RIMB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIMB1_HUMAN
• UniProt AC: O95153
• Protein Name: Peripheral-type benzodiazepine receptor-associated protein 1
• Gene Name: TSPOAP1 {ECO:0000312|HGNC:HGNC:16831}
• Organism: Homo sapiens (Human).
• Sequence Length: 1857
• Subcellular Localization: Cytoplasm . Mitochondrion . Preferentially expressed in the mitochondria in the presence of TSPO.
• Protein Sequence: MEQLTTLPRPGDPGAMEPWALPTWHSWTPGRGGEPSSAAPSIADTPPAALQLQELRSEESSKPKGDGSSRPVGGTDPEGAEACLPSLGQQASSSGPACQRPEDEEVEAFLKAKLNMSFGDRPNLELLRALGELRQRCAILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERARKLQETNLRVVSAPLPRPGTSLELCRKALARQRARDLSETASALLAKDKQIAALQRECRELQARLTLVGKEGPQWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSLLPAAPEGSRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVNGELRQALGPGAPPKAVLENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWERLEQRAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAPASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDTAELGVHLVNSLVDHGRNSDLSDIQEEEEEEEEEEEEELGSRTCSFQKQVAGNSIRENGAKSQPDPFCETDSDEEILEQILELPLQQFCSKKLFSIPEEEEEEEEDEEEEKSGAGCSSRDPGPPEPALLGLGCDSGQPRRPGQCPLSPESSRAGDCLEDMPGLVGGSSRRRGGGSPEKPPSRRRPPDPREHCSRLLSNNGPQASGRLGPTRERGGLPVIEGPRTGLEASGRGRLGPSRRCSRGRALEPGLASCLSPKCLEISIEYDSEDEQEAGSGGISITSSCYPGDGEAWGTATVGRPRGPPKANSGPKPYPRLPAWEKGEPERRGRSATGRAKEPLSRATETGEARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDREPRTPQAESQRTRRRRVQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
155	Phosphorylation	RKSSFPETEEKVRRL HHCCCCHHHHHHHHH	50.08	-
174	Methylation	AELAVIAKRLEERAR HHHHHHHHHHHHHHH	46.52	24129315
174	Trimethylation	AELAVIAKRLEERAR HHHHHHHHHHHHHHH	46.52	-
192	Phosphorylation	ETNLRVVSAPLPRPG HCCCEEEECCCCCCC	22.70	-
200	Phosphorylation	APLPRPGTSLELCRK CCCCCCCCCHHHHHH	32.59	-
201	Phosphorylation	PLPRPGTSLELCRKA CCCCCCCCHHHHHHH	26.26	-
387	Phosphorylation	ARLVEENSRLSGRAT HHHHHHHHCCCCCCC	37.57	30576142
461	Phosphorylation	EHEQARLSLREKQEE HHHHHHHHHHHHHHH	21.59	23532336
574	Phosphorylation	DLDLPPGSPGRCTPK CCCCCCCCCCCCCCC	29.92	30001349
579	Phosphorylation	PGSPGRCTPKSSEPA CCCCCCCCCCCCCCC	32.18	29759185
582	Phosphorylation	PGRCTPKSSEPAPAT CCCCCCCCCCCCCCC	40.93	29759185
583	Phosphorylation	GRCTPKSSEPAPATL CCCCCCCCCCCCCCC	54.44	23911959
589	Phosphorylation	SSEPAPATLTGVPRR CCCCCCCCCCCCCHH	24.64	23911959
591	Phosphorylation	EPAPATLTGVPRRTA CCCCCCCCCCCHHHH	31.60	29759185
603	Phosphorylation	RTAKKAESLSNSSHS HHHHHHHHHCCCCCC	41.79	28555341
612	Phosphorylation	SNSSHSESIHNSPKS CCCCCCHHHCCCCCC	31.96	28555341
1082	Phosphorylation	TPALAPASLPARVSC CCCCCCCCCCCCCCC	33.55	24719451
1091	Phosphorylation	PARVSCPSPHPSPEA CCCCCCCCCCCCHHH	39.92	28450419
1095	Phosphorylation	SCPSPHPSPEARAPL CCCCCCCCHHHCCCC	32.13	27732954
1134	Phosphorylation	PPGAPPASPSREMAK CCCCCCCCCCHHHHC	29.22	28348404
1136	Phosphorylation	GAPPASPSREMAKGS CCCCCCCCHHHHCCC	38.08	-
1204	Phosphorylation	EACPASSSTQGARAQ CCCCCCCCCCCHHHH	23.43	-
1205	Phosphorylation	ACPASSSTQGARAQQ CCCCCCCCCCHHHHC	32.73	-
1255	Phosphorylation	LVDHGRNSDLSDIQE HHHCCCCCCHHHHHH	38.27	-
1279	Phosphorylation	EEELGSRTCSFQKQV HHHHHHCCHHHHHHH	17.75	-
1298	Phosphorylation	IRENGAKSQPDPFCE HHCCCCCCCCCCCCC	46.54	-
1383	Phosphorylation	RPGQCPLSPESSRAG CCCCCCCCCCCCCCC	16.27	28450419
1386	Phosphorylation	QCPLSPESSRAGDCL CCCCCCCCCCCCCCC	28.63	28450419
1387	Phosphorylation	CPLSPESSRAGDCLE CCCCCCCCCCCCCCC	25.20	24719451
1460	Phosphorylation	PVIEGPRTGLEASGR CEEECCCCCCCCCCC	49.61	-
1465	Phosphorylation	PRTGLEASGRGRLGP CCCCCCCCCCCCCCC	21.46	-
1473	Phosphorylation	GRGRLGPSRRCSRGR CCCCCCCCCCCCCCC	30.47	-
1491	Phosphorylation	PGLASCLSPKCLEIS CCHHHHCCCHHEEEE	27.00	20860994
1576	Phosphorylation	GRAKEPLSRATETGE CCCCCCCCCCCCCCC	30.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIMB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIMB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIMB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSPO_HUMAN	TSPO	physical	9915832
RIMB1_HUMAN	BZRAP1	physical	24722188
DISC1_HUMAN	DISC1	physical	24722188
DLX2_HUMAN	DLX2	physical	24722188
BEND5_HUMAN	BEND5	physical	24722188
CEP76_HUMAN	CEP76	physical	24722188
GASP2_HUMAN	GPRASP2	physical	24722188
REL_HUMAN	REL	physical	24722188
ITF2_HUMAN	TCF4	physical	24722188
T22D4_HUMAN	TSC22D4	physical	24722188

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.