSPVVSPTE CCCCCCCCCCCCCCC	29.37	30266825
1334	Phosphorylation	RAPSPVVSPTEMNKE CCCCCCCCCCCCCCC	26.74	27362937
1336	Phosphorylation	PSPVVSPTEMNKETL CCCCCCCCCCCCCCC	40.12	21406692
1351	Phosphorylation	PAPLSAATASPSPAL CCCCCCCCCCCCCCH	27.64	28348404
1353	Phosphorylation	PLSAATASPSPALSD CCCCCCCCCCCCHHH	22.89	28348404
1355	Phosphorylation	SAATASPSPALSDVF CCCCCCCCCCHHHHC	21.95	28348404
1359	Phosphorylation	ASPSPALSDVFSLPS CCCCCCHHHHCCCCC	33.56	28348404
1363	Phosphorylation	PALSDVFSLPSQPPS CCHHHHCCCCCCCCC	38.94	28348404
1382	Phosphorylation	GLNPAGRSRSPSPSI CCCCCCCCCCCCCCH	35.87	21406692
1384	Phosphorylation	NPAGRSRSPSPSILQ CCCCCCCCCCCCHHC	30.86	21406692
1386	Phosphorylation	AGRSRSPSPSILQQP CCCCCCCCCCHHCCC	32.31	21406692
1388	Phosphorylation	RSRSPSPSILQQPIS CCCCCCCCHHCCCCC	40.02	21406692
1395	Phosphorylation	SILQQPISNKPFTTK CHHCCCCCCCCCCCC	45.55	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHAN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHAN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHAN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRC8_HUMAN	CTTN	physical	9742101
ARHG7_HUMAN	ARHGEF7	physical	12626503
DLG4_HUMAN	DLG4	physical	10844022
DYL2_HUMAN	DYNLL2	physical	10844022
DYL1_HUMAN	DYNLL1	physical	10844022
DLGP1_HUMAN	DLGAP1	physical	10844022
MYO5A_HUMAN	MYO5A	physical	10844022
DLGP1_HUMAN	DLGAP1	physical	10527873
DLG4_HUMAN	DLG4	physical	10527873
DLGP2_HUMAN	DLGAP2	physical	10527873
DLGP3_HUMAN	DLGAP3	physical	10527873
DLGP4_HUMAN	DLGAP4	physical	10527873
SSR2_RAT	Sstr2	physical	10373412
SHRPN_HUMAN	SHARPIN	physical	23897824

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613436: Autism 17 (AUTS17)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.