dbPTM

DLGP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DLGP4_HUMAN
UniProt AC	Q9Y2H0
Protein Name	Disks large-associated protein 4
Gene Name	DLGAP4
Organism	Homo sapiens (Human).
Sequence Length	992
Subcellular Localization	Membrane Peripheral membrane protein.
Protein Description	May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane..
Protein Sequence	MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREARFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPSHAQATKINRLPANLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGTAGKVGGNGSKKGGMEDGKGRRAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAFRSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPPPAPPATCPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQVPGGGGEWSTTLLSPRETDAAAEGPIPCRRMRSGSYIKAMGDEDSDESGGSPKPSPKTAARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCISQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRSRSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTGSLSNSRTLPSSSCLVAYKKTPPPVPPRTTSKPFISVTVQSSTESAQDTYLDSQDHKSEVTSQSGLSNSSDSLDSSTRPPSVTRGGVAPAPEAPEPPPKHAALKSEQGTLTSSESHPEAAPKRKLSSIGIQVDCIQPVPKEEPSPATKFQSIGVQVEDDWRSSVPSHSMSSRRDTDSDTQDANDSSCKSSERSLPDCTPHPNSISIDAGPRQAPKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPGACRRDGYWFLKLLQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQKFQQFRGLCEQNLNPDANPRPTAQDLAGFWDLLQLSIEDISMKFDELYHLKANSWQLVETPEKRKEEKKPPPPVPKKPAKSKPAVSRDKASDASDKQRQEARKRLLAAKRAASVRQNSATESADSIEIYVPEAQTRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12 (in isoform 3)	Phosphorylation	-	6.85	22468782
13	Phosphorylation	DSRPRHLSDSLDPPH CCCCCCCCCCCCCCC	21.01	24719451
13 (in isoform 3)	Phosphorylation	-	21.01	22468782
15	Phosphorylation	RPRHLSDSLDPPHEP CCCCCCCCCCCCCCC	31.15	27542207
18 (in isoform 3)	Phosphorylation	-	37.12	22468782
27	Phosphorylation	HEPLFAGTDRNPYLL CCCCCCCCCCCCCCC	28.49	27542207
32	Phosphorylation	AGTDRNPYLLSPTEA CCCCCCCCCCCHHHH	24.67	27542207
35	Phosphorylation	DRNPYLLSPTEAFAR CCCCCCCCHHHHHHH	27.47	27542207
37	Phosphorylation	NPYLLSPTEAFAREA CCCCCCHHHHHHHHC	36.25	27542207
156	Phosphorylation	LFFTKAPSLEGTAGK HHHCCCCCCCCCCCC	43.86	24076635
160	Phosphorylation	KAPSLEGTAGKVGGN CCCCCCCCCCCCCCC	23.90	22985185
206	Phosphorylation	SNISGWWSSDDNLDG CCCCCCCCCCCCCCC	19.85	-
207	Phosphorylation	NISGWWSSDDNLDGE CCCCCCCCCCCCCCC	34.95	-
241	Phosphorylation	AERSQPRYFMHAYNT HHHHCCCHHHHHHHH	16.37	-
246	Phosphorylation	PRYFMHAYNTISGHM CCHHHHHHHHHCCCC	9.73	-
291	Methylation	TDTNYVKRGSWSTLT CCCCCCCCCCCCCEE	34.04	-
293	Phosphorylation	TNYVKRGSWSTLTLS CCCCCCCCCCCEEHH	23.14	24719451
295	Phosphorylation	YVKRGSWSTLTLSHA CCCCCCCCCEEHHHH	18.42	26552605
296	Phosphorylation	VKRGSWSTLTLSHAH CCCCCCCCEEHHHHH	19.94	26552605
298	Phosphorylation	RGSWSTLTLSHAHEV CCCCCCEEHHHHHHH	26.71	26552605
300	Phosphorylation	SWSTLTLSHAHEVCQ CCCCEEHHHHHHHHH	17.25	26552605
309	Phosphorylation	AHEVCQKTSATLDKS HHHHHHHCCCCCCHH	9.56	20068231
310	Phosphorylation	HEVCQKTSATLDKSL HHHHHHCCCCCCHHH	26.71	20068231
312	Phosphorylation	VCQKTSATLDKSLLK HHHHCCCCCCHHHHH	34.94	20068231
316	Phosphorylation	TSATLDKSLLKSKSC CCCCCCHHHHHCCCC	38.30	20068231
331	Phosphorylation	HQGLAYHYLQVPGGG CCCEEEEEEECCCCC	6.02	-
343	Phosphorylation	GGGGEWSTTLLSPRE CCCCCCEEEEECHHH	23.65	-
344	Phosphorylation	GGGEWSTTLLSPRET CCCCCEEEEECHHHC	21.86	-
347	Phosphorylation	EWSTTLLSPRETDAA CCEEEEECHHHCCHH	25.64	24719451
351	Phosphorylation	TLLSPRETDAAAEGP EEECHHHCCHHHCCC	32.02	-
368	Phosphorylation	CRRMRSGSYIKAMGD CEECCCCCCEEECCC	25.57	24719451
369	Phosphorylation	RRMRSGSYIKAMGDE EECCCCCCEEECCCC	15.23	18083107
378	Phosphorylation	KAMGDEDSDESGGSP EECCCCCCCCCCCCC	41.03	25307156
381	Phosphorylation	GDEDSDESGGSPKPS CCCCCCCCCCCCCCC	54.14	-
384	Phosphorylation	DSDESGGSPKPSPKT CCCCCCCCCCCCHHH	33.02	25307156
388	Phosphorylation	SGGSPKPSPKTAARR CCCCCCCCHHHHHHH	45.19	-
397	Phosphorylation	KTAARRQSYLRATQQ HHHHHHHHHHHHHHH	25.07	24719451
405	Phosphorylation	YLRATQQSLGEQSNP HHHHHHHHHHCCCCC	28.64	-
415	Phosphorylation	EQSNPRRSLDRLDSV CCCCCCCCCHHHHHC	35.58	27732954
421	Phosphorylation	RSLDRLDSVDMLLPS CCCHHHHHCCCCCCC	25.30	27732954
428	Phosphorylation	SVDMLLPSKCPSWEE HCCCCCCCCCCCCCC	47.03	24719451
534	Phosphorylation	SVSLQSLSPPPSTGS CCCCCCCCCCCCCCC	40.38	24076635
547	O-linked_Glycosylation	GSLSNSRTLPSSSCL CCCCCCCCCCCCCEE	42.73	28411811
560	Phosphorylation	CLVAYKKTPPPVPPR EEEEEECCCCCCCCC	36.55	25307156
568	Phosphorylation	PPPVPPRTTSKPFIS CCCCCCCCCCCCEEE	40.99	27251275
569	Phosphorylation	PPVPPRTTSKPFISV CCCCCCCCCCCEEEE	35.71	27251275
570	Phosphorylation	PVPPRTTSKPFISVT CCCCCCCCCCEEEEE	37.40	27251275
580	Phosphorylation	FISVTVQSSTESAQD EEEEEEECCCCCHHH	34.59	-
581	Phosphorylation	ISVTVQSSTESAQDT EEEEEECCCCCHHHH	21.07	-
589	Phosphorylation	TESAQDTYLDSQDHK CCCHHHHCCCCCCHH	19.46	22817900
597	Phosphorylation	LDSQDHKSEVTSQSG CCCCCHHHHHHCCCC	33.60	25850435
600	Phosphorylation	QDHKSEVTSQSGLSN CCHHHHHHCCCCCCC	19.59	23663014
601	Phosphorylation	DHKSEVTSQSGLSNS CHHHHHHCCCCCCCC	27.76	23663014
603	Phosphorylation	KSEVTSQSGLSNSSD HHHHHCCCCCCCCCC	41.28	23663014
606	Phosphorylation	VTSQSGLSNSSDSLD HHCCCCCCCCCCCCC	37.89	30278072
608	Phosphorylation	SQSGLSNSSDSLDSS CCCCCCCCCCCCCCC	31.95	30278072
609	Phosphorylation	QSGLSNSSDSLDSST CCCCCCCCCCCCCCC	35.15	30278072
611	Phosphorylation	GLSNSSDSLDSSTRP CCCCCCCCCCCCCCC	35.70	27362937
614	Phosphorylation	NSSDSLDSSTRPPSV CCCCCCCCCCCCCCC	38.61	23663014
615	Phosphorylation	SSDSLDSSTRPPSVT CCCCCCCCCCCCCCC	28.27	23663014
616	Phosphorylation	SDSLDSSTRPPSVTR CCCCCCCCCCCCCCC	51.66	23663014
620	Phosphorylation	DSSTRPPSVTRGGVA CCCCCCCCCCCCCCC	38.51	25159151
622	Phosphorylation	STRPPSVTRGGVAPA CCCCCCCCCCCCCCC	28.12	23663014
651	Phosphorylation	SEQGTLTSSESHPEA CCCCCCCCCCCCCCC	34.91	25627689
652	Phosphorylation	EQGTLTSSESHPEAA CCCCCCCCCCCCCCC	37.57	25159151
654	Phosphorylation	GTLTSSESHPEAAPK CCCCCCCCCCCCCCC	46.41	23312004
665	Phosphorylation	AAPKRKLSSIGIQVD CCCCCCHHHCCEEEE	23.97	27273156
665 (in isoform 2)	Phosphorylation	-	23.97	18669648
666	Phosphorylation	APKRKLSSIGIQVDC CCCCCHHHCCEEEEE	34.96	30266825
683	Phosphorylation	PVPKEEPSPATKFQS CCCCCCCCCCCCCCC	30.37	28985074
686	Phosphorylation	KEEPSPATKFQSIGV CCCCCCCCCCCCCCE	35.46	29396449
695 (in isoform 1)	Phosphorylation	-	8.94	23663014
696 (in isoform 1)	Phosphorylation	-	32.91	23663014
698 (in isoform 1)	Phosphorylation	-	29.23	23663014
699 (in isoform 1)	Phosphorylation	-	17.87	23663014
701	Phosphorylation	QVEDDWRSSVPSHSM EECCCHHHCCCCCCC	31.28	23663014
702	Phosphorylation	VEDDWRSSVPSHSMS ECCCHHHCCCCCCCC	29.49	23663014
702 (in isoform 1)	Phosphorylation	-	29.49	23663014
704 (in isoform 1)	Phosphorylation	-	28.42	23663014
705	Phosphorylation	DWRSSVPSHSMSSRR CHHHCCCCCCCCCCC	26.49	23663014
706 (in isoform 1)	Phosphorylation	-	22.81	23663014
707	Phosphorylation	RSSVPSHSMSSRRDT HHCCCCCCCCCCCCC	25.38	23663014
707 (in isoform 1)	Phosphorylation	-	25.38	23663014
709	Phosphorylation	SVPSHSMSSRRDTDS CCCCCCCCCCCCCCC	24.57	23663014
710	Phosphorylation	VPSHSMSSRRDTDSD CCCCCCCCCCCCCCC	23.77	23663014
714	Phosphorylation	SMSSRRDTDSDTQDA CCCCCCCCCCCCCCC	35.27	27273156
716	Phosphorylation	SSRRDTDSDTQDAND CCCCCCCCCCCCCCH	44.65	25849741
718	Phosphorylation	RRDTDSDTQDANDSS CCCCCCCCCCCCHHH	32.09	30242111
724	Phosphorylation	DTQDANDSSCKSSER CCCCCCHHHCCCCCC	37.13	23312004
725	Phosphorylation	TQDANDSSCKSSERS CCCCCHHHCCCCCCC	28.55	23312004
732	Phosphorylation	SCKSSERSLPDCTPH HCCCCCCCCCCCCCC	39.95	26657352
737	Phosphorylation	ERSLPDCTPHPNSIS CCCCCCCCCCCCCCE	31.82	26657352
742	Phosphorylation	DCTPHPNSISIDAGP CCCCCCCCCEECCCC	23.36	25849741
744	Phosphorylation	TPHPNSISIDAGPRQ CCCCCCCEECCCCCC	17.78	26657352
763	Phosphorylation	AQIKRNLSYGDNSDP HHHHHHHCCCCCCCH	30.53	30183078
764	Phosphorylation	QIKRNLSYGDNSDPA HHHHHHCCCCCCCHH	31.50	28450419
768	Phosphorylation	NLSYGDNSDPALEAS HHCCCCCCCHHHHHH	50.11	28450419
775	Phosphorylation	SDPALEASSLPPPDP CCHHHHHHCCCCCCC	24.04	28450419
776	Phosphorylation	DPALEASSLPPPDPW CHHHHHHCCCCCCCC	52.52	28450419
786	Phosphorylation	PPDPWLETSSSSPAE CCCCCCCCCCCCCCC	31.57	28450419
787	Phosphorylation	PDPWLETSSSSPAEP CCCCCCCCCCCCCCC	20.88	28450419
788	Phosphorylation	DPWLETSSSSPAEPA CCCCCCCCCCCCCCC	42.10	28450419
789	Phosphorylation	PWLETSSSSPAEPAQ CCCCCCCCCCCCCCC	39.86	28450419
790	Phosphorylation	WLETSSSSPAEPAQP CCCCCCCCCCCCCCC	30.03	28450419
827	Acetylation	GWCCQMDKETKENNL HHHHCCCHHHHHCCC	63.04	25953088
830	Acetylation	CQMDKETKENNLSEE HCCCHHHHHCCCCHH	60.58	20167786
909	Phosphorylation	LYHLKANSWQLVETP HHHHHCCCEEEECCH	22.51	23403867
912	Phosphorylation	LKANSWQLVETPEKR HHCCCEEEECCHHHH	2.82	19664995
915	Phosphorylation	NSWQLVETPEKRKEE CCEEEECCHHHHHHC	29.30	19664994
915 (in isoform 2)	Phosphorylation	-	29.30	18669648
941	O-linked_Glycosylation	AKSKPAVSRDKASDA CCCCCCCCHHHCCCC	36.55	OGP
946	Phosphorylation	AVSRDKASDASDKQR CCCHHHCCCCCHHHH	39.18	24719451
968	Phosphorylation	LAAKRAASVRQNSAT HHHHHHHHHHHCCCC	19.49	22777824
972	Phosphorylation	RAASVRQNSATESAD HHHHHHHCCCCCCCC	24.05	18669648
973	Phosphorylation	AASVRQNSATESADS HHHHHHCCCCCCCCC	28.38	25159151
975	Phosphorylation	SVRQNSATESADSIE HHHHCCCCCCCCCEE	30.23	30266825
975 (in isoform 2)	Phosphorylation	-	30.23	18669648
977	Phosphorylation	RQNSATESADSIEIY HHCCCCCCCCCEEEE	32.78	30266825
980	Phosphorylation	SATESADSIEIYVPE CCCCCCCCEEEECCH	23.10	30266825
984	Phosphorylation	SADSIEIYVPEAQTR CCCCEEEECCHHHHC	9.36	30266825
990	Phosphorylation	IYVPEAQTRL----- EECCHHHHCC-----	100.00	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DLGP4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DLGP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DLGP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
BIN1_HUMAN	BIN1	physical	16275660

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DLGP4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-915, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-915, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-915, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-369, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-984, AND MASSSPECTROMETRY.	17053785 [Abstract]