DLX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLX2_HUMAN
• UniProt AC: Q07687
• Protein Name: Homeobox protein DLX-2
• Gene Name: DLX2
• Organism: Homo sapiens (Human).
• Sequence Length: 328
• Subcellular Localization: Nucleus .
• Protein Description: Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis..
• Protein Sequence: MTGVFDSLVADMHSTQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSPANNEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPPCASPPVSAPASWDFGVPQRMAGGGGPGSGGSGAGSSGSSPSSAASAFLGNYPWYHQTSGSASHLQATAPLLHPTQTPQPHHHHHHHGGGGAPVSAGTIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
122	Phosphorylation	AYTSYAPYGTSSSPA EEEECCCCCCCCCCC	25.51	18669648
127	Phosphorylation	APYGTSSSPANNEPE CCCCCCCCCCCCCCC	28.00	-
157	Phosphorylation	KKVRKPRTIYSSFQL CCCCCCCCHHHHHHH	32.56	24114839
159	Phosphorylation	VRKPRTIYSSFQLAA CCCCCCHHHHHHHHH	9.54	24114839
160	Phosphorylation	RKPRTIYSSFQLAAL CCCCCHHHHHHHHHH	22.33	24114839
161	Phosphorylation	KPRTIYSSFQLAALQ CCCCHHHHHHHHHHH	10.47	24114839
173	Ubiquitination	ALQRRFQKTQYLALP HHHHHHHHHHHHCCH	34.58	21890473
173	Ubiquitination	ALQRRFQKTQYLALP HHHHHHHHHHHHCCH	34.58	21890473
173	Ubiquitination	ALQRRFQKTQYLALP HHHHHHHHHHHHCCH	34.58	21890473
213	Phosphorylation	KFKKMWKSGEIPSEQ HHHHHHHCCCCCCCC	26.58	26074081
218	Phosphorylation	WKSGEIPSEQHPGAS HHCCCCCCCCCCCCC	56.39	28387310
225	Phosphorylation	SEQHPGASASPPCAS CCCCCCCCCCCCCCC	34.88	30576142
227	Phosphorylation	QHPGASASPPCASPP CCCCCCCCCCCCCCC	27.21	22617229
232	Phosphorylation	SASPPCASPPVSAPA CCCCCCCCCCCCCCC	36.13	22617229
236	Phosphorylation	PCASPPVSAPASWDF CCCCCCCCCCCCCCC	34.02	26074081
240	Phosphorylation	PPVSAPASWDFGVPQ CCCCCCCCCCCCCCC	26.56	26074081
257	Phosphorylation	AGGGGPGSGGSGAGS CCCCCCCCCCCCCCC	43.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DLX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MSX1_HUMAN	MSX1	physical	9111364
MSX2_HUMAN	MSX2	physical	9111364
DLX2_HUMAN	DLX2	physical	9111364
DLX5_HUMAN	DLX5	physical	9111364
HXC8_HUMAN	HOXC8	physical	9111364
P85A_HUMAN	PIK3R1	physical	21988832
GRN_HUMAN	GRN	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227 AND SER-232, ANDMASS SPECTROMETRY.
PubMed: 18220336