dbPTM

DLX5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DLX5_HUMAN
UniProt AC	P56178
Protein Name	Homeobox protein DLX-5
Gene Name	DLX5
Organism	Homo sapiens (Human).
Sequence Length	289
Subcellular Localization	Nucleus .
Protein Description	Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding..
Protein Sequence	MTGVFDRRVPSIRSGDFQAPFQTSAAMHHPSQESPTLPESSATDSDYYSPTGGAPHGYCSPTSASYGKALNPYQYQYHGVNGSAGSYPAKAYADYSYASSYHQYGGAYNRVPSATNQPEKEVTEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYTSAASSINSHLPPPGSLQHPLALASGTLY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	MHHPSQESPTLPESS CCCCCCCCCCCCCCC	18.62	-
60	Phosphorylation	GAPHGYCSPTSASYG CCCCCCCCCCCCCCH	23.80	-
66	Phosphorylation	CSPTSASYGKALNPY CCCCCCCCHHCCCCE	23.51	-
142	Phosphorylation	KKVRKPRTIYSSFQL CCCCCCCCHHHHHHH	32.56	24114839
144	Phosphorylation	VRKPRTIYSSFQLAA CCCCCCHHHHHHHHH	9.54	24114839
145	Phosphorylation	RKPRTIYSSFQLAAL CCCCCHHHHHHHHHH	22.33	24114839
146	Phosphorylation	KPRTIYSSFQLAALQ CCCCHHHHHHHHHHH	10.47	24114839
158	Ubiquitination	ALQRRFQKTQYLALP HHHHHHHHHHHHCCH	34.58	2189047
158	Ubiquitination	ALQRRFQKTQYLALP HHHHHHHHHHHHCCH	34.58	21890473
173	Phosphorylation	ERAELAASLGLTQTQ HHHHHHHHCCCCHHH	19.84	22964224
179	Phosphorylation	ASLGLTQTQVKIWFQ HHCCCCHHHHHHHHH	30.05	22964224
217	Phosphorylation	SDPMACNSPQSPAVW CCCCCCCCCCCCCCC	24.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
34	S	Phosphorylation	Kinase	MAPK14	Q16539	Uniprot
217	S	Phosphorylation	Kinase	MAPK14	Q16539	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
34	S	Phosphorylation	-
Phosphorylation of Ser-34 and Ser-217 by MAPK14 enhances its transcriptional activity.
217	S	Phosphorylation	-
Phosphorylation of Ser-34 and Ser-217 by MAPK14 enhances its transcriptional activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DLX5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MSX1_HUMAN	MSX1	physical	9111364
MSX2_HUMAN	MSX2	physical	9111364
DLX2_HUMAN	DLX2	physical	9111364
DLX5_HUMAN	DLX5	physical	9111364
HXC8_HUMAN	HOXC8	physical	9111364

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DLX5_HUMAN

Related Literatures of Post-Translational Modification