OBF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OBF1_HUMAN
• UniProt AC: Q16633
• Protein Name: POU domain class 2-associating factor 1
• Gene Name: POU2AF1
• Organism: Homo sapiens (Human).
• Sequence Length: 256
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers..
• Protein Sequence: MLWQKPTAPEQAPAPARPYQGVRVKEPVKELLRRKRGHASSGAAPAPTAVVLPHQPLATYTTVGPSCLDMEGSVSAVTEEAALCAGWLSQPTPATLQPLAPWTPYTEYVPHEAVSCPYSADMYVQPVCPSYTVVGPSSVLTYASPPLITNVTTRSSATPAVGPPLEGPEHQAPLTYFPWPQPLSTLPTSTLQYQPPAPALPGPQFVQLPISIPEPVLQDMEDPRRAASSLTIDKLLLEEEDSDAYALNHTLSVEGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLWQKPTAPEQAPA -CCCCCCCCCCCCCC	62.98	-
19	Phosphorylation	APAPARPYQGVRVKE CCCCCCCCCCCCCCH	16.61	-
29	Ubiquitination	VRVKEPVKELLRRKR CCCCHHHHHHHHHHC	54.05	-
40	Phosphorylation	RRKRGHASSGAAPAP HHHCCCCCCCCCCCC	24.51	-
130	O-linked_Glycosylation	YVQPVCPSYTVVGPS EEECCCCCCEEECCH	28.45	29351928
184	Phosphorylation	FPWPQPLSTLPTSTL CCCCCCCCCCCCCCC	34.28	9211847
228	Phosphorylation	EDPRRAASSLTIDKL CCHHHHHHHCCHHHH	25.54	28348404
242	Phosphorylation	LLLEEEDSDAYALNH HHCCCCCCCCHHHCC	27.67	28674151
245	Phosphorylation	EEEDSDAYALNHTLS CCCCCCCHHHCCCEE	19.33	28674151
252	Phosphorylation	YALNHTLSVEGF--- HHHCCCEEECCC---	21.19	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH2	O43255	PMID:11483517
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH1	Q8IUQ4	PMID:11483517

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OBF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OBF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PO2F1_HUMAN	POU2F1	physical	10541551
PO2F1_HUMAN	POU2F1	physical	9418884
PO2F1_HUMAN	POU2F1	physical	11380252
SIAH1_HUMAN	SIAH1	physical	11483517
SIAH1_HUMAN	SIAH1	genetic	11483517
TCP4_HUMAN	SUB1	physical	9632764
PAX8_HUMAN	PAX8	physical	20211142
RHXF2_HUMAN	RHOXF2	physical	20211142
GTF2I_HUMAN	GTF2I	physical	21549311
SIAH1_HUMAN	SIAH1	physical	11483518
ATE1_HUMAN	ATE1	physical	26186194
ATE1_HUMAN	ATE1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.