DLGP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLGP2_HUMAN
• UniProt AC: Q9P1A6
• Protein Name: Disks large-associated protein 2 {ECO:0000305}
• Gene Name: DLGAP2 {ECO:0000312|HGNC:HGNC:2906}
• Organism: Homo sapiens (Human).
• Sequence Length: 1054
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Postsynaptic density of neuronal cells..
• Protein Description: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane..
• Protein Sequence: MGTAQVLPGILQKHCCILPDRNTESQCTLCGEPEEEEAGDLVQPGISFPGPAEEDLDPQYSWSPTQHFNEERYSPAPRSMKGLSGSRTQPPLCSGHTCGLAPPEDCEHLHHGPDARPPYLLSPADSCPGGRHRCSPRSSVHSECVMMPVVLGDHVSSSTFPRMHYSSHYDTRDDCAVAHAGAKINRIPANLLDQFEKQLPLHRDGFHTLQYQRTSAAAEQRSESPGRIRHLVHSVQKLFTKSHSLEGSSKSNANGTKADGRADDHHHAHHAKHSKRSKSKERKPEGKPRPGMSSWWSSDDNLDSDSTYRTPSVLNRHHLGPVAHCYPDALQSPFGDLSLKTSKSNNDVKCSACEGLALTPDAKYLKRSSWSTLTVSQAKEAYRKSSLNLDKPLLHQDAKPALRPCHYLQVPQDEWGGYPTGGKDEEIPCRRMRSGSYIKAMGDEESGESDSSPKTSPKSAILPEPLLKSIGQRPLGEHQTQTYLQAASDVPVGHSLDPAANYNSPKFRSRNQSYMRAVSTLSQASCVSQVSEAEINGQFESVCESVFSEVESQAMDALDLPGCFRTRSHSYLRAIQAGYSQDDECIPMMTPSDITSTIRSTAAVSYTNYKKTPPPVPPRTTSKPLISVTAQSSTESTQDAYQDSRAQRMSPWPQDSRGLYNSTDSLDSNKAMNLALETAAAQRHLPESQSSSVRTSDKAILVSKAEELLKSRCSSIGIQDSEFPEHQPYPRSDVETATDSDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTAAVQADLELEGFPGHITTEDKGLQFGSSFQRHSEPSTPTQYSAVRTVRTQGLFSYREDYRTQVDTSTLPPPDPWLEPAIDTVETGRMSPCRRDGSWFLKLLHAETKRMEGWCKEMEREAEENDLSEEILGKIRSAVGSAQLLMSQKFQQFYWLCQQNMDPSAMPRPTSQDLAGYWDMLQLSIEDVSMKFDELQRLRLNDWKMMESPERKEERKVPPPIPKKPPKGKFPITREKSLDLPDRQRQEARRRLMAAKRAASFRQNSASERADSIEIYIPEAQTRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	SMKGLSGSRTQPPLC CCCCCCCCCCCCCCC	28.86	-
157	Phosphorylation	VLGDHVSSSTFPRMH EECCCCCCCCCCCCC	32.10	-
211	Phosphorylation	DGFHTLQYQRTSAAA CCCCHHHHHHHHHHH	11.77	27196784
297	Phosphorylation	PGMSSWWSSDDNLDS CCCCCCCCCCCCCCC	20.03	27732954
298	Phosphorylation	GMSSWWSSDDNLDSD CCCCCCCCCCCCCCC	34.95	27732954
304	Phosphorylation	SSDDNLDSDSTYRTP CCCCCCCCCCCCCCH	36.31	-
351	Phosphorylation	SNNDVKCSACEGLAL CCCCCCCCHHCCEEE	30.18	-
351	O-linked_Glycosylation	SNNDVKCSACEGLAL CCCCCCCCHHCCEEE	30.18	28657654
357	Phosphorylation	CSACEGLALTPDAKY CCHHCCEEECCCHHH	21.90	-
359	Phosphorylation	ACEGLALTPDAKYLK HHCCEEECCCHHHHH	17.32	24114839
364	Phosphorylation	ALTPDAKYLKRSSWS EECCCHHHHHHCCCC	21.12	28555341
368	Phosphorylation	DAKYLKRSSWSTLTV CHHHHHHCCCCCEEH	34.27	27732954
369	Phosphorylation	AKYLKRSSWSTLTVS HHHHHHCCCCCEEHH	29.13	27732954
371	Phosphorylation	YLKRSSWSTLTVSQA HHHHCCCCCEEHHHH	18.58	27732954
372	Phosphorylation	LKRSSWSTLTVSQAK HHHCCCCCEEHHHHH	21.86	27732954
374	Phosphorylation	RSSWSTLTVSQAKEA HCCCCCEEHHHHHHH	20.42	27732954
386	Phosphorylation	KEAYRKSSLNLDKPL HHHHHHHCCCCCCCC	25.06	-
407	Phosphorylation	PALRPCHYLQVPQDE HHCCCCEEEECCHHH	12.92	-
436	Phosphorylation	CRRMRSGSYIKAMGD CHHHCCCCCEEECCC	25.57	24719451
437	Phosphorylation	RRMRSGSYIKAMGDE HHHCCCCCEEECCCC	15.23	18083107
446	Phosphorylation	KAMGDEESGESDSSP EECCCCCCCCCCCCC	45.90	25307156
449	Phosphorylation	GDEESGESDSSPKTS CCCCCCCCCCCCCCC	46.44	25307156
451	Phosphorylation	EESGESDSSPKTSPK CCCCCCCCCCCCCCC	58.79	25307156
452	Phosphorylation	ESGESDSSPKTSPKS CCCCCCCCCCCCCCH	35.09	25307156
455	Phosphorylation	ESDSSPKTSPKSAIL CCCCCCCCCCCHHCC	54.36	25307156
456	Phosphorylation	SDSSPKTSPKSAILP CCCCCCCCCCHHCCC	36.13	25307156
502	Phosphorylation	SLDPAANYNSPKFRS CCCHHHCCCCHHHHH	16.58	25332170
504	Phosphorylation	DPAANYNSPKFRSRN CHHHCCCCHHHHHCC	21.07	25332170
596	Phosphorylation	MTPSDITSTIRSTAA CCHHHHHHHHHHCCE	23.36	-
597	Phosphorylation	TPSDITSTIRSTAAV CHHHHHHHHHHCCEE	16.26	-
600	Phosphorylation	DITSTIRSTAAVSYT HHHHHHHHCCEEEEC	20.67	29396449
601	Phosphorylation	ITSTIRSTAAVSYTN HHHHHHHCCEEEECC	14.59	29396449
605	Phosphorylation	IRSTAAVSYTNYKKT HHHCCEEEECCCCCC	22.85	29396449
606	Phosphorylation	RSTAAVSYTNYKKTP HHCCEEEECCCCCCC	7.75	29396449
607	Phosphorylation	STAAVSYTNYKKTPP HCCEEEECCCCCCCC	25.27	29396449
609	Phosphorylation	AAVSYTNYKKTPPPV CEEEECCCCCCCCCC	13.18	29396449
612	Phosphorylation	SYTNYKKTPPPVPPR EECCCCCCCCCCCCC	36.55	29396449
622	Phosphorylation	PVPPRTTSKPLISVT CCCCCCCCCCEEEEE	31.50	24719451
632	Phosphorylation	LISVTAQSSTESTQD EEEEEECCCCCCHHH	36.44	24076635
633	Phosphorylation	ISVTAQSSTESTQDA EEEEECCCCCCHHHH	24.90	24076635
662	Phosphorylation	DSRGLYNSTDSLDSN CCCCCCCCCCCCCHH	21.75	27732954
663	Phosphorylation	SRGLYNSTDSLDSNK CCCCCCCCCCCCHHH	26.43	27732954
665	Phosphorylation	GLYNSTDSLDSNKAM CCCCCCCCCCHHHHH	33.88	24076635
668	Phosphorylation	NSTDSLDSNKAMNLA CCCCCCCHHHHHHHH	45.59	24076635
671	Phosphorylation	DSLDSNKAMNLALET CCCCHHHHHHHHHHH	9.06	-
673	Phosphorylation	LDSNKAMNLALETAA CCHHHHHHHHHHHHH	27.33	-
715	Phosphorylation	LLKSRCSSIGIQDSE HHHHHHHHCCCCCCC	28.58	-
732	Phosphorylation	EHQPYPRSDVETATD CCCCCCHHHCCCCCC	41.31	-
736	Phosphorylation	YPRSDVETATDSDTE CCHHHCCCCCCCCCH	34.40	30576142
738	Phosphorylation	RSDVETATDSDTESR HHHCCCCCCCCCHHC	43.38	30576142
740	Phosphorylation	DVETATDSDTESRGL HCCCCCCCCCHHCCC	41.92	25332170
742	Phosphorylation	ETATDSDTESRGLRE CCCCCCCCHHCCCHH	39.55	25332170
750	Phosphorylation	ESRGLREYHSVGVQV HHCCCHHHHCCEEEE	7.92	-
752	Phosphorylation	RGLREYHSVGVQVED CCCHHHHCCEEEEEC	21.47	30576142
771	Phosphorylation	GRFKRSNSVTAAVQA CCCCCCCCCCCEEEC	23.30	-
806	Phosphorylation	GSSFQRHSEPSTPTQ CCCCCCCCCCCCCCC	54.08	-
810	Phosphorylation	QRHSEPSTPTQYSAV CCCCCCCCCCCHHEE	40.86	24076635
827	Phosphorylation	VRTQGLFSYREDYRT HHHCCCCCCCHHHCC	28.46	-
978	Phosphorylation	NDWKMMESPERKEER CCCCCCCCHHHHHHC	17.73	-
1007	Phosphorylation	FPITREKSLDLPDRQ CCCCCCCCCCCCHHH	23.51	28857561
1042	Phosphorylation	SASERADSIEIYIPE CHHHHCCEEEEECCH	22.57	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DLGP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLGP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLGP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG4_HUMAN	DLG4	physical	9115257
RIMB1_HUMAN	BZRAP1	physical	24722188
KRA42_HUMAN	KRTAP4-2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.