DLGP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLGP3_HUMAN
• UniProt AC: O95886
• Protein Name: Disks large-associated protein 3
• Gene Name: DLGAP3
• Organism: Homo sapiens (Human).
• Sequence Length: 979
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Postsynaptic density of neuronal cells..
• Protein Description: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane..
• Protein Sequence: MRGYHGDRGSHPRPARFADQQHMDVGPAARAPYLLGSREAFSTEPRFCAPRAGLGHISPEGPLSLSEGPSVGPEGGPAGAGVGGGSSTFPRMYPGQGPFDTCEDCVGHPQGKGAPRLPPTLLDQFEKQLPVQQDGFHTLPYQRGPAGAGPGPAPGTGTAPEPRSESPSRIRHLVHSVQKLFAKSHSLEAPGKRDYNGPKAEGRGGSGGDSYPGPGSGGPHTSHHHHHHHHHHHHQSRHGKRSKSKDRKGDGRHQAKSTGWWSSDDNLDSDSGFLAGGRPPGEPGGPFCLEGPDGSYRDLSFKGRSGGSEGRCLACTGMSMSLDGQSVKRSAWHTMMVSQGRDGYPGAGPGKGLLGPETKAKARTYHYLQVPQDDWGGYPTGGKDGEIPCRRMRSGSYIKAMGDEESGDSDGSPKTSPKAVARRFTTRRSSSVDQARINCCVPPRIHPRSSIPGYSRSLTTGQLSDELNQQLEAVCGSVFGELESQAVDALDLPGCFRMRSHSYLRAIQAGCSQDDDCLPLLATPAAVSGRPGSSFNFRKAPPPIPPGSQAPPRISITAQSSTDSAHESFTAAEGPARRCSSADGLDGPAMGARTLELAPVPPRASPKPPTLIIKTIPGREELRSLARQRKWRPSIGVQVETISDSDTENRSRREFHSIGVQVEEDKRRARFKRSNSVTAGVQADLELEGLAGLATVATEDKALQFGRSFQRHASEPQPGPRAPTYSVFRTVHTQGQWAYREGYPLPYEPPATDGSPGPAPAPTPGPGAGRRDSWIERGSRSLPDSGRASPCPRDGEWFIKMLRAEVEKLEHWCQQMEREAEDYELPEEILEKIRSAVGSTQLLLSQKVQQFFRLCQQSMDPTAFPVPTFQDLAGFWDLLQLSIEDVTLKFLELQQLKANSWKLLEPKEEKKVPPPIPKKPLRGRGVPVKERSLDSVDRQRQEARKRLLAAKRAASFRHSSATESADSIEIYIPEAQTRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	RAGLGHISPEGPLSL CCCCCCCCCCCCCCC	15.95	24076635
64	Phosphorylation	ISPEGPLSLSEGPSV CCCCCCCCCCCCCCC	32.74	24076635
127	Ubiquitination	TLLDQFEKQLPVQQD HHHHHHHHHCCCCCC	59.43	30230243
138	Phosphorylation	VQQDGFHTLPYQRGP CCCCCCCCCCCCCCC	27.45	22210691
141	Phosphorylation	DGFHTLPYQRGPAGA CCCCCCCCCCCCCCC	17.60	22210691
158	Phosphorylation	GPAPGTGTAPEPRSE CCCCCCCCCCCCCCC	38.59	22210691
186	Phosphorylation	KLFAKSHSLEAPGKR HHHHHHCCCCCCCCC	34.69	25849741
300	Phosphorylation	DGSYRDLSFKGRSGG CCCCCCCCCCCCCCC	29.24	24719451
316	Phosphorylation	EGRCLACTGMSMSLD CCCEEEECCCCEEEC	30.25	-
330	Phosphorylation	DGQSVKRSAWHTMMV CCCCHHHHHHEEEEE	29.96	28348404
334	Phosphorylation	VKRSAWHTMMVSQGR HHHHHHEEEEEECCC	9.03	28348404
338	Phosphorylation	AWHTMMVSQGRDGYP HHEEEEEECCCCCCC	14.71	28348404
351	Ubiquitination	YPGAGPGKGLLGPET CCCCCCCCCCCCHHH	49.90	30230243
359	Ubiquitination	GLLGPETKAKARTYH CCCCHHHHHCCEEEE	46.35	30230243
365	Phosphorylation	TKAKARTYHYLQVPQ HHHCCEEEEEEECCC	5.28	27196784
396	Phosphorylation	CRRMRSGSYIKAMGD CCCCCCCCCEEECCC	25.57	24719451
397	Phosphorylation	RRMRSGSYIKAMGDE CCCCCCCCEEECCCC	15.23	18083107
406	Phosphorylation	KAMGDEESGDSDGSP EECCCCCCCCCCCCC	45.94	22210691
409	Phosphorylation	GDEESGDSDGSPKTS CCCCCCCCCCCCCCC	47.61	25307156
412	Phosphorylation	ESGDSDGSPKTSPKA CCCCCCCCCCCCHHH	28.37	25307156
415	Phosphorylation	DSDGSPKTSPKAVAR CCCCCCCCCHHHHHH	54.36	25307156
416	Phosphorylation	SDGSPKTSPKAVARR CCCCCCCCHHHHHHH	30.45	22210691
449	Phosphorylation	PPRIHPRSSIPGYSR CCCCCCCCCCCCCCC	36.75	21712546
450	Phosphorylation	PRIHPRSSIPGYSRS CCCCCCCCCCCCCCC	33.80	-
454	Phosphorylation	PRSSIPGYSRSLTTG CCCCCCCCCCCCCCC	8.78	-
455	Phosphorylation	RSSIPGYSRSLTTGQ CCCCCCCCCCCCCCC	22.70	-
564	Phosphorylation	TAQSSTDSAHESFTA EEECCCCCHHHHHCC	31.45	24076635
641	Phosphorylation	SIGVQVETISDSDTE CCCEEEEECCCCCCC	27.24	24076635
643	Phosphorylation	GVQVETISDSDTENR CEEEEECCCCCCCCC	38.18	24076635
645	Phosphorylation	QVETISDSDTENRSR EEEECCCCCCCCCCH	39.37	-
695	Phosphorylation	EGLAGLATVATEDKA CCHHCCCEEECHHHH	18.73	-
698	Phosphorylation	AGLATVATEDKALQF HCCCEEECHHHHHHH	40.14	-
714	Phosphorylation	RSFQRHASEPQPGPR HHHHHHCCCCCCCCC	43.62	28348404
725	Phosphorylation	PGPRAPTYSVFRTVH CCCCCCCCCEEEEEE	11.19	27196784
773	Phosphorylation	PGAGRRDSWIERGSR CCCCCCCCHHHCCCC	28.30	23927012
789	Phosphorylation	LPDSGRASPCPRDGE CCCCCCCCCCCCCHH	26.19	25332170
800	Ubiquitination	RDGEWFIKMLRAEVE CCHHHHHHHHHHHHH	23.55	30230243
823	Phosphorylation	MEREAEDYELPEEIL HHHHHHHCCCCHHHH	15.75	27196784
832	Ubiquitination	LPEEILEKIRSAVGS CCHHHHHHHHHHHHH	39.72	30230243
839	Phosphorylation	KIRSAVGSTQLLLSQ HHHHHHHHHHHHHHH	13.33	23911959
840	Phosphorylation	IRSAVGSTQLLLSQK HHHHHHHHHHHHHHH	19.80	23911959
847	Ubiquitination	TQLLLSQKVQQFFRL HHHHHHHHHHHHHHH	38.34	30230243
897	Ubiquitination	FLELQQLKANSWKLL HHHHHHHHHCCCCCC	40.98	30230243
932	Phosphorylation	GVPVKERSLDSVDRQ CCCCCCCCCCHHHHH	37.31	25307156
935	Phosphorylation	VKERSLDSVDRQRQE CCCCCCCHHHHHHHH	31.07	-
962	Phosphorylation	SFRHSSATESADSIE HHCCCCCCCCCCCEE	32.21	26657352
967	Phosphorylation	SATESADSIEIYIPE CCCCCCCCEEEECCH	23.10	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DLGP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLGP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLGP3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DLGP3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.