MSX2_HUMAN - dbPTM
MSX2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSX2_HUMAN
UniProt AC P35548
Protein Name Homeobox protein MSX-2
Gene Name MSX2
Organism Homo sapiens (Human).
Sequence Length 267
Subcellular Localization Nucleus.
Protein Description Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter..
Protein Sequence MASPSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEERRVKVSSLPFSVEALMSDKKPPKEASPLPAESASAGATLRPLLLSGHGAREAHSPGPLVKPFETASVKSENSEDGAAWMQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSSFSLPFPISSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASPSKGNDL
-----CCCCCCCCCC		28.5425849741
5Phosphorylation---MASPSKGNDLFS
---CCCCCCCCCCCC		51.1825849741
12PhosphorylationSKGNDLFSPDEEGPA
CCCCCCCCCCCCCCE		38.4425841592
43PhosphorylationEERRVKVSSLPFSVE
HHHCEEECCCCCCHH		22.0529083192
44PhosphorylationERRVKVSSLPFSVEA
HHCEEECCCCCCHHH		42.9529083192
48PhosphorylationKVSSLPFSVEALMSD
EECCCCCCHHHHHCC		19.6729083192
54PhosphorylationFSVEALMSDKKPPKE
CCHHHHHCCCCCCCC		47.3229083192
63PhosphorylationKKPPKEASPLPAESA
CCCCCCCCCCCHHHH		28.2325849741
91PhosphorylationHGAREAHSPGPLVKP
CCCCCCCCCCCCCCC		38.3030278072
122PhosphorylationWMQEPGRYSPPPRHM
HHCCCCCCCCCCCCC		31.2928985074
123PhosphorylationMQEPGRYSPPPRHMS
HCCCCCCCCCCCCCC		29.5725849741
130PhosphorylationSPPPRHMSPTTCTLR
CCCCCCCCCCCCCCC		16.9924719451
135PhosphorylationHMSPTTCTLRKHKTN
CCCCCCCCCCCCCCC		27.7522633971
141PhosphorylationCTLRKHKTNRKPRTP
CCCCCCCCCCCCCCC		39.7222633971
160AcetylationQLLALERKFRQKQYL
HHHHHHHHHHHHHHH		35.2124469431
164AcetylationLERKFRQKQYLSIAE
HHHHHHHHHHHHHHH		36.3324469439
207UbiquitinationLQEAELEKLKMAAKP
HHHHHHHHHHHHHCC		67.0622817900
209UbiquitinationEAELEKLKMAAKPML
HHHHHHHHHHHCCCC		37.2522817900
218PhosphorylationAAKPMLPSSFSLPFP
HHCCCCCCCCCCCCC		39.8025002506
219PhosphorylationAKPMLPSSFSLPFPI
HCCCCCCCCCCCCCC		19.5425002506
221PhosphorylationPMLPSSFSLPFPISS
CCCCCCCCCCCCCCC		36.7625002506
227PhosphorylationFSLPFPISSPLQAAS
CCCCCCCCCCCHHHH		26.5825002506
228PhosphorylationSLPFPISSPLQAASI
CCCCCCCCCCHHHHH		30.2825002506
234PhosphorylationSSPLQAASIYGASYP
CCCCHHHHHHCCCCC		21.2525002506
236PhosphorylationPLQAASIYGASYPFH
CCHHHHHHCCCCCCC		12.2525002506
239PhosphorylationAASIYGASYPFHRPV
HHHHHCCCCCCCCCC		29.0425002506
240PhosphorylationASIYGASYPFHRPVL
HHHHCCCCCCCCCCC		14.9125002506
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
135TPhosphorylationKinasePRKCBP05771
GPS
141TPhosphorylationKinasePRKCBP05771
GPS
-KUbiquitinationE3 ubiquitin ligaseFBXW2Q9UKT8
PMID:31548378
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSX2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSX2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CEBPA_HUMANCEBPAphysical
12925529
MSX1_HUMANMSX1physical
9111364
MSX2_HUMANMSX2physical
9111364
DLX2_HUMANDLX2physical
9111364
DLX5_HUMANDLX5physical
9111364
T2FA_HUMANGTF2F1physical
9265625
T2FB_HUMANGTF2F2physical
9265625
OBF1_HUMANPOU2AF1physical
20211142
PPARG_HUMANPPARGphysical
20211142
TLE1_HUMANTLE1physical
20211142
TLE2_HUMANTLE2physical
20211142
ZDHC2_HUMANZDHHC2physical
20211142
PIAS2_HUMANPIAS2physical
9256341
HBS1L_HUMANHBS1Lphysical
26186194
ZN703_HUMANZNF703physical
26186194
ANR40_HUMANANKRD40physical
28514442
ZN703_HUMANZNF703physical
28514442
HBS1L_HUMANHBS1Lphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
168500Parietal foramina 1 (PFM1)
168550Parietal foramina with cleidocranial dysplasia (PFMCCD)
604757Craniosynostosis 2 (CRS2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSX2_HUMAN

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